Drug Design, Development and Therapy, Volume 16, Issue (2022)

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Drug Design, Development and Therapy, Volume 16, Issue (2022)

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ORIGINAL RESEARCH

Article
The Efficacy of Cyclophosphamide Combined with Prednisone in Membranous Nephropathy Patients with Different Cytochrome P450 2B6 Gene Polymorphisms and Analysis of Factors Influencing the Efficacy
Min Zhang, Yao Lv & Haokui Liu
Pages: 3655-3662
Published online: 05 Dec 2023
AbstractforThe Efficacy of Cyclophosphamide Combined with Prednisone in Membranous Nephropathy Patients with Different Cytochrome P450 2B6 Gene Polymorphisms and Analysis of Factors Influencing the Efficacy | Full Text | References | PDF (414.2 KB) | EPUB
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Article
Targeting mTOR Complex 2 in Castration-Resistant Prostate Cancer with Acquired Docetaxel Resistance
Yujie Huang, You Zhai, Meijia Wu, Chengdong Chang, Jindan Luo, Dongsheng Hong, Qingwei Zhao, Yao Dai & Jian Liu
Pages: 3817-3828
Published online: 05 Dec 2023
AbstractforTargeting mTOR Complex 2 in Castration-Resistant Prostate Cancer with Acquired Docetaxel Resistance | Full Text | References | PDF (6.8 MB) | EPUB
  • 76 Views
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REVIEW

Review
Biological Mechanisms and Related Natural Inhibitors of CD36 in Nonalcoholic Fatty Liver
Yanan Feng, Wenxiu Sun, Fengcui Sun, Guoliang Yin, Pengpeng Liang, Suwen Chen, Xiangyi Liu, Tongfei Jiang & Fengxia Zhang
Pages: 3829-3845
Published online: 05 Dec 2023
AbstractforBiological Mechanisms and Related Natural Inhibitors of CD36 in Nonalcoholic Fatty Liver | Full Text | References | PDF (1.7 MB) | EPUB
  • 264 Views
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Open Access

ORIGINAL RESEARCH

Article
Integrated Microbiome and Metabolome Analysis Reveals Correlations Between Gut Microbiota Components and Metabolic Profiles in Mice with Methotrexate-Induced Hepatoxicity
Changshui Wang, Shuzhen Zhao, Yuan Xu, Wenxue Sun, Yuanyuan Feng, Deshuai Liang & Yun Guan
Pages: 3877-3891
Published online: 05 Dec 2023
AbstractforIntegrated Microbiome and Metabolome Analysis Reveals Correlations Between Gut Microbiota Components and Metabolic Profiles in Mice with Methotrexate-Induced Hepatoxicity | Full Text | References | PDF (9.5 MB) | EPUB
  • 108 Views
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Open Access
Article
Comparative Pharmacokinetics and Safety of Imrecoxib, a Novel Selective Cyclooxygenase-2 Inhibitor, in Elderly Healthy Subjects
Ling Yang, Qi Shen, Chao Hu, Ying Wang, Xiaohong Zhu, Shiqing Shu & Zhu Luo
Pages: 3865-3876
Published online: 05 Dec 2023
AbstractforComparative Pharmacokinetics and Safety of Imrecoxib, a Novel Selective Cyclooxygenase-2 Inhibitor, in Elderly Healthy Subjects | Full Text | References | PDF (5 MB) | EPUB
  • 87 Views
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Open Access
Article
Screening of Adapalene Microsponges Fabrication Parameters with Insight on the In vitro Biological Effectiveness
Rania M Yehia, Dalia A Attia, Mohamed M Elmazar, Mohamed A El-Nabarawi & Mahmoud H Teaima
Pages: 3847-3864
Published online: 05 Dec 2023
AbstractforScreening of Adapalene Microsponges Fabrication Parameters with Insight on the In vitro Biological Effectiveness | Full Text | References | PDF (9.2 MB) | EPUB
  • 140 Views
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Open Access
Article
Metabolomics Provides Insights into Renoprotective Effects of Semaglutide in Obese Mice
Xing Chen, Shuchun Chen, Qingjuan Ren, Shu Niu, Xiaoyu Pan, Lin Yue, Zelin Li, Ruiyi Zhu, Zhuoya Jia, Xiaoyi Chen, Ruoxi Zhen & Jiangli Ban
Pages: 3893-3913
Published online: 05 Dec 2023
AbstractforMetabolomics Provides Insights into Renoprotective Effects of Semaglutide in Obese Mice | Full Text | References | PDF (15.1 MB) | EPUB
  • 248 Views
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Open Access

REVIEW

Review
Dose Adjustment of Poly (ADP‑Ribose) Polymerase Inhibitors in Patients with Hepatic or Renal Impairment
Dehua Zhao, Xiaoqing Long & Jisheng Wang
Pages: 3947-3955
Published online: 05 Dec 2023
AbstractforDose Adjustment of Poly (ADP‑Ribose) Polymerase Inhibitors in Patients with Hepatic or Renal Impairment | Full Text | References | PDF (1.5 MB) | EPUB
  • 84 Views
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Open Access

ORIGINAL RESEARCH

Article
ED-71 Prevents Glucocorticoid-Induced Osteoporosis by Regulating Osteoblast Differentiation via Notch and Wnt/β-Catenin Pathways
Xing Rong, Yuying Kou, Yuan Zhang, Panpan Yang, Rong Tang, Hongrui Liu & Minqi Li
Pages: 3929-3946
Published online: 05 Dec 2023
AbstractforED-71 Prevents Glucocorticoid-Induced Osteoporosis by Regulating Osteoblast Differentiation via Notch and Wnt/β-Catenin Pathways | Full Text | References | PDF (17.8 MB) | EPUB
  • 118 Views
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Open Access

Review

Review
Remimazolam: An Updated Review of a New Sedative and Anaesthetic
Qinxue Hu, Xing Liu, Chengli Wen, Duo Li & Xianying Lei
Pages: 3957-3974
Published online: 05 Dec 2023
AbstractforRemimazolam: An Updated Review of a New Sedative and Anaesthetic | Full Text | References | PDF (3.1 MB) | EPUB
  • 327 Views
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Open Access

REVIEW

Review
Diroximel Fumarate as a Novel Oral Immunomodulating Therapy for Relapsing Forms of Multiple Sclerosis: A Review on the Emerging Data
Larissa Hauer & Johann Sellner
Pages: 3915-3927
Published online: 05 Dec 2023
AbstractforDiroximel Fumarate as a Novel Oral Immunomodulating Therapy for Relapsing Forms of Multiple Sclerosis: A Review on the Emerging Data | Full Text | References | PDF (853.7 KB) | EPUB
  • 255 Views
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ORIGINAL RESEARCH

Article
Preliminary Exploration of Clinical Efficacy and Pharmacological Mechanism of Modified Danggui-Shaoyao San in the Treatment of Depression in Patients with Chronic Kidney Disease
Mengdi Xia, Na Ai & Junjie Pang
Pages: 3975-3989
Published online: 05 Dec 2023
AbstractforPreliminary Exploration of Clinical Efficacy and Pharmacological Mechanism of Modified Danggui-Shaoyao San in the Treatment of Depression in Patients with Chronic Kidney Disease | Full Text | References | PDF (3.9 MB) | EPUB
  • 82 Views
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Open Access
Article
Decoding the Key Functional Combined Components Group and Uncovering the Molecular Mechanism of Longdan Xiegan Decoction in Treating Uveitis
Yi-Xu Zheng, Ke-Xin Wang, Si-Jin Chen, Mu-Xi Liao, Yu-Peng Chen, Dao-Gang Guan, Jing Wu & Ke Xiong
Pages: 3991-4011
Published online: 05 Dec 2023
AbstractforDecoding the Key Functional Combined Components Group and Uncovering the Molecular Mechanism of Longdan Xiegan Decoction in Treating Uveitis | Full Text | References | PDF (12.6 MB) | EPUB
  • 76 Views
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Open Access

RETRACTION

Retraction
Preparation of Novel Pirfenidone Microspheres for Lung-Targeted Delivery: In vitro and in vivo Study [Retraction]
Pages: 4017-4018
Published online: 05 Dec 2023
CitationforPreparation of Novel Pirfenidone Microspheres for Lung-Targeted Delivery: In vitro and in vivo Study [Retraction] | Full Text | PDF (242.4 KB) | EPUB
  • 64 Views
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Open Access
Retraction
Development of a Nanoliposomal Formulation of Erlotinib for Lung Cancer and in vitro/In vivo Antitumoral Evaluation [Retraction]
Pages: 4019-4020
Published online: 05 Dec 2023
CitationforDevelopment of a Nanoliposomal Formulation of Erlotinib for Lung Cancer and in vitro/In vivo Antitumoral Evaluation [Retraction] | Full Text | PDF (242.5 KB) | EPUB
  • 52 Views
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Open Access
Retraction
A Novel Glycyrrhetinic Acid-Modified Oxaliplatin Liposome for Liver-Targeting and in vitro/vivo Evaluation [Retraction]
Pages: 4013-4014
Published online: 05 Dec 2023
CitationforA Novel Glycyrrhetinic Acid-Modified Oxaliplatin Liposome for Liver-Targeting and in vitro/vivo Evaluation [Retraction] | Full Text | PDF (241.5 KB) | EPUB
  • 60 Views
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Open Access
Retraction
A Novel Tetrandrine-Loaded Chitosan Microsphere: Characterization and in vivo Evaluation [Retraction]
Pages: 4015-4016
Published online: 05 Dec 2023
CitationforA Novel Tetrandrine-Loaded Chitosan Microsphere: Characterization and in vivo Evaluation [Retraction] | Full Text | PDF (241 KB) | EPUB
  • 67 Views
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Open Access
Retraction
Coffee and Caffeine Potentiate the Antiamyloidogenic Activity of Melatonin via Inhibition of Aβ Oligomerization and Modulation of theTau-Mediated Pathway in N2a/APP Cells [Retraction]
Pages: 4041-4042
Published online: 05 Dec 2023
CitationforCoffee and Caffeine Potentiate the Antiamyloidogenic Activity of Melatonin via Inhibition of Aβ Oligomerization and Modulation of theTau-Mediated Pathway in N2a/APP Cells [Retraction] | Full Text | PDF (305.4 KB) | EPUB
  • 52 Views
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ORIGINAL RESEARCH

Article
Design of 1,4-Dihydropyridine Hybrid Benzamide Derivatives: Synthesis and Evaluation of Analgesic Activity and Their Molecular Docking Studies
Idhayadhulla Akbar, Surendrakumar Radhakrishnan, Karpakavalli Meenakshisundaram, Aseer Manilal, Ashraf Atef Hatamleh, Bassam Khalid Alnafisi, Anis Ahamed & Ravindran Balasubramani
Pages: 4021-4039
Published online: 05 Dec 2023
AbstractforDesign of 1,4-Dihydropyridine Hybrid Benzamide Derivatives: Synthesis and Evaluation of Analgesic Activity and Their Molecular Docking Studies | Full Text | References | PDF (11.2 MB) | EPUB
  • 111 Views
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Open Access
Article
Design, Synthesis and Pharmacological Evaluation of 2-(3-BenzoyI-4-Hydroxy-1,1-Dioxido-2H-Benzo[e][1,2]thiazin-2-yI)-N-(2-Bromophenyl) Acetamide as Antidiabetic Agent
Fatima Rashid, Matloob Ahmad, Usman Ali Ashfaq, Aamal A Al-Mutairi & Sami A Al-Hussain
Pages: 4043-4060
Published online: 05 Dec 2023
AbstractforDesign, Synthesis and Pharmacological Evaluation of 2-(3-BenzoyI-4-Hydroxy-1,1-Dioxido-2H-Benzo[e][1,2]thiazin-2-yI)-N-(2-Bromophenyl) Acetamide as Antidiabetic Agent | Full Text | References | PDF (8.8 MB) | EPUB
  • 199 Views
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Article
Integrated Network Pharmacology Analysis and Experimental Validation to Investigate the Molecular Mechanism of Triptolide in the Treatment of Membranous Nephropathy
Ping Na Zhang, Jing Yi Tang, Ke Zhen Yang, Qi Yan Zheng, Zhao Cheng Dong, Yun Ling Geng, Yu Ning Liu & Wei Jing Liu
Pages: 4061-4076
Published online: 05 Dec 2023
AbstractforIntegrated Network Pharmacology Analysis and Experimental Validation to Investigate the Molecular Mechanism of Triptolide in the Treatment of Membranous Nephropathy | Full Text | References | PDF (11.9 MB) | EPUB
  • 97 Views
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CORRIGENDUM

Correction
Ropivacaine with Dexmedetomidine or Dexamethasone in a Thoracic Paravertebral Nerve Block Combined with an Erector Spinae Plane Block for Thoracoscopic Lobectomy Analgesia: A Randomized Controlled Trial [Corrigendum]
Pages: 4077-4078
Published online: 05 Dec 2023
CitationforRopivacaine with Dexmedetomidine or Dexamethasone in a Thoracic Paravertebral Nerve Block Combined with an Erector Spinae Plane Block for Thoracoscopic Lobectomy Analgesia: A Randomized Controlled Trial [Corrigendum] | Full Text | PDF (236.1 KB) | EPUB
  • 53 Views
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ORIGINAL RESEARCH

Article
Evaluation of the Effect of Eslicarbazepine Acetate on the Pharmacokinetics of Perampanel in Rats by Isotope-Dilution-UHPLC-MS/MS
Ping Liu, Jing An & Huizhen Wu
Pages: 4091-4099
Published online: 05 Dec 2023
AbstractforEvaluation of the Effect of Eslicarbazepine Acetate on the Pharmacokinetics of Perampanel in Rats by Isotope-Dilution-UHPLC-MS/MS | Full Text | References | PDF (4.9 MB) | EPUB
  • 56 Views
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Open Access
Article
Effects of Salidroside Combined with Paclitaxel on Proliferation, Migration, and Epithelial Mesenchyme of Colorectal Cancer Cells
Yanjiao Hao, Zhiyu Li, Mingzhi Chang & Xiaoli Zhang
Pages: 4079-4089
Published online: 05 Dec 2023
AbstractforEffects of Salidroside Combined with Paclitaxel on Proliferation, Migration, and Epithelial Mesenchyme of Colorectal Cancer Cells | Full Text | References | PDF (8.7 MB) | EPUB
  • 80 Views
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CLINICAL TRIAL REPORT

Remimazolam Tosylate Combined with Low-Dose Propofol Improves Sedation and Safety in Hysteroscopy
Fan Zhang, Huan Chang, Wenxiang Qing, Rili Yu, Qin Liao & Jianbin Tong
Pages: 4101-4108
Published online: 05 Dec 2023
AbstractforRemimazolam Tosylate Combined with Low-Dose Propofol Improves Sedation and Safety in Hysteroscopy | Full Text | References | PDF (521.8 KB) | EPUB
  • 93 Views
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Open Access

RETRACTION

Retraction
A Novel Ocular Delivery of Brinzolamide Based on Gellan Gum: In vitro and in vivo Evaluation [Retraction]
Pages: 4109-4110
Published online: 05 Dec 2023
CitationforA Novel Ocular Delivery of Brinzolamide Based on Gellan Gum: In vitro and in vivo Evaluation [Retraction] | Full Text | PDF (236.2 KB) | EPUB
  • 47 Views
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ORIGINAL RESEARCH

Article
Liquiritin Protects Against Cardiac Fibrosis After Myocardial Infarction by Inhibiting CCL5 Expression and the NF-κB Signaling Pathway
Xue Han, Yakun Yang, Muqing Zhang, Li Li, Yucong Xue, Qingzhong Jia, Xiangting Wang & Shengjiang Guan
Pages: 4111-4125
Published online: 05 Dec 2023
AbstractforLiquiritin Protects Against Cardiac Fibrosis After Myocardial Infarction by Inhibiting CCL5 Expression and the NF-κB Signaling Pathway | Full Text | References | PDF (9.5 MB) | EPUB
  • 112 Views
  • 6 CrossRef citations
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Open Access
Article
Thalidomide Attenuates Skin Lesions and Inflammation in Rosacea-Like Mice Induced by Long-Term Exposure of LL-37
Yumeng Kang, Chuanxi Zhang, Yang He, Ziyan Zhang, Heliang Liu, Zhongqiu Wei & Jie Yang
Pages: 4127-4138
Published online: 05 Dec 2023
AbstractforThalidomide Attenuates Skin Lesions and Inflammation in Rosacea-Like Mice Induced by Long-Term Exposure of LL-37 | Full Text | References | PDF (8.9 MB) | EPUB
  • 74 Views
  • 2 CrossRef citations
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Open Access
Article
Dual-Drug Nanosystem: Etoposide Prodrug and Cisplatin Coloaded Nanostructured Lipid Carriers for Lung Cancer Therapy
Min Du & Jianbo Yin
Pages: 4139-4149
Published online: 05 Dec 2023
AbstractforDual-Drug Nanosystem: Etoposide Prodrug and Cisplatin Coloaded Nanostructured Lipid Carriers for Lung Cancer Therapy | Full Text | References | PDF (5.2 MB) | EPUB
  • 99 Views
  • 2 CrossRef citations
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Open Access
Article
Effect of Remimazolam Tosilate on Respiratory Depression in Elderly Patients Undergoing Gastroscopy: A Multicentered, Prospective, and Randomized Study
Bailong Hu, Ke Jiang, Wenyan Shi, Shixiang Xiao, Shili Zhang, Yongguo Zhang, Yuancheng Zhou, Chengwei Tan, Songjiang Tan & Xiaohua Zou
Pages: 4151-4159
Published online: 05 Dec 2023
AbstractforEffect of Remimazolam Tosilate on Respiratory Depression in Elderly Patients Undergoing Gastroscopy: A Multicentered, Prospective, and Randomized Study | Full Text | References | PDF (1.3 MB) | EPUB
  • 72 Views
  • 8 CrossRef citations
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Open Access
Article
Canagliflozin Attenuates Hepatic Steatosis and Atherosclerosis Progression in Western Diet-Fed ApoE-Knockout Mice
Qingjuan Zuo, Guorui Zhang, Lili He, Sai Ma, Huijuan Ma, Jianlong Zhai, Zhongli Wang, Tingting Zhang, Yan Wang & Yifang Guo
Pages: 4161-4177
Published online: 05 Dec 2023
AbstractforCanagliflozin Attenuates Hepatic Steatosis and Atherosclerosis Progression in Western Diet-Fed ApoE-Knockout Mice | Full Text | References | PDF (9.7 MB) | EPUB
  • 81 Views
  • 3 CrossRef citations
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Open Access
Article
Methanolic Extract of Aerva javanica Leaves Prevents LPS-Induced Depressive Like Behavior in Experimental Mice
Hafiza Maida Arshad, Fiaz-ud-Din Ahmad & Arslan Hussain Lodhi
Pages: 4179-4204
Published online: 05 Dec 2023
AbstractforMethanolic Extract of Aerva javanica Leaves Prevents LPS-Induced Depressive Like Behavior in Experimental Mice | Full Text | References | PDF (12.7 MB) | EPUB
  • 167 Views
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Open Access
Article
Keloid Patient Plasma-Derived Exosomal hsa_circ_0020792 Promotes Normal Skin Fibroblasts Proliferation, Migration, and Fibrogenesis via Modulating miR-193a-5p and Activating TGF-β1/Smad2/3 Signaling
Huan Hu, Guangyu Mao, Jianghong Zheng & Feng Guo
Pages: 4223-4234
Published online: 05 Dec 2023
AbstractforKeloid Patient Plasma-Derived Exosomal hsa_circ_0020792 Promotes Normal Skin Fibroblasts Proliferation, Migration, and Fibrogenesis via Modulating miR-193a-5p and Activating TGF-β1/Smad2/3 Signaling | Full Text | References | PDF (9.9 MB) | EPUB
  • 74 Views
  • 3 CrossRef citations
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Open Access
Article
Molecular Mechanisms of Luteolin Against Atopic Dermatitis Based on Network Pharmacology and in vivo Experimental Validation
Liu Tang, Jiefang Gao, Xiaolei Li, Xiaoqin Cao & Benhong Zhou
Pages: 4205-4221
Published online: 05 Dec 2023
AbstractforMolecular Mechanisms of Luteolin Against Atopic Dermatitis Based on Network Pharmacology and in vivo Experimental Validation | Full Text | References | PDF (16.6 MB) | EPUB
  • 276 Views
  • 6 CrossRef citations
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Article
Development, in vitro Evaluation, and in vivo Study of Adhesive Buccal Films for the Treatment of Diabetic Pediatrics via Trans Mucosal Delivery of Gliclazide
Dalia A Gaber, Abeer I Alburaykan, Lama M Alruthea, Njoud S Aldohan, Raneem F Alharbi, Alhanoof R Aljohani, Helah M Albilaihi & Somaiah S Adogim
Pages: 4235-4250
Published online: 05 Dec 2023
AbstractforDevelopment, in vitro Evaluation, and in vivo Study of Adhesive Buccal Films for the Treatment of Diabetic Pediatrics via Trans Mucosal Delivery of Gliclazide | Full Text | References | PDF (5.6 MB) | EPUB
  • 235 Views
  • 1 CrossRef citations
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STUDY PROTOCOL

Efficiency and Safety of Baofei Granules in Chronic Obstructive Pulmonary Disease (Lung and Spleen Qi Deficiency Syndrome): A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase II Clinical Trial
Yuan Sun, Xuan Chen, Lei Zhang, Wei-an Yuan, Qi Chen, Yi-bao Zhang, Lu-jiong Liu, Wei Zhang & Meng Sun
Pages: 4251-4267
Published online: 05 Dec 2023
AbstractforEfficiency and Safety of Baofei Granules in Chronic Obstructive Pulmonary Disease (Lung and Spleen Qi Deficiency Syndrome): A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase II Clinical Trial | Full Text | References | PDF (2.5 MB) | EPUB
  • 114 Views
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ORIGINAL RESEARCH

