Investigation of triamterene as an inhibitor of the TGR5 receptor: identification in cells and animals

References

• KawamataYFujiiRHosoyaMA G protein-coupled receptor responsive to bile acidsJ Biol Chem200327811 9435 944012524422
   PubMed Web of Science ®Google Scholar
• MaruyamaTMiyamotoYNakamuraTIdentification of membrane-type receptor for bile acids (M-BAR)Biochem Biophys Res Commun20022985 714 71912419312
   PubMed Web of Science ®Google Scholar
• PolsTWNoriegaLGNomuraMAuwerxJSchoonjansKThe bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammationJ Hepatol2011546 1263 127221145931
   PubMed Web of Science ®Google Scholar
• PierceKLPremontRTLefkowitzRJSeven-transmembrane receptorsNat Rev Mol Cell Biol200239 639 65012209124
   PubMed Web of Science ®Google Scholar
• ReimannFHabibAMTolhurstGParkerHERogersGJGribbleFMGlucose sensing in L cells: a primary cell studyCell Metab200886 532 53919041768
   PubMed Web of Science ®Google Scholar
• PrawittJCaronSStaelsBBile acid metabolism and the pathogenesis of type 2 diabetesCurr Diab Rep2011113 160 16621431855
   PubMed Web of Science ®Google Scholar
• CoppleBLLiTPharmacology of bile acid receptors: evolution of bile acids from simple detergents to complex signaling moleculesPharmacol Res2016104 9 2126706784
   PubMed Web of Science ®Google Scholar
• AgarwalSPatilAAwareUDiscovery of a potent and orally efficacious TGR5 receptor agonistACS Med Chem Lett201671 51 5526819665
   PubMed Web of Science ®Google Scholar
• AlemiFKwonEPooleDPThe TGR5 receptor mediates bile acid-induced itch and analgesiaJ Clin Invest20131234 1513 153023524965
   PubMed Web of Science ®Google Scholar
• BriereDARuanXChengCCNovel Small Molecule Agonist of TGR5 Possesses Anti-Diabetic Effects but Causes Gallbladder Filling in MicePLoS One2015108 e013687326312995
   PubMed Web of Science ®Google Scholar
• ReichMDeutschmannKSommerfeldATGR5 is essential for bile acid-dependent cholangiocyte proliferation in vivo and in vitroGut2016653 487 50126420419
   PubMed Web of Science ®Google Scholar
• CarinoAGraziosiLD’AmoreCThe bile acid receptor GPBAR1 (TGR5) is expressed in human gastric cancers and promotes epithelial-mesenchymal transition in gastric cancer cell linesOncotarget2016738 61021 6103527409173
   PubMedGoogle Scholar
• GuoCSuJLiZThe G-protein-coupled bile acid receptor Gpbar1 (TGR5) suppresses gastric cancer cell proliferation and migration through antagonizing STAT3 signaling pathwayOncotarget2015633 34402 3441326417930
   PubMedGoogle Scholar
• SepeVRengaBFestaCInvestigation on bile acid receptor regulators. Discovery of cholanoic acid derivatives with dual G-protein coupled bile acid receptor 1 (GPBAR1) antagonistic and farnesoid X receptor (FXR) modulatory activitySteroids2016105 59 6726607331
   PubMed Web of Science ®Google Scholar
• LuisMLFragaJMJimenezAIJimenezFHernandezOAriasJJApplication of PLS regression to fluorimetric data for the determination of furosemide and triamterene in pharmaceutical preparations and triamterene in urineTalanta2004622 307 31618969296
   PubMed Web of Science ®Google Scholar
• HorisbergerJDGiebischGPotassium-sparing diureticsRen Physiol1987103–4 198 2202455308
   PubMedGoogle Scholar
• BuschAESuessbrichHKunzelmannKBlockade of epithelial Na+ channels by triamterenes – underlying mechanisms and molecular basisPflugers Arch19964325 760 7668772124
   PubMed Web of Science ®Google Scholar
• SmetanaGWTriamterene in the treatment of hypertension: more than just potassium sparing?J Gen Intern Med2016311 7 826385116
   PubMed Web of Science ®Google Scholar
• JeongKWLeeJYLeeSADynamics of a heparin-binding domain of VEGF(165) complexed with its inhibitor triamtereneBiochemistry20115022 4843 485421545128
   PubMed Web of Science ®Google Scholar
• ZhuJDongXLiuQHydrophobic bile acids relax rat detru-sor contraction via inhibiting the opening of the Na+/Ca2+ exchangerSci Rep20166 2135826892434
   PubMed Web of Science ®Google Scholar
• ChengJTLiuIMChiTCTzengTFLuFHChangCJPlasma glucose-lowering effect of tramadol in streptozotocin-induced diabetic ratsDiabetes20015012 2815 282111723065
   PubMed Web of Science ®Google Scholar
• LoSHChengKCLiYXChangCHChengJTLeeKSDevelopment of betulinic acid as an agonist of TGR5 receptor using a new in vitro assayDrug Des Devel Ther201610 2669 2676
   PubMed Web of Science ®Google Scholar
• ChengKCLiYXAsakawaACharacterization of preptin-induced insulin secretion in pancreatic beta-cellsJ Endocrinol20122151 43 4922787110
   PubMed Web of Science ®Google Scholar
• AmranMSHommaNHashimotoKPharmacology of KB-R7943: a Na+-Ca2+ exchange inhibitorCardiovasc Drug Rev2003214 255 27614647531
   PubMed Web of Science ®Google Scholar
• WangXYZhangSYLiJLiuHNXieXNanFJHighly lipophilic 3-epi-betulinic acid derivatives as potent and selective TGR5 agonists with improved cellular efficacyActa Pharmacol Sin20143511 1463 147225283506
   PubMed Web of Science ®Google Scholar
• ChenXLouGMengZHuangWTGR5: a novel target for weight maintenance and glucose metabolismExp Diabetes Res20112011 85350121754919
   PubMedGoogle Scholar
• LieuTJayaweeraGZhaoPThe bile acid receptor TGR5 activates the TRPA1 channel to induce itch in miceGastroenterology20141476 1417 142825194674
   PubMed Web of Science ®Google Scholar
• FickertPFuchsbichlerAMarschallHULithocholic acid feeding induces segmental bile duct obstruction and destructive cholangitis in miceAm J Pathol20061682 410 42216436656
   PubMed Web of Science ®Google Scholar
• JangHJKokrashviliZTheodorakisMJGut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1Proc Natl Acad Sci U S A200710438 15069 1507417724330
   PubMed Web of Science ®Google Scholar
• AbramochkinDVVornanenMInhibition of the cardiac ATP-dependent potassium current by KB-R7943Comp Biochem Physiol A Mol Integr Physiol2014175 38 4524845199
   PubMed Web of Science ®Google Scholar
• KuhreREHolstJJKappeCThe regulation of function, growth and survival of GLP-1-producing L-cellsClin Sci (Lond)20161302 79 9126637406
   PubMed Web of Science ®Google Scholar
• HansenMScheltemaMJSonneDPEffect of chenodeoxycholic acid and the bile acid sequestrant colesevelam on glucagon-like peptide-1 secretionDiabetes Obes Metab2016186 571 58026888164
   PubMed Web of Science ®Google Scholar
• DruckerDJDipeptidyl peptidase-4 inhibition and the treatment of type 2 diabetes: preclinical biology and mechanisms of actionDiabetes Care2007306 1335 134317337495
   PubMed Web of Science ®Google Scholar