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Original Research

Population Pharmacokinetics and Dosing Optimization of Gentamicin in Critically Ill Patients Undergoing Continuous Renal Replacement Therapy

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Pages 13-22 | Published online: 06 Jan 2022

References

  • Genga KR, Russell JA. Update of sepsis in the intensive care unit. J Innate Immun. 2017;9(5):441–455. doi:10.1159/000477419
  • Fleischmann-Struzek C, Mellhammar L, Rose N, et al. Incidence and mortality of hospital- and ICU-treated sepsis: results from an updated and expanded systematic review and meta-analysis. Intensive Care Med. 2020;46(8):1552–1562. doi:10.1007/s00134-020-06151-x
  • Garnacho-Montero J, Garcia-Garmendia JL, Barrero-Almodovar A, Jimenez-Jimenez FJ, Perez-Paredes C, Ortiz-Leyba C. Impact of adequate empirical antibiotic therapy on the outcome of patients admitted to the intensive care unit with sepsis. Crit Care Med. 2003;31(12):2742–2751. doi:10.1097/01.CCM.0000098031.24329.10
  • Kumar A, Roberts D, Wood KE, et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med. 2006;34(6):1589–1596. doi:10.1097/01.CCM.0000217961.75225.E9
  • Evans L, Rhodes A, Alhazzani W, et al. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021. Crit Care Med. 2021;49(11):e1063–e1143. doi:10.1097/CCM.0000000000005337
  • Dellinger RP, Levy MM, Rhodes A, et al. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med. 2013;39(2):165–228. doi:10.1007/s00134-012-2769-8
  • Rhodes A, Evans LE, Alhazzani W, et al. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock: 2016. Intensive Care Med. 2017;43(3):304–377. doi:10.1007/s00134-017-4683-6
  • Becker B, Cooper MA. Aminoglycoside antibiotics in the 21st century. ACS Chem Biol. 2013;8(1):105–115. doi:10.1021/cb3005116
  • Hansen M, Christrup LL, Jarlov JO, Kampmann JP, Bonde J. Gentamicin dosing in critically ill patients. Acta Anaesthesiol Scand. 2001;45(6):734–740. doi:10.1034/j.1399-6576.2001.045006734.x
  • Fuchs A, Guidi M, Giannoni E, et al. Population pharmacokinetic study of gentamicin in a large cohort of premature and term neonates. Br J Clin Pharmacol. 2014;78(5):1090–1101. doi:10.1111/bcp.12444
  • Petejova N, Zahalkova J, Duricova J, et al. Gentamicin pharmacokinetics during continuous venovenous hemofiltration in critically ill septic patients. J Chemother. 2012;24(2):107–112. doi:10.1179/1120009X12Z.0000000006
  • Veinstein A, Venisse N, Badin J, Pinsard M, Robert R, Dupuis A. Gentamicin in hemodialyzed critical care patients: early dialysis after administration of a high dose should be considered. Antimicrob Agents Chemother. 2013;57(2):977–982. doi:10.1128/AAC.01762-12
  • Roberts JA, Field J, Visser A, et al. Using population pharmacokinetics to determine gentamicin dosing during extended daily diafiltration in critically ill patients with acute kidney injury. Antimicrob Agents Chemother. 2010;54(9):3635–3640. doi:10.1128/AAC.00222-10
  • Ambrose PG, Jones RN. Aminoglycoside in vitro Susceptibility Test Interpretive Criteria Evaluations. USCAST 0002; 2019.
  • Chuk AC, Saeed F, Kousar N, et al. Variable pharmacokinetics of extended interval tobramycin or gentamicin among critically ill patients undergoing continuous venovenous hemofiltration. Clin Nephrol. 2015;84(10):214–221. doi:10.5414/CN108559
  • Bos JC, Prins JM, Misticio MC, et al. Population pharmacokinetics with Monte Carlo simulations of gentamicin in a population of severely ill adult patients from Sub-Saharan Africa. Antimicrob Agents Chemother. 2019;63(4). doi:10.1128/AAC.02328-18