Article
Efficacy and Safety of the PD-1 Inhibitor Combined with Albumin-Bound Paclitaxel and Nedaplatin in Preoperative Neoadjuvant Therapy of Unresectable Stage III Lung Squamous Cell Carcinoma
Hongyan Xu, Wenjing Wang, Junlei Yin, Chengcun Song, Lin Li & Zhi Sun
Pages: 4269-4277
Published online: 05 Dec 2023
AbstractforEfficacy and Safety of the PD-1 Inhibitor Combined with Albumin-Bound Paclitaxel and Nedaplatin in Preoperative Neoadjuvant Therapy of Unresectable Stage III Lung Squamous Cell Carcinoma | Full Text | References | PDF (2.9 MB) | EPUB
  • 88 Views
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Open Access
Article
Exosomes Derived from Hypoxic Glioma Cells Reduce the Sensitivity of Glioma Cells to Temozolomide Through Carrying miR-106a-5p
Peizhang Wu, Jun Guo, Hongwei Yang, Debin Yuan, Chaoxiang Wang & Zhong Wang
Pages: 3589-3598
Published online: 05 Dec 2023
AbstractforExosomes Derived from Hypoxic Glioma Cells Reduce the Sensitivity of Glioma Cells to Temozolomide Through Carrying miR-106a-5p | Full Text | References | PDF (6.1 MB) | EPUB
  • 77 Views
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Article
Design and Optimization of Rivaroxaban-Cyclodextrin-Polymer Triple Complex Formulation with Improved Solubility
Ji-Hyun Kang, Ji-Eun Lee, So-Jeong Jeong, Chun-Woong Park, Dong-Wook Kim & Kwon-Yeon Weon
Pages: 4279-4289
Published online: 05 Dec 2023
AbstractforDesign and Optimization of Rivaroxaban-Cyclodextrin-Polymer Triple Complex Formulation with Improved Solubility | Full Text | References | PDF (3.5 MB) | EPUB
  • 183 Views
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Article
Effects of the Different Doses of Esketamine on Postoperative Quality of Recovery in Patients Undergoing Modified Radical Mastectomy: A Randomized, Double-Blind, Controlled Trial
Min Zhu, Siqi Xu, Xia Ju, Shengbin Wang & Xitong Yu
Pages: 4291-4299
Published online: 05 Dec 2023
AbstractforEffects of the Different Doses of Esketamine on Postoperative Quality of Recovery in Patients Undergoing Modified Radical Mastectomy: A Randomized, Double-Blind, Controlled Trial | Full Text | References | PDF (419.7 KB) | EPUB
  • 160 Views
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Article
Effect of Rifampicin on the Pharmacokinetics of Evogliptin in Healthy Volunteers
Yesong Shin, Chungam Choi, Eun Sil Oh, Choon Ok Kim, Kyungsoo Park & Min Soo Park
Pages: 4301-4310
Published online: 05 Dec 2023
AbstractforEffect of Rifampicin on the Pharmacokinetics of Evogliptin in Healthy Volunteers | Full Text | References | PDF (4.1 MB) | EPUB
  • 117 Views
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Article
Antiviral Activity of Oridonin Against Herpes Simplex Virus Type 1
Kai Jiang, Jing Feng, Xia Qi, Lili Ran & Lixin Xie
Pages: 4311-4323
Published online: 05 Dec 2023
AbstractforAntiviral Activity of Oridonin Against Herpes Simplex Virus Type 1 | Full Text | References | PDF (6.9 MB) | EPUB
  • 152 Views
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Article
Network Pharmacology Integrated with Transcriptomics Analysis Reveals Ermiao Wan Alleviates Atopic Dermatitis via Suppressing MAPK and Activating the EGFR/AKT Signaling
Ting Xia, Xiao Liang, Chang-Shun Liu, Yan-Nan Hu, Zhen-Ye Luo & Xiao-Mei Tan
Pages: 4325-4341
Published online: 05 Dec 2023
AbstractforNetwork Pharmacology Integrated with Transcriptomics Analysis Reveals Ermiao Wan Alleviates Atopic Dermatitis via Suppressing MAPK and Activating the EGFR/AKT Signaling | Full Text | References | PDF (10.9 MB) | EPUB
  • 189 Views
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Article
Metabolomics Study of Shaoyao Plants Decoction on the Proximal and Distal Colon in Mice with Dextran Sulfate Sodium-Induced Colitis by UPLC-Q-TOF-MS
Yiting Luo, Jin Wu, Yingchao Liu, Yan Shen, Fangyuan Zhu, Jiaqian Wu & Yuyao Hu
Pages: 4343-4364
Published online: 05 Dec 2023
AbstractforMetabolomics Study of Shaoyao Plants Decoction on the Proximal and Distal Colon in Mice with Dextran Sulfate Sodium-Induced Colitis by UPLC-Q-TOF-MS | Full Text | References | PDF (20.4 MB) | EPUB
  • 114 Views
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REVIEW

Review
Chemical Chaperones to Inhibit Endoplasmic Reticulum Stress: Implications in Diseases
Jae-Ho Jeon, Somyoung Im, Hyo Shin Kim, Dongyun Lee, Kwiwan Jeong, Jin-Mo Ku & Tae-Gyu Nam
Pages: 4385-4397
Published online: 05 Dec 2023
AbstractforChemical Chaperones to Inhibit Endoplasmic Reticulum Stress: Implications in Diseases | Full Text | References | PDF (6 MB) | EPUB
  • 175 Views
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ORIGINAL RESEARCH

Article
Notoginsenoside R1 Promotes Proliferation and Osteogenic Differentiation of hPDLSCs via Wnt/β-Catenin Signaling Pathway
Ruiqi Han, Wenjuan Zhang, Lina Zhang, Jinghua Zou, Yanran Yang, Hongkun Li & Jun Zhang
Pages: 4399-4409
Published online: 05 Dec 2023
AbstractforNotoginsenoside R1 Promotes Proliferation and Osteogenic Differentiation of hPDLSCs via Wnt/β-Catenin Signaling Pathway | Full Text | References | PDF (5.3 MB) | EPUB
  • 89 Views
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Article
Anti-Inflammatory Activation of Phellodendri Chinensis Cortex is Mediated by Berberine Erythrocytes Self-Assembly Targeted Delivery System
Minhua Li, Zehui Qin, Qiuxia Yu, Ziwei Huang, Juanjuan Cheng, Linjiang Zhong, Yuhong Liu, Jianhui Xie, Yucui Li, Jiannan Chen, Ruoting Zhan & Ziren Su
Pages: 4365-4383
Published online: 05 Dec 2023
AbstractforAnti-Inflammatory Activation of Phellodendri Chinensis Cortex is Mediated by Berberine Erythrocytes Self-Assembly Targeted Delivery System | Full Text | References | PDF (10 MB) | EPUB
  • 113 Views
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Article
Ketamine Attenuates Airway Inflammation via Inducing Inflammatory Cells Apoptosis and Activating Nrf2 Pathway in a Mixed-Granulocytic Murine Asthma Model
Shilin Xiao, Ying Zhou, Qianyu Wang & Dong Yang
Pages: 4411-4428
Published online: 05 Dec 2023
AbstractforKetamine Attenuates Airway Inflammation via Inducing Inflammatory Cells Apoptosis and Activating Nrf2 Pathway in a Mixed-Granulocytic Murine Asthma Model | Full Text | References | PDF (15.3 MB) | EPUB
  • 169 Views
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Open Access
Article
Pharmacokinetics of a Fixed-Dose Combination of Teneligliptin Hydrochloride Hydrate and Modified-Release Metformin Under Fasting and Fed Conditions in Healthy Subjects
In Sun Goak, Jin A Lee, Min Ho Jeong, Seol Ju Moon & Min Gul Kim
Pages: 4439-4448
Published online: 05 Dec 2023
AbstractforPharmacokinetics of a Fixed-Dose Combination of Teneligliptin Hydrochloride Hydrate and Modified-Release Metformin Under Fasting and Fed Conditions in Healthy Subjects | Full Text | References | PDF (1.6 MB) | EPUB
  • 183 Views
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Article
Risk Factors for Hepatic Encephalopathy in Hepatocellular Carcinoma After Sorafenib or Lenvatinib Treatment: A Real-World Study
Bowen Chen, Linzhi Zhang, Jiamin Cheng, Tong Wu, Jin Lei, Xu Yang, Rongling Zhang, Rifaat Safadi, Yinyin Li, Tongguo Si & Yinying Lu
Pages: 4429-4437
Published online: 05 Dec 2023
AbstractforRisk Factors for Hepatic Encephalopathy in Hepatocellular Carcinoma After Sorafenib or Lenvatinib Treatment: A Real-World Study | Full Text | References | PDF (856.9 KB) | EPUB
  • 84 Views
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REVIEW

Review
Clinical Insight on Semaglutide for Chronic Weight Management in Adults: Patient Selection and Special Considerations
Ariana M Chao, Jena Shaw Tronieri, Anastassia Amaro & Thomas A Wadden
Pages: 4449-4461
Published online: 05 Dec 2023
AbstractforClinical Insight on Semaglutide for Chronic Weight Management in Adults: Patient Selection and Special Considerations | Full Text | References | PDF (492.2 KB) | EPUB
  • 835 Views
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Review

Review Article
Disease Modifying Therapies for the Management of Children with Spinal Muscular Atrophy (5q SMA): An Update on the Emerging Evidence
Helgi Thor Hjartarson, Kristofer Nathorst-Böös & Thomas Sejersen
Pages: 1865-1883
Published online: 16 Jun 2022
AbstractforDisease Modifying Therapies for the Management of Children with Spinal Muscular Atrophy (5q SMA): An Update on the Emerging Evidence | Full Text | References | PDF (1.7 MB) | EPUB
  • 641 Views
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Review Article
Clinical Utility of Elosulfase Alfa in the Treatment of Morquio A Syndrome
Chung-Lin Lee, Chih-Kuang Chuang, Huei-Ching Chiu, Ru-Yi Tu, Yun-Ting Lo, Ya-Hui Chang, Shuan-Pei Lin & Hsiang-Yu Lin
Pages: 143-154
Published online: 10 Jan 2022
AbstractforClinical Utility of Elosulfase Alfa in the Treatment of Morquio A Syndrome | Full Text | References | PDF (1.2 MB) | EPUB
  • 369 Views
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Review Article
Efficacy and Safety Profile of Fostemsavir for the Treatment of People with Human Immunodeficiency Virus-1 (HIV-1): Current Evidence and Place in Therapy
Camilla Muccini, Diana Canetti, Antonella Castagna & Vincenzo Spagnuolo
Pages: 297-304
Published online: 25 Jan 2022
AbstractforEfficacy and Safety Profile of Fostemsavir for the Treatment of People with Human Immunodeficiency Virus-1 (HIV-1): Current Evidence and Place in Therapy | Full Text | References | PDF (1.7 MB) | EPUB
  • 358 Views
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Review Article
Spotlight on Givosiran as a Treatment Option for Adults with Acute Hepatic Porphyria: Design, Development, and Place in Therapy
Chaudry Nasir Majeed, Christopher D Ma, Ted Xiao, Sean Rudnick & Herbert L Bonkovsky
Pages: 1827-1845
Published online: 16 Jun 2022
AbstractforSpotlight on Givosiran as a Treatment Option for Adults with Acute Hepatic Porphyria: Design, Development, and Place in Therapy | Full Text | References | PDF (5.9 MB) | EPUB
  • 470 Views
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Review Article
Current Perspectives in the Treatment of Locally Advanced Basal Cell Carcinoma
Neha Gupta & Emily S Ruiz
Pages: 183-190
Published online: 14 Jan 2022
AbstractforCurrent Perspectives in the Treatment of Locally Advanced Basal Cell Carcinoma | Full Text | References | PDF (1.6 MB) | EPUB
  • 177 Views
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Review Article
Promising Natural Products in New Drug Design, Development, and Therapy for Skin Disorders: An Overview of Scientific Evidence and Understanding Their Mechanism of Action
Nurul Amirah Mohd Zaid, Mahendran Sekar, Srinivasa Reddy Bonam, Siew Hua Gan, Pei Teng Lum, M Yasmin Begum, Nur Najihah Izzati Mat Rani, Jaishree Vaijanathappa, Yuan Seng Wu, Vetriselvan Subramaniyan, Neeraj Kumar Fuloria & Shivkanya Fuloria
Pages: 23-66
Published online: 06 Jan 2022
AbstractforPromising Natural Products in New Drug Design, Development, and Therapy for Skin Disorders: An Overview of Scientific Evidence and Understanding Their Mechanism of Action | Full Text | References | PDF (11 MB) | EPUB
  • 3916 Views
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Original Research

Article
Integrated Network Pharmacology and Metabolomics Analysis to Reveal the Potential Mechanism of Siwu Paste on Aplastic Anemia Induced by Chemotherapy Drugs
Dan He, Wan Dan, Qing Du, Bing-Bing Shen, Lin Chen, Liang-zi Fang, Jian-Jun Kuang, Chun-yu Tang, Ping Cai, Rong Yu, Shui-han Zhang & Jian-hua Huang
Pages: 1231-1254
Published online: 28 Apr 2022
AbstractforIntegrated Network Pharmacology and Metabolomics Analysis to Reveal the Potential Mechanism of Siwu Paste on Aplastic Anemia Induced by Chemotherapy Drugs | Full Text | References | PDF (10.3 MB) | EPUB
  • 334 Views
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Article
Network Pharmacology and Molecular Docking Study of the Chinese Miao Medicine Sidaxue in the Treatment of Rheumatoid Arthritis
Ning Wu, Taohua Yuan, ZhiXin Yin, Xiaotian Yuan, Jianfei Sun, Zunqiu Wu, Qilong Zhang, Carl Redshaw, Shenggang Yang & Xiaotian Dai
Pages: 435-466
Published online: 19 Feb 2022
AbstractforNetwork Pharmacology and Molecular Docking Study of the Chinese Miao Medicine Sidaxue in the Treatment of Rheumatoid Arthritis | Full Text | References | PDF (13.2 MB) | EPUB
  • 1268 Views
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Article
Comparison of Metaraminol, Phenylephrine, and Norepinephrine Infusion for Prevention of Hypotension During Combined Spinal-Epidural Anaesthesia for Elective Caesarean Section: A Three-Arm, Randomized, Double-Blind, Non-Inferiority Trial
Youfa Zhou, Yunyun Yu, Miaofei Chu, Yanting Zhang, Xin Yu & Gang Chen
Pages: 117-127
Published online: 07 Jan 2022
AbstractforComparison of Metaraminol, Phenylephrine, and Norepinephrine Infusion for Prevention of Hypotension During Combined Spinal-Epidural Anaesthesia for Elective Caesarean Section: A Three-Arm, Randomized, Double-Blind, Non-Inferiority Trial | Full Text | References | PDF (3.6 MB) | EPUB
  • 320 Views
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Review

Review Article
Combination Therapy of Ezetimibe and Rosuvastatin for Dyslipidemia: Current Insights
Maya R Chilbert, Dylan VanDuyn, Sara Salah, Collin M Clark & Qing Ma
Pages: 2177-2186
Published online: 07 Jul 2022
AbstractforCombination Therapy of Ezetimibe and Rosuvastatin for Dyslipidemia: Current Insights | Full Text | References | PDF (375.9 KB) | EPUB
  • 525 Views
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Original Research

Article
Dexmedetomidine Combined with Femoral Nerve Block Provides Effective Analgesia Similar to Femoral Nerve Combined with Sciatic Nerve Block in Patients Undergoing Total Knee Arthroplasty: A Randomized Controlled Study
Rui Xiao, Li-Fang Liu, Ya-Ru Luo, Chang Liu, Xiao-Bin Jin, Wei Zhou & Guang-Hong Xu
Pages: 155-164
Published online: 13 Jan 2022
AbstractforDexmedetomidine Combined with Femoral Nerve Block Provides Effective Analgesia Similar to Femoral Nerve Combined with Sciatic Nerve Block in Patients Undergoing Total Knee Arthroplasty: A Randomized Controlled Study | Full Text | References | PDF (2.4 MB) | EPUB
  • 330 Views
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Article
Determining the Minimum Effective Concentration of Ropivacaine in Epidural Anesthesia for Tolerable Pain in Transforaminal Percutaneous Endoscopic Lumbar Discectomy to Avoid Nerve Injury: A Double-Blind Study Using a Biased-Coin Design
Bingwei Hu, Liang Li, Hongwei Wang, Tingting Ma, Zhimei Fu, Xianhui Kang & Zhiying Feng
Pages: 315-323
Published online: 09 Feb 2022
AbstractforDetermining the Minimum Effective Concentration of Ropivacaine in Epidural Anesthesia for Tolerable Pain in Transforaminal Percutaneous Endoscopic Lumbar Discectomy to Avoid Nerve Injury: A Double-Blind Study Using a Biased-Coin Design | Full Text | References | PDF (2 MB) | EPUB
  • 189 Views
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Review

Review Article
Evaluating the Therapeutic Potential of Ritlecitinib for the Treatment of Alopecia Areata
Hassiel Aurelio Ramírez-Marín & Antonella Tosti
Pages: 363-374
Published online: 17 Feb 2022
AbstractforEvaluating the Therapeutic Potential of Ritlecitinib for the Treatment of Alopecia Areata | Full Text | References | PDF (356.7 KB) | EPUB
  • 1621 Views
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Original Research

Article
Safety, Pharmacokinetics and Pharmacodynamics of the Selective Glucocorticoid Receptor Modulator Velsecorat (AZD7594) Following Inhalation in Healthy Volunteers
Susanne Prothon, Magnus Aurivillius, Ulrika Tehler, Ulf G Eriksson, Ajay Aggarwal & Yingxue Chen
Pages: 485-497
Published online: 23 Feb 2022
AbstractforSafety, Pharmacokinetics and Pharmacodynamics of the Selective Glucocorticoid Receptor Modulator Velsecorat (AZD7594) Following Inhalation in Healthy Volunteers | Full Text | References | PDF (4.9 MB) | EPUB
  • 238 Views
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Article
Chrysin Attenuates High Glucose-Induced BMSC Dysfunction via the Activation of the PI3K/AKT/Nrf2 Signaling Pathway
Yu Li & Ximei Wang
Pages: 165-182
Published online: 13 Jan 2022
AbstractforChrysin Attenuates High Glucose-Induced BMSC Dysfunction via the Activation of the PI3K/AKT/Nrf2 Signaling Pathway | Full Text | References | PDF (16.5 MB) | EPUB
  • 364 Views
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Article
Inhibition of CXCR4 in Spinal Cord and DRG with AMD3100 Attenuates Colon-Bladder Cross-Organ Sensitization
Hengshuai Zhang, Xingyou Dong, Zhenxing Yang, Jiang Zhao, Qudong Lu, Jingzhen Zhu, Longkun Li, Shanhong Yi & Jie Xu
Pages: 67-81
Published online: 06 Jan 2022
AbstractforInhibition of CXCR4 in Spinal Cord and DRG with AMD3100 Attenuates Colon-Bladder Cross-Organ Sensitization | Full Text | References | PDF (12.5 MB) | EPUB
  • 185 Views
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Review

Review Article
Spotlight on Lonapegsomatropin Once-Weekly Injection and Its Potential in the Treatment of Growth Hormone Deficiency in Pediatric Patients
Bradley S Miller & Kevin C J Yuen
Pages: 2055-2066
Published online: 29 Jun 2022
AbstractforSpotlight on Lonapegsomatropin Once-Weekly Injection and Its Potential in the Treatment of Growth Hormone Deficiency in Pediatric Patients | Full Text | References | PDF (1.5 MB) | EPUB
  • 672 Views
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Review Article
The Role of Progesterone Receptors in Breast Cancer
Zhuo Li, Hongrui Wei, Siyan Li, Pei Wu & Xiaoyun Mao
Pages: 305-314
Published online: 26 Jan 2022
AbstractforThe Role of Progesterone Receptors in Breast Cancer | Full Text | References | PDF (962.5 KB) | EPUB
  • 951 Views
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Original Research

Article
Pharmacokinetics and Pharmacodynamics of YYD601, a Dual Delayed-Release Formulation of Esomeprazole, Following Single and Multiple Doses in Healthy Adult Volunteers Under Fasting and Fed Conditions
Hae Won Lee, Woo Youl Kang, Wookjae Jung, Mi-Ri Gwon, Kyunghee Cho, Young-Ran Yoon & Sook Jin Seong
Pages: 619-634
Published online: 06 Mar 2022
AbstractforPharmacokinetics and Pharmacodynamics of YYD601, a Dual Delayed-Release Formulation of Esomeprazole, Following Single and Multiple Doses in Healthy Adult Volunteers Under Fasting and Fed Conditions | Full Text | References | PDF (8.1 MB) | EPUB
  • 489 Views
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Article
The Effect of Naringin on the Apoptosis of Degenerative Nucleus Pulposus Cells: A Study on the Function and Mechanism
Zhenzhen Yuan & Zhao Yang
Pages: 499-508
Published online: 26 Feb 2022
AbstractforThe Effect of Naringin on the Apoptosis of Degenerative Nucleus Pulposus Cells: A Study on the Function and Mechanism | Full Text | References | PDF (5.6 MB) | EPUB
  • 159 Views
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Article
Berbamine Suppresses the Growth of Gastric Cancer Cells by Inactivating the BRD4/c-MYC Signaling Pathway
Hongchun Li, Kexue Luo, Zhuying Yang, Miao Chen, Xiuyun Yang, Jiesheng Wang, Yin Ying, Dengxuan Wu & Qinxian Wang
Pages: 129-141
Published online: 11 Jan 2022
AbstractforBerbamine Suppresses the Growth of Gastric Cancer Cells by Inactivating the BRD4/c-MYC Signaling Pathway | Full Text | References | PDF (7.8 MB) | EPUB
  • 214 Views
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Article
Open-Label, Phase I, Pharmacokinetic Studies in Healthy Chinese Subjects to Evaluate the Bioequivalence and Food Effect of a Novel Formulation of Abiraterone Acetate Tablets
Zeying Feng, Yaxin Liu, Yun Kuang, Shuang Yang, Jinlei Li, Ling Ye, Jie Huang, Qi Pei, Yuanyuan Huang & Guoping Yang
Pages: 3-12
Published online: 03 Jan 2022
AbstractforOpen-Label, Phase I, Pharmacokinetic Studies in Healthy Chinese Subjects to Evaluate the Bioequivalence and Food Effect of a Novel Formulation of Abiraterone Acetate Tablets | Full Text | References | PDF (1.9 MB) | EPUB
  • 395 Views
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Review

Review Article
Research Progress in the Pharmacological Activities, Toxicities, and Pharmacokinetics of Sophoridine and Its Derivatives
Qiong Tang, Yao Liu, Xi Peng, Baojun Wang, Fei Luan & Nan Zeng
Pages: 191-212
Published online: 18 Jan 2022
AbstractforResearch Progress in the Pharmacological Activities, Toxicities, and Pharmacokinetics of Sophoridine and Its Derivatives | Full Text | References | PDF (8.9 MB) | EPUB
  • 450 Views
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Review Article
Evaluating Upadacitinib in the Treatment of Moderate-to-Severe Active Ulcerative Colitis: Design, Development, and Potential Position in Therapy
Maria Napolitano, Ferdinando D’Amico, Elisa Ragaini, Laurent Peyrin-Biroulet & Silvio Danese
Pages: 1897-1913
Published online: 17 Jun 2022
AbstractforEvaluating Upadacitinib in the Treatment of Moderate-to-Severe Active Ulcerative Colitis: Design, Development, and Potential Position in Therapy | Full Text | References | PDF (918.9 KB) | EPUB
  • 1116 Views
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Original Research

Article
Uncovering the Potential Mechanisms of Coptis chinensis Franch. for Serious Mental Illness by Network Pharmacology and Pharmacology-Based Analysis
Yiyu Qi, Saijia Ni, Xia Heng, Shuyue Qu, Pingyuan Ge, Xin Zhao, Zengying Yao, Rui Guo, Nianyun Yang, Qichun Zhang & Huaxu Zhu
Pages: 325-342
Published online: 09 Feb 2022
AbstractforUncovering the Potential Mechanisms of Coptis chinensis Franch. for Serious Mental Illness by Network Pharmacology and Pharmacology-Based Analysis | Full Text | References | PDF (9.5 MB) | EPUB
  • 334 Views
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Article
Intramuscular Corticosteroid Therapy in the Treatment of Alopecia Areata: A Time-to-Event Analysis
Kumutnart Chanprapaph, Cherrin Pomsoong, Chaninan Kositkuljorn & Poonkiat Suchonwanit
Pages: 107-116
Published online: 07 Jan 2022
AbstractforIntramuscular Corticosteroid Therapy in the Treatment of Alopecia Areata: A Time-to-Event Analysis | Full Text | References | PDF (1.2 MB) | EPUB
  • 279 Views
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Article
Clinical Characteristics and Risk Factors of Lung Injury Induced by Nab-Paclitaxel
Keiichiro Yoshioka, Mitsuhiro Abe, Yuki Shiko, Ken Koshikawa, Yohei Kawasaki, Shunichiro Iwasawa, Jiro Terada, Kenji Tsushima, Koichiro Tatsumi & Takuji Suzuki
Pages: 759-767
Published online: 22 Mar 2022
AbstractforClinical Characteristics and Risk Factors of Lung Injury Induced by Nab-Paclitaxel | Full Text | References | PDF (1.1 MB) | EPUB
  • 170 Views
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Review

