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Original Research

Pharmacokinetics and relative bioavailability of fixed-dose combination of clopidogrel and aspirin versus coadministration of individual formulations in healthy Korean men

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Pages 3493-3499 | Published online: 25 Oct 2016

References

  • AmsterdamEAWengerNKBrindisRG2014 AHA/ACC guideline for the management of patients with non-ST-elevation acute coronary syndromes: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice GuidelinesCirculation2014130252354239425249586
  • JarvisBSimpsonKClopidogrel: a review of its use in the prevention of atherothrombosisDrugs200060234737710983738
  • VeldersMAAbtanJAngiolilloDJSafety and efficacy of ticagrelor and clopidogrel in primary percutaneous coronary interventionHeart2016102861762526848185
  • BurgerWChemnitiusJMKneisslGDRuckerGLow-dose aspirin for secondary cardiovascular prevention – cardiovascular risks after its perioperative withdrawal versus bleeding risks with its continuation – review and meta-analysisJ Intern Med2005257539941415836656
  • TerpeningCAn appraisal of dual antiplatelet therapy with clopidogrel and aspirin for prevention of cardiovascular eventsJ Am Board Fam Med2009221515619124633
  • ZhangQWangCZhengMAspirin plus clopidogrel as secondary prevention after stroke or transient ischemic attack: a systematic review and meta-analysisCerebrovasc Dis2015391132225547900
  • DeharoPQuiliciJBonnetGFixed-dose aspirin-clopidogrel combination enhances compliance to aspirin after acute coronary syndromeInt J Cardiol20141721e1e224438924
  • WertheimerAIThe economics of polypharmacology: fixed dose combinations and drug cocktailsCurr Med Chem201320131635163823410163
  • CaplainHDonatFGaudCNecciariJPharmacokinetics of clopidogrelSemin Thromb Hemost199925Suppl 2252810440419
  • Ministry of Food and Drug SafetyKorea Good Clinical Practice GuidelineChungcheongbuk-do, South KoreaMFDS2011 Korean
  • BenedekIHJoshiASPieniaszekHJKingSYKornhauserDMVariability in the pharmacokinetics and pharmacodynamics of low dose aspirin in healthy male volunteersJ Clin Pharmacol19953512118111868750369
  • US Food and Drug AdministrationGuidance for Industry: Statistical Approaches to Establishing BioequivalenceSilver Springs, MDFDA2001
  • ZhangHLauWCHollenbergPFFormation of the thiol conjugates and active metabolite of clopidogrel by human liver microsomesMol Pharmacol201282230230922584220
  • DubovskaDPiotrovskijVKGajdosMKrivosikovaZSpustovaVTrnovecTPharmacokinetics of acetylsalicylic acid and its metabolites at low doses: a compartmental modelingMethods Find Exp Clin Pharmacol199517167777623523
  • BaeSKSeoKAJungEJDetermination of acetylsalicylic acid and its major metabolite, salicylic acid, in human plasma using liquid chromatography-tandem mass spectrometry: application to pharmacokinetic study of Astrix in Korean healthy volunteersBiomed Chromatogr200822659059518254152
  • JungJAKimTEKimJRThe pharmacokinetics and safety of a fixed-dose combination of acetylsalicylic acid and clopidogrel compared with the concurrent administration of acetylsalicylic acid and clopidogrel in healthy subjects: a randomized, open-label, 2-sequence, 2-period, single-dose crossover studyClin Ther201335798599423870608
  • TangMMukundanMYangJAntiplatelet agents aspirin and clopidogrel are hydrolyzed by distinct carboxylesterases, and clopidogrel is transesterificated in the presence of ethyl alcoholJ Pharmacol Exp Ther200631931467147616943252
  • SwigerKJYousufOBlidenKPTantryUSGurbelPACigarette smoking and clopidogrel interactionCurr Cardiol Rep201315536123591705
  • HolmesMVPerelPShahTHingoraniADCasasJPCYP2C19 genotype, clopidogrel metabolism, platelet function, and cardiovascular events: a systematic review and meta-analysisJAMA2011306242704271422203539
  • XheliliEEichelbergerBKoppCWKoppensteinerRPanzerSGremmelTThe antiplatelet effect of clopidogrel decreases with patient ageAngiology Epub292016
  • MareeAOFitzgeraldDJVariable platelet response to aspirin and clopidogrel in atherothrombotic diseaseCirculation2007115162196220717452618