Mahuang Decoction Attenuates Airway Inflammation and Remodeling in Asthma via Suppression of the SP1/FGFR3/PI3K/AKT Axis

References

• Sobeih AA, Behairy OG, Abd Almonaem ER, Mohammad OI, Mn Abdelrahman A. Clusterin in atopic and non-atopic childhood asthma. Scand J Clin Lab Invest. 2019;79(6):368–371. doi:10.1080/00365513.2019.1624976
   PubMed Web of Science ®Google Scholar
• Tyler SR, Bunyavanich S. Leveraging -omics for asthma endotyping. J Allergy Clin Immunol. 2019;144(1):13–23. doi:10.1016/j.jaci.2019.05.015
   PubMed Web of Science ®Google Scholar
• Simoneau T, Cloutier MM. Controversies in Pediatric Asthma. Pediatr Ann. 2019;48(3):e128–e134. doi:10.3928/19382359-20190226-01
   PubMed Web of Science ®Google Scholar
• Fehrenbach H, Wagner C, Wegmann M. Airway remodeling in asthma: what really matters. Cell Tissue Res. 2017;367(3):551–569. doi:10.1007/s00441-016-2566-8
   PubMed Web of Science ®Google Scholar
• Zhao Y, Jia L, Wang J, Zou W, Yang H, Xiao X. Cold/hot pad differentiating assay of property differences of Mahuang and Maxingshigan decoctions. Pharm Biol. 2016;54(7):1298–1302. doi:10.3109/13880209.2015.1057650
   PubMed Web of Science ®Google Scholar
• Ko JW, Seo CS, Shin NR, et al. Modificated Mahuang-Tang, a traditional herbal medicine suppresses inflammatory responses induced by cigarette smoke in human airway epithelial cell and mice. Phytomedicine. 2019;59:152777. doi:10.1016/j.phymed.2018.11.037
   Web of Science ®Google Scholar
• He Y, Lou X, Jin Z, Yu L, Deng L, Wan H. Mahuang decoction mitigates airway inflammation and regulates IL-21/STAT3 signaling pathway in rat asthma model. J Ethnopharmacol. 2018;224:373–380. doi:10.1016/j.jep.2018.06.011
   Web of Science ®Google Scholar
• Huang P, Tang Y, Li C, et al. Correlation study between the pharmacokinetics of seven main active ingredients of Mahuang decoction and its pharmacodynamics in asthmatic rats. J Pharm Biomed Anal. 2020;183:113144. doi:10.1016/j.jpba.2020.113144
   Web of Science ®Google Scholar
• O’Connor L, Gilmour J, Bonifer C. The Role of the Ubiquitously Expressed Transcription Factor Sp1 in Tissue-specific Transcriptional Regulation and in Disease. Yale J Biol Med. 2016;89(4):513–525.
   PubMedGoogle Scholar
• Kim JS, Shin IS, Shin NR, Nam JY, Kim C. Genomewide analysis of DNA methylation and gene expression changes in an ovalbumininduced asthma mouse model. Mol Med Rep. 2020;22(3):1709–1716. doi:10.3892/mmr.2020.11245
   Web of Science ®Google Scholar
• Kumawat K, Menzen MH, Slegtenhorst RM, Halayko AJ, Schmidt M, Gosens R. TGF-beta-activated kinase 1 (TAK1) signaling regulates TGF-beta-induced WNT-5A expression in airway smooth muscle cells via Sp1 and beta-catenin. PLoS One. 2014;9(4):e94801. doi:10.1371/journal.pone.0094801
   PubMed Web of Science ®Google Scholar
• Chadalapaka G, Jutooru I, Safe S. Celastrol decreases specificity proteins (Sp) and fibroblast growth factor receptor-3 (FGFR3) in bladder cancer cells. Carcinogenesis. 2012;33(4):886–894. doi:10.1093/carcin/bgs102
   PubMed Web of Science ®Google Scholar
• Lee HY, Hur J, Kim IK, et al. Effect of nintedanib on airway inflammation and remodeling in a murine chronic asthma model. Exp Lung Res. 2017;43(4–5):187–196. doi:10.1080/01902148.2017.1339141
   PubMed Web of Science ®Google Scholar