Review Article
Less Well-Known Consequences of the Long-Term Use of Opioid Analgesics: A Comprehensive Literature Review
Aleksandra Kotlińska-Lemieszek & Zbigniew Żylicz
Pages: 251-264
Published online: 18 Jan 2022
AbstractforLess Well-Known Consequences of the Long-Term Use of Opioid Analgesics: A Comprehensive Literature Review | Full Text | References | PDF (597 KB) | EPUB
  • 573 Views
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Original Research

Article
Network Pharmacology and Experimental Verification to Explore the Potential Mechanism of Yin-Huo-Tang for Lung Adenocarcinoma Recurrence
Dianna Liu, Shicheng Lin, Yuan Li, Tian Zhou, Kaiwen Hu & Quanwang Li
Pages: 375-395
Published online: 17 Feb 2022
AbstractforNetwork Pharmacology and Experimental Verification to Explore the Potential Mechanism of Yin-Huo-Tang for Lung Adenocarcinoma Recurrence | Full Text | References | PDF (15.2 MB) | EPUB
  • 327 Views
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Article
Population Pharmacokinetics and Dosing Optimization of Gentamicin in Critically Ill Patients Undergoing Continuous Renal Replacement Therapy
Sha He, Zeneng Cheng & Feifan Xie
Pages: 13-22
Published online: 06 Jan 2022
AbstractforPopulation Pharmacokinetics and Dosing Optimization of Gentamicin in Critically Ill Patients Undergoing Continuous Renal Replacement Therapy | Full Text | References | PDF (2.4 MB) | EPUB
  • 258 Views
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Article
Spray with Nitric Oxide Donor Accelerates Wound Healing: Potential Off-the-Shelf Solution for Therapy?
Alexandra Igrunkova, Alexey Fayzullin, Semyon Churbanov, Polina Shevchenko, Natalia Serejnikova, Natalia Chepelova, Dmitry Pahomov, Ekaterina Blinova, Karen Mikaelyan, Victoria Zaborova, Konstantin Gurevich, Aleksandr Urakov, Anatoly Vanin, Peter Timashev & Anatoly Shekhter
Pages: 349-362
Published online: 16 Feb 2022
AbstractforSpray with Nitric Oxide Donor Accelerates Wound Healing: Potential Off-the-Shelf Solution for Therapy? | Full Text | References | PDF (17.7 MB) | EPUB
  • 279 Views
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Article
Feasibility of Catalpol Intranasal Administration and Its Protective Effect on Acute Cerebral Ischemia in Rats via Anti-Oxidative and Anti-Apoptotic Mechanisms
Jinghui Wang, Yuhua Zhang, Meifeng Zhang, Si Sun, Yang Zhong, Lei Han, Yitong Xu, Dong Wan, Junhui Zhang & Huifeng Zhu
Pages: 279-296
Published online: 25 Jan 2022
AbstractforFeasibility of Catalpol Intranasal Administration and Its Protective Effect on Acute Cerebral Ischemia in Rats via Anti-Oxidative and Anti-Apoptotic Mechanisms | Full Text | References | PDF (13.7 MB) | EPUB
  • 211 Views
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Article
Carvacrol Alleviates Hyperuricemia-Induced Oxidative Stress and Inflammation by Modulating the NLRP3/NF-κB Pathwayt
Muhammad Riaz, Lina Tariq Al Kury, Noreen Atzaz, Abdullah Alattar, Reem Alshaman, Fawad ali Shah & Shupeng Li
Pages: 1159-1170
Published online: 22 Apr 2022
AbstractforCarvacrol Alleviates Hyperuricemia-Induced Oxidative Stress and Inflammation by Modulating the NLRP3/NF-κB Pathwayt | Full Text | References | PDF (4.2 MB) | EPUB
  • 483 Views
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Review

Review Article
Advances in Engineered Three-Dimensional (3D) Body Articulation Unit Models
Ying Chen, Ying Wang, Sheng-Chang Luo, Xiang Zheng, Ranjith Kumar Kankala, Shi-Bin Wang & Ai-Zheng Chen
Pages: 213-235
Published online: 18 Jan 2022
AbstractforAdvances in Engineered Three-Dimensional (3D) Body Articulation Unit Models | Full Text | References | PDF (7.7 MB) | EPUB
  • 385 Views
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Original Research

Article
Protective Effects of Remimazolam on Cerebral Ischemia/Reperfusion Injury in Rats by Inhibiting of NLRP3 Inflammasome-Dependent Pyroptosis
Min Shi, Jing Chen, Tianxiao Liu, Weixin Dai, Zhan Zhou, Lifei Chen & Yubo Xie
Pages: 413-423
Published online: 18 Feb 2022
AbstractforProtective Effects of Remimazolam on Cerebral Ischemia/Reperfusion Injury in Rats by Inhibiting of NLRP3 Inflammasome-Dependent Pyroptosis | Full Text | References | PDF (5.7 MB) | EPUB
  • 311 Views
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Article
Wnt/β-Catenin Participates in the Repair of Acute Respiratory Distress Syndrome-Associated Early Pulmonary Fibrosis via Mesenchymal Stem Cell Microvesicles
Xingcai Zhang, Lifang Ye, Wan Tang, Yiqin Ji, Li Zheng, Yijun Chen, Qidong Ge & Changshun Huang
Pages: 237-247
Published online: 19 Jan 2022
AbstractforWnt/β-Catenin Participates in the Repair of Acute Respiratory Distress Syndrome-Associated Early Pulmonary Fibrosis via Mesenchymal Stem Cell Microvesicles | Full Text | References | PDF (6.4 MB) | EPUB
  • 161 Views
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Article
New Series of VEGFR-2 Inhibitors and Apoptosis Enhancers: Design, Synthesis and Biological Evaluation
Abdallah E Abdallah, Reda R Mabrouk, Mohamed R Elnagar, Amel Mostafa Farrag, Mohamed H Kalaba, Mohamed H Sharaf, Esmail M El-Fakharany, Dina Abed Bakhotmah, Eslam B Elkaeed & Maged Mohammed Saleh Al Ward
Pages: 587-606
Published online: 03 Mar 2022
AbstractforNew Series of VEGFR-2 Inhibitors and Apoptosis Enhancers: Design, Synthesis and Biological Evaluation | Full Text | References | PDF (12.8 MB) | EPUB
  • 495 Views
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Article
Ultrasound-Assisted Extraction of Total Saponins from Aralia taibaiensis: Process Optimization, Phytochemical Characterization, and Mechanism of α-Glucosidase Inhibition
Huan Li, Bingtao Zhai, Jing Sun, Yu Fan, Junbo Zou, Jiangxue Cheng, Xiaofei Zhang, Yajun Shi & Dongyan Guo
Pages: 83-105
Published online: 06 Jan 2022
AbstractforUltrasound-Assisted Extraction of Total Saponins from Aralia taibaiensis: Process Optimization, Phytochemical Characterization, and Mechanism of α-Glucosidase Inhibition | Full Text | References | PDF (15.6 MB) | EPUB
  • 533 Views
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Article
Blockade of the P2Y2 Receptor Attenuates Alcoholic Liver Inflammation by Targeting the EGFR-ERK1/2 Signaling Pathway
Zhen-Ni Liu, Qian-Qian Su, Yu-Hui Wang, Xue Wu & Xiong-Wen Lv
Pages: 1107-1120
Published online: 13 Apr 2022
AbstractforBlockade of the P2Y2 Receptor Attenuates Alcoholic Liver Inflammation by Targeting the EGFR-ERK1/2 Signaling Pathway | Full Text | References | PDF (11 MB) | EPUB
  • 164 Views
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Article
The Astragaloside IV Derivative LS-102 Ameliorates Obesity-Related Nephropathy
Ziyu Li, Wei Yang, Yong Yang, Jianbo Wu, Pei Luo & Yong Liu
Pages: 647-664
Published online: 14 Mar 2022
AbstractforThe Astragaloside IV Derivative LS-102 Ameliorates Obesity-Related Nephropathy | Full Text | References | PDF (8.2 MB) | EPUB
  • 251 Views
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Article
Metabolism and Mass Balance in Rats Following Oral Administration of the Novel Antifibrotic Drug Fluorofenidone
Wei Wu & Ze-neng Cheng
Pages: 973-979
Published online: 30 Mar 2022
AbstractforMetabolism and Mass Balance in Rats Following Oral Administration of the Novel Antifibrotic Drug Fluorofenidone | Full Text | References | PDF (1.3 MB) | EPUB
  • 150 Views
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Article
Determination of the Dose-Response Relationship of Epidural Dexmedetomidine Combined with Ropivacaine for Labor Analgesia
Jian-Xin Ni, Jia-Li Feng, Sheng-Jie Yao, Li-Feng Ni, Shao-Bo Song, Cong-Zhong Song, Xiao-Wei Qian, Zhong Mei & Jing Yu
Pages: 609-618
Published online: 06 Mar 2022
AbstractforDetermination of the Dose-Response Relationship of Epidural Dexmedetomidine Combined with Ropivacaine for Labor Analgesia | Full Text | References | PDF (500.8 KB) | EPUB
  • 239 Views
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Article
Analysis of Acrylamide and Glycidamide in Dried Blood Spot of Smokers Using Ultra-High-Performance Liquid Chromatography–Tandem Mass Spectrometry
Yahdiana Harahap, Afaf Amma Lahilla, Anastasia Sharon Jautan, Amiral Hafidz & Sunarsih Sunarsih
Pages: 521-531
Published online: 28 Feb 2022
AbstractforAnalysis of Acrylamide and Glycidamide in Dried Blood Spot of Smokers Using Ultra-High-Performance Liquid Chromatography–Tandem Mass Spectrometry | Full Text | References | PDF (3.9 MB) | EPUB
  • 175 Views
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Review

Review Article
Immunotherapy and CRISPR Cas Systems: Potential Cure of COVID-19?
Xuesong He & Xiao Xue Zeng
Pages: 951-972
Published online: 30 Mar 2022
AbstractforImmunotherapy and CRISPR Cas Systems: Potential Cure of COVID-19? | Full Text | References | PDF (2.3 MB) | EPUB
  • 451 Views
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Original Research

Article
The Therapeutic Effect and the Possible Mechanism of C-Phycocyanin in Lipopolysaccharide and Seawater-Induced Acute Lung Injury
Leifang Zhang, Deyi Kong, Junxia Huang, Qiongfen Wang & Lilin Shao
Pages: 1025-1040
Published online: 06 Apr 2022
AbstractforThe Therapeutic Effect and the Possible Mechanism of C-Phycocyanin in Lipopolysaccharide and Seawater-Induced Acute Lung Injury | Full Text | References | PDF (11.7 MB) | EPUB
  • 232 Views
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Article
Discovery of Biomarkers and Potential Mechanisms of Agarwood Incense Smoke Intervention by Untargeted Metabolomics and Network Pharmacology
Meiyue Dong, Haitao Du, Xueling Li, Ling Zhang, Xiaoming Wang, Zhenguo Wang & Haiqiang Jiang
Pages: 265-278
Published online: 26 Jan 2022
AbstractforDiscovery of Biomarkers and Potential Mechanisms of Agarwood Incense Smoke Intervention by Untargeted Metabolomics and Network Pharmacology | Full Text | References | PDF (8.1 MB) | EPUB
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Review

Review Article
The Role of Glucagon-Like Peptide-1 Receptor Agonists (GLP-1 RA) in Diabetes-Related Neurodegenerative Diseases
Dihe Cheng, Shuo Yang, Xue Zhao & Guixia Wang
Pages: 665-684
Published online: 14 Mar 2022
AbstractforThe Role of Glucagon-Like Peptide-1 Receptor Agonists (GLP-1 RA) in Diabetes-Related Neurodegenerative Diseases | Full Text | References | PDF (1.1 MB) | EPUB
  • 998 Views
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Original Research

Article
Yishen Qingli Heluo Granule in the Treatment of Chronic Kidney Disease: Network Pharmacology Analysis and Experimental Validation
Xian Sun, Yiting Huang, Sha Zhu, Jin Yan, Ke Gan, Zijing Xu, Shuaishuai Wang, Xiaoyu Kang, Junfeng Zhang & Wei Sun
Pages: 769-787
Published online: 24 Mar 2022
AbstractforYishen Qingli Heluo Granule in the Treatment of Chronic Kidney Disease: Network Pharmacology Analysis and Experimental Validation | Full Text | References | PDF (9.7 MB) | EPUB
  • 344 Views
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Article
α-Mangostin Treats Early-Stage Adjuvant-Induced Arthritis of Rat by Regulating the CAP-SIRT1 Pathway in Macrophages
Wen-Gang Chen, Sa-Sa Zhang, Shu Pan, Zhong-Fang Wang, Jin-Ying Xu, Xue-He Sheng, Qin Yin & Yi-Jin Wu
Pages: 509-520
Published online: 27 Feb 2022
Abstractforα-Mangostin Treats Early-Stage Adjuvant-Induced Arthritis of Rat by Regulating the CAP-SIRT1 Pathway in Macrophages | Full Text | References | PDF (10.9 MB) | EPUB
  • 193 Views
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Article
Pharmacokinetic Drug Interaction Between Amlodipine and Tadalafil: An Open-Label, Randomized, Multiple-Dose Crossover Study in Healthy Male Volunteers
Hyungsub Kim, Shi Hyang Lee, Jina Jung, Sunghee Hong & Hyeong-Seok Lim
Pages: 425-433
Published online: 19 Feb 2022
AbstractforPharmacokinetic Drug Interaction Between Amlodipine and Tadalafil: An Open-Label, Randomized, Multiple-Dose Crossover Study in Healthy Male Volunteers | Full Text | References | PDF (2.8 MB) | EPUB
  • 685 Views
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Article
Network Pharmacology Analysis of Hewei Jiangni Granule for Gastroesophageal Reflux Disease and Experimental Verification of Its Anti-Neurogenic Inflammation Mechanism
Yuan Cheng, Fushun Kou, Xiaosi Zhang, Yi Dai, Lei Shi, Chune Xie, Xiaohong Li & Junxiang Li
Pages: 1349-1363
Published online: 05 May 2022
AbstractforNetwork Pharmacology Analysis of Hewei Jiangni Granule for Gastroesophageal Reflux Disease and Experimental Verification of Its Anti-Neurogenic Inflammation Mechanism | Full Text | References | PDF (9.4 MB) | EPUB
  • 182 Views
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Review

Review Article
Matrine Exerts Pharmacological Effects Through Multiple Signaling Pathways: A Comprehensive Review
Yingda Lin, Fuming He, Ling Wu, Yuan Xu & Qiu Du
Pages: 533-569
Published online: 01 Mar 2022
AbstractforMatrine Exerts Pharmacological Effects Through Multiple Signaling Pathways: A Comprehensive Review | Full Text | References | PDF (621.1 KB) | EPUB
  • 389 Views
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Original Research

Article
Molecular Mechanism Underlying Effects of Wumeiwan on Steroid-Dependent Asthma: A Network Pharmacology, Molecular Docking, and Experimental Verification Study
Mingsheng Lyu, Yahui Wang, Qiuyi Chen, Jingbo Qin, Dan Hou, Shuaiyang Huang, Dongmei Shao, Xuefeng Gong, Guirui Huang, Shiyu Zhang, Zhijie Zhang & Hongsheng Cui
Pages: 909-929
Published online: 30 Mar 2022
AbstractforMolecular Mechanism Underlying Effects of Wumeiwan on Steroid-Dependent Asthma: A Network Pharmacology, Molecular Docking, and Experimental Verification Study | Full Text | References | PDF (11.2 MB) | EPUB
  • 405 Views
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Article
Targets Exploration of Hydroxychloroquine for Pigmentation and Cell Protection Effect in Melanocytes: The Clue for Vitiligo Treatment
Bo Xie, Yi Chen, Yebei Hu, Yan Zhao, Haixin Luo, Jinhui Xu & Xiuzu Song
Pages: 1011-1024
Published online: 05 Apr 2022
AbstractforTargets Exploration of Hydroxychloroquine for Pigmentation and Cell Protection Effect in Melanocytes: The Clue for Vitiligo Treatment | Full Text | References | PDF (8.6 MB) | EPUB
  • 384 Views
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Article
Programmed Intermittent Epidural Bolus in Comparison with Continuous Epidural Infusion for Uterine Contraction Pain Relief After Cesarean Section: A Randomized, Double-Blind Clinical Trial
Xiaofei Mo, Tianyun Zhao, Jinghui Chen, Xiang Li, Jun Liu, Cuiyi Xu & Xingrong Song
Pages: 999-1009
Published online: 02 Apr 2022
AbstractforProgrammed Intermittent Epidural Bolus in Comparison with Continuous Epidural Infusion for Uterine Contraction Pain Relief After Cesarean Section: A Randomized, Double-Blind Clinical Trial | Full Text | References | PDF (2.8 MB) | EPUB
  • 231 Views
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Article
Noncanonical Wnt5a Signaling Suppresses Hippo/TAZ-Mediated Osteogenesis Partly Through the Canonical Wnt Pathway in SCAPs
Yajing Fu, Dan Ma, Fengyan Fan, Tongke Sun, Ruiqi Han, Yanran Yang & Jun Zhang
Pages: 469-483
Published online: 22 Feb 2022
AbstractforNoncanonical Wnt5a Signaling Suppresses Hippo/TAZ-Mediated Osteogenesis Partly Through the Canonical Wnt Pathway in SCAPs | Full Text | References | PDF (11 MB) | EPUB
  • 278 Views
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Article
Preparation, in vitro and in vivo Evaluation of Thermosensitive in situ Gel Loaded with Ibuprofen-Solid Lipid Nanoparticles for Rectal Delivery
Chun-hui Huang, Peng-yi Hu, Qiu-yan Wu, Ming-yan Xia, Wen-liu Zhang, Zhi-qiang Lei, Dong-xun Li, Guo-song Zhang & Jian-fang Feng
Pages: 1407-1431
Published online: 12 May 2022
AbstractforPreparation, in vitro and in vivo Evaluation of Thermosensitive in situ Gel Loaded with Ibuprofen-Solid Lipid Nanoparticles for Rectal Delivery | Full Text | References | PDF (17.6 MB) | EPUB
  • 818 Views
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Article
cRGD Urokinase Liposomes for Thrombolysis in Rat Model of Acute Pulmonary Microthromboembolism
Chunting Liang, Tongtong Huang, Xiaofeng Zhang, Huaqing Rao, Zhiru Jin, Xiaoxiong Pan, Jingtao Li, Yingying Mo, Yongzhi Cai & Ji Wu
Pages: 801-816
Published online: 25 Mar 2022
AbstractforcRGD Urokinase Liposomes for Thrombolysis in Rat Model of Acute Pulmonary Microthromboembolism | Full Text | References | PDF (9.3 MB) | EPUB
  • 203 Views
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Article
Design, Synthesis, and Biological Evaluation of 2-Anilino-4-Triazolpyrimidine Derivatives as CDK4/HDACs Inhibitors
Suhua Wang, Siyuan Han, Weiyan Cheng, Ruoyang Miao, Shasha Li, Xin Tian & Quancheng Kan
Pages: 1083-1097
Published online: 11 Apr 2022
AbstractforDesign, Synthesis, and Biological Evaluation of 2-Anilino-4-Triazolpyrimidine Derivatives as CDK4/HDACs Inhibitors | Full Text | References | PDF (8.3 MB) | EPUB
  • 253 Views
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Article
Didymin Ameliorates Liver Fibrosis by Alleviating Endoplasmic Reticulum Stress and Glycerophospholipid Metabolism: Based on Transcriptomics and Metabolomics
Yan Li, Cuiyu Li, Yuhua Xiong, Bin Fang, Xing Lin & Quanfang Huang
Pages: 1713-1729
Published online: 07 Jun 2022
AbstractforDidymin Ameliorates Liver Fibrosis by Alleviating Endoplasmic Reticulum Stress and Glycerophospholipid Metabolism: Based on Transcriptomics and Metabolomics | Full Text | References | PDF (16.9 MB) | EPUB
  • 347 Views
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Article
Alleviating Aspirin-Induced Gastric Injury by Binding Aspirin to β-Lactoglobulin
Jin Chen, Min Gong, Zhuo Huang, Fang Wang, Yajing Wang, Zuquan Hu, Zhu Zeng & Yun Wang
Pages: 571-586
Published online: 01 Mar 2022
AbstractforAlleviating Aspirin-Induced Gastric Injury by Binding Aspirin to β-Lactoglobulin | Full Text | References | PDF (7.1 MB) | EPUB
  • 188 Views
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Article
Nintedanib Treatment After Ovulation is an Effective Therapeutic Strategy for the Alleviation of Ovarian Hyperstimulation Syndrome (OHSS) in a Mouse Model
Shutian Jiang, Wenzhi Li, Xinxi Zhao, Li Chen & Yanping Kuang
Pages: 397-411
Published online: 18 Feb 2022
AbstractforNintedanib Treatment After Ovulation is an Effective Therapeutic Strategy for the Alleviation of Ovarian Hyperstimulation Syndrome (OHSS) in a Mouse Model | Full Text | References | PDF (7.2 MB) | EPUB
  • 215 Views
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Article
Antidepressant-Like Effect and Mechanism of Ginsenoside Rd on Rodent Models of Depression
Yu Li, Mei-Ling Wang, Bo Zhang, Xiao-Xu Fan, Qin Tang, Xue Yu, Li-Na Li, Ang-Ran Fan, Hong-Sheng Chang & Lan-Zhen Zhang
Pages: 843-861
Published online: 28 Mar 2022
AbstractforAntidepressant-Like Effect and Mechanism of Ginsenoside Rd on Rodent Models of Depression | Full Text | References | PDF (10.2 MB) | EPUB
  • 279 Views
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Article
“PFH/AGM-CBA/HSV-TK/LIPOSOME-Affibody”: Novel Targeted Nano Ultrasound Contrast Agents for Ultrasound Imaging and Inhibited the Growth of ErbB2-Overexpressing Gastric Cancer Cells
Houren Zhou, Hui Liu, Yue Zhang, Ying Xin, Chi Huang, Mingzhong Li, Xiaoyun Zhao, Pingtian Ding & Zhijun Liu
Pages: 1515-1530
Published online: 18 May 2022
Abstractfor“PFH/AGM-CBA/HSV-TK/LIPOSOME-Affibody”: Novel Targeted Nano Ultrasound Contrast Agents for Ultrasound Imaging and Inhibited the Growth of ErbB2-Overexpressing Gastric Cancer Cells | Full Text | References | PDF (9.4 MB) | EPUB
  • 254 Views
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Article
Changes of Optical Coherence Tomography Biomarkers in Macular Edema Secondary to Retinal Vein Occlusion After Anti-VEGF and Anti-Inflammatory Therapies
Xuefei Ding, Yijun Hu, Honghua Yu & Qiuming Li
Pages: 717-725
Published online: 15 Mar 2022
AbstractforChanges of Optical Coherence Tomography Biomarkers in Macular Edema Secondary to Retinal Vein Occlusion After Anti-VEGF and Anti-Inflammatory Therapies | Full Text | References | PDF (506.9 KB) | EPUB
  • 314 Views
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Article
Intrathecal Injection of Ropivacaine Reduces Cervical Resistance in Late-Pregnant Rats
Yu Hu, Li-Jun Fan, Yue-Ming Jiang, Hong Liu, Hui Yong & Chong Peng
Pages: 1183-1189
Published online: 26 Apr 2022
AbstractforIntrathecal Injection of Ropivacaine Reduces Cervical Resistance in Late-Pregnant Rats | Full Text | References | PDF (1.7 MB) | EPUB
  • 172 Views
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Article
Gancao Xiexin Decoction Ameliorates Ulcerative Colitis in Mice via Modulating Gut Microbiota and Metabolites
Yi-ting Luo, Jin Wu, Fang-yuan Zhu, Jia-qian Wu, Pei Wu & Ying-chao Liu
Pages: 1383-1405
Published online: 09 May 2022
AbstractforGancao Xiexin Decoction Ameliorates Ulcerative Colitis in Mice via Modulating Gut Microbiota and Metabolites | Full Text | References | PDF (19.4 MB) | EPUB
  • 301 Views
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Article
Efficacy of Nimodipine Combined with Latanoprost in Treating Open-Angle Glaucoma and Its Influence on Ocular Hemodynamics and Visual Field Defects
Hui-Ping Duan & Rong Liu
Pages: 749-757
Published online: 21 Mar 2022
AbstractforEfficacy of Nimodipine Combined with Latanoprost in Treating Open-Angle Glaucoma and Its Influence on Ocular Hemodynamics and Visual Field Defects | Full Text | References | PDF (2.5 MB) | EPUB
  • 173 Views
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Article
The Antithrombotic Effect of Recombinant Neorudin on Thrombi
Yu-Bin Liu, Lin Zhang, Xing-Chen Zhou, Ying Zhou, Yun Liu, Can Zheng, Xiao Xu, Pan-Pan Geng, Chun-Hua Hao, Zhuan-You Zhao, Chu-Tse Wu & Ji-De Jin
Pages: 1667-1678
Published online: 02 Jun 2022
AbstractforThe Antithrombotic Effect of Recombinant Neorudin on Thrombi | Full Text | References | PDF (4.1 MB) | EPUB
  • 181 Views
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Article
Synergistic Effect of Combined Sub-Tenon Triamcinolone and Intravitreal Anti-VEGF Therapy for Uveitic Macular Edema
Dan Lin, Jiajiang Hu, Ke Wu, Kemi Feng, Xia Zhao, Qingqing Lu, Mingxue Ren, Junlin Cao, Ruru Liu, Mali Dai, Kaihui Nan & Yuqin Wang
Pages: 1055-1066
Published online: 08 Apr 2022
AbstractforSynergistic Effect of Combined Sub-Tenon Triamcinolone and Intravitreal Anti-VEGF Therapy for Uveitic Macular Edema | Full Text | References | PDF (2.2 MB) | EPUB
  • 204 Views
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Review