  • Hodiamont CJ, Juffermans NP, Bouman CS, de Jong MD, Mathot RA, van Hest RM. Determinants of gentamicin concentrations in critically ill patients: a population pharmacokinetic analysis. Int J Antimicrob Agents. 2017;49(2):204–211. doi:10.1016/j.ijantimicag.2016.10.022
  • Ernest D, Cutler DJ. Gentamicin clearance during continuous arteriovenous hemodiafiltration. Crit Care Med. 1992;20(5):586–589. doi:10.1097/00003246-199205000-00007
  • Tang GJ, Tang JJ, Lin BS, Kong CW, Lee TY. Factors affecting gentamicin pharmacokinetics in septic patients. Acta Anaesthesiol Scand. 1999;43(7):726–730. doi:10.1034/j.1399-6576.1999.430707.x
  • Bellomo R, Kellum JA, Ronco C, et al. Acute kidney injury in sepsis. Intensive Care Med. 2017;43(6):816–828. doi:10.1007/s00134-017-4755-7
  • Tandukar S, Palevsky PM. Continuous renal replacement therapy who, when, why, and how. Chest. 2019;155(3):626–638. doi:10.1016/j.chest.2018.09.004
  • Radigan EA, Gilchrist NA, Miller MA. Management of aminoglycosides in the intensive care unit. J Intensive Care Med. 2010;25(6):327–342. doi:10.1177/0885066610377968
  • Xie F, Li S, Cheng Z. Population pharmacokinetics and dosing considerations of daptomycin in critically ill patients undergoing continuous renal replacement therapy. J Antimicrob Chemother. 2020;75(6):1559–1566. doi:10.1093/jac/dkaa028
  • D’Arcy DM, Corrigan OI, Deasy E, Gowing CM, Donnelly MB. Gentamicin pharmacokinetics in critically ill patients during treatment with continuous venovenous haemodiafiltration (CVVHDF). Eur J Clin Pharmacol. 2015;71(3):377–378. doi:10.1007/s00228-014-1765-z
  • Baud FJ, Houze P, Carli P, Lamhaut L. Alteration of the pharmacokinetics of aminoglycosides by adsorption in a filter during continuous renal replacement therapy. An in vitro assessment. Therapie. 2020;76(5):415–424.
  • Bergstrand M, Hooker AC, Wallin JE, Karlsson MO. Prediction-corrected visual predictive checks for diagnosing nonlinear mixed-effects models. AAPS J. 2011;13(2):143–151. doi:10.1208/s12248-011-9255-z
  • Johnson AEW, Pollard TJ, Shen L, et al. MIMIC-III, a freely accessible critical care database. Sci Data. 2016;3(1):160035. doi:10.1038/sdata.2016.35
  • Boisson M, Mimoz O, Hadzic M, et al. Pharmacokinetics of intravenous and nebulized gentamicin in critically ill patients. J Antimicrob Chemother. 2018;73(10):2830–2837. doi:10.1093/jac/dky239
  • Rea RS, Capitano B, Bies R, Bigos KL, Smith R, Lee H. Suboptimal aminoglycoside dosing in critically ill patients. Ther Drug Monit. 2008;30(6):674–681. doi:10.1097/FTD.0b013e31818b6b2f
  • Bukkems LH, Roger C, Hodiamont CJ, et al. Predictive performance of a gentamicin population pharmacokinetic model in two western populations of critically ill patients. Int J Antimicrob Agents. 2018;52(2):218–225. doi:10.1016/j.ijantimicag.2018.04.016
  • D’Arcy DM, Casey E, Gowing CM, Donnelly MB, Corrigan OI. An open prospective study of amikacin pharmacokinetics in critically ill patients during treatment with continuous venovenous haemodiafiltration. BMC Pharmacol Toxicol. 2012;13:14. doi:10.1186/2050-6511-13-14
  • Blot SI, Pea F, Lipman J. The effect of pathophysiology on pharmacokinetics in the critically ill patient–concepts appraised by the example of antimicrobial agents. Adv Drug Deliv Rev. 2014;77:3–11. doi:10.1016/j.addr.2014.07.006
  • Goncalves-Pereira J, Martins A, Povoa P. Pharmacokinetics of gentamicin in critically ill patients: pilot study evaluating the first dose. Clin Microbiol Infect. 2010;16(8):1258–1263. doi:10.1111/j.1469-0691.2009.03074.x
  • Hodiamont CJ, Janssen JM, de Jong MD, Mathot RA, Juffermans NP, van Hest RM. Therapeutic drug monitoring of gentamicin peak concentrations in critically ill patients. Ther Drug Monit. 2017;39(5):522–530. doi:10.1097/FTD.0000000000000432