References
- GibbsJBMechanism-based target identification and drug discovery in cancer researchScience200028754601969197310720316
- WHO Media Centre [webpage on the Internet]Fast sheet Nº 2972013 Available from: http://www.who.int/mediacentre/factsheets/fs297/en/index.htmlAccessed February 4, 2014
- [webpage on the Internet]Globocan Fast Stats2008 Available from: http://www.iarc.fr/en/media-centre/iarcnews/2010/globocan2008.phpAccessed August 4, 2013
- NewmanDJCraggGMSnaderKMThe influence of natural products upon drug discoveryNat Prod Rep200017321523410888010
- HostettmannKTerreauxCSearch for new lead compounds from higher plantsChimia20005411652657
- SaklaniAKuttySKPlant-derived compounds in clinical trialsDrug Discov Today200813316117118275914
- SalimAAChinYWKinghornADDrug discovery from plantsRamawatKGMerillonJMBioactive Molecules and Medicinal PlantsHeidelbergSpringer2008124
- KinghornADPanLFletcherJNChaiHThe relevance of higher plants in lead compound discovery programsJ Nat Prod20117461539155521650152
- GrothausPGCraggGMNewmanDJPlant natural products in anticancer drug discoveryCurr Org Chem2010141617811791
- AshutoshKMedicinal ChemistryNew Delhi, IndiaNew Age International Ltd2007794
- DesaiAGQaziGNGanjuRKMedicinal plants and cancer chemopreventionCurr Drug Metab20089758159118781909
- HeinrichMBremnerPEthnobotany and ethnopharmacy – their role for anti-cancer drug developmentCurr Drug Targets20067323924516515525
- CraggGMNewmanDJNature: a vital source of leads for anticancer drug developmentPhytochem Rev200982313331
- HollósyFKériGPlant-derived protein tyrosine kinase inhibitors as anticancer agentsCurr Med Chem Anticancer Agents20044217319715032721
- ClardyJWalshCLessons from natural moleculesNature2004432701982983715602548
- ReddyLOdhavBBhoolaKDNatural products for cancer prevention: a global perspectivePharmacol Ther200399111312804695
- LucasDMStillPCPérezLBGreverMRKinghornADPotential of plant-derived natural products in the treatment of leukemia and lymphomaCurr Drug Targets201011781282220370646
- WangHKLeeKHPlant-derived anticancer agents and their analogs currently in clinical use or in clinical trialsBot Bull Acad Sinica199738225235
- PanLChaiHKinghornADThe continuing search for antitumor agents from higher plantsPhytochem Lett2010311820228943
- CraggGMNewmanDJPlants as a source of anti-cancer agentsJ Ethnopharmacol20051001727916009521
- BalunasMJKinghornADDrug discovery from medicinal plantsLife Sci200578543144116198377
- SrivastavaVNegiASKumarJKGuptaMMKhanujaSPPlant-based anticancer molecules: a chemical and biological profile of some important leadsBioorg Med Chem200513215892590816129603
- CraggGMGrothausPGNewmanDJImpact of natural products on developing new anti-cancer agentsChem Rev200910973012304319422222
- Gurib-FakimAMedicinal plants: traditions of yesterday and drugs of tomorrowMol Aspects Med200627119316105678
- NobiliSLippiDWitortENatural compounds for cancer treatment and preventionPharmacol Res200959636537819429468
- LeeKHAnticancer drug design based on plant-derived natural productsJ Biomed Sci19996423625010420081
- GordalizaMNatural products as leads to anticancer drugsClin Transl Oncol200791276777618158980
- ConnorsTAnticancer drug development: the way forwardOncologist19961318018110387985
- FadeyiSAFadeyiOOAdejumoAAOkoroCMylesELIn vitro anticancer screening of 24 locally used Nigerian medicinal plantsBMC Complement Altern Med20131317923565862
- Ntie-KangFZofouDBabiakaSBAfroDb: a select highly potent and diverse natural product library from African medicinal plantsPLoS One2013810e7808524205103
- SawadogoWRSchumacherMTeitenMHDicatoMDiederichMTraditional West African pharmacopeia, plants and derived compounds for cancer therapyBiochem Pharmacol201284101225124022846603
- Ntie-KangFNwodoJNIbezimAMolecular modeling of potential anticancer agents from African medicinal plantsJ Chem Inf Model20145492433245025116740
- Ntie-KangFLifongoLLJudsonPNSipplWEfangeSMNHow “drug-like” are naturally occurring anti-cancer compounds?J Mol Model2014201113
- MangalMSagarPSinghHRaghavaGPAgarwalSMNPACT: naturally occurring plant-based anti-cancer compound-activity-target databaseNucleic Acids Res201341D1D1124D112923203877
- CraggGMNewmanDJPlants as a source of anti-cancer and anti-HIV agentsAnn Appl Biol20031432127133
