Magnesium Lithospermate B Protects Against Cisplatin-Induced Acute Kidney Injury via Alleviating Mitochondrial Dysfunction

References

• Duan Z, Cai G, Li J, Chen X. Cisplatin-induced renal toxicity in elderly people. Ther Adv Med Oncol. 2020;12:1758835920923430. doi:10.1177/1758835920923430
   Web of Science ®Google Scholar
• McSweeney KR, Gadanec LK, Qaradakhi T, Ali BA, Zulli A, Apostolopoulos V. Mechanisms of cisplatin-induced acute kidney injury: pathological mechanisms, pharmacological interventions, and genetic mitigations. Cancers. 2021;13(7):1572. doi:10.3390/cancers13071572
   PubMed Web of Science ®Google Scholar
• Volarevic V, Djokovic B, Jankovic MG, et al. Molecular mechanisms of cisplatin-induced nephrotoxicity: a balance on the knife edge between renoprotection and tumor toxicity. J Biomed Sci. 2019;26(1):25. doi:10.1186/s12929-019-0518-9
   PubMed Web of Science ®Google Scholar
• Bhargava P, Schnellmann RG. Mitochondrial energetics in the kidney. Nat Rev Nephrol. 2017;13(10):629–646. doi:10.1038/nrneph.2017.107
   PubMed Web of Science ®Google Scholar
• Brooks C, Wei Q, Cho SG, Dong Z. Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models. J Clin Invest. 2009;119(5):1275–1285. doi:10.1172/JCI37829
   PubMed Web of Science ®Google Scholar
• Chang CR, Blackstone C. Dynamic regulation of mitochondrial fission through modification of the dynamin-related protein Drp1. Ann N Y Acad Sci. 2010;1201:34–39. doi:10.1111/j.1749-6632.2010.05629.x
   PubMed Web of Science ®Google Scholar
• Perry HM, Huang L, Wilson RJ, et al. Dynamin-related protein 1 deficiency promotes recovery from AKI. J Am Soc Nephrol. 2018;29(1):194–206. doi:10.1681/ASN.2017060659
   PubMed Web of Science ®Google Scholar
• Cho SG, Du Q, Huang S, Dong Z. Drp1 dephosphorylation in ATP depletion-induced mitochondrial injury and tubular cell apoptosis. Am J Physiol Renal Physiol. 2010;299(1):F199–206. doi:10.1152/ajprenal.00716.2009
   PubMed Web of Science ®Google Scholar
• Sumida M, Doi K, Ogasawara E, et al. Regulation of mitochondrial dynamics by dynamin-related protein-1 in acute cardiorenal syndrome. J Am Soc Nephrol. 2015;26(10):2378–2387. doi:10.1681/ASN.2014080750
   PubMed Web of Science ®Google Scholar
• Tongqiang L, Shaopeng L, Xiaofang Y, et al. Salvianolic acid B prevents iodinated contrast media-induced acute renal injury in rats via the PI3K/Akt/Nrf2 pathway. Oxid Med Cell Longev. 2016;2016:7079487. doi:10.1155/2016/7079487
   PubMed Web of Science ®Google Scholar
• Gao F, Li JM, Xi C, et al. Magnesium lithospermate B protects the endothelium from inflammation-induced dysfunction through activation of Nrf2 pathway. Acta Pharmacol Sin. 2019;40(7):867–878. doi:10.1038/s41401-018-0189-1
   PubMed Web of Science ®Google Scholar
• Jeong JW, Lee B, Kim DH, et al. Mechanism of action of magnesium lithospermate B against aging and obesity-induced ER stress, insulin resistance, and inflammsome formation in the liver. Molecules. 2018;23(9):2098. doi:10.3390/molecules23092098
   PubMed Web of Science ®Google Scholar
• Luo X, Deng Q, Xue Y, et al. Anti-fibrosis effects of magnesium lithospermate B in experimental pulmonary fibrosis: by inhibiting TGF-betaRI/Smad signaling. Molecules. 2021;26(6):1715. doi:10.3390/molecules26061715