• Starska K, Forma E, Lewy-Trenda I, Stasikowska-Kanicka O, Skora M, Brys M. Fibroblast growth factor receptor 1 and 3 expression is associated with regulatory PI3K/AKT kinase activity, as well as invasion and prognosis, in human laryngeal cancer. Cell Oncol. 2018;41(3):253–268. doi:10.1007/s13402-017-0367-z
   Web of Science ®Google Scholar
• Li X, Zhou L, Zhang Z, Liu Y, Liu J, Zhang C. IL-27 alleviates airway remodeling in a mouse model of asthma via PI3K/Akt pathway. Exp Lung Res. 2020;46(3–4):98–108. doi:10.1080/01902148.2020.1740356
   PubMed Web of Science ®Google Scholar
• Liu Y, Zhang H, Ni R, Jia WQ, Wang YY. IL-4R suppresses airway inflammation in bronchial asthma by inhibiting the IL-4/STAT6 pathway. Pulm Pharmacol Ther. 2017;43:32–38. doi:10.1016/j.pupt.2017.01.006
   PubMed Web of Science ®Google Scholar
• Lee J, Rhee CK, Lee JH, et al. Effect of nintedanib on airway inflammation in a mouse model of acute asthma. J Asthma. 2020;57(1):11–20. doi:10.1080/02770903.2018.1544641
   PubMed Web of Science ®Google Scholar
• Perez-Castro AV, Wilson J, Altherr MR. Genomic organization of the mouse fibroblast growth factor receptor 3 (Fgfr3) gene. Genomics. 1995;30(2):157–162. doi:10.1006/geno.1995.9890
   Web of Science ®Google Scholar
• Ahn SY, Chang YS, Sung DK, Sung SI, Park WS. Hypothermia broadens the therapeutic time window of mesenchymal stem cell transplantation for severe neonatal hypoxic ischemic encephalopathy. Sci Rep. 2018;8(1):7665. doi:10.1038/s41598-018-25902-x
   Web of Science ®Google Scholar
• Campa CC, Silva RL, Margaria JP, et al. Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis. Nat Commun. 2018;9(1):5232. doi:10.1038/s41467-018-07698-6
   Web of Science ®Google Scholar
• Perlikos F, Hillas G, Loukides S. Phenotyping and Endotyping Asthma Based on Biomarkers. Curr Top Med Chem. 2016;16(14):1582–1586. doi:10.2174/1568026616666150930120803
   Web of Science ®Google Scholar
• Chen L, Yao C, Li J, et al. Systematic characterization of chemical constituents in Mahuang decoction by UHPLC tandem linear ion trap-Orbitrap mass spectrometry coupled with feature-based molecular networking. J Sep Sci. 2021;44(14):2717–2727. doi:10.1002/jssc.202100121
   Web of Science ®Google Scholar
• He Y, Zhu Y, Zhang R, Ge L, Wan H. Simultaneous quantification of nine major active components in traditional Chinese prescription Mahuang decoction and the influence of herbal compatibility on their contents. Pharmacogn Mag. 2014;10(Suppl 1):S72–79. doi:10.4103/0973-1296.127346
   Web of Science ®Google Scholar
• Lin CC, Wang YY, Chen SM, et al. Shegan-Mahuang Decoction ameliorates asthmatic airway hyperresponsiveness by downregulating Th2/Th17 cells but upregulating CD4+FoxP3+ Tregs. J Ethnopharmacol. 2020;253:112656. doi:10.1016/j.jep.2020.112656
   Web of Science ®Google Scholar
• Jiao J, Wu J, Wang J, et al. Ma Huang Tang ameliorates bronchial asthma symptoms through the TLR9 pathway. Pharm Biol. 2018;56(1):580–593. doi:10.1080/13880209.2018.1517184
   PubMed Web of Science ®Google Scholar
• Lim HS, Seo CS, Jin SE, et al. Ma Huang Tang Suppresses the Production and Expression of Inflammatory Chemokines via Downregulating STAT1 Phosphorylation in HaCaT Keratinocytes. Evid Based Complement Alternat Med. 2016;2016:7831291. doi:10.1155/2016/7831291
   Web of Science ®Google Scholar