- NewmanDJCraggGMNatural products as sources of new drugs over the 30 years from 1981 to 2010J Nat Prod201275331133522316239
- NewmanDJCraggGMNatural products as sources of new drugs over the last 25 yearsJ Nat Prod200770346147717309302
- HostettmannKMarstonANdjokoKWolfenderJLThe potential of African plants as a source of drugsCurr Org Chem20004109731010
- SandbergFPerera-IvarssonPEl-SeediHRA Swedish collection of medicinal plants from CameroonJ Ethnopharmacol2005102333634316098698
- El-SeediHRBurmanRMansourAThe traditional medical uses and cytotoxic activities of sixty-one Egyptian plants: discovery of an active cardiac glycoside from Urginea maritimaJ Ethnopharmacol2013145374675723228916
- EfangeSMNNatural products: a continuing source of inspiration for the medicinal chemistIwuMMWoottonJCEthnomedicine and Drug Discovery; Advances in Phytomedicine1Amsterdam, NetherlandsElsevier Science20026169
- DiMasiJAHansenRWGrabowskiHGThe price of innovation: new estimates of drug development costsJ Health Econ200322215118512606142
- KlebeGVirtual ligand screening strategies; perspective and limitationsDrug Discov Today2006111358059416793526
- KubinyiHStructure-based design of enzyme inhibitors and receptor ligandsCurr Opin Drug Discov Devel199811415
- ChenHYaoKNadasJPrediction of molecular targets of cancer preventing flavonoid compounds using computational methodsPLoS One201275e3826122693608
- PaulJGnanamRJayadeepaRMArulLAnti cancer activity on Graviola, an exciting medicinal plant extract vs various cancer cell lines and a detailed computational study on its potent anti-cancerous leadsCurr Top Med Chem201313141666167323889049
- VyasVKGhateMGoelAPharmacophore modeling, virtual screening, docking and in silico ADMET analysis of protein Kinase B (PKB β) inhibitorsJ Mol Graph Model201342172523507201
- FanYShiLMKohnKWPommierYWeinsteinJNQuantitative structure-antitumor activity relationships of camptothecin analogues: cluster analysis and genetic algorithm-based studiesJ Med Chem200144203254326311563924
- ZhouHWuSZhaiSDesign, synthesis, cytoselective toxicity, structure-activity relationships, and pharmacophore of thiazolidinone derivatives targeting drug-resistant lung cancer cellsJ Med Chem20085151242125118257542
- ChiangYKKuoCCWuYSGeneration of ligand-based pharmacophore model and virtual screening for identification of novel tubulin inhibitors with potent anticancer activityJ Med Chem200952144221423319507860
- KimDYKimKHKimNDDesign and biological evaluation of novel tubulin inhibitors as antimitotic agents using a pharmacophore binding model with tubulinJ Med Chem200649195664567016970393
- OjimaIChakravartySInoueTA common pharmacophore for cytotoxic natural products that stabilize microtubulesProc Natl Acad Sci U S A19999684256426110200249
- Pérez-SacauEDíaz-PenãteRGEstévez-BraunASynthesis and pharmacophore modeling of naphthoquinone derivatives with cytotoxic activity in human promyelocytic leukemia HL-60 cell lineJ Med Chem200750469670617249647
- Ntie-KangFMbahJAMbazeLMCamMedNP: building the Cameroonian 3D structural natural products database for virtual screeningBMC Complement Altern Med2013138823590173
- Ntie-KangFOnguénéPAScharfeMConMedNP: a natural product library from medicinal plants in Central AfricaRSC Adv20144409419
- Ntie-KangFAmoa OnguénéPFotsoGWVirtualizing the p-ANAPL library: a step towards drug discovery from African medicinal plantsPLoS One201493e9065524599120
- Ntie-KangFLifongoLLMbahJAIn silico drug metabolism and pharmacokinetic profiles of natural products from medicinal plants in the Congo BasinIn Silico Pharmacol201311225505657
- Ntie-KangFMbahJALifongoLLAssessing the pharmacokinetic profile of the CamMedNP natural products database: an in silico approachOrg Med Chem Lett2013311024229455
- OnguénéPANtie-KangFMbahJAThe potential of anti-malarial compounds derived from African medicinal plants, part III: an in silico evaluation of drug metabolism and pharmacokinetics profilingOrg Med Chem Lett201441626548985
- WolberGLangerTLigandScout: 3D-pharmacophores derived from protein-bound ligands and their use as virtual screening filtersJ Chem Inf Model200545116016915667141
- BermanHMWestbrookJFengZThe protein data bankNucleic Acids Res200028123524210592235
- Chemical Computing Group IncMolecular Operating Environment, Version 2010MontrealChemical Computing Group Inc2010