   PubMed Web of Science ®Google Scholar
• Xiao Z, Liu W, Mu YP, et al. Pharmacological effects of salvianolic acid B against oxidative damage. Front Pharmacol. 2020;11:572373. doi:10.3389/fphar.2020.572373
   PubMed Web of Science ®Google Scholar
• Wang M, Yang L, Yang J, Zhou Y, Wang C. Magnesium lithospermate B attenuates renal injury in 5/6 renal ablation/infarction rats by mitochondrial pathway of apoptosis. Biomed Pharmacother. 2019;118:109316. doi:10.1016/j.biopha.2019.109316
   PubMed Web of Science ®Google Scholar
• Liang Y, Liu H, Fang Y, et al. Salvianolate ameliorates oxidative stress and podocyte injury through modulation of NOX4 activity in db/db mice. J Cell Mol Med. 2021;25(2):1012–1023. doi:10.1111/jcmm.16165
   PubMed Web of Science ®Google Scholar
• Li T, Peng JJ, Wang EL, et al. Magnesium lithospermate B derived from salvia miltiorrhiza ameliorates right ventricle remodeling in pulmonary hypertensive rats via inhibition of NOX/VPO1 pathway. Planta Med. 2019;85(9–10):708–718. doi:10.1055/a-0863-4741
   PubMed Web of Science ®Google Scholar
• Guo M, Xu J, Zhao S, et al. Suppressing syndecan-1 shedding to protect against renal ischemia/reperfusion injury by maintaining polarity of tubular epithelial cells. Shock. 2021. doi:10.1097/shk.0000000000001838
   Web of Science ®Google Scholar
• Han B, Li S, Lv Y, et al. Dietary melatonin attenuates chromium-induced lung injury via activating the Sirt1/Pgc-1α/Nrf2 pathway. Food Funct. 2019;10(9):5555–5565. doi:10.1039/c9fo01152h
   PubMed Web of Science ®Google Scholar
• Song N, Lu Z, Zhang J, et al. Acid-sensing ion channel 1a is involved in ischaemia/reperfusion induced kidney injury by increasing renal epithelia cell apoptosis. J Cell Mol Med. 2019;23(5):3429–3440. doi:10.1111/jcmm.14238
   PubMed Web of Science ®Google Scholar
• Yang D, Yang Q, Fu N, et al. Hexavalent chromium induced heart dysfunction via Sesn2-mediated impairment of mitochondrial function and energy supply. Chemosphere. 2021;264(Pt2):128547. doi:10.1016/j.chemosphere.2020.128547
   PubMed Web of Science ®Google Scholar
• Han B, Lv Z, Han X, et al. Harmful effects of inorganic mercury exposure on kidney cells: mitochondrial dynamics disorder and excessive oxidative stress. Biol Trace Elem Res. 2022;200(4):1591–1597. doi:10.1007/s12011-021-02766-3
   PubMed Web of Science ®Google Scholar
• Yuan Y, Zhu L, Li L, et al. S-sulfhydration of SIRT3 by hydrogen sulfide attenuates mitochondrial dysfunction in cisplatin-induced acute kidney injury. Antioxid Redox Signal. 2019;31(17):1302–1319. doi:10.1089/ars.2019.7728
   PubMed Web of Science ®Google Scholar
• Hu X, Ma Z, Wen L, Li S, Dong Z. Autophagy in cisplatin nephrotoxicity during cancer therapy. Cancers. 2021;13(22):5618. doi:10.3390/cancers13225618
   PubMed Web of Science ®Google Scholar
• Han Y, Kim J, Jang G, Park K. Cisplatin induces lung cell cilia disruption and lung damage via oxidative stress. Free Radic Biol Med. 2021;177:270–277. doi:10.1016/j.freeradbiomed.2021.10.032
   PubMed Web of Science ®Google Scholar
• Mapuskar KA, Steinbach EJ, Zaher A, et al. Mitochondrial superoxide dismutase in cisplatin-induced kidney injury. Antioxidants. 2021;10(9):1329. doi:10.3390/antiox10091329
   Web of Science ®Google Scholar