Review Article
Therapeutic Potential of Janus Kinase Inhibitors for the Management of Interstitial Lung Disease
Rongxiu Huo, Qianyu Guo, Junping Hu, Na Li, Rui Gao, Liangyu Mi, Zhaoliang Zhang, Hechao Liu, Zhiying Guo, Hanxi Zhao, Liyun Zhang & Ke Xu
Pages: 991-998
Published online: 02 Apr 2022
AbstractforTherapeutic Potential of Janus Kinase Inhibitors for the Management of Interstitial Lung Disease | Full Text | References | PDF (1.8 MB) | EPUB
  • 414 Views
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Original Research

Article
Gemcitabine Combined with Cisplatin Has a Better Effect in the Treatment of Recurrent/Metastatic Advanced Nasopharyngeal Carcinoma
Qiao Yang, Yue Hua Nie, Man Bo Cai, Zhi Min Li, Hong Bo Zhu & Ye Ru Tan
Pages: 1191-1198
Published online: 26 Apr 2022
AbstractforGemcitabine Combined with Cisplatin Has a Better Effect in the Treatment of Recurrent/Metastatic Advanced Nasopharyngeal Carcinoma | Full Text | References | PDF (1.8 MB) | EPUB
  • 198 Views
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Article
Clotrimazole Inhibits HCC Migration and Invasion by Modulating the ERK-p65 Signaling Pathway
Xudong Liu, Jie Gao, Yaohui Sun, Feng Zhang, Wenzhi Guo & Shuijun Zhang
Pages: 863-871
Published online: 29 Mar 2022
AbstractforClotrimazole Inhibits HCC Migration and Invasion by Modulating the ERK-p65 Signaling Pathway | Full Text | References | PDF (6 MB) | EPUB
  • 150 Views
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Article
Co-Administration with Voriconazole Doubles the Exposure of Ruxolitinib in Patients with Hematological Malignancies
Yingxin Zhao, Peng Chen, Liping Dou, Fei Li, Meng Li, Lingmin Xu, Jing Chen, Mingyu Jia, Sai Huang, Nan Wang, Songhua Luan, Jinling Yang, Nan Bai & Daihong Liu
Pages: 817-825
Published online: 25 Mar 2022
AbstractforCo-Administration with Voriconazole Doubles the Exposure of Ruxolitinib in Patients with Hematological Malignancies | Full Text | References | PDF (2.6 MB) | EPUB
  • 210 Views
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Article
Analagesic and Anti-Inflammatory Potentials of a Less Ulcerogenic Thiadiazinethione Derivative in Animal Models: Biochemical and Histochemical Correlates
Khista Rahman, Gowhar Ali, Rasool Khan, Imad Khan, Izaz Ali, Osama F Mosa, Alshebli Ahmed, Muhammad Ayaz, Asif Nawaz & H C Ananda Murthy
Pages: 1143-1157
Published online: 21 Apr 2022
AbstractforAnalagesic and Anti-Inflammatory Potentials of a Less Ulcerogenic Thiadiazinethione Derivative in Animal Models: Biochemical and Histochemical Correlates | Full Text | References | PDF (5 MB) | EPUB
  • 251 Views
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Review

Review Article
A Systematic Review of the Global Intervention for SARS-CoV-2 Combating: From Drugs Repurposing to Molnupiravir Approval
Nada A Ashour, Ayman Abo Elmaaty, Amany A Sarhan, Eslam B Elkaeed, Ahmed M Moussa, Ibrahim Ali Erfan & Ahmed A Al-Karmalawy
Pages: 685-715
Published online: 15 Mar 2022
AbstractforA Systematic Review of the Global Intervention for SARS-CoV-2 Combating: From Drugs Repurposing to Molnupiravir Approval | Full Text | References | PDF (4.4 MB) | EPUB
  • 1589 Views
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Original Research

Article
Design, Synthesis and Biological Evaluation of New 3,4-Dihydro-2(1H)-Quinolinone-Dithiocarbamate Derivatives as Multifunctional Agents for the Treatment of Alzheimer’s Disease
Jie Guo, Airen Xu, Maojun Cheng, Yang Wan, Rikang Wang, Yuanying Fang, Yi Jin, Sai-Sai Xie & Jing Liu
Pages: 1495-1514
Published online: 18 May 2022
AbstractforDesign, Synthesis and Biological Evaluation of New 3,4-Dihydro-2(1H)-Quinolinone-Dithiocarbamate Derivatives as Multifunctional Agents for the Treatment of Alzheimer’s Disease | Full Text | References | PDF (6.6 MB) | EPUB
  • 309 Views
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Article
Network Pharmacology Analysis and Experimental Validation to Investigate the Mechanism of Total Flavonoids of Rhizoma Drynariae in Treating Rheumatoid Arthritis
Guang-yao Chen, Jing Luo, Yi Liu, Xin-bo Yu, Xiao-yu Liu & Qing-wen Tao
Pages: 1743-1766
Published online: 08 Jun 2022
AbstractforNetwork Pharmacology Analysis and Experimental Validation to Investigate the Mechanism of Total Flavonoids of Rhizoma Drynariae in Treating Rheumatoid Arthritis | Full Text | References | PDF (17.7 MB) | EPUB
  • 554 Views
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Review

Review Article
The Emerging Potential of Parthenolide Nanoformulations in Tumor Therapy
Tao An, Huanhuan Yin, Yanting Lu & Feng Liu
Pages: 1255-1272
Published online: 29 Apr 2022
AbstractforThe Emerging Potential of Parthenolide Nanoformulations in Tumor Therapy | Full Text | References | PDF (4.7 MB) | EPUB
  • 475 Views
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Corrigendum

Correction
Fatostatin in Combination with Tamoxifen Induces Synergistic Inhibition in ER-Positive Breast Cancer [Corrigendum]
Pages: 1-2
Published online: 05 Jan 2022
CitationforFatostatin in Combination with Tamoxifen Induces Synergistic Inhibition in ER-Positive Breast Cancer [Corrigendum] | Full Text | PDF (1.6 MB) | EPUB
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Correction
Curcumin Protects Against Myocardial Infarction-Induced Cardiac Fibrosis via SIRT1 Activation in vivo and in vitro [Corrigendum]
Pages: 343-344
Published online: 14 Feb 2022
CitationforCurcumin Protects Against Myocardial Infarction-Induced Cardiac Fibrosis via SIRT1 Activation in vivo and in vitro [Corrigendum] | Full Text | PDF (1.6 MB) | EPUB
  • 111 Views
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Original Research

Article
Novel Liposomal Rolipram Formulation for Clinical Application to Reduce Emesis
Leila Gobejishvili, Walter E Rodriguez, Philip Bauer, Yali Wang, Chirag Soni, Todd Lydic, Shirish Barve, Craig McClain & Claudio Maldonado
Pages: 1301-1309
Published online: 03 May 2022
AbstractforNovel Liposomal Rolipram Formulation for Clinical Application to Reduce Emesis | Full Text | References | PDF (2 MB) | EPUB
  • 185 Views
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Article
Nano Sized Hydroxyapatite-Polylactic Acid-Vancomycin in Alleviation of Chronic Osteomyelitis
Xiao-Feng Lv, Dong-Ming Zhou, Xiao-Hong Sun & Ze Zhao
Pages: 1983-1993
Published online: 27 Jun 2022
AbstractforNano Sized Hydroxyapatite-Polylactic Acid-Vancomycin in Alleviation of Chronic Osteomyelitis | Full Text | References | PDF (8.3 MB) | EPUB
  • 255 Views
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Review

Review Article
Global Trends and Hotspots in Esketamine Research: A Bibliometric Analysis of Past and Estimation of Future Trends
Xiang Li, Ping Xiang, Jianfen Liang, Yifan Deng & Jingyi Du
Pages: 1131-1142
Published online: 21 Apr 2022
AbstractforGlobal Trends and Hotspots in Esketamine Research: A Bibliometric Analysis of Past and Estimation of Future Trends | Full Text | References | PDF (8.6 MB) | EPUB
  • 313 Views
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Original Research

Article
Palmatine Protects Against MSU-Induced Gouty Arthritis via Regulating the NF-κB/NLRP3 and Nrf2 Pathways
Juan-Juan Cheng, Xing-Dong Ma, Gao-Xiang Ai, Qiu-Xia Yu, Xiao-Ying Chen, Fang Yan, Yu-Cui Li, Jian-Hui Xie, Zi-Ren Su & Qing-Feng Xie
Pages: 2119-2132
Published online: 02 Jul 2022
AbstractforPalmatine Protects Against MSU-Induced Gouty Arthritis via Regulating the NF-κB/NLRP3 and Nrf2 Pathways | Full Text | References | PDF (9.9 MB) | EPUB
  • 459 Views
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Article
Ruscogenin Attenuates Lipopolysaccharide-Induced Septic Vascular Endothelial Dysfunction by Modulating the miR-146a-5p/NRP2/SSH1 Axis
Danhong Pan, Jinqiang Zhu, Liexiang Cao, Beilei Zhu & Lili Lin
Pages: 1099-1106
Published online: 12 Apr 2022
AbstractforRuscogenin Attenuates Lipopolysaccharide-Induced Septic Vascular Endothelial Dysfunction by Modulating the miR-146a-5p/NRP2/SSH1 Axis | Full Text | References | PDF (3.8 MB) | EPUB
  • 164 Views
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Article
A Dose-Response Relationship Study of Prophylactic Nalbuphine to Reduce Pain During the Awakening Period in Patients Undergoing Laparoscopic Total Hysterectomy: A Randomized, Controlled, Double-Blind Clinical Study
Min Wang, Dongyue Wang, Jingzhi Zuo, Tianyu Liu, Zheng Niu, Juan Xie & Dunyi Qi
Pages: 981-990
Published online: 31 Mar 2022
AbstractforA Dose-Response Relationship Study of Prophylactic Nalbuphine to Reduce Pain During the Awakening Period in Patients Undergoing Laparoscopic Total Hysterectomy: A Randomized, Controlled, Double-Blind Clinical Study | Full Text | References | PDF (1.1 MB) | EPUB
  • 228 Views
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Article
Design, Synthesis and Biological Evaluation of 1,4-Benzenesulfonamide Derivatives as Glyoxalase I Inhibitors
Suaad Abdallah Audat, Qosay Ali Al-Balas, Buthina Abdallah Al-Oudat, Mo’ad Jamil Athamneh & Amanda Bryant-Friedrich
Pages: 873-885
Published online: 28 Mar 2022
AbstractforDesign, Synthesis and Biological Evaluation of 1,4-Benzenesulfonamide Derivatives as Glyoxalase I Inhibitors | Full Text | References | PDF (3.4 MB) | EPUB
  • 266 Views
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Review

Review Article
Expanding the Clinical Use of CDK4/6 Inhibitors in the Treatment of Hormone Receptor-Positive, HER2-Negative Breast Cancer from Metastatic Setting to Adjuvant Setting
Hikmat Abdel-Razeq & Baha’ Sharaf
Pages: 727-735
Published online: 16 Mar 2022
AbstractforExpanding the Clinical Use of CDK4/6 Inhibitors in the Treatment of Hormone Receptor-Positive, HER2-Negative Breast Cancer from Metastatic Setting to Adjuvant Setting | Full Text | References | PDF (712.3 KB) | EPUB
  • 498 Views
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Original Research

Article
Silibinin Schiff Base Derivatives Counteract CCl4-Induced Acute Liver Injury by Enhancing Anti-Inflammatory and Antiapoptotic Bioactivities
Rong Xu, Siyan Qiu, Jie Zhang, Xiaoli Liu, Ling Zhang, Haizhu Xing, Min You, Man Wang, Yuting Lu, Peng Zhang & Jing Zhu
Pages: 1441-1456
Published online: 16 May 2022
AbstractforSilibinin Schiff Base Derivatives Counteract CCl4-Induced Acute Liver Injury by Enhancing Anti-Inflammatory and Antiapoptotic Bioactivities | Full Text | References | PDF (12.6 MB) | EPUB
  • 253 Views
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Review

Review Article
Platelet Rich Plasma and Its Use in Hair Regrowth: A Review
Anon Paichitrojjana & Anand Paichitrojjana
Pages: 635-645
Published online: 10 Mar 2022
AbstractforPlatelet Rich Plasma and Its Use in Hair Regrowth: A Review | Full Text | References | PDF (340.2 KB) | EPUB
  • 1881 Views
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Perspectives

Discussion
Dezocine Has the Potential to Regulate the Clinical and Biological Features of Tumors
Xudong Hu, Bing Luo, Lei Qiu, Shaosen Chen, Qing Wu, Qingbiao Chen, Xingqing Liu, Chen Ling, Shuping Deng, Manjuan Yuan & Peicun Hu
Pages: 1121-1129
Published online: 20 Apr 2022
AbstractforDezocine Has the Potential to Regulate the Clinical and Biological Features of Tumors | Full Text | References | PDF (1.4 MB) | EPUB
  • 177 Views
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Clinical Trial Report

Case Report
Effect of Intravenous Infusion of Lidocaine Compared with Ultrasound-Guided Transverse Abdominal Plane Block on the Quality of Postoperative Recovery in Patients Undergoing Laparoscopic Bariatric Surgery
Jing Sun, Shan Wang, Jun Wang, Xiuxiu Gao & Guanglei Wang
Pages: 739-748
Published online: 21 Mar 2022
AbstractforEffect of Intravenous Infusion of Lidocaine Compared with Ultrasound-Guided Transverse Abdominal Plane Block on the Quality of Postoperative Recovery in Patients Undergoing Laparoscopic Bariatric Surgery | Full Text | References | PDF (3 MB) | EPUB
  • 287 Views
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Original Research

Article
Dietary Supplement of Anoectochilus roxburghii (Wall.) Lindl. Polysaccharides Ameliorates Cognitive Dysfunction Induced by High Fat Diet via “Gut-Brain” Axis
Liya Fu, Wanlong Zhu, Dongmei Tian, Yong Tang, Yun Ye, Qiming Wei, Chengbin Zhang, Wenqiao Qiu, Dalian Qin, Xuping Yang & Yilan Huang
Pages: 1931-1945
Published online: 20 Jun 2022
AbstractforDietary Supplement of Anoectochilus roxburghii (Wall.) Lindl. Polysaccharides Ameliorates Cognitive Dysfunction Induced by High Fat Diet via “Gut-Brain” Axis | Full Text | References | PDF (10.8 MB) | EPUB
  • 258 Views
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Article
Effects of Cartilage Progenitor Cells, Bone Marrow Mesenchymal Stem Cells and Chondrocytes on Cartilage Repair as Seed Cells: An in vitro Study
Jiaxiang Gu, Bin Wang, Tianliang Wang, Naichen Zhang, Hongjun Liu, Jianchao Gui & Yiming Lu
Pages: 1217-1230
Published online: 28 Apr 2022
AbstractforEffects of Cartilage Progenitor Cells, Bone Marrow Mesenchymal Stem Cells and Chondrocytes on Cartilage Repair as Seed Cells: An in vitro Study | Full Text | References | PDF (8.2 MB) | EPUB
  • 315 Views
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Review

Review Article
Use of Antivirals in SARS-CoV-2 Infection. Critical Review of the Role of Remdesivir
Santiago Moreno, Bernardino Alcázar, Carlos Dueñas, Juan González del Castillo, Julián Olalla & Antonio Antela
Pages: 827-841
Published online: 25 Mar 2022
AbstractforUse of Antivirals in SARS-CoV-2 Infection. Critical Review of the Role of Remdesivir | Full Text | References | PDF (1.1 MB) | EPUB
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Original Research

Article
Reduced the Food Effect and Enhanced the Oral Bioavailability of Ivacaftor by Self-Nanoemulsifying Drug Delivery System (SNEDDS) Using a New Oil Phase
Yanfei Miao, Shihua Zhao, Jian Zuo, Jiqin Sun & Jingnan Wang
Pages: 1531-1546
Published online: 23 May 2022
AbstractforReduced the Food Effect and Enhanced the Oral Bioavailability of Ivacaftor by Self-Nanoemulsifying Drug Delivery System (SNEDDS) Using a New Oil Phase | Full Text | References | PDF (4.5 MB) | EPUB
  • 456 Views
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Article
Novel 2-(5-Aryl-4,5-Dihydropyrazol-1-yl)thiazol-4-One as EGFR Inhibitors: Synthesis, Biological Assessment and Molecular Docking Insights
Tarfah Al-Warhi, Ahmed M El Kerdawy, Mohamed A Said, Amgad Albohy, Zainab M Elsayed, Nada Aljaeed, Eslam B Elkaeed, Wagdy M Eldehna, Hatem A Abdel-Aziz & Miral A Abdelmoaz
Pages: 1457-1471
Published online: 16 May 2022
AbstractforNovel 2-(5-Aryl-4,5-Dihydropyrazol-1-yl)thiazol-4-One as EGFR Inhibitors: Synthesis, Biological Assessment and Molecular Docking Insights | Full Text | References | PDF (7 MB) | EPUB
  • 465 Views
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Article
Involvement of Huanglian Jiedu Decoction on Microglia with Abnormal Sphingolipid Metabolism in Alzheimer’s Disease
Yi-Yu Qi, Xia Heng, Zeng-Ying Yao, Shu-Yue Qu, Ping-Yuan Ge, Xin Zhao, Sai-jia Ni, Rui Guo, Nian-Yun Yang, Qi-Chun Zhang & Hua-Xu Zhu
Pages: 931-950
Published online: 30 Mar 2022
AbstractforInvolvement of Huanglian Jiedu Decoction on Microglia with Abnormal Sphingolipid Metabolism in Alzheimer’s Disease | Full Text | References | PDF (11.4 MB) | EPUB
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Corrigendum

Correction
Inhibition of JNK Phosphorylation by Curcumin Analog C66 Protects LPS-Induced Acute Lung Injury [Corrigendum]
Pages: 249-250
Published online: 19 Jan 2022
CitationforInhibition of JNK Phosphorylation by Curcumin Analog C66 Protects LPS-Induced Acute Lung Injury [Corrigendum] | Full Text | PDF (135.4 KB) | EPUB
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Review

Review Article
Knee Osteoarthritis Therapy: Recent Advances in Intra-Articular Drug Delivery Systems
Luoyang Ma, Xiaoyan Zheng, Rui Lin, Antonia RuJia Sun, Jintong Song, Zhiqiang Ye, Dahong Liang, Min Zhang, Jia Tian, Xin Zhou, Liao Cui, Yuyu Liu & Yanzhi Liu
Pages: 1311-1347
Published online: 04 May 2022
AbstractforKnee Osteoarthritis Therapy: Recent Advances in Intra-Articular Drug Delivery Systems | Full Text | References | PDF (4.8 MB) | EPUB
  • 1659 Views
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Original Research

Article
Network Pharmacology-Based Strategy Combined with Molecular Docking and in vitro Validation Study to Explore the Underlying Mechanism of Huo Luo Xiao Ling Dan in Treating Atherosclerosis
Taoli Sun, Wenjuan Quan, Sha Peng, Dongmei Yang, Jiaqin Liu, Chaoping He, Yu Chen, Bo Hu & Qinhui Tuo
Pages: 1621-1645
Published online: 30 May 2022
AbstractforNetwork Pharmacology-Based Strategy Combined with Molecular Docking and in vitro Validation Study to Explore the Underlying Mechanism of Huo Luo Xiao Ling Dan in Treating Atherosclerosis | Full Text | References | PDF (17.8 MB) | EPUB
  • 343 Views
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Article
Comparison of Prophylactic Norepinephrine and Phenylephrine Infusions During Spinal Anaesthesia for Primary Caesarean Delivery in Twin Pregnancies: A Randomized Double-Blinded Clinical Study
Weijia Du, Yujie Song, Jiang Li, Xianjin Zhou, Zhendong Xu & Zhiqiang Liu
Pages: 789-798
Published online: 24 Mar 2022
AbstractforComparison of Prophylactic Norepinephrine and Phenylephrine Infusions During Spinal Anaesthesia for Primary Caesarean Delivery in Twin Pregnancies: A Randomized Double-Blinded Clinical Study | Full Text | References | PDF (2.4 MB) | EPUB
  • 252 Views
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Article
Comprehensive Analysis of Metabolic Changes in Male Mice Exposed to Sodium Valproate Based on GC-MS Analysis
Yahao Gao, Di Jiang, Changshui Wang, Gang An, Li Zhu & Changmeng Cui
Pages: 1915-1930
Published online: 17 Jun 2022
AbstractforComprehensive Analysis of Metabolic Changes in Male Mice Exposed to Sodium Valproate Based on GC-MS Analysis | Full Text | References | PDF (4.1 MB) | EPUB
  • 362 Views
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Article
Shaoyao Gancao Decoction Ameliorates Paclitaxel-Induced Peripheral Neuropathy via Suppressing TRPV1 and TLR4 Signaling Expression in Rats
Yu Chen, Ruohuang Lu, Yang Wang & Pingping Gan
Pages: 2067-2081
Published online: 30 Jun 2022
AbstractforShaoyao Gancao Decoction Ameliorates Paclitaxel-Induced Peripheral Neuropathy via Suppressing TRPV1 and TLR4 Signaling Expression in Rats | Full Text | References | PDF (8.4 MB) | EPUB
  • 254 Views
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Clinical Trial Report