- HalgrenTAMerck molecular forcefieldJ Comput Chem199617490441
- SchrödingerLLCLigPrep Software, Version 2.5New YorkSchrödinger LLC2011
- MysingerMMCarchiaMIrwinJJShoichetBKDirectory of useful decoys, enhanced (DUD-E): better ligands and decoys for better benchmarkingJ Med Chem201255146582659422716043
- GünerOFHenryDRPharmacophore perception, development, and use in drug designGünerOFMetric for Analyzing Hit Lists and Pharmacophores; IUL Biotechnology SeriesLa Jolla, CAInternational University Line2000191212
- GünerOFWaldmanMHoffmannRDKimJHPharmacophore perception, development, and use in drug designGünerOFStrategies for Database Mining and Pharmacophore DevelopmentIUL Biotechnology Series1st EditionLa Jolla, CAInternational University Line2000213236
- LangerTHoffmannRDPharmacophores and Pharmacophore SearchesWeinheim, GermanyWILEY-VCH2006338340
- Lhasa Limited [webpage on the Internet]Derek Nexus Available from: http://www.lhasalimited.org/products/derek-nexus.htmAccessed May 19, 2015
- WoldSEsbensenKGeladiPPrincipal component analysisChemometr Intell Lab Syst198723752
- LewellXQJuddDBWatsonSPHannMMRECAP – retrosynthetic combinatorial analysis procedure: a powerful new technique for identifying privileged molecular fragments with useful applications in combinatorial chemistryJ Chem Inf Comput Sci19983835115229611787
- ChemAxon [webpage on the Internet]JChem Software, Version 5.11.32012 Available from: https://www.chemaxon.com/jchem/doc/user/LibMCS.htmlAccessed May 19, 2015
- NagarBBornmannWGPellicenaPCrystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571)Cancer Res200262154236424312154025
- WisniewskiDLambekCLLiuCCharacterization of potent inhibitors of the Bcr-Abl and the c-Kit receptor tyrosine kinasesCancer Res200262154244425512154026
- ZimmermannJBuchdungerEMettHMeyerTLydonNBPotent and selective inhibitors of the Abl-kinase: phenylaminopyrimidine (Pap) derivativesBioorg Med Chem Lett19973297187192
- KrakerAJHartlBGAmarAMBarvianMRShowalterHDMooreCWBiochemical and cellular effects of c-Src kinase-selective pyrido[2, 3-d]pyrimidine tyrosine kinase inhibitorsBiochem Pharmacol200060788589810974196
- McHardyTCaldwellJJCheungKMDiscovery of 4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides as selective, orally active inhibitors of protein kinase B (Akt)J Med Chem20105352239224920151677
- CaldwellJJDaviesTGDonaldAIdentification of 4-(4-aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as selective inhibitors of protein kinase B through fragment elaborationJ Med Chem20085172147215718345609
- DonaldAMcHardyTRowlandsMGRapid evolution of 6-phenylpurine inhibitors of protein kinase B through structure-based designJ Med Chem200750102289229217451235
- WangSGriffithsGMidgleyCADiscovery and characterization of 2-anilino-4-(thiazol-5-yl)pyrimidine transcriptional CDK inhibitors as anticancer agentsChem Biol201017101111112121035734
- HastMAFletcherSCummingsCGStructural basis for binding and selectivity of antimalarial and anticancer ethylenediamine inhibitors to protein farnesyltransferaseChem Biol200916218119219246009
- BattistuttaRCozzaGPierreFUnprecedented selectivity and structural determinants of a new class of protein kinase ck2 inhibitors in clinical trials for the treatment of cancerBiochemistry201150398478848821870818
- PierreFStefanENédellecAS7-(4H-1,2,4-triazol-3-yl) benzo[c][2,6]naphthyridines: a novel class of Pim kinase inhibitors with potent cell antiproliferative activityBioorg Med Chem Lett201121226687669221982499
- HouZNakanishiIKinoshitaTStructure-based design of novel potent protein kinase CK2 (CK2) inhibitors with phenyl-azole scaffoldsJ Med Chem20125562899290322339433
- PierreFReganCFChevrelMCNovel potent dual inhibitors of CK2 and Pim kinases with antiproliferative activity against cancer cellsBioorg Med Chem Lett20122293327333122460033
- BergSBerghMHellbergSDiscovery of novel potent and highly selective glycogen synthase kinase-3β (GSK3β) inhibitors for Alzheimer’s disease: design, synthesis, and characterization of pyrazinesJ Med Chem201255219107911922489897
- CoghlanMPCulbertAACrossDASelective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcriptionChem Biol200071079380311033082