• Li Z, Liu Z, Luo M, et al. The pathological role of damaged organelles in renal tubular epithelial cells in the progression of acute kidney injury. Cell Death Discov. 2022;8(1):239. doi:10.1038/s41420-022-01034-0
   PubMed Web of Science ®Google Scholar
• Ding M, Feng N, Tang D, et al. Melatonin prevents Drp1-mediated mitochondrial fission in diabetic hearts through SIRT1-PGC1alpha pathway. J Pineal Res. 2018;65(2):e12491. doi:10.1111/jpi.12491
   PubMed Web of Science ®Google Scholar
• Chen Z, Ma Y, Yang Q, et al. AKAP1 mediates high glucose-induced mitochondrial fission through the phosphorylation of Drp1 in podocytes. J Cell Physiol. 2020;235(10):7433–7448. doi:10.1002/jcp.29646
   PubMed Web of Science ®Google Scholar
• Linkermann A, Chen G, Dong G, Kunzendorf U, Krautwald S, Dong Z. Regulated cell death in AKI. J Am Soc Nephrol. 2014;25(12):2689–2701. doi:10.1681/asn.2014030262
   PubMed Web of Science ®Google Scholar
• Huang Z, Li Q, Yuan Y, et al. Renalase attenuates mitochondrial fission in cisplatin-induced acute kidney injury via modulating sirtuin-3. Life Sci. 2019;222:78–87. doi:10.1016/j.lfs.2019.02.042
   PubMed Web of Science ®Google Scholar
• Wang J, Zhu P, Li R, Ren J, Zhou H. Fundc1-dependent mitophagy is obligatory to ischemic preconditioning-conferred renoprotection in ischemic AKI via suppression of Drp1-mediated mitochondrial fission. Redox Biol. 2020;30:101415. doi:10.1016/j.redox.2019.101415
   PubMed Web of Science ®Google Scholar
• Brooks C, Wei Q, Feng L, et al. Bak regulates mitochondrial morphology and pathology during apoptosis by interacting with mitofusins. Proc Natl Acad Sci USA. 2007;104(28):11649–11654. doi:10.1073/pnas.0703976104
   PubMed Web of Science ®Google Scholar
• D’Orsi B, Mateyka J, Prehn JHM. Control of mitochondrial physiology and cell death by the Bcl-2 family proteins Bax and Bok. Neurochem Int. 2017;109:162–170. doi:10.1016/j.neuint.2017.03.010
   PubMed Web of Science ®Google Scholar
• Rasmussen ML, Gama V. A connection in life and death: the BCL-2 family coordinates mitochondrial network dynamics and stem cell fate. Int Rev Cell Mol Biol. 2020;353:255–284. doi:10.1016/bs.ircmb.2019.12.005
   PubMed Web of Science ®Google Scholar
• Cho SG, Xiao X, Wang S, et al. Bif-1 interacts with prohibitin-2 to regulate mitochondrial inner membrane during cell stress and apoptosis. J Am Soc Nephrol. 2019;30(7):1174–1191. doi:10.1681/ASN.2018111117
   PubMed Web of Science ®Google Scholar
• Cao X, Nie X, Xiong S, et al. Renal protective effect of polysulfide in cisplatin-induced nephrotoxicity. Redox Biol. 2018;15:513–521. doi:10.1016/j.redox.2018.01.012
   PubMed Web of Science ®Google Scholar
• Wang XL, Wang L, Lin FL, Li SS, Lin TX, Jiang RW. Protective effect of penetratin analogue-tagged SOD1 on cisplatin-induced nephrotoxicity through inhibiting oxidative stress and JNK/p38 MAPK signaling pathway. Oxid Med Cell Longev. 2021;2021:5526053. doi:10.1155/2021/5526053
   PubMed Web of Science ®Google Scholar
• Wang D, Lu X, Wang E, Shi L, Ma C, Tan X. Salvianolic acid B attenuates oxidative stress-induced injuries in enterocytes by activating Akt/GSK3beta signaling and preserving mitochondrial function. Eur J Pharmacol. 2021;909:174408. doi:10.1016/j.ejphar.2021.174408
   PubMed Web of Science ®Google Scholar