Case Report
Added Syrup as a Flavoring to Oral Midazolam Intravenous Solution Premedication Improves Tolerability in Pediatric Patients
Qineng Xue, Junming Xia, Jin Lu & Xia Shen
Pages: 1211-1216
Published online: 28 Apr 2022
AbstractforAdded Syrup as a Flavoring to Oral Midazolam Intravenous Solution Premedication Improves Tolerability in Pediatric Patients | Full Text | References | PDF (1.1 MB) | EPUB
  • 230 Views
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Case Report
Effects of Intravenous Analgesia Using Tramadol on Postoperative Depression State and Sleep Quality in Women Undergoing Abdominal Endoscopic Surgery: A Randomized Controlled Trial
Mengyue Fu, Shi Chen, Rui Xu, Jie Chen, Xuehan Chen, Wanxia Gan, He Huang & Guangyou Duan
Pages: 1289-1300
Published online: 02 May 2022
AbstractforEffects of Intravenous Analgesia Using Tramadol on Postoperative Depression State and Sleep Quality in Women Undergoing Abdominal Endoscopic Surgery: A Randomized Controlled Trial | Full Text | References | PDF (3.4 MB) | EPUB
  • 252 Views
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Review

Review Article
The Role of Dexmedetomidine in Tumor-Progressive Factors in the Perioperative Period and Cancer Recurrence: A Narrative Review
Qiang Cai, Guoqing Liu, Linsheng Huang, Yuting Guan, Huixia Wei, Zhiqian Dou, Dexi Liu, Yang Hu & Meiling Gao
Pages: 2161-2175
Published online: 06 Jul 2022
AbstractforThe Role of Dexmedetomidine in Tumor-Progressive Factors in the Perioperative Period and Cancer Recurrence: A Narrative Review | Full Text | References | PDF (1.4 MB) | EPUB
  • 396 Views
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Original Research

Article
Effectiveness and Safety of Anlotinib with or without PD-1 Blockades in the Treatment of Patients with Advanced Primary Hepatocellular Carcinoma: A Retrospective, Real-World Study in China
Xiao-Qi Chen, Yun-Xia Zhao, Chuan-Lei Zhang, Xin-Ting Wang, Xin Zhang, Xi Chen, Chang-Wei Yuan, Qing Zhao & Xin-Ju Chen
Pages: 1483-1493
Published online: 17 May 2022
AbstractforEffectiveness and Safety of Anlotinib with or without PD-1 Blockades in the Treatment of Patients with Advanced Primary Hepatocellular Carcinoma: A Retrospective, Real-World Study in China | Full Text | References | PDF (3.4 MB) | EPUB
  • 209 Views
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Article
Efficacy and Prognostic Factors for Response to PD-1 Inhibitors in Advanced Cervical Carcinoma: A Retrospective Study
Mingxia Cheng, Haihong Wang, Yingchao Zhao & Guiling Li
Pages: 887-897
Published online: 29 Mar 2022
AbstractforEfficacy and Prognostic Factors for Response to PD-1 Inhibitors in Advanced Cervical Carcinoma: A Retrospective Study | Full Text | References | PDF (4 MB) | EPUB
  • 198 Views
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Article
Protective Effect of Hedyotis diffusa Willd. Ethanol Extract on Isoniazid-Induced Liver Injury in the Zebrafish Model
Xin Wang, Jie Zhao, Rui Zhang, Xinlu Liu, Chuanjiang Ma, Guangshang Cao, Yongli Wei & Peimin Yang
Pages: 1995-2015
Published online: 27 Jun 2022
AbstractforProtective Effect of Hedyotis diffusa Willd. Ethanol Extract on Isoniazid-Induced Liver Injury in the Zebrafish Model | Full Text | References | PDF (21.4 MB) | EPUB
  • 256 Views
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Article
Lung-Protective Effects of Lidocaine Infusion on Patients with Intermediate/ High Risk of Postoperative Pulmonary Complications: A Double-Blind Randomized Controlled Trial
Xinghe Wang, Kedi Guo, Ye Zhao, Tong Li, Yuping Yang, Lingfei Xu & Su Liu
Pages: 1041-1053
Published online: 08 Apr 2022
AbstractforLung-Protective Effects of Lidocaine Infusion on Patients with Intermediate/ High Risk of Postoperative Pulmonary Complications: A Double-Blind Randomized Controlled Trial | Full Text | References | PDF (1.1 MB) | EPUB
  • 228 Views
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Article
Magnesium Lithospermate B Protects Against Cisplatin-Induced Acute Kidney Injury via Alleviating Mitochondrial Dysfunction
Daoqi Shen, Man Guo, Xuemei Geng, Jinbo Yu, Zhen Zhang, Jing Lin, Pan Lin, Xiaoqiang Ding & Xialian Xu
Pages: 2293-2304
Published online: 15 Jul 2022
AbstractforMagnesium Lithospermate B Protects Against Cisplatin-Induced Acute Kidney Injury via Alleviating Mitochondrial Dysfunction | Full Text | References | PDF (8.4 MB) | EPUB
  • 175 Views
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Article
Switching from a Non-Protease inhibitor-Based Regimen To the Fixed Dose Combination of Darunavir/Cobicistat/Emtricitabine/Tenofovir Alafenamide in Clinical Practice
Martina Ranzenigo, Nicola Gianotti, Laura Galli, Andrea Poli, Andrea Mastrangelo, Elena Bruzzesi, Matteo Chiurlo, Silvia Nozza, Simona Bossolasco, Vincenzo Spagnuolo, Daniela Mancusi, Roberta Termini, Elisabetta Carini, Adriano Lazzarin & Antonella Castagna
Pages: 1975-1982
Published online: 27 Jun 2022
AbstractforSwitching from a Non-Protease inhibitor-Based Regimen To the Fixed Dose Combination of Darunavir/Cobicistat/Emtricitabine/Tenofovir Alafenamide in Clinical Practice | Full Text | References | PDF (330.2 KB) | EPUB
  • 161 Views
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Review

Review Article
Designing a Dual GLP-1R/GIPR Agonist from Tirzepatide: Comparing Residues Between Tirzepatide, GLP-1, and GIP
Lijing Wang
Pages: 1547-1559
Published online: 25 May 2022
AbstractforDesigning a Dual GLP-1R/GIPR Agonist from Tirzepatide: Comparing Residues Between Tirzepatide, GLP-1, and GIP | Full Text | References | PDF (3 MB) | EPUB
  • 1783 Views
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Review Article
Progress on SARS-CoV-2 3CLpro Inhibitors: Inspiration from SARS-CoV 3CLpro Peptidomimetics and Small-Molecule Anti-Inflammatory Compounds
Jiajie Zhu, Haiyan Zhang, Qinghong Lin, Jingting Lyu, Lu Lu, Hanxi Chen, Xuning Zhang, Yanjun Zhang & Keda Chen
Pages: 1067-1082
Published online: 08 Apr 2022
AbstractforProgress on SARS-CoV-2 3CLpro Inhibitors: Inspiration from SARS-CoV 3CLpro Peptidomimetics and Small-Molecule Anti-Inflammatory Compounds | Full Text | References | PDF (4.7 MB) | EPUB
  • 690 Views
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Original Research

Article
Inhibition of Axitinib on Buspirone Metabolism in vitro and in vivo
Bo-Wen Zhang, Ni-Hong Pang, Ren-Ai Xu, Gao-Er Qu & Cong-Rong Tang
Pages: 2031-2042
Published online: 30 Jun 2022
AbstractforInhibition of Axitinib on Buspirone Metabolism in vitro and in vivo | Full Text | References | PDF (7.1 MB) | EPUB
  • 233 Views
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Clinical Trial Report

Case Report
Quality of Recovery After General Anesthesia with Remimazolam in Patients’ Undergoing Urologic Surgery: A Randomized Controlled Trial Comparing Remimazolam with Propofol
Yuanyuan Mao, Jin Guo, Jingjing Yuan, Erxian Zhao & Jianjun Yang
Pages: 1199-1209
Published online: 27 Apr 2022
AbstractforQuality of Recovery After General Anesthesia with Remimazolam in Patients’ Undergoing Urologic Surgery: A Randomized Controlled Trial Comparing Remimazolam with Propofol | Full Text | References | PDF (774.6 KB) | EPUB
  • 751 Views
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Original Research

Article
Pharmacokinetics and Safety of Single and Multiple Doses of Peficitinib (ASP015K) in Healthy Chinese Subjects
Xin Gao, Xuemei He, Hiroyuki Oshima, Daisuke Miyatake, Yukio Otsuka, Kota Kato, Chunxiao Cai, Tomasz Wojtkowski, Nan Song, Yuichiro Kaneko & Aixin Shi
Pages: 1365-1381
Published online: 09 May 2022
AbstractforPharmacokinetics and Safety of Single and Multiple Doses of Peficitinib (ASP015K) in Healthy Chinese Subjects | Full Text | References | PDF (6 MB) | EPUB
  • 201 Views
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Letter

Letter
Comparing Efficacy of Analgesic Modalities in Patients Undergoing Total Knee Arthroplasty [Letter]
Ying Gao, Fu-Shan Xue & Cheng-Wen Li
Pages: 467-468
Published online: 22 Feb 2022
CitationforComparing Efficacy of Analgesic Modalities in Patients Undergoing Total Knee Arthroplasty [Letter] | Full Text | References | PDF (196.8 KB) | EPUB
  • 122 Views
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Original Research

Article
Effect of Systemic Lidocaine on Postoperative Early Recovery Quality in Patients Undergoing Supratentorial Tumor Resection
Kai Zhao, Yushan Dong, Gaowei Su, Yaolin Wang, Tao Ji, Nanling Wu, Xiaojie Cui, Wenzhan Li, Yanming Yang & Xiuxia Chen
Pages: 1171-1181
Published online: 22 Apr 2022
AbstractforEffect of Systemic Lidocaine on Postoperative Early Recovery Quality in Patients Undergoing Supratentorial Tumor Resection | Full Text | References | PDF (495.8 KB) | EPUB
  • 272 Views
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Article
Evaluation of Different Surface Coating Agents for Selenium Nanoparticles: Enhanced Anti-Inflammatory Activity and Drug Loading Capacity
Aml I Mekkawy, M Fathy & Hebatallah B Mohamed
Pages: 1811-1825
Published online: 13 Jun 2022
AbstractforEvaluation of Different Surface Coating Agents for Selenium Nanoparticles: Enhanced Anti-Inflammatory Activity and Drug Loading Capacity | Full Text | References | PDF (13.4 MB) | EPUB
  • 414 Views
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Article
Astragaloside IV Alleviates Renal Tubular Epithelial-Mesenchymal Transition via CX3CL1-RAF/MEK/ERK Signaling Pathway in Diabetic Kidney Disease
Yonghui Hu, Wangna Tang, Wenjie Liu, Zhibo Hu & Congqing Pan
Pages: 1605-1620
Published online: 31 May 2022
AbstractforAstragaloside IV Alleviates Renal Tubular Epithelial-Mesenchymal Transition via CX3CL1-RAF/MEK/ERK Signaling Pathway in Diabetic Kidney Disease | Full Text | References | PDF (11.4 MB) | EPUB
  • 225 Views
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Review

Review Article
Anti-Hyperglycemic Agents in the Adjuvant Treatment of Sepsis: Improving Intestinal Barrier Function
Yi-Feng Wang, Jia-Wei Li, Da-Peng Wang, Ke Jin, Jiao-Jie Hui & Hong-Yang Xu
Pages: 1697-1711
Published online: 04 Jun 2022
AbstractforAnti-Hyperglycemic Agents in the Adjuvant Treatment of Sepsis: Improving Intestinal Barrier Function | Full Text | References | PDF (534.4 KB) | EPUB
  • 299 Views
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Original Research

Article
6-Methoxyflavone and Donepezil Behavioral Plus Neurochemical Correlates in Reversing Chronic Ethanol and Withdrawal Induced Cognitive Impairment
Mehreen Arif, Khalid Rauf, Naeem Ur Rehman, Ahmed Tokhi, Muhammad Ikram & Robert D Sewell
Pages: 1573-1593
Published online: 28 May 2022
Abstractfor6-Methoxyflavone and Donepezil Behavioral Plus Neurochemical Correlates in Reversing Chronic Ethanol and Withdrawal Induced Cognitive Impairment | Full Text | References | PDF (11.6 MB) | EPUB
  • 329 Views
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Article
Integrating Network Pharmacology and Experimental Verification to Explore the Pharmacological Mechanisms of Aloin Against Gastric Cancer
Jia Gao, Sifu Yang, Guanqun Xie, Jieli Pan & Feiye Zhu
Pages: 1947-1961
Published online: 20 Jun 2022
AbstractforIntegrating Network Pharmacology and Experimental Verification to Explore the Pharmacological Mechanisms of Aloin Against Gastric Cancer | Full Text | References | PDF (13.6 MB) | EPUB
  • 526 Views
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Corrigendum

Correction
Emodin-Induced Autophagy Against Cell Apoptosis Through the PI3K/AKT/mTOR Pathway in Human Hepatocytes [Corrigendum]
Pages: 345-347
Published online: 16 Feb 2022
First Page PreviewforEmodin-Induced Autophagy Against Cell Apoptosis Through the PI3K/AKT/mTOR Pathway in Human Hepatocytes [Corrigendum] | Full Text | PDF (1.5 MB) | EPUB
  • 115 Views
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Original Research

Article
Effects of Dexmedetomidine Administered Through Different Routes on Kidney Tissue in Rats with Spinal Cord Ischaemia–Reperfusion Injury
Necmiye Şengel, Zeynep Köksal, Ali Doğan Dursun, Ömer Kurtipek, Şaban Cem Sezen, Mustafa Arslan & Mustafa Kavutçu
Pages: 2229-2239
Published online: 13 Jul 2022
AbstractforEffects of Dexmedetomidine Administered Through Different Routes on Kidney Tissue in Rats with Spinal Cord Ischaemia–Reperfusion Injury | Full Text | References | PDF (3.1 MB) | EPUB
  • 207 Views
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Article
Ginsenoside Rb1 Alleviates Bleomycin-Induced Pulmonary Inflammation and Fibrosis by Suppressing Central Nucleotide-Binding Oligomerization-, Leucine-Rich Repeat-, and Pyrin Domains-Containing Protein Three Inflammasome Activation and the NF-κB Pathway
Jingjing Liu, Guoqing Fan, Ningning Tao, Feifei Feng, Chao Meng & Tieying Sun
Pages: 1793-1809
Published online: 13 Jun 2022
AbstractforGinsenoside Rb1 Alleviates Bleomycin-Induced Pulmonary Inflammation and Fibrosis by Suppressing Central Nucleotide-Binding Oligomerization-, Leucine-Rich Repeat-, and Pyrin Domains-Containing Protein Three Inflammasome Activation and the NF-κB Pathway | Full Text | References | PDF (13.6 MB) | EPUB
  • 206 Views
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Article
Exploration of the Effect and Potential Mechanism of Echinacoside Against Endometrial Cancer Based on Network Pharmacology and in vitro Experimental Verification
Wan Shu, Ziwei Wang, Rong Zhao, Rui Shi, Jun Zhang, Wei Zhang & Hongbo Wang
Pages: 1847-1863
Published online: 16 Jun 2022
AbstractforExploration of the Effect and Potential Mechanism of Echinacoside Against Endometrial Cancer Based on Network Pharmacology and in vitro Experimental Verification | Full Text | References | PDF (14.8 MB) | EPUB
  • 273 Views
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Article
Salidroside Protects Acute Kidney Injury in Septic Rats by Inhibiting Inflammation and Apoptosis
Heng Fan, Bin-jie Su, Jian-wei Le & Jian-hua Zhu
Pages: 899-907
Published online: 30 Mar 2022
AbstractforSalidroside Protects Acute Kidney Injury in Septic Rats by Inhibiting Inflammation and Apoptosis | Full Text | References | PDF (5.9 MB) | EPUB
  • 181 Views
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Response to Letter

Letter
Comparing Efficacy of Different Analgesic Modalities in Patients Undergoing Total Knee Arthroplasty [Response To Letter]
Rui Xiao, Li-Fang Liu, Ya-Ru Luo, Chang Liu, Xiao-Bin Jin, Wei Zhou & Guang-Hong Xu
Pages: 737-738
Published online: 18 Mar 2022
CitationforComparing Efficacy of Different Analgesic Modalities in Patients Undergoing Total Knee Arthroplasty [Response To Letter] | Full Text | References | PDF (191.5 KB) | EPUB
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Original Research

Article
Population Pharmacokinetic Modelling for Nifedipine to Evaluate the Effect of Parathyroid Hormone on CYP3A in Patients with Chronic Kidney Disease
Chengxiao Fu, Qi Pei, Wu Liang, Bo Yang, Wei Li, Jun Liu, Hongyi Tan, Chengxian Guo, Hao Zhang & Guoping Yang
Pages: 2261-2274
Published online: 13 Jul 2022
AbstractforPopulation Pharmacokinetic Modelling for Nifedipine to Evaluate the Effect of Parathyroid Hormone on CYP3A in Patients with Chronic Kidney Disease | Full Text | References | PDF (2.7 MB) | EPUB
  • 187 Views
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Article
Isoliquiritigenin Ameliorates Ischemia-Induced Myocardial Injury via Modulating the Nrf2/HO-1 Pathway in Mice
Deshan Yao, Bo Shi, Sichuan Wang, Liuxiang Bao, Meng Tan, Hui Shen, Zhengang Zhang, Xin Pan, Yi Yang, Yong Wu & Kaizheng Gong
Pages: 1273-1287
Published online: 29 Apr 2022
AbstractforIsoliquiritigenin Ameliorates Ischemia-Induced Myocardial Injury via Modulating the Nrf2/HO-1 Pathway in Mice | Full Text | References | PDF (12.5 MB) | EPUB
  • 223 Views
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Article
Orexin-A Reverse Bone Mass Loss Induced by Chronic Intermittent Hypoxia Through OX1R-Nrf2/HIF-1α Pathway
Hong Gu, Yiwen Ru, Wei Wang, Guanhui Cai, Lanxin Gu, Junjie Ye, Wei-Bing Zhang & Lin Wang
Pages: 2145-2160
Published online: 05 Jul 2022
AbstractforOrexin-A Reverse Bone Mass Loss Induced by Chronic Intermittent Hypoxia Through OX1R-Nrf2/HIF-1α Pathway | Full Text | References | PDF (10.7 MB) | EPUB
  • 198 Views
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Article
Compatibility and Stability of Ten Commonly Used Clinical Drugs in Pediatric Electrolyte Supplements Injection
Hongxin Shen, Yuzhi Fu, Ying Chen, Wenxing Xia, Zhi-Jun Jia, Qin Yu, Lingli Zhang & Lu Han
Pages: 1433-1440
Published online: 12 May 2022
AbstractforCompatibility and Stability of Ten Commonly Used Clinical Drugs in Pediatric Electrolyte Supplements Injection | Full Text | References | PDF (325.3 KB) | EPUB
  • 287 Views
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Article
THSD7B Mutation Induces Platinum Resistance in Small Cell Lung Cancer Patients
Zifu Yao, Anqi Lin, Yonglin Yi, Weitao Shen, Jian Zhang & Peng Luo
Pages: 1679-1695
Published online: 03 Jun 2022
AbstractforTHSD7B Mutation Induces Platinum Resistance in Small Cell Lung Cancer Patients | Full Text | References | PDF (15.9 MB) | EPUB
  • 202 Views
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Article
Effects of Super-Activated Platelet Lysate on Early Healing of Tooth Extraction Sockets in Rats
Xiaorui Guo, Huiying Lu, Chunxiang Liu, Yi Zhang & Liangjia Bi
Pages: 2213-2227
Published online: 13 Jul 2022
AbstractforEffects of Super-Activated Platelet Lysate on Early Healing of Tooth Extraction Sockets in Rats | Full Text | References | PDF (10.5 MB) | EPUB
  • 293 Views
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Article
Effects of Ethanolic Extract of Schisandra sphenanthera on the Pharmacokinetics of Rosuvastatin in Rats
Qing Sun, Li Li & Quan Zhou
Pages: 1473-1481
Published online: 17 May 2022
AbstractforEffects of Ethanolic Extract of Schisandra sphenanthera on the Pharmacokinetics of Rosuvastatin in Rats | Full Text | References | PDF (3 MB) | EPUB
  • 217 Views
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Article
Shikonin Could Be Used to Treat Tubal Pregnancy via Enhancing Ferroptosis Sensitivity
Yuling Lai, Fuling Zeng, Zhenyue Chen, Min Feng, Yanxi Huang, Pin Qiu, Lihua Zeng, Yan Ke, Gaopi Deng & Jie Gao
Pages: 2083-2099
Published online: 01 Jul 2022
AbstractforShikonin Could Be Used to Treat Tubal Pregnancy via Enhancing Ferroptosis Sensitivity | Full Text | References | PDF (10.7 MB) | EPUB
  • 250 Views
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Article
Design, Synthesis, and Anti-Inflammatory Activity of Some Coumarin Schiff Base Derivatives: In silico and in vitro Study
Shokhan J Hamid & Twana Salih
Pages: 2275-2288
Published online: 14 Jul 2022
AbstractforDesign, Synthesis, and Anti-Inflammatory Activity of Some Coumarin Schiff Base Derivatives: In silico and in vitro Study | Full Text | References | PDF (6.2 MB) | EPUB
  • 1276 Views
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Review

Review Article
Pharmacological Aspects of Natural Quercetin in Rheumatoid Arthritis
Mengshi Tang, Yan Zeng, Weijun Peng, Xi Xie, Yongyu Yang, Biting Ji & Fen Li
Pages: 2043-2053
Published online: 29 Jun 2022
AbstractforPharmacological Aspects of Natural Quercetin in Rheumatoid Arthritis | Full Text | References | PDF (1.5 MB) | EPUB
  • 961 Views
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Open Access
Review Article
Research Progress of Liujunzi Decoction in the Treatment of Tumor-Associated Anorexia
Xipei Wu, Yongzhao Dai & Ke Nie
Pages: 1731-1741
Published online: 07 Jun 2022
AbstractforResearch Progress of Liujunzi Decoction in the Treatment of Tumor-Associated Anorexia | Full Text | References | PDF (2.7 MB) | EPUB
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Review Article
Population Pharmacokinetics of Tigecycline: A Systematic Review
Can-Can Zhou, Fang Huang, Jing-Ming Zhang & Yu-Gang Zhuang
Pages: 1885-1896
Published online: 17 Jun 2022
AbstractforPopulation Pharmacokinetics of Tigecycline: A Systematic Review | Full Text | References | PDF (2.2 MB) | EPUB
  • 384 Views
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Original Research