- GoodJAWangFRathOOptimized S-trityl-L-cysteine-based inhibitors of kinesin spindle protein with potent in vivo antitumor activity in lung cancer xenograft modelsJ Med Chem20135651878189323394180
- TojoSKohnoTTanakaTCrystal structures and structure-activity relationships of imidazothiazole derivatives as IDO1 inhibitorsACS Med Chem Lett20145101119112325313323
- FawcettTAn introduction to ROC analysisPattern Recognit Lett2006278861874
- YangJMShenTWA Pharmacophore-based evolutionary approach for screening selective estrogen receptor modulatorsProteins200559220522015726586
- MueggeISelection criteria for drug-like compoundsMed Res Rev200323330232112647312
- Ntie-KangFKannanSWichapongKOwono OwonoLCSipplWMegnassanEBinding of pyrazole-based inhibitors to Mycobacterium tuberculosis pantothenate synthetase: docking and MM-GB(PB)SA analysisMol Biosyst201410222323924240974
- LiaoHSLiuHLChenWHHoYStructure-based pharmacophore modeling and virtual screening to identify novel inhibitors for anthrax lethal factorMed Chem Res201423837253732
- KoideYUemotoKHasegawaTPharmacophore-based design of sphingosine 1-phosphate-3 receptor antagonists that include a 3,4-dialkoxybenzophenone scaffoldJ Med Chem200750344245417266196
- LuSHWuJWLiuHLThe discovery of potential acetylcholinesterase inhibitors: a combination of pharmacophore modeling, virtual screening, and molecular docking studiesJ Biomed Sci201118821251245
- SealAYogeeswariPSriramDOSDD ConsortiumWildDJEnhanced ranking of PknB inhibitors using data fusion methodsJ Cheminform201351223317154
- KalvaSAzhagiya SingamERRajapandianVSaleenaLMSubramanianVDiscovery of potent inhibitor for matrix metalloproteinase-9 by pharmacophore based modeling and dynamics simulation studiesJ Mol Graph Model201449253724473069
- SandersonDMEarnshawCGComputer prediction of possible toxic action from chemical structure; the DEREK systemHum Exp Toxicol19911042612731679649
- GreeneNJudsonPNLangowskiJJMarchantCAKnowledge-based expert systems for toxicity and metabolism prediction: DEREK, StAR and METEORSAR QSAR Environ Res1999102–329931410491855
- MarchantCABriggsKALongAIn silico tools for sharing data and knowledge on toxicity and metabolism: Derek for Windows, Meteor, and ViticToxicol Mech Methods2008182–317718720020913
- RidingsJEBarrattMDCaryRComputer prediction of possible toxic action from chemical structure: an update on the DEREK systemToxicology19961061–32672798571398
- GreeneNComputer software for risk assessmentJ Chem Inf Comput Sci1997371148150
- MarchantCAComputational toxicology: a tool for all industriesWiley Interdiscip Rev Comput Mol Sci201223424434
- SherhodRGilletVJJudsonPNVesseyJDAutomating knowledge discovery for toxicity prediction using jumping emerging pattern miningJ Chem Inf Model201252113074308723092382
- HappiENWaffoAFWansiJDNgadjuiBTSewaldNO-prenylated acridone alkaloids from the stems of Balsamocitrus paniculata (Rutaceae)Planta Med201177993493821243586
- TsassiVBHussainHMeffoBYAntimicrobial coumarins from the stem bark of Afraegle paniculataNat Prod Commun20105455956120433072
- WallMEWaniMCHughesTJTaylorHPlant antimutagenic agents, 1. General bioassay and isolation procedureJ Nat Prod19885158668733060564
- ZhangYCaoYZhanYDuanHHeLFuranocoumarins-imperatorin inhibits myocardial hypertrophy both in vitro and in vivoFitoterapia20108181188119520691250
- KhalidHAbdallaWEAbdelgadirHOpatzTEfferthTGems from traditional North-African medicine: medicinal and aromatic plants from SudanNat Prod Bioprospect20122392103
- National Toxicology Program (NTP)Toxicology and carcinogenesis studies of 8-methoxypsoralen (CAS No 298-81-7) in F344/N rats (gavage studies)National Toxicology Program Report, Additional Content: TR-359Chapel Hill, USA1989
- Dall’AcquaFTerbojevichMMarcianiSVedaldiDRecherMInvestigation of the dark interaction between furocoumarins and DNAChem Biol Interact1978211103115566637
- QuintoIAverbeckDMoustacchiEHrisohoZMoronJFrameshift mutagenicity in Salmonella typhimurium of furocoumarins in the darkMutat Res1984136149546371513
- FergusonLRDennyWAThe genetic toxicology of acridinesMutat Res199125821231601881402
- AlbertiniSBösMGockeEKirchnerSMusterWWichmannJSuppression of mutagenic activity of a series of 5HT2c receptor agonists by the incorporation of a gem-dimethyl group: SAR using the Ames test and a DNA unwinding assayMutagenesis19981343974039717178