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Review

Spotlight on dupilumab in the treatment of atopic dermatitis: design, development, and potential place in therapy

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Pages 1473-1480 | Published online: 15 May 2017

References

  • ShawTECurrieGPKoudelkaCWSimpsonELEczema prevalence in the United States: data from the 2003 National Survey of Children’s HealthJ Invest Dermatol20111311 67 7320739951
  • OdhiamboJAWilliamsHCClaytonTORobertsonCFAsherMIISAAC Phase Three Study GroupGlobal variations in prevalence of eczema symptoms in children from ISAAC Phase ThreeJ Allergy Clin Immunol20091246 1251 1258.e2320004783
  • BosJDBrenninkmeijerEESchramMEMiddelkamp-HupMASpulsPISmittJHAtopic eczema or atopiform dermatitisExp Dermatol2010194 325 33120100192
  • BieberTAtopic dermatitisAnn Dermatol2010222 125 13720548901
  • MalajianDGuttman-YasskyENew pathogenic and therapeutic paradigms in atopic dermatitisCytokine2015732 311 31825542094
  • LeungDYGuttman-YasskyEDeciphering the complexities of atopic dermatitis: shifting paradigms in treatment approachesJ Allergy Clin Immunol20141344 769 77925282559
  • RomagnaniSThe increased prevalence of allergy and the hygiene hypothesis: missing immune deviation, reduced immune suppression, or both?Immunology20041123 352 36315196202
  • GarnHRenzHEpidemiological and immunological evidence for the hygiene hypothesisImmunobiology20072126 441 45217544829
  • GittlerJKKruegerJGGuttman-YasskyEAtopic dermatitis results in intrinsic barrier and immune abnormalities: implications for contact dermatitisJ Allergy Clin Immunol20131312 300 31322939651
  • SeidenariSGiustiGObjective assessment of the skin of children affected by atopic dermatitis: a study of pH, capacitance and TEWL in eczematous and clinically uninvolved skinActa Derm Venereol1995756 429 4338651017
  • Guttman-YasskyESuárez-FariñasMChiricozziABroad defects in epidermal cornification in atopic dermatitis identified through genomic analysisJ Allergy Clin Immunol20091246 1235 1244.e5820004782
  • Guttman-YasskyEKruegerJGPsoriasis: evolution of pathogenic concepts and new therapies through phases of translational researchBr J Dermatol20071576 1103 111517714560
  • Suárez-FariñasMTintleSJShemerANonlesional atopic dermatitis skin is characterized by broad terminal differentiation defects and variable immune abnormalitiesJ Allergy Clin Immunol20111274 954 964 e1 e421388663
  • BoguniewiczMLeungDYAtopic dermatitis: a disease of altered skin barrier and immune dysregulationImmunol Rev20112421 233 24621682749
  • FujitaHThe role of IL-22 and Th22 cells in human skin diseasesJ Dermatol Sci2013721 3 823746568
  • NogralesKEZabaLCShemerAIL-22-producing “T22” T cells account for upregulated IL-22 in atopic dermatitis despite reduced IL-17-producing TH17 T cellsJ Allergy Clin Immunol20091236 1244 1252.e219439349
  • ZhengYDanilenkoDMValdezPInterleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosisNature20074457128 648 65117187052
  • KaminishiKSomaYKawaYMizoguchiMFlow cytometric analysis of IL-4, IL-13 and IFN-gamma expression in peripheral blood mono-nuclear cells and detection of circulating IL-13 in patients with atopic dermatitis provide evidence for the involvement of type 2 cytokines in the diseaseJ Dermatol Sci2002291 19 2512007717
  • AkkocTde KoningPJRückertBBarlanIAkdisMAkdisCAIncreased activation-induced cell death of high IFN-gammaproducing T(H)1 cells as a mechanism of T(H)2 predominance in atopic diseasesJ Allergy Clin Immunol20081213 652 658.e118328893
  • Suárez-FariñasMDhingraNGittlerJIntrinsic atopic dermatitis shows similar TH2 and higher TH17 immune activation compared with extrinsic atopic dermatitisJ Allergy Clin Immunol20131322 361 37023777851
  • FlohrCMannJNew insights into the epidemiology of childhood atopic dermatitisAllergy2014691 3 1624417229
  • GooderhamMLyndeCWPappKReview of systemic treatment options for adult atopic dermatitisJ Cutan Med Surg2017211 31 3927635033
  • BieberTAtopic dermatitis 2.0: from the clinical phenotype to the molecular taxonomy and stratified medicineAllergy20126712 1475 148223106343
  • D’ErmeAMWilsmann-TheisDWagenpfeilJIL-36γ (IL-1F9) is a biomarker for psoriasis skin lesionsJ Invest Dermatol20151354 1025 103225525775
  • HelloMAubertHBernierCNéelABarbarotSAtopic dermatitis of the adultRev Med Interne2016372 91 9926617291
  • BieberTD’ErmeAMAkdisCClinical phenotypes and endophenotypes of atopic dermatitis: Where are we and where should we go?J Alllergy Clin Immunol20171394S S58 S64