Article
Effects of Simvastatin on the Metabolism of Vonoprazan in Rats Both in vitro and in vivo
Yun Hong, Da-Peng Dai, Jian-Ping Cai, Shuang-Hu Wang, Yi-Ran Wang, Fang-Ling Zhao, Shan Zhou, Quan Zhou, Pei-Wu Geng, Yun-Fang Zhou, Xue Xu, Ji-Hua Shi & Qing-Feng Luo
Pages: 1779-1789
Published online: 09 Jun 2022
AbstractforEffects of Simvastatin on the Metabolism of Vonoprazan in Rats Both in vitro and in vivo | Full Text | References | PDF (5.8 MB) | EPUB
  • 345 Views
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Article
Determination of the Cut-off Value for Imatinib Plasma Levels Linked to Occurrence of Bone Pain in CML Patients
Marwa S Hamza, Samia A Shouman, Raafat Abdelfattah, Heba S Moussa & Mervat M Omran
Pages: 1595-1604
Published online: 30 May 2022
AbstractforDetermination of the Cut-off Value for Imatinib Plasma Levels Linked to Occurrence of Bone Pain in CML Patients | Full Text | References | PDF (2.4 MB) | EPUB
  • 161 Views
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Article
Ropivacaine with Dexmedetomidine or Dexamethasone in a Thoracic Paravertebral Nerve Block Combined with an Erector Spinae Plane Block for Thoracoscopic Lobectomy Analgesia: A Randomized Controlled Trial
Jing Yang, Min Zhao, Xiao-Rui Zhang, Xiao-Rui Wang, Zhi-Hao Wang, Xiao-Yue Feng, Ya-Juan Lei & Jian-Wen Zhang
Pages: 1561-1571
Published online: 26 May 2022
AbstractforRopivacaine with Dexmedetomidine or Dexamethasone in a Thoracic Paravertebral Nerve Block Combined with an Erector Spinae Plane Block for Thoracoscopic Lobectomy Analgesia: A Randomized Controlled Trial | Full Text | References | PDF (1.6 MB) | EPUB
  • 439 Views
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Article
Transferrin-Modified Mangiferin-Loaded SLNs: Preparation, Characterization, and Application in A549 Lung Cancer Cell
Qi Zhou, Kezhu Hou & Zhiqiang Fu
Pages: 1767-1778
Published online: 08 Jun 2022
AbstractforTransferrin-Modified Mangiferin-Loaded SLNs: Preparation, Characterization, and Application in A549 Lung Cancer Cell | Full Text | References | PDF (5.8 MB) | EPUB
  • 279 Views
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Article
Carbon Monoxide-Releasing Molecule-3 Enhances Osteogenic Differentiation of Rat Bone Marrow Mesenchymal Stem Cells via miR-195-5p/Wnt3a Pathway
Jingyuan Li, Qingbin Han, Hui Chen, Tingting Liu, Jiahui Song, Meng Hou, Lingling Wei & Hui Song
Pages: 2101-2117
Published online: 02 Jul 2022
AbstractforCarbon Monoxide-Releasing Molecule-3 Enhances Osteogenic Differentiation of Rat Bone Marrow Mesenchymal Stem Cells via miR-195-5p/Wnt3a Pathway | Full Text | References | PDF (10.6 MB) | EPUB
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Retraction

Retraction
Lycium barbarum Polysaccharide Prevents Cisplatin Induced MLTC-1 Cell Apoptosis and Autophagy via Regulating Endoplasmic Reticulum Stress Pathway [Retraction]
Pages: 799-800
Published online: 25 Mar 2022
CitationforLycium barbarum Polysaccharide Prevents Cisplatin Induced MLTC-1 Cell Apoptosis and Autophagy via Regulating Endoplasmic Reticulum Stress Pathway [Retraction] | Full Text | PDF (141.2 KB) | EPUB
  • 117 Views
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Original Research

Article
Human Growth Hormone Fragment 176–191 Peptide Enhances the Toxicity of Doxorubicin-Loaded Chitosan Nanoparticles Against MCF-7 Breast Cancer Cells
Mahmoud M Habibullah, Syam Mohan, Nabeel Kashan Syed, Hafiz A Makeen, Qazi Mohammad Sajid Jamal, Hani Alothaid, Farkad Bantun, Alaa Alhazmi, Ali Hakamy, Yahia A Kaabi, Ghalia Samlan, Mohtashim Lohani, Neelaveni Thangavel & Mohamed Ahmed Al-Kasim
Pages: 1963-1974
Published online: 27 Jun 2022
AbstractforHuman Growth Hormone Fragment 176–191 Peptide Enhances the Toxicity of Doxorubicin-Loaded Chitosan Nanoparticles Against MCF-7 Breast Cancer Cells | Full Text | References | PDF (3 MB) | EPUB
  • 2534 Views
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Review

Review Article
Recent Progress in the Development of Opaganib for the Treatment of Covid-19
Charles D Smith, Lynn W Maines, Staci N Keller, Vered Katz Ben-Yair, Reza Fathi, Terry F Plasse & Mark L Levitt
Pages: 2199-2211
Published online: 12 Jul 2022
AbstractforRecent Progress in the Development of Opaganib for the Treatment of Covid-19 | Full Text | References | PDF (1.1 MB) | EPUB
  • 333 Views
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Review Article
Quality of Evidence Supporting the Role of Tripterygium Glycosides for the Treatment of Diabetic Kidney Disease: An Overview of Systematic Reviews and Meta-Analyses
Hongshuo Shi, Pin Deng, Chengda Dong, Rongchen Lu, Guomin Si & Tiantian Yang
Pages: 1647-1665
Published online: 31 May 2022
AbstractforQuality of Evidence Supporting the Role of Tripterygium Glycosides for the Treatment of Diabetic Kidney Disease: An Overview of Systematic Reviews and Meta-Analyses | Full Text | References | PDF (592.6 KB) | EPUB
  • 201 Views
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Original Research

Article
Sorafenib Attenuates Fibrotic Hepatic Injury Through Mediating Lysine Crotonylation
Xiao-Feng Chen & Shaoxiu Ji
Pages: 2133-2144
Published online: 03 Jul 2022
AbstractforSorafenib Attenuates Fibrotic Hepatic Injury Through Mediating Lysine Crotonylation | Full Text | References | PDF (10.1 MB) | EPUB
  • 203 Views
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Article
Comparative Dose-Response Study of Phenylephrine Bolus for the Treatment of the First Episode of Spinal Anesthesia-Induced Hypotension for Cesarean Delivery in Severe Preeclamptic versus Normotensive Parturients
Li-Juan Hu, Zhong Mei, Yan-Ping Shen, Hao-Tian Sun, Zhi-Min Sheng, Xin-Zhong Chen & Xiao-Wei Qian
Pages: 2189-2198
Published online: 08 Jul 2022
AbstractforComparative Dose-Response Study of Phenylephrine Bolus for the Treatment of the First Episode of Spinal Anesthesia-Induced Hypotension for Cesarean Delivery in Severe Preeclamptic versus Normotensive Parturients | Full Text | References | PDF (2.2 MB) | EPUB
  • 273 Views
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Article
Paeoniflorin Ameliorates BiPN by Reducing IL6 Levels and Regulating PARKIN-Mediated Mitochondrial Autophagy
Runjie Sun, Jiang Liu, Manya Yu, Mengting Xia, Yanyu Zhang, Xiaoqi Sun, Yunsheng Xu & Xing Cui
Pages: 2241-2259
Published online: 13 Jul 2022
AbstractforPaeoniflorin Ameliorates BiPN by Reducing IL6 Levels and Regulating PARKIN-Mediated Mitochondrial Autophagy | Full Text | References | PDF (9.9 MB) | EPUB
  • 225 Views
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Article
Appropriate Dose of Dapagliflozin Improves Cardiac Outcomes by Normalizing Mitochondrial Fission and Reducing Cardiomyocyte Apoptosis After Acute Myocardial Infarction
Zhong-guo Fan, Yang Xu, Xi Chen, Ming-yue Ji & Gen-shan Ma
Pages: 2017-2030
Published online: 28 Jun 2022
AbstractforAppropriate Dose of Dapagliflozin Improves Cardiac Outcomes by Normalizing Mitochondrial Fission and Reducing Cardiomyocyte Apoptosis After Acute Myocardial Infarction | Full Text | References | PDF (12.8 MB) | EPUB
  • 302 Views
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Open Access

Corrigendum

Correction
The Steady-State Comparative Bioavailability of Intramuscular Risperidone ISM and Oral Risperidone: An Open-Label, One-Sequence Study [Corrigendum]
Pages: 1791-1792
Published online: 13 Jun 2022
CitationforThe Steady-State Comparative Bioavailability of Intramuscular Risperidone ISM and Oral Risperidone: An Open-Label, One-Sequence Study [Corrigendum] | Full Text | PDF (229.9 KB) | EPUB
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Retraction

Retraction
Senkyunolide A Protects Neural Cells against Corticosterone-Induced Apoptosis by Modulating Protein Phosphatase 2A and α-Synuclein Signaling [Retraction]
Pages: 2187-2188
Published online: 12 Jul 2022
CitationforSenkyunolide A Protects Neural Cells against Corticosterone-Induced Apoptosis by Modulating Protein Phosphatase 2A and α-Synuclein Signaling [Retraction] | Full Text | PDF (256.2 KB) | EPUB
  • 113 Views
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Retraction
Novel Purine Thioglycoside Analogs: Synthesis, Nanoformulation and Biological Evaluation in in vitro Human Liver and Breast Cancer Models [Retraction]
Pages: 2289-2290
Published online: 15 Jul 2022
CitationforNovel Purine Thioglycoside Analogs: Synthesis, Nanoformulation and Biological Evaluation in in vitro Human Liver and Breast Cancer Models [Retraction] | Full Text | PDF (242.3 KB) | EPUB
  • 132 Views
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Retraction
Development and Evaluation of in-situ Nasal Gel Formulations of Nanosized Transferosomal Sumatriptan: Design, Optimization, in vitro and in vivo Evaluation [Retraction]
Pages: 2291-2292
Published online: 15 Jul 2022
CitationforDevelopment and Evaluation of in-situ Nasal Gel Formulations of Nanosized Transferosomal Sumatriptan: Design, Optimization, in vitro and in vivo Evaluation [Retraction] | Full Text | PDF (235.9 KB) | EPUB
  • 134 Views
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REVIEW

Review
Albumin-Fusion Recombinant FIX in the Management of People with Hemophilia B: An Evidence-Based Review
Samantha Pasca & Ezio Zanon
Pages: 3109-3116
Published online: 05 Dec 2023
AbstractforAlbumin-Fusion Recombinant FIX in the Management of People with Hemophilia B: An Evidence-Based Review | Full Text | References | PDF (400.4 KB) | EPUB
  • 131 Views
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Review
Management of Axial Spondyloarthritis – Insights into Upadacitinib
Jürgen Braun, Uta Kiltz & Xenofon Baraliakos
Pages: 3609-3620
Published online: 05 Dec 2023
AbstractforManagement of Axial Spondyloarthritis – Insights into Upadacitinib | Full Text | References | PDF (5.6 MB) | EPUB
  • 212 Views
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Review
Current Perspectives: Evidence to Date on BTK Inhibitors in the Management of Multiple Sclerosis
Edgar Carnero Contentti & Jorge Correale
Pages: 3473-3490
Published online: 05 Dec 2023
AbstractforCurrent Perspectives: Evidence to Date on BTK Inhibitors in the Management of Multiple Sclerosis | Full Text | References | PDF (2.2 MB) | EPUB
  • 339 Views
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Open Access

ORIGINAL RESEARCH

Article
A Potent EGFR Inhibitor, N-Phenyl Pyrazoline Derivative Suppresses Aggressiveness and Cancer Stem Cell-Like Phenotype of Cervical Cancer Cells
Mustofa, Pamungkas Bagus Satriyo, Artania Adnin Tri Suma, Stephanus Satria Wira Waskitha, Tutik Dwi Wahyuningsih & Eti Nurwening Sholikhah
Pages: 2325-2339
Published online: 05 Dec 2023
AbstractforA Potent EGFR Inhibitor, N-Phenyl Pyrazoline Derivative Suppresses Aggressiveness and Cancer Stem Cell-Like Phenotype of Cervical Cancer Cells | Full Text | References | PDF (8 MB) | EPUB
  • 156 Views
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Article
Mahuang Decoction Attenuates Airway Inflammation and Remodeling in Asthma via Suppression of the SP1/FGFR3/PI3K/AKT Axis
Lina Wei, Xulei Gou, Baoning Su, Haiqiong Han, Tingting Guo, Liang Liu, Lei Wang, Lina Zhang & Weibin Chen
Pages: 2833-2850
Published online: 05 Dec 2023
AbstractforMahuang Decoction Attenuates Airway Inflammation and Remodeling in Asthma via Suppression of the SP1/FGFR3/PI3K/AKT Axis | Full Text | References | PDF (12.4 MB) | EPUB
  • 218 Views
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Article
The Flavagline Compound 1-(2-(dimethylamino)acetyl)-Rocaglaol Induces Apoptosis in K562 Cells by Regulating the PI3K/Akt/mTOR, JAK2/STAT3, and MAPK Pathways
Xinmei Yang, Xijun Wu, Xiaosen Wu, Lei Huang, Jingrui Song, Chunmao Yuan, Zhixu He & Yanmei Li
Pages: 2545-2557
Published online: 05 Dec 2023
AbstractforThe Flavagline Compound 1-(2-(dimethylamino)acetyl)-Rocaglaol Induces Apoptosis in K562 Cells by Regulating the PI3K/Akt/mTOR, JAK2/STAT3, and MAPK Pathways | Full Text | References | PDF (8 MB) | EPUB
  • 90 Views
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Article
Pleiotropic Effects of Ticagrelor: Influence on CYP4F2 Gene and Protein Expression in HUVEC and HepG2, and Escherichia coli Bacterial Survival
Ugne Meskauskaite, Silvija Andruskeviciute, Ieva Ciapiene, Agne Giedraitiene, Vaiva Lesauskaite & Vacis Tatarunas
Pages: 2559-2568
Published online: 05 Dec 2023
AbstractforPleiotropic Effects of Ticagrelor: Influence on CYP4F2 Gene and Protein Expression in HUVEC and HepG2, and Escherichia coli Bacterial Survival | Full Text | References | PDF (1.9 MB) | EPUB
  • 110 Views
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Article
Design, Synthesis, and Spectroscopic Studies of Some New α-Aminophosphonate Analogues Derived from 4-Hydroxybenzaldehyde with Special Reference to Anticancer Activity
Omar M Ali, Mohammed T Alotaibi, Yasser H Zaki & Hamada H Amer
Pages: 2589-2599
Published online: 05 Dec 2023
AbstractforDesign, Synthesis, and Spectroscopic Studies of Some New α-Aminophosphonate Analogues Derived from 4-Hydroxybenzaldehyde with Special Reference to Anticancer Activity | Full Text | References | PDF (694.3 KB) | EPUB
  • 158 Views
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REVIEW

Review
A Review of Herbal Medicine-Based Phytochemical of Garcinia as Molecular Therapy for Breast Cancer
Komang Suma Triyasa, Ajeng Diantini & Melisa Intan Barliana
Pages: 3573-3588
Published online: 05 Dec 2023
AbstractforA Review of Herbal Medicine-Based Phytochemical of Garcinia as Molecular Therapy for Breast Cancer | Full Text | References | PDF (7.5 MB) | EPUB
  • 187 Views
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Open Access

ORIGINAL RESEARCH

Article
Trimetazidine Reduces Cardiac Fibrosis in Rats by Inhibiting NOX2-Mediated Endothelial-to-Mesenchymal Transition
Xingxing Chen, Xue Xia, Tiancheng Dong, Zhiwei Lin, Leilei Du & Hao Zhou
Pages: 2517-2527
Published online: 05 Dec 2023
AbstractforTrimetazidine Reduces Cardiac Fibrosis in Rats by Inhibiting NOX2-Mediated Endothelial-to-Mesenchymal Transition | Full Text | References | PDF (7.7 MB) | EPUB
  • 123 Views
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Article
The Extract of Ilex cornuta Bark Promotes Bone Healing by Activating Adenosine A2A Receptor
Xi Zheng, Jingyi Wang, Junlin Zhou & Dong Wang
Pages: 2569-2587
Published online: 05 Dec 2023
AbstractforThe Extract of Ilex cornuta Bark Promotes Bone Healing by Activating Adenosine A2A Receptor | Full Text | References | PDF (15.7 MB) | EPUB
  • 122 Views
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Article
Influences of Bifid Triple Viable Capsules Plus Cetirizine on Gut Microbiota and Immune Function in Children with Eczema
Zhenxing Su & Yaqin Kang
Pages: 2509-2515
Published online: 05 Dec 2023
AbstractforInfluences of Bifid Triple Viable Capsules Plus Cetirizine on Gut Microbiota and Immune Function in Children with Eczema | Full Text | References | PDF (1.3 MB) | EPUB
  • 88 Views
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Article
Effects of Lactobacillus plantarum HFY15 on Lupus Nephritis in Mice by Regulation of the TGF-β1 Signaling Pathway
Lin Cheng, Pu Yao, Hongping Wang, Qian Yuan, Xiaowen Wang, Wei Feng, Fengjun Sun & Qian Wang
Pages: 2851-2860
Published online: 05 Dec 2023
AbstractforEffects of Lactobacillus plantarum HFY15 on Lupus Nephritis in Mice by Regulation of the TGF-β1 Signaling Pathway | Full Text | References | PDF (3.3 MB) | EPUB
  • 101 Views
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Article
Effects of Uremic Clearance Granules on p38 MAPK/NF-κB Signaling Pathway, Microbial and Metabolic Profiles in End-Stage Renal Disease Rats Receiving Peritoneal Dialysis
Xiaosheng Li, Jie Zheng, Jian Wang, Xianhu Tang, Fengxia Zhang, Shufeng Liu, Yunqiang Liao, Xiaoqing Chen, Wenjuan Xie & Yang Tang
Pages: 2529-2544
Published online: 05 Dec 2023
AbstractforEffects of Uremic Clearance Granules on p38 MAPK/NF-κB Signaling Pathway, Microbial and Metabolic Profiles in End-Stage Renal Disease Rats Receiving Peritoneal Dialysis | Full Text | References | PDF (10.6 MB) | EPUB
  • 105 Views
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Article
Anti-Inflammatory Effects and Molecular Mechanisms of Shenmai Injection in Treating Acute Pancreatitis: Network Pharmacology Analysis and Experimental Verification
Yanqiu He, Cheng Hu, Shiyu Liu, Mingjie Xu, Ge Liang, Dan Du, Tingting Liu, Fei Cai, Zhiyao Chen, Qingyuan Tan, Lihui Deng & Qing Xia
Pages: 2479-2495
Published online: 05 Dec 2023
AbstractforAnti-Inflammatory Effects and Molecular Mechanisms of Shenmai Injection in Treating Acute Pancreatitis: Network Pharmacology Analysis and Experimental Verification | Full Text | References | PDF (9.5 MB) | EPUB
  • 131 Views
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Article
Corosolic Acid Protects Rat Chondrocytes Against IL-1β-Induced ECM Degradation by Activating Autophagy via PI3K/AKT/mTOR Pathway and Ameliorates Rat Osteoarthritis
Hui Han, Ming Chen, Zhenyu Li, Siqi Zhou, Yingbin Wu & Jian Wei
Pages: 2627-2637
Published online: 05 Dec 2023
AbstractforCorosolic Acid Protects Rat Chondrocytes Against IL-1β-Induced ECM Degradation by Activating Autophagy via PI3K/AKT/mTOR Pathway and Ameliorates Rat Osteoarthritis | Full Text | References | PDF (6.6 MB) | EPUB
  • 123 Views
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REVIEW

Review
Chikungunya Vaccine Candidates: Current Landscape and Future Prospects
Christin Schmidt & Barbara S Schnierle
Pages: 3663-3673
Published online: 05 Dec 2023
AbstractforChikungunya Vaccine Candidates: Current Landscape and Future Prospects | Full Text | References | PDF (1.5 MB) | EPUB
  • 288 Views
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ORIGINAL RESEARCH

Article
Identification of Drug Combination Therapies for SARS-CoV-2: A Molecular Dynamics Simulations Approach
Heba Abdel-Halim, Malak Hajar, Luma Hasouneh & Suzanne MA Abdelmalek
Pages: 2995-3013
Published online: 05 Dec 2023
AbstractforIdentification of Drug Combination Therapies for SARS-CoV-2: A Molecular Dynamics Simulations Approach | Full Text | References | PDF (7 MB) | EPUB
  • 153 Views
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Article
A Novel Delivery System of RGD-HSA Loaded GEM/CUR Nanoparticles for the Treatment of Pancreatic Cancer Therapy
Tao Ma, Jin-Ling Jiang, Wei-Xiang Qi, Jia-Yi Chen & Hao-Ping Xu
Pages: 2395-2406
Published online: 05 Dec 2023
AbstractforA Novel Delivery System of RGD-HSA Loaded GEM/CUR Nanoparticles for the Treatment of Pancreatic Cancer Therapy | Full Text | References | PDF (5.5 MB) | EPUB
  • 98 Views
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Article
Study of the Mechanism of Antiemetic Effect of Lavandula angustifolia Mill. Essential Oil Based on Ca2+/CaMKII/ERK1/2 Pathway
Jia Li, Xiao Wang, Shining Xun, Qiuting Guo, Yao Wang, Yanzuo Jia, Wenfei Wang, Yujiao Wang, Taotao Li, Tiantian Tang, Junbo Zou, Mei Wang, Ming Yang, Fang Wang, Xiaofei Zhang & Changli Wang
Pages: 2407-2422
Published online: 05 Dec 2023
AbstractforStudy of the Mechanism of Antiemetic Effect of Lavandula angustifolia Mill. Essential Oil Based on Ca2+/CaMKII/ERK1/2 Pathway | Full Text | References | PDF (9.2 MB) | EPUB
  • 190 Views
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Article
Prostate Cancer Therapy Using Docetaxel and Formononetin Combination: Hyaluronic Acid and Epidermal Growth Factor Receptor Targeted Peptide Dual Ligands Modified Binary Nanoparticles to Facilitate the in vivo Anti-Tumor Activity
Zhaoqiang Dong, Yuzhen Wang, Jing Guo, Chuan Tian, Wengu Pan, Hongwei Wang & Jieke Yan
Pages: 2683-2693
Published online: 05 Dec 2023
AbstractforProstate Cancer Therapy Using Docetaxel and Formononetin Combination: Hyaluronic Acid and Epidermal Growth Factor Receptor Targeted Peptide Dual Ligands Modified Binary Nanoparticles to Facilitate the in vivo Anti-Tumor Activity | Full Text | References | PDF (4.3 MB) | EPUB
  • 161 Views
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REVIEW

Review
Protective Effects of Pioglitazone on Cognitive Impairment and the Underlying Mechanisms: A Review of Literature
Ahmad Alhowail, Rawan Alsikhan, May Alsaud, Maha Aldubayan & Syed Imam Rabbani
Pages: 2919-2931
Published online: 05 Dec 2023
AbstractforProtective Effects of Pioglitazone on Cognitive Impairment and the Underlying Mechanisms: A Review of Literature | Full Text | References | PDF (1.6 MB) | EPUB
  • 303 Views
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CLINICAL TRIAL REPORT

Aframomum melegueta Seed Extract with Standardized Content of 6-Paradol Reduces Visceral Fat and Enhances Energy Expenditure in Overweight Adults – A Randomized Double-Blind, Placebo-Controlled Clinical Study
Heggar Venkataramana Sudeep, Khanna Aman, Thomas V Jestin & Kodimule Shyamprasad
Pages: 3777-3791
Published online: 05 Dec 2023
AbstractforAframomum melegueta Seed Extract with Standardized Content of 6-Paradol Reduces Visceral Fat and Enhances Energy Expenditure in Overweight Adults – A Randomized Double-Blind, Placebo-Controlled Clinical Study | Full Text | References | PDF (3.6 MB) | EPUB
  • 175 Views
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ORIGINAL RESEARCH

Article
Network and Experimental Pharmacology to Decode the Action of Wendan Decoction Against Generalized Anxiety Disorder
Qi Jin, Jie Li, Guang-Yao Chen, Zi-Yu Wu, Xiao-Yu Liu, Yi Liu, Lin Chen, Xin-Yi Wu, Yan Liu, Xin Zhao & Yue-Han Song
Pages: 3297-3314
Published online: 05 Dec 2023
AbstractforNetwork and Experimental Pharmacology to Decode the Action of Wendan Decoction Against Generalized Anxiety Disorder | Full Text | References | PDF (16.4 MB) | EPUB
  • 172 Views
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REVIEW

Review
Diosgenin and Its Analogs: Potential Protective Agents Against Atherosclerosis
Dan Wang & Xiaolong Wang
Pages: 2305-2323
Published online: 05 Dec 2023
AbstractforDiosgenin and Its Analogs: Potential Protective Agents Against Atherosclerosis | Full Text | References | PDF (5.5 MB) | EPUB
  • 239 Views
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Review
Spotlight on Faricimab in the Treatment of Wet Age-Related Macular Degeneration: Design, Development and Place in Therapy
Archana A Nair, Avni P Finn & Paul Sternberg Jr
Pages: 3395-3400
Published online: 05 Dec 2023
AbstractforSpotlight on Faricimab in the Treatment of Wet Age-Related Macular Degeneration: Design, Development and Place in Therapy | Full Text | References | PDF (366.2 KB) | EPUB
  • 282 Views
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ORIGINAL RESEARCH