• Banno A, Reddy AT, Lakshmi SP, Reddy RC. Bidirectional interaction of airway epithelial remodeling and inflammation in asthma. Clin Sci (Lond). 2020;134(9):1063–1079. doi:10.1042/CS20191309
   PubMed Web of Science ®Google Scholar
• Boulet LP. Airway remodeling in asthma: update on mechanisms and therapeutic approaches. Curr Opin Pulm Med. 2018;24(1):56–62. doi:10.1097/MCP.0000000000000441
   PubMed Web of Science ®Google Scholar
• Huang XF, Cheng WB, Jiang Y, et al. A network pharmacology-based strategy for predicting anti-inflammatory targets of ephedra in treating asthma. Int Immunopharmacol. 2020;83:106423. doi:10.1016/j.intimp.2020.106423
   Web of Science ®Google Scholar
• Bai H, Zhou M, Zhou H, et al. Licochalcone A suppresses Sp1 expression with potential anti-myeloma activity. Cancer Commun. 2021;41(11):1239–1242. doi:10.1002/cac2.12223
   Web of Science ®Google Scholar
• Zhao S, Wu J, Tang Q, et al. Chinese herbal medicine Xiaoji decoction inhibited growth of lung cancer cells through AMPKalpha-mediated inhibition of Sp1 and DNA methyltransferase 1. J Ethnopharmacol. 2016;181:172–181. doi:10.1016/j.jep.2016.01.041
   Web of Science ®Google Scholar
• Zhang H, Yu W, Ji L, et al. Guifu Dihuang Pills Ameliorated Mucus Hypersecretion by Suppressing Muc5ac Expression and Inactivating the ERK-SP1 Pathway in Lipopolysaccharide/Cigarette Smoke-Induced Mice. Evid Based Complement Alternat Med. 2021;2021:9539218. doi:10.1155/2021/9539218
   Web of Science ®Google Scholar
• Moheimani F, Koops J, Williams T, et al. Influenza A virus infection dysregulates the expression of microRNA-22 and its targets; CD147 and HDAC4, in epithelium of asthmatics. Respir Res. 2018;19(1):145. doi:10.1186/s12931-018-0851-7
   PubMed Web of Science ®Google Scholar
• Lee KE, Jee HM, Hong JY, et al. German Cockroach Extract Induces Matrix Metalloproteinase-1 Expression, Leading to Tight Junction Disruption in Human Airway Epithelial Cells. Yonsei Med J. 2018;59(10):1222–1231. doi:10.3349/ymj.2018.59.10.1222
   Web of Science ®Google Scholar
• Naveed SU, Clements D, Jackson DJ, et al. Matrix Metalloproteinase-1 Activation Contributes to Airway Smooth Muscle Growth and Asthma Severity. Am J Respir Crit Care Med. 2017;195(8):1000–1009. doi:10.1164/rccm.201604-0822OC
   PubMed Web of Science ®Google Scholar
• McEwen DG, Ornitz DM. Regulation of the fibroblast growth factor receptor 3 promoter and intron I enhancer by Sp1 family transcription factors. J Biol Chem. 1998;273(9):5349–5357. doi:10.1074/jbc.273.9.5349
   Web of Science ®Google Scholar
• Okada T, Enkhjargal B, Travis ZD, et al. FGF-2 Attenuates Neuronal Apoptosis via FGFR3/PI3k/Akt Signaling Pathway After Subarachnoid Hemorrhage. Mol Neurobiol. 2019;56(12):8203–8219. doi:10.1007/s12035-019-01668-9
   PubMed Web of Science ®Google Scholar
• Pan J, Yang Q, Zhou Y, et al. MicroRNA-221 Modulates Airway Remodeling via the PI3K/AKT Pathway in OVA-Induced Chronic Murine Asthma. Front Cell Dev Biol. 2020;8:495. doi:10.3389/fcell.2020.00495
   PubMed Web of Science ®Google Scholar
• Liu Y, Li X, He C, et al. Emodin ameliorates ovalbumin-induced airway remodeling in mice by suppressing airway smooth muscle cells proliferation. Int Immunopharmacol. 2020;88:106855. doi:10.1016/j.intimp.2020.106855
   Web of Science ®Google Scholar