  • BieberTAkdisCLauenerRGlobal Allergy Forum and 3rd Davos Declaration 2015: atopic dermatitis/eczema: challenges and opportunities toward precision medicineAllergy2016715 588 59227023268
  • MansouriYGuttman-YasskyEImmune pathways in atopic dermatitis, and definition of biomarkers through broad and targeted therapeuticsJ Clin Med201545 858 87326239452
  • WollenbergAOranjeADeleuranMEuropean Task Force on Atopic Dermatitis/EADV Eczema Task ForceETFAD/EADV eczema task force 2015 position paper on diagnosis and treatment of atopic dermatitis in adult and paediatric patientsJ Eur Acad Dermatol Venereol2016305 729 74727004560
  • RingJAlomarABieberTEuropean Dermatology Forum (EDF)European Academy of Dermatology and Venereology (EADV)European Federation of Allergy (EFA)European Task Force on Atopic Dermatitis (ETFAD)European Society of Pediatric Dermatology (ESPD)Global Allergy and Asthma European Network (GA2LEN)Guidelines for treatment of atopic eczema (atopic dermatitis) part IJ Eur Acad Dermatol Venereol2012268 1045 106022805051
  • RingJAlomarABieberTEuropean Dermatology ForumEuropean Academy of Dermatology and VenereologyEuropean Task Force on Atopic DermatitisEuropean Federation of AllergyEuropean Society of Pediatric DermatologyGlobal Allergy and Asthma European NetworkGuidelines for treatment of atopic eczema (atopic dermatitis) Part IIJ Eur Acad Dermatol Venereol2012269 1176 119322813359
  • D’ErmeAMHohlDUse of emollient in atopic dermatitis preventionDermatol Ther2016294 286 28726950266
  • McGregorSFarhangianMEFeldmanSRDupilumab for the treatment of atopic dermatitis: a clinical trial reviewExpert Opin Biol Ther20151511 1657 1660
  • NotaroERSidburyRSystemic agents for severe atopic dermatitis in childrenPaediatr Drugs2015176 449 45726547214
  • BiedermannTWerfelTStatus quo and prospects for systemic therapy of atopic dermatitis. Biologics ante portasHautarzt2015662 108 11325645542
  • D’ErmeAMThe beginning of biological treatment era in the atopic dermatitis managementDermatol Ther2016293 208 20926331894
  • LaufferFRingJTarget-oriented therapy: emerging drugs for atopic dermatitisExpert Opin Emerg Drugs2016211 81 8926808004
  • WangHHLiYCHuangYCEfficacy of omalizumab in patients with atopic dermatitis: a systematic review and meta-analysisJ Allergy Clin Immunol20161386 1719 1722.e127543070
  • OldhoffJMDarsowUWerfelTAnti-IL-5 recombinant humanized monoclonal antibody (mepolizumab) for the treatment of atopic dermatitisAllergy2005605 693 69615813818
  • BlakelyKGooderhamMPappKDupilumab, a monoclonal antibody for atopic dermatitis: a review of current literatureSkin Therapy Lett2016212 1 5
  • KovalenkoPDiCioccioATDavisJDExploratory population PK analysis of dupilumab, a fully human monoclonal antibody against IL-4Rα, in atopic dermatitis patients and normal volunteersCPT Pharmacometrics Syst Pharmacol2016511 617 62427778477
  • HamiltonJDSuárez-FariñasMDhingraNDupilumab improves the molecular signature in skin of patients with moderate-to-severe atopic dermatitisJ Allergy Clin Immunol20141346 1293 130025482871
  • BeckLAThaçiDHamiltonJDDupilumab treatment in adults with moderate-to-severe atopic dermatitisN Engl J Med20143712 130 13925006719
  • ThaçiDSimpsonELBeckLAEfficacy and safety of dupilumab in adults with moderate-to-severe atopic dermatitis inadequately controlled by topical treatments: a randomised, placebo-controlled, dose-ranging phase 2b trialLancet201638710013 40 5226454361
  • SimpsonELGadkariAWormMDupilumab therapy provides clinically meaningful improvement in patient-reported outcomes (PROs): a phase IIb, randomized, placebo-controlled, clinical trial in adult patients with moderate to severe atopic dermatitis (AD)J Am Acad Dermatol2016753 506 51527268421
  • WollenbergABieberTProactive therapy of atopic dermatitis – an emerging conceptAllergy2009642 276 27819076538
  • HamiltonJDUngarBGuttman-YasskyEDrug evaluation review: dupilumab in atopic dermatitisImmunotherapy2015710 1043 105826598956
  • SimpsonELBieberTGuttman-YasskyESOLO 1 and SOLO 2 InvestigatorsTwo phase 3 trials of dupilumab versus placebo in atopic dermatitisN Engl J Med201637524 2335 234827690741
  • SantiniGMoresNMalerbaMDupilumab for the treatment of asthmaExpert Opin Investig Drugs2017263 357 366
  • OzdemirCMonoclonal antibodies in allergy; updated applications and promising trialsRecent Pat Inflamm Allergy Drug Discov201591 54 6525706526