Article
Impact of Remdesivir on SARS-CoV-2 Clearance in a Real-Life Setting: A Matched-Cohort Study
Vincenzo Spagnuolo, Marta Voarino, Marco Tonelli, Laura Galli, Andrea Poli, Elena Bruzzesi, Sara Racca, Nicola Clementi, Chiara Oltolini, Moreno Tresoldi, Patrizia Rovere Querini, Lorenzo Dagna, Alberto Zangrillo, Fabio Ciceri, Massimo Clementi, Antonella Castagna & On behalf of the COVID-BioB Study Group
Pages: 3645-3654
Published online: 05 Dec 2023
AbstractforImpact of Remdesivir on SARS-CoV-2 Clearance in a Real-Life Setting: A Matched-Cohort Study | Full Text | References | PDF (2.2 MB) | EPUB
  • 96 Views
  • 3 CrossRef citations
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Article
Study on the Mechanism of Improving HIV/AIDS Immune Function with Jian Aikang Concentrated Pill Based on Network Pharmacology Combined with Experimental Validation
Cancan Shao, Haojie Wang, Feng Sang & Liran Xu
Pages: 2731-2753
Published online: 05 Dec 2023
AbstractforStudy on the Mechanism of Improving HIV/AIDS Immune Function with Jian Aikang Concentrated Pill Based on Network Pharmacology Combined with Experimental Validation | Full Text | References | PDF (14.8 MB) | EPUB
  • 141 Views
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Article
Baicalein Inhibits the Progression and Promotes Radiosensitivity of Esophageal Squamous Cell Carcinoma by Targeting HIF-1A
Dongli Guo, Jing Jin, Jianghui Liu, Yingying Wang, Daojuan Li & Yutong He
Pages: 2423-2436
Published online: 05 Dec 2023
AbstractforBaicalein Inhibits the Progression and Promotes Radiosensitivity of Esophageal Squamous Cell Carcinoma by Targeting HIF-1A | Full Text | References | PDF (6.2 MB) | EPUB
  • 110 Views
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LETTER

The Minimal Clinically Important Differences as Well as Statistical Differences of Main Endpoints are Important in Comparing Postoperative Benefits of Different Analgesic Modalities [Letter]
Tian Tian, Xin-Tao Li & Fu-Shan Xue
Pages: 3195-3196
Published online: 05 Dec 2023
CitationforThe Minimal Clinically Important Differences as Well as Statistical Differences of Main Endpoints are Important in Comparing Postoperative Benefits of Different Analgesic Modalities [Letter] | Full Text | References | PDF (298.3 KB) | EPUB
  • 65 Views
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Article
Alpha-Chymotrypsin Protects Against Acute Lung, Kidney, and Liver Injuries and Increases Survival in CLP-Induced Sepsis in Rats Through Inhibition of TLR4/NF-κB Pathway
Shaymaa Ramzy Senousy, Al-Shaimaa F Ahmed, Dalia A Abdelhafeez, Mohamed Montaser A Khalifa, Mohammed AS Abourehab & Mahmoud El-Daly
Pages: 3023-3039
Published online: 05 Dec 2023
AbstractforAlpha-Chymotrypsin Protects Against Acute Lung, Kidney, and Liver Injuries and Increases Survival in CLP-Induced Sepsis in Rats Through Inhibition of TLR4/NF-κB Pathway | Full Text | References | PDF (15.5 MB) | EPUB
  • 367 Views
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Article
Network Pharmacology-Based Combined with Experimental Validation Study to Explore the Underlying Mechanism of Agrimonia pilosa Ledeb. Extract in Treating Acute Myocardial Infarction
Muqing Zhang, Jian Chen, Yanwei Wang, Guobin Kang, Yixin Zhang & Xue Han
Pages: 3117-3132
Published online: 05 Dec 2023
AbstractforNetwork Pharmacology-Based Combined with Experimental Validation Study to Explore the Underlying Mechanism of Agrimonia pilosa Ledeb. Extract in Treating Acute Myocardial Infarction | Full Text | References | PDF (11.6 MB) | EPUB
  • 176 Views
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Article
Dioscin Regulating Bone Marrow Apoptosis in Aplastic Anemia
Le Zhang, Runfeng Ni, Jiani Li, Liwei Fan, Yanqi Song, Haijin Wang, Aidi Wang & Baoshan Liu
Pages: 3041-3053
Published online: 05 Dec 2023
AbstractforDioscin Regulating Bone Marrow Apoptosis in Aplastic Anemia | Full Text | References | PDF (8.4 MB) | EPUB
  • 108 Views
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Article
Cyclosporine A (0.05%) Ophthalmic Gel in the Treatment of Dry Eye Disease: A Multicenter, Randomized, Double-Masked, Phase III, COSMO Trial
Wenyan Peng, Xiuying Jiang, Lei Zhu, Xiaofeng Li, Qizhi Zhou, Ying Jie, Zhipeng You, Miaoqin Wu, Xiuming Jin, Xiaoyi Li & Shiyou Zhou
Pages: 3183-3194
Published online: 05 Dec 2023
AbstractforCyclosporine A (0.05%) Ophthalmic Gel in the Treatment of Dry Eye Disease: A Multicenter, Randomized, Double-Masked, Phase III, COSMO Trial | Full Text | References | PDF (4.1 MB) | EPUB
  • 223 Views
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REVIEW

Review
Allosteric Binding Sites of the SARS-CoV-2 Main Protease: Potential Targets for Broad-Spectrum Anti-Coronavirus Agents
Lara Alzyoud, Mohammad A Ghattas & Noor Atatreh
Pages: 2463-2478
Published online: 05 Dec 2023
AbstractforAllosteric Binding Sites of the SARS-CoV-2 Main Protease: Potential Targets for Broad-Spectrum Anti-Coronavirus Agents | Full Text | References | PDF (10.9 MB) | EPUB
  • 202 Views
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ORIGINAL RESEARCH

Article
SIRT1/FOXO1 Axis-Mediated Hippocampal Angiogenesis is Involved in the Antidepressant Effect of Chaihu Shugan San
Shan Zhang, Yujia Lu, Wei Shi, Yi Ren, Kaihui Xiao, Wei Chen, Li Li & Jingjie Zhao
Pages: 2783-2801
Published online: 05 Dec 2023
AbstractforSIRT1/FOXO1 Axis-Mediated Hippocampal Angiogenesis is Involved in the Antidepressant Effect of Chaihu Shugan San | Full Text | References | PDF (12.1 MB) | EPUB
  • 135 Views
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Article
Comparison of 3 Rates for the Continuous Infusion of Mivacurium During Ambulatory Vitreoretinal Surgery Under General Anesthesia: A Prospective, Randomized, Controlled Clinical Trial
Yi Zhang, Chunhua Xi, Jianying Yue, Mengmeng Zhao & Guyan Wang
Pages: 3133-3143
Published online: 05 Dec 2023
AbstractforComparison of 3 Rates for the Continuous Infusion of Mivacurium During Ambulatory Vitreoretinal Surgery Under General Anesthesia: A Prospective, Randomized, Controlled Clinical Trial | Full Text | References | PDF (2 MB) | EPUB
  • 167 Views
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Article
Preclinical Pharmacokinetics, Tissue Distribution and in vitro Metabolism of FHND6091, a Novel Oral Proteasome Inhibitor
Xu Yang, Amin Liu, Lin Yang, Tiantian Wen, Jia Wang, Jingmiao Shi, Hui Zhou, Zhimeng Chen, Meng Lei & Yongqiang Zhu
Pages: 3087-3107
Published online: 05 Dec 2023
AbstractforPreclinical Pharmacokinetics, Tissue Distribution and in vitro Metabolism of FHND6091, a Novel Oral Proteasome Inhibitor | Full Text | References | PDF (9.5 MB) | EPUB
  • 105 Views
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Article
Identifying the Antitumor Effects of Curcumin on Lung Adenocarcinoma Using Comprehensive Bioinformatics Analysis
Fei-Ran Yang, Si-Yi Li, Xi-Wen Hu, Xiu-Rong Li & Hui-Jie Li
Pages: 2365-2382
Published online: 05 Dec 2023
AbstractforIdentifying the Antitumor Effects of Curcumin on Lung Adenocarcinoma Using Comprehensive Bioinformatics Analysis | Full Text | References | PDF (10.4 MB) | EPUB
  • 150 Views
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Article
Pharmacokinetic Study of Nalbuphine in Surgical Patients Undergoing General Anesthesia with Varying Degrees of Liver Dysfunction
Xiao-nan Gao, Xu-yang Nie, Jing-lin Gao, Tian-fang Heng, Yu-qi Zhang, Li Hua, Ya-qi Sun, Zhang-ying Feng, Ming-xia Wang & Li Jia
Pages: 2383-2393
Published online: 05 Dec 2023
AbstractforPharmacokinetic Study of Nalbuphine in Surgical Patients Undergoing General Anesthesia with Varying Degrees of Liver Dysfunction | Full Text | References | PDF (2.2 MB) | EPUB
  • 89 Views
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Article
Guanmaitong Granule Attenuates Atherosclerosis by Inhibiting Inflammatory Immune Response in ApoE−/− Mice Fed High-Fat Diet
Mengqi Yang, Huachen Jiao, Yan Li, Lei Zhang, Juan Zhang, Xia Zhong & Yitao Xue
Pages: 3145-3168
Published online: 05 Dec 2023
AbstractforGuanmaitong Granule Attenuates Atherosclerosis by Inhibiting Inflammatory Immune Response in ApoE−/− Mice Fed High-Fat Diet | Full Text | References | PDF (18.4 MB) | EPUB
  • 193 Views
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Article
Predicting Outcome in Combination Treatment of TACE and Camrelizumab for Advanced Hepatocellular carcinoma: Tumor Hypervascularity and Reactive Cutaneous Capillary Endothelial Proliferation
Liang Yin, Kai-Cai Liu, Wei-Fu Lv, Shao-Bao Xu, Dong Lu, Chun-Ze Zhou, De-Lei Cheng, Zong-Gen Gao, Chang-Sheng Shi & Ming-Xue Su
Pages: 3421-3429
Published online: 05 Dec 2023
AbstractforPredicting Outcome in Combination Treatment of TACE and Camrelizumab for Advanced Hepatocellular carcinoma: Tumor Hypervascularity and Reactive Cutaneous Capillary Endothelial Proliferation | Full Text | References | PDF (1.8 MB) | EPUB
  • 102 Views
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Article
Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Sotagliflozin After Multiple Ascending Doses in Chinese Healthy Subjects
Xuemei He, Xin Gao, Panpan Xie, Yuan Liu, Wenjing Bai, Yue Liu & Aixin Shi
Pages: 2967-2980
Published online: 05 Dec 2023
AbstractforPharmacokinetics, Pharmacodynamics, Safety and Tolerability of Sotagliflozin After Multiple Ascending Doses in Chinese Healthy Subjects | Full Text | References | PDF (2.5 MB) | EPUB
  • 164 Views
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Article
Synthesis and Bioactivity Evaluation of a Novel 1,2,4-Oxadiazole Derivative in vitro and in 3×Tg Mice
Zhuohui Luo, Yongcheng Wang, Shuo Pang, Shan Gao, Ning Liu, Xiang Gao, Li Zhang, Xiaolong Qi, Yajun Yang & Lianfeng Zhang
Pages: 3285-3296
Published online: 05 Dec 2023
AbstractforSynthesis and Bioactivity Evaluation of a Novel 1,2,4-Oxadiazole Derivative in vitro and in 3×Tg Mice | Full Text | References | PDF (6.9 MB) | EPUB
  • 116 Views
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REVIEW

Review
Evolving Role of Silodosin for the Treatment of Urological Disorders – A Narrative Review
Luo Jindan, Wang Xiao & Xie Liping
Pages: 2861-2884
Published online: 05 Dec 2023
AbstractforEvolving Role of Silodosin for the Treatment of Urological Disorders – A Narrative Review | Full Text | References | PDF (376.6 KB) | EPUB
  • 342 Views
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Review
New Oral Anticoagulants Open New Horizons for Cancer Patients with Venous Thromboembolism
Kaidireyahan Wumaier, Wenqian Li & Jiuwei Cui
Pages: 2497-2507
Published online: 05 Dec 2023
AbstractforNew Oral Anticoagulants Open New Horizons for Cancer Patients with Venous Thromboembolism | Full Text | References | PDF (359.6 KB) | EPUB
  • 158 Views
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ORIGINAL RESEARCH

Article
Efficacy and Safety of Remimazolam Tosilate versus Dexmedetomidine for Sedation in Non-Intubated Older Patients with Agitated Delirium After Orthopedic Surgery: A Randomized Controlled Trial
Yang Deng, Zhijun Qin, Qianyun Wu, Linsong Liu, Xi Yang, Xuan Ju, Ying Zhang & Lei Liu
Pages: 2439-2451
Published online: 05 Dec 2023
AbstractforEfficacy and Safety of Remimazolam Tosilate versus Dexmedetomidine for Sedation in Non-Intubated Older Patients with Agitated Delirium After Orthopedic Surgery: A Randomized Controlled Trial | Full Text | References | PDF (2.2 MB) | EPUB
  • 289 Views
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REVIEW

Review
Targeting Indoleamine Dioxygenase and Tryptophan Dioxygenase in Cancer Immunotherapy: Clinical Progress and Challenges
Xuerun Peng, Zhipeng Zhao, Liwen Liu, Lan Bai, Rongsheng Tong, Hao Yang & Lei Zhong
Pages: 2639-2657
Published online: 05 Dec 2023
AbstractforTargeting Indoleamine Dioxygenase and Tryptophan Dioxygenase in Cancer Immunotherapy: Clinical Progress and Challenges | Full Text | References | PDF (3.3 MB) | EPUB
  • 222 Views
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ORIGINAL RESEARCH

Article
Development and Evaluation of Puerarin Loaded-Albumin Nanoparticles Thermoresponsive in situ Gel for Ophthalmic Delivery
Lixiu Hu, Yong Xu & Hui Meng
Pages: 3315-3326
Published online: 05 Dec 2023
AbstractforDevelopment and Evaluation of Puerarin Loaded-Albumin Nanoparticles Thermoresponsive in situ Gel for Ophthalmic Delivery | Full Text | References | PDF (3.3 MB) | EPUB
  • 131 Views
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Article
Levistilide a Induces Ferroptosis by Activating the Nrf2/HO-1 Signaling Pathway in Breast Cancer Cells
Shangwen Jing, Yantong Lu, Jing Zhang, Yan Ren, Yousheng Mo, Dongdong Liu, Lining Duan, Zhongyu Yuan, Changjun Wang & Qi Wang
Pages: 2981-2993
Published online: 05 Dec 2023
AbstractforLevistilide a Induces Ferroptosis by Activating the Nrf2/HO-1 Signaling Pathway in Breast Cancer Cells | Full Text | References | PDF (10.5 MB) | EPUB
  • 179 Views
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REVIEW

Review
Smilax glabra Roxb.: A Review of Its Traditional Usages, Phytochemical Constituents, Pharmacological Properties, and Clinical Applications
Hao Wu, Yu Wang, Bing Zhang, Yao-lei Li, Zhi-xin Ren, Jing-jian Huang, Zhi-qi Zhang, Zhi-jian Lin & Xiao-meng Zhang
Pages: 3621-3643
Published online: 05 Dec 2023
AbstractforSmilax glabra Roxb.: A Review of Its Traditional Usages, Phytochemical Constituents, Pharmacological Properties, and Clinical Applications | Full Text | References | PDF (14.5 MB) | EPUB
  • 450 Views
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Review
Emerging Therapeutic Strategies of Different Immunotherapy Approaches Combined with PD-1/PD-L1 Blockade in Cervical Cancer
Yanjun Ge, Yuchen Zhang, Kong-Nan Zhao & Haiyan Zhu
Pages: 3055-3070
Published online: 05 Dec 2023
AbstractforEmerging Therapeutic Strategies of Different Immunotherapy Approaches Combined with PD-1/PD-L1 Blockade in Cervical Cancer | Full Text | References | PDF (2.5 MB) | EPUB
  • 211 Views
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ORIGINAL RESEARCH

Article
Dehydrozingerone Alleviates Hyperalgesia, Oxidative Stress and Inflammatory Factors in Complete Freund’s Adjuvant-Induced Arthritic Rats
Chunhong Liu, Yetian Li, Chaoling Wen, Zheng Yan, Opeyemi Joshua Olatunji & Zongsheng Yin
Pages: 3015-3022
Published online: 05 Dec 2023
AbstractforDehydrozingerone Alleviates Hyperalgesia, Oxidative Stress and Inflammatory Factors in Complete Freund’s Adjuvant-Induced Arthritic Rats | Full Text | References | PDF (3.6 MB) | EPUB
  • 152 Views
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Article
The Mechanism of Alisol B23 Acetate Inhibiting Lung Cancer: Targeted Regulation of CD11b/CD18 to Influence Macrophage Polarization
Yingna Chen, Jieya Lu, Zhihao Xie, Jialing Tang, Xuejiao Lian & Xiuwen Li
Pages: 3677-3689
Published online: 05 Dec 2023
AbstractforThe Mechanism of Alisol B23 Acetate Inhibiting Lung Cancer: Targeted Regulation of CD11b/CD18 to Influence Macrophage Polarization | Full Text | References | PDF (12.8 MB) | EPUB
  • 92 Views
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Article
Integrated Metabonomics and Network Pharmacology to Reveal the Action Mechanism Effect of Shaoyao Decoction on Ulcerative Colitis
Jin Wu, Yiting Luo, Yan Shen, Yuyao Hu, Fangyuan Zhu, Jiaqian Wu & Yingchao Liu
Pages: 3739-3776
Published online: 05 Dec 2023
AbstractforIntegrated Metabonomics and Network Pharmacology to Reveal the Action Mechanism Effect of Shaoyao Decoction on Ulcerative Colitis | Full Text | References | PDF (29.5 MB) | EPUB
  • 260 Views
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REVIEW

Review
Recent Advances in Nano-Formulations for Skin Wound Repair Applications
Yue Lin, Zheyan Chen, Yinai Liu, Jiawen Wang, Wang Lv & Renyi Peng
Pages: 2707-2728
Published online: 05 Dec 2023
AbstractforRecent Advances in Nano-Formulations for Skin Wound Repair Applications | Full Text | References | PDF (9.2 MB) | EPUB
  • 293 Views
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Review
Profile of Remimazolam in Anesthesiology: A Narrative Review of Clinical Research Progress
Mi Wang, Xian Zhao, Pengfei Yin, Xiuxia Bao, Hongli Tang & Xianhui Kang
Pages: 3431-3444
Published online: 05 Dec 2023
AbstractforProfile of Remimazolam in Anesthesiology: A Narrative Review of Clinical Research Progress | Full Text | References | PDF (497 KB) | EPUB
  • 244 Views
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ORIGINAL RESEARCH

Article
A Real-World Study on the Effect of Imrecoxib for Patients with Axial Spondyloarthritis
He-xiang Zong, Sheng-qian Xu, Jian-xiong Wang, Yi-ran Chu, Ke-ming Chen, Cong Wang, Wan-qiu Tong & Xi-le Wang
Pages: 2755-2765
Published online: 05 Dec 2023
AbstractforA Real-World Study on the Effect of Imrecoxib for Patients with Axial Spondyloarthritis | Full Text | References | PDF (5.4 MB) | EPUB
  • 71 Views
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REVIEW

Review
The Role of Histone H3 Methylation in Acute Kidney Injury
Yi-Bo Zhao, Wei Wei, Xiao-Xi Lin, Yan-Fen Chai & Heng Jin
Pages: 2453-2461
Published online: 05 Dec 2023
AbstractforThe Role of Histone H3 Methylation in Acute Kidney Injury | Full Text | References | PDF (1 MB) | EPUB
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CLINICAL TRIAL REPORT

Non-Inferior Efficacy of Tenofovir Disoproxil to Tenofovir Disoproxil Fumarate in Virologically Suppressed Chronic Hepatitis B Patients
Hyung Joon Yim, Ji Hoon Kim, Yong Kyun Cho, Young Oh Kweon, Hyun Chin Cho, Jae Seok Hwang, Changhyeong Lee, Moon Soo Koh, Yang-Hyun Baek, Young-Min Park, Jeong-Hoon Lee, Seung Up Kim, Min-Kyu Kang, Neung Hwa Park, June Sung Lee, Young Eun Chon, Gab Jin Cheon, Hee Bok Chae, Joo Hyun Sohn & Young-Suk Lim
Pages: 3263-3274
Published online: 05 Dec 2023
AbstractforNon-Inferior Efficacy of Tenofovir Disoproxil to Tenofovir Disoproxil Fumarate in Virologically Suppressed Chronic Hepatitis B Patients | Full Text | References | PDF (2.8 MB) | EPUB
  • 119 Views
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Article
Metabolomics Combined with Network Pharmacology-Based Strategy to Reveal the Underlying Mechanism of Zhenhuang Submicron Emulsion in Treating Oropharyngeal Mucositis Complications of Radiation Therapy for Head and Neck Cancer
Wei Chen, Chunyu Li, Dujia Jin, Yafei Shi, Mingyu Zhang, Mingming Bo, Di Qian, Mengyang Wang & Guohui Li
Pages: 3169-3182
Published online: 05 Dec 2023
AbstractforMetabolomics Combined with Network Pharmacology-Based Strategy to Reveal the Underlying Mechanism of Zhenhuang Submicron Emulsion in Treating Oropharyngeal Mucositis Complications of Radiation Therapy for Head and Neck Cancer | Full Text | References | PDF (12.2 MB) | EPUB
  • 169 Views
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Article
Intravenous Lidocaine Significantly Reduces the Propofol Dose in Elderly Patients Undergoing Gastroscopy: A Randomized Controlled Trial
Song Hu, Mingxia Wang, Siyu Li, Wenyu Zhou, Yi Zhang, Haobing Shi, Pengcheng Ye, Jixiong Sun, Feng Liu, Wei Zhang, Li Zheng, Qianhao Hou, Yue Wang, Weixin Sun, Yuanli Chen, Zhenzhen Lu, Zhonghua Ji, Lijun Liao, Xin Lv, Yinglin Wang, Xiangrui Wang & Hao Yang
Pages: 2695-2705
Published online: 05 Dec 2023
AbstractforIntravenous Lidocaine Significantly Reduces the Propofol Dose in Elderly Patients Undergoing Gastroscopy: A Randomized Controlled Trial | Full Text | References | PDF (1.6 MB) | EPUB
  • 156 Views
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Article
Ginsenoside Rd Promotes Cardiac Repair After Myocardial Infarction by Modulating Monocytes/Macrophages Subsets Conversion
Tingyao Zhao, Xinting Wang, Qian Liu, Tianshu Yang, Huiyan Qu & Hua Zhou
Pages: 2767-2782
Published online: 05 Dec 2023
AbstractforGinsenoside Rd Promotes Cardiac Repair After Myocardial Infarction by Modulating Monocytes/Macrophages Subsets Conversion | Full Text | References | PDF (11.7 MB) | EPUB
  • 86 Views
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REVIEW

Review
Brolucizumab for the Treatment of Degenerative Macular Conditions: A Review of Clinical Studies
Evdoxia-Maria Karasavvidou, Paris Tranos & Georgios D Panos
Pages: 2659-2680
Published online: 05 Dec 2023
AbstractforBrolucizumab for the Treatment of Degenerative Macular Conditions: A Review of Clinical Studies | Full Text | References | PDF (854 KB) | EPUB
  • 188 Views
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ORIGINAL RESEARCH

Article
Comparative Dose–Response Study on the Infusion of Norepinephrine Combined with Crystalloid Coload versus Colloid Coload for Preventing Hypotension During Spinal Anesthesia for Cesarean Delivery
Wei-dong Jin, Jun-qin Mao, Jie Liu, Gang Liang, Chao Jiang & Zhi-min Sheng
Pages: 2617-2626
Published online: 05 Dec 2023
AbstractforComparative Dose–Response Study on the Infusion of Norepinephrine Combined with Crystalloid Coload versus Colloid Coload for Preventing Hypotension During Spinal Anesthesia for Cesarean Delivery | Full Text | References | PDF (3.1 MB) | EPUB
  • 112 Views
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Article
Dihydromyricetin Attenuates Cerebral Ischemia Reperfusion Injury by Inhibiting SPHK1/mTOR Signaling and Targeting Ferroptosis
Jiangbo Xie, Tingting Zhang, Peichun Li, Dong Wang, Tao Liu & Shunliang Xu
Pages: 3071-3085
Published online: 05 Dec 2023
AbstractforDihydromyricetin Attenuates Cerebral Ischemia Reperfusion Injury by Inhibiting SPHK1/mTOR Signaling and Targeting Ferroptosis | Full Text | References | PDF (10.1 MB) | EPUB
  • 163 Views
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Article
Non-Selective Alpha-Blockers Provide More Stable Intraoperative Hemodynamic Control Compared with Selective Alpha1-Blockers in Patients with Pheochromocytoma and Paraganglioma: A Single-Center Retrospective Cohort Study with a Propensity Score-Matched Analysis from China
Yang Yang, Jie Zhang, Liqun Fang, Xue Jia & Wensheng Zhang
Pages: 3599-3608
Published online: 05 Dec 2023
AbstractforNon-Selective Alpha-Blockers Provide More Stable Intraoperative Hemodynamic Control Compared with Selective Alpha1-Blockers in Patients with Pheochromocytoma and Paraganglioma: A Single-Center Retrospective Cohort Study with a Propensity Score-Matched Analysis from China | Full Text | References | PDF (1.5 MB) | EPUB
  • 95 Views
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REVIEW

Review
The Beneficial Effects of Geniposide on Glucose and Lipid Metabolism: A Review
Siting Gao & Qin Feng
Pages: 3365-3383
Published online: 05 Dec 2023
AbstractforThe Beneficial Effects of Geniposide on Glucose and Lipid Metabolism: A Review | Full Text | References | PDF (3.6 MB) | EPUB
  • 152 Views
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ORIGINAL RESEARCH

Article
Atorvastatin Inhibits High-Fat Diet-Induced Lipid Metabolism Disorders in Rats by Inhibiting Bacteroides Reduction and Improving Metabolism
Huimin Li, Shue Wang, Shuai Wang, Hai Yu, Wenhao Yu, Xiaomin Ma & Xiaodong He
Pages: 3805-3816
Published online: 05 Dec 2023
AbstractforAtorvastatin Inhibits High-Fat Diet-Induced Lipid Metabolism Disorders in Rats by Inhibiting Bacteroides Reduction and Improving Metabolism | Full Text | References | PDF (5.2 MB) | EPUB
  • 115 Views
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Article
Sinomenine Inhibits Orthodontic Tooth Movement and Root Resorption in Rats and Enhances Osteogenic Differentiation of PDLSCs
Hongkun Li, Yilin Li, Jinghua Zou, Yanran Yang, Ruiqi Han & Jun Zhang
Pages: 2949-2965
Published online: 05 Dec 2023
AbstractforSinomenine Inhibits Orthodontic Tooth Movement and Root Resorption in Rats and Enhances Osteogenic Differentiation of PDLSCs | Full Text | References | PDF (17.3 MB) | EPUB
  • 155 Views
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REVIEW

Review
Recent Updates on the Development of Deuterium-Containing Drugs for the Treatment of Cancer
Tafere Mulaw Belete
Pages: 3465-3472
Published online: 05 Dec 2023
AbstractforRecent Updates on the Development of Deuterium-Containing Drugs for the Treatment of Cancer | Full Text | References | PDF (411.6 KB) | EPUB
  • 322 Views
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ORIGINAL RESEARCH

Article
Baicalin Alleviates Contrast-Induced Acute Kidney Injury Through ROS/NLRP3/Caspase-1/GSDMD Pathway-Mediated Proptosis in vitro
Yanyan Li, Junda Wang, Dan Huang & Chao Yu
Pages: 3353-3364
Published online: 05 Dec 2023
AbstractforBaicalin Alleviates Contrast-Induced Acute Kidney Injury Through ROS/NLRP3/Caspase-1/GSDMD Pathway-Mediated Proptosis in vitro | Full Text | References | PDF (6.4 MB) | EPUB
  • 122 Views
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Article
Effect of Puerarin on Osteogenic Differentiation in vitro and on New Bone Formation in vivo
Yanran Yang, Daiyun Chen, Yilin Li, Jinghua Zou, Ruiqi Han, Hongkun Li & Jun Zhang
Pages: 2885-2900
Published online: 05 Dec 2023
AbstractforEffect of Puerarin on Osteogenic Differentiation in vitro and on New Bone Formation in vivo | Full Text | References | PDF (12.5 MB) | EPUB
  • 173 Views
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Article
Protective Effects of p-CA Against Acute Liver Damage Induced by LPS/D-GalN in Wistar Albino Rats
Seerat Mehdi, Fiaz-ud-Din Ahmad, Arslan Hussain Lodhi, Umair Khurshid, Ahmed Awais Khalid, Sheikh Safeena Sidiq, Liaqat Hussain & Mirza Shaharyar Baig
Pages: 3327-3342
Published online: 05 Dec 2023
AbstractforProtective Effects of p-CA Against Acute Liver Damage Induced by LPS/D-GalN in Wistar Albino Rats | Full Text | References | PDF (12.5 MB) | EPUB
  • 171 Views
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REVIEW

Review
Oral Selective Estrogen Receptor Degraders (SERDs) in Breast Cancer: Advances, Challenges, and Current Status
Teesha Downton, Fiona Zhou, Davendra Segara, Rinath Jeselsohn & Elgene Lim
Pages: 2933-2948
Published online: 05 Dec 2023
AbstractforOral Selective Estrogen Receptor Degraders (SERDs) in Breast Cancer: Advances, Challenges, and Current Status | Full Text | References | PDF (1.4 MB) | EPUB
  • 418 Views
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ORIGINAL RESEARCH

Article
An Effective Glucagon-Like Peptide-1 Receptor Agonists, Semaglutide, Improves Sarcopenic Obesity in Obese Mice by Modulating Skeletal Muscle Metabolism
Qingjuan Ren, Shuchun Chen, Xing Chen, Shu Niu, Lin Yue, Xiaoyu Pan, Zelin Li & Xiaoyi Chen
Pages: 3723-3735
Published online: 05 Dec 2023
AbstractforAn Effective Glucagon-Like Peptide-1 Receptor Agonists, Semaglutide, Improves Sarcopenic Obesity in Obese Mice by Modulating Skeletal Muscle Metabolism | Full Text | References | PDF (8.2 MB) | EPUB
  • 326 Views
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CLINICAL TRIAL REPORT

Remimazolam for the Prevention of Emergence Delirium in Children Following Tonsillectomy and Adenoidectomy Under Sevoflurane Anesthesia: A Randomized Controlled Study
Xue Yang, Chuantao Lin, Sisi Chen, Yuezhou Huang, Qiong Cheng & Yusheng Yao
Pages: 3413-3420
Published online: 05 Dec 2023
AbstractforRemimazolam for the Prevention of Emergence Delirium in Children Following Tonsillectomy and Adenoidectomy Under Sevoflurane Anesthesia: A Randomized Controlled Study | Full Text | References | PDF (1.6 MB) | EPUB
  • 185 Views
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ORIGINAL RESEARCH

Article
ED50 and ED95 of Propofol Combined with Different Doses of Intravenous Lidocaine for First-Trimester Uterine Aspiration: A Prospective Dose-Finding Study Using Up-and-Down Sequential Allocation Method
Jingwen Zhang, Linglingli Kong & Juan Ni
Pages: 3343-3352
Published online: 05 Dec 2023
AbstractforED50 and ED95 of Propofol Combined with Different Doses of Intravenous Lidocaine for First-Trimester Uterine Aspiration: A Prospective Dose-Finding Study Using Up-and-Down Sequential Allocation Method | Full Text | References | PDF (2.3 MB) | EPUB
  • 119 Views
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RETRACTION

Retraction
Theaflavin Alleviates Inflammatory Response and Brain Injury Induced by Cerebral Hemorrhage via Inhibiting the Nuclear Transcription Factor Kappa β-Related Pathway in Rats [Retraction]
Pages: 2341-2342
Published online: 05 Dec 2023
CitationforTheaflavin Alleviates Inflammatory Response and Brain Injury Induced by Cerebral Hemorrhage via Inhibiting the Nuclear Transcription Factor Kappa β-Related Pathway in Rats [Retraction] | Full Text | PDF (153.1 KB) | EPUB
  • 65 Views
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ORIGINAL RESEARCH

Article
Madecassic Acid Ameliorates the Progression of Osteoarthritis: An in vitro and in vivo Study
Xuejie Fu, Shuangjian He, Liang Wang, Yangyang Xue, Shigang Qiao, Jianzhong An & Tingting Xia
Pages: 3793-3804
Published online: 05 Dec 2023
AbstractforMadecassic Acid Ameliorates the Progression of Osteoarthritis: An in vitro and in vivo Study | Full Text | References | PDF (7.4 MB) | EPUB
  • 93 Views
  • 3 CrossRef citations
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RETRACTION

Retraction
Induction of Apoptosis and Autophagy via sirtuin1- and PI3K/Akt/mTOR-Mediated Pathways by Plumbagin in Human Prostate Cancer Cells [Retraction]
Pages: 2437-2438
Published online: 05 Dec 2023
CitationforInduction of Apoptosis and Autophagy via sirtuin1- and PI3K/Akt/mTOR-Mediated Pathways by Plumbagin in Human Prostate Cancer Cells [Retraction] | Full Text | PDF (136.5 KB) | EPUB
  • 45 Views
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ORIGINAL RESEARCH

Article
Pharmacokinetics of Herb-Drug Interactions of Plumbagin and Tazemetostat in Rats by UPLC-MS/MS
Heng Li, Ying-Jie Wang, Xiao-Nan Geng, Yao-Ren Kang, Yi-Lin Wang & Xiang-Jun Qiu
Pages: 3385-3394
Published online: 05 Dec 2023
AbstractforPharmacokinetics of Herb-Drug Interactions of Plumbagin and Tazemetostat in Rats by UPLC-MS/MS | Full Text | References | PDF (2.7 MB) | EPUB
  • 145 Views
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REVIEW

Review
A Review of Population Pharmacokinetic Models of Posaconazole
Qin Ding, Shuqi Huang, Zexu Sun, Kaifeng Chen, Xin Li & Qi Pei
Pages: 3691-3709
Published online: 05 Dec 2023
AbstractforA Review of Population Pharmacokinetic Models of Posaconazole | Full Text | References | PDF (4.9 MB) | EPUB
  • 142 Views
  • 2 CrossRef citations
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CORRIGENDUM

Correction
Efficacy and Safety of Remimazolam Besylate versus Dexmedetomidine for Sedation in Non-Intubated Older Patients with Agitated Delirium After Orthopedic Surgery: A Randomized Controlled Trial [Corrigendum]
Pages: 2681-2682
Published online: 05 Dec 2023
CitationforEfficacy and Safety of Remimazolam Besylate versus Dexmedetomidine for Sedation in Non-Intubated Older Patients with Agitated Delirium After Orthopedic Surgery: A Randomized Controlled Trial [Corrigendum] | Full Text | PDF (126.7 KB) | EPUB
  • 92 Views
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ORIGINAL RESEARCH

Article
The Combination of Zinc and Melatonin Enhanced Neuroprotection and Attenuated Neuropathy in Oxaliplatin-Induced Neurotoxicity
Mayyadah Ali & Tavga Aziz
Pages: 3447-3463
Published online: 05 Dec 2023
AbstractforThe Combination of Zinc and Melatonin Enhanced Neuroprotection and Attenuated Neuropathy in Oxaliplatin-Induced Neurotoxicity | Full Text | References | PDF (6.5 MB) | EPUB
  • 189 Views
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RETRACTION

Retraction
Sulfasalazine Inhibits Inflammation and Fibrogenesis in Pancreas via NF-κB Signaling Pathway in Rats with Oxidative Stress-Induced Pancreatic Injury [Retraction]
Pages: 2729-2730
Published online: 05 Dec 2023
CitationforSulfasalazine Inhibits Inflammation and Fibrogenesis in Pancreas via NF-κB Signaling Pathway in Rats with Oxidative Stress-Induced Pancreatic Injury [Retraction] | Full Text | PDF (144.2 KB) | EPUB
  • 64 Views
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Retraction
Preparation, in vitro and in vivo Evaluation of Thermosensitive in situ Gel Loaded with Ibuprofen-Solid Lipid Nanoparticles for Rectal Delivery [Retraction]
Pages: 3445-3446
Published online: 05 Dec 2023
CitationforPreparation, in vitro and in vivo Evaluation of Thermosensitive in situ Gel Loaded with Ibuprofen-Solid Lipid Nanoparticles for Rectal Delivery [Retraction] | Full Text | PDF (235.9 KB) | EPUB
  • 67 Views
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CORRIGENDUM

Correction
Quality of Evidence Supporting the Role of Tripterygium Glycosides for the Treatment of Diabetic Kidney Disease: An Overview of Systematic Reviews and Meta-Analyses [Corrigendum]
Pages: 3675-3676
Published online: 05 Dec 2023
CitationforQuality of Evidence Supporting the Role of Tripterygium Glycosides for the Treatment of Diabetic Kidney Disease: An Overview of Systematic Reviews and Meta-Analyses [Corrigendum] | Full Text | PDF (233.4 KB) | EPUB
  • 71 Views
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ORIGINAL RESEARCH

Article
The Preventive and Therapeutic Effects of Ajwa Date Fruit Extract Against Acute Diclofenac Toxicity-Induced Colopathy: An Experimental Study
Shaimaa Mohamed Abdelfattah Hassan, Moutasem Salih Aboonq, Emad A Albadawi, Yasmeen Aljehani, Hytham Mahmoud Abdel-Latif, Reham A Mariah, Noha M Shafik, Tamer M Soliman, Abdelhady Ragab Abdel-Gawad, Faten M Omran, Wafaa A Abdellah, Ahmed Shehata, Husam Shahada, Hussam H Baghdadi, Hanan Yousef Aly, Alfarazdeg Saad, Manal Mohamed Helmy Nabo, Abdullah Almilaibary, Heba M Eltahir, Salah Mohamed El Sayed, Mustafa AM Abu-Elnaga & Yasser M Elbastawisy
Pages: 2601-2616
Published online: 05 Dec 2023
AbstractforThe Preventive and Therapeutic Effects of Ajwa Date Fruit Extract Against Acute Diclofenac Toxicity-Induced Colopathy: An Experimental Study | Full Text | References | PDF (5.7 MB) | EPUB
  • 366 Views
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Article
Characterization of Selective and Potent JAK1 Inhibitors Intended for the Inhaled Treatment of Asthma
Magnus Nilsson, Magdalena Rhedin, Ramon Hendrickx, Susanne Berglund, Antonio Piras, Parmis Blomgran, Anders Cavallin, Mia Collins, Göran Dahl, Bilel Dekkak, Therese Ericsson, Niklas Hagberg, Ann Aurell Holmberg, Agnes Leffler, Anders J Lundqvist, Thomais Markou, James Pinkerton, Lars Rönnblom, Stacey Siu, Vanessa Taylor, Tiiu Wennberg, Dimitrios Zervas, Arian D J Laurence, Suman Mitra, Maria G Belvisi, Mark Birrell & Annika Borde
Pages: 2901-2917
Published online: 05 Dec 2023
AbstractforCharacterization of Selective and Potent JAK1 Inhibitors Intended for the Inhaled Treatment of Asthma | Full Text | References | PDF (1.8 MB) | EPUB
  • 306 Views
  • 6 CrossRef citations
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Article
Combined Treatment of Tanshinone I and Epirubicin Revealed Enhanced Inhibition of Hepatocellular Carcinoma by Targeting PI3K/AKT/HIF-1α
Jiali Zhao, En Lin, Chaonong Cai, Manyao Zhang, Decheng Li, Shanglin Cai, Guifang Zeng, Zeren Yin, Bo Wang, Peiping Li, Xiaopeng Hong, Jiafan Chen, Baojia Zou & Jian Li
Pages: 3197-3213
Published online: 05 Dec 2023
AbstractforCombined Treatment of Tanshinone I and Epirubicin Revealed Enhanced Inhibition of Hepatocellular Carcinoma by Targeting PI3K/AKT/HIF-1α | Full Text | References | PDF (13.3 MB) | EPUB
  • 230 Views
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Article
Tackling Microbial Resistance with Isatin-Decorated Thiazole Derivatives: Design, Synthesis, and in vitro Evaluation of Antimicrobial and Antibiofilm Activity
Refaie M Kassab, Sami A Al-Hussain, Nooran S Elleboudy, Amgad Albohy, Magdi EA Zaki, Khaled AM Abouzid & Zeinab A Muhammad
Pages: 2817-2832
Published online: 05 Dec 2023
AbstractforTackling Microbial Resistance with Isatin-Decorated Thiazole Derivatives: Design, Synthesis, and in vitro Evaluation of Antimicrobial and Antibiofilm Activity | Full Text | References | PDF (1.5 MB) | EPUB
  • 285 Views
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Article
Icariin and Competing Endogenous RNA Network: A Potential Protective Strategy Against Contrast-Induced Acute Kidney Injury
Yan Lin, Gaofeng Zhu, Xiaoyong Li, Huaxiao Yu, Yuhang Luo, Jiaqiong Lin, Renyuan Li & Zena Huang
Pages: 2343-2363
Published online: 05 Dec 2023
AbstractforIcariin and Competing Endogenous RNA Network: A Potential Protective Strategy Against Contrast-Induced Acute Kidney Injury | Full Text | References | PDF (12.8 MB) | EPUB
  • 142 Views
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REVIEW

Review
Ibrutinib-Associated Cardiotoxicity: From the Pharmaceutical to the Clinical
Rong Dong, Youyou Yan, Xiaokang Zeng, Nengming Lin & Biqin Tan
Pages: 3225-3239
Published online: 05 Dec 2023
AbstractforIbrutinib-Associated Cardiotoxicity: From the Pharmaceutical to the Clinical | Full Text | References | PDF (1.4 MB) | EPUB
  • 328 Views
  • 5 CrossRef citations
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Review
The Novel Compounds with Biological Activity Derived from Soil Fungi in the Past Decade
Danyu Zhang, Shoujie Li, Mohan Fan & Changqi Zhao
Pages: 3493-3555
Published online: 05 Dec 2023
AbstractforThe Novel Compounds with Biological Activity Derived from Soil Fungi in the Past Decade | Full Text | References | PDF (62.4 MB) | EPUB
  • 302 Views
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PERSPECTIVES

Article
Scientific Rationale for Waiving Clinical Efficacy Testing of Biosimilars
Sarfaraz Niazi
Pages: 2803-2815
Published online: 05 Dec 2023
AbstractforScientific Rationale for Waiving Clinical Efficacy Testing of Biosimilars | Full Text | References | PDF (833.1 KB) | EPUB
  • 378 Views
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CLINICAL TRIAL REPORT

Effect of Weight-Adjusted Phenylephrine, Norepinephrine, and Metaraminol for Elective Cesarean Delivery on Neonatal Acid–Base Status: A Randomized Controlled Trial
Tianyu Liu, Zhiyong Cheng, Shiya Zou, Chao Xu, Shoudong Pan, Huabei Zeng, Yidong Shan, Yi Feng & Hong Zhang
Pages: 3215-3223
Published online: 05 Dec 2023
AbstractforEffect of Weight-Adjusted Phenylephrine, Norepinephrine, and Metaraminol for Elective Cesarean Delivery on Neonatal Acid–Base Status: A Randomized Controlled Trial | Full Text | References | PDF (2.3 MB) | EPUB
  • 159 Views
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ORIGINAL RESEARCH

Article
The Temporal Topography of Central Serous Chorioretinopathy in the Chinchilla Rabbits Induced by Intravenous Injection of Adrenaline: An in vivo Study
Weiming Yan, Pan Long, Lei Zhang, Meizhu Chen, Zuoming Zhang & Tao Chen
Pages: 3275-3283
Published online: 05 Dec 2023
AbstractforThe Temporal Topography of Central Serous Chorioretinopathy in the Chinchilla Rabbits Induced by Intravenous Injection of Adrenaline: An in vivo Study | Full Text | References | PDF (2.7 MB) | EPUB
  • 100 Views
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REVIEW

Review
Progress and Challenges of Anti-VEGF Agents and Their Sustained-Release Strategies for Retinal Angiogenesis
Manhong Xu, Ruiyan Fan, Xiaoe Fan, Yan Shao & Xiaorong Li
Pages: 3241-3262
Published online: 05 Dec 2023
AbstractforProgress and Challenges of Anti-VEGF Agents and Their Sustained-Release Strategies for Retinal Angiogenesis | Full Text | References | PDF (1.4 MB) | EPUB
  • 528 Views
  • 8 CrossRef citations
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ORIGINAL RESEARCH

Article
Semaglutide May Alleviate Hepatic Steatosis in T2DM Combined with NFALD Mice via miR-5120/ABHD6
Ran Li, Zhengqin Ye, Dunmin She, Ping Fang, Guannan Zong, Kerong Hu, Dehong Kong, Wei Xu, Ling Li, Yun Zhou, Keqin Zhang & Ying Xue
Pages: 3557-3572
Published online: 05 Dec 2023
AbstractforSemaglutide May Alleviate Hepatic Steatosis in T2DM Combined with NFALD Mice via miR-5120/ABHD6 | Full Text | References | PDF (4.9 MB) | EPUB
  • 304 Views
  • 1 CrossRef citations
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CORRIGENDUM

Correction
Efficacy of Chloral Hydrate Oral Solution for Sedation in Pediatrics: a Systematic Review and Meta-Analysis [Corrigendum]
Pages: 3491-3492
Published online: 05 Dec 2023
CitationforEfficacy of Chloral Hydrate Oral Solution for Sedation in Pediatrics: a Systematic Review and Meta-Analysis [Corrigendum] | Full Text | PDF (128.4 KB) | EPUB
  • 95 Views
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CLINICAL TRIAL REPORT

Continuous Erector Spinae Plane Block Using Programmed Intermittent Bolus Regimen versus Intravenous Patient-Controlled Opioid Analgesia Within an Enhanced Recovery Program After Open Liver Resection in Patients with Coagulation Disorder: A Randomized, Controlled, Non-Inferiority Trial
Jiali Wang, Fang Du, Yimei Ma, Yuncen Shi, Jie Fang, Jing Xv, Jing Cang, Changhong Miao & Xiaoguang Zhang
Pages: 3401-3412
Published online: 05 Dec 2023
AbstractforContinuous Erector Spinae Plane Block Using Programmed Intermittent Bolus Regimen versus Intravenous Patient-Controlled Opioid Analgesia Within an Enhanced Recovery Program After Open Liver Resection in Patients with Coagulation Disorder: A Randomized, Controlled, Non-Inferiority Trial | Full Text | References | PDF (3.3 MB) | EPUB
  • 197 Views
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