6-Methoxyflavone and Donepezil Behavioral Plus Neurochemical Correlates in Reversing Chronic Ethanol and Withdrawal Induced Cognitive Impairment

References

• Avchalumov Y, Oliver RJ, Trenet W, et al. Chronic ethanol exposure differentially alters neuronal function in the medial prefrontal cortex and dentate gyrus. Neuropharmacol. 2021;185:108438. doi:10.1016/j.neuropharm.2020.108438
   PubMed Web of Science ®Google Scholar
• Somkuwar SS, Villalpando EG, Quach LW, et al. Abstinence from ethanol dependence produces concomitant cortical gray matter abnormalities, microstructural deficits and cognitive dysfunction. Eur Neuropsychopharmacol. 2021;42:22–34. doi:10.1016/j.euroneuro.2020.11.010
   PubMed Web of Science ®Google Scholar
• Fadda F, Rossetti ZL. Chronic ethanol consumption: from neuroadaptation to neurodegeneration. Progress Neurobiol. 1998;56(4):385–431. doi:10.1016/S0301-0082(98)00032-X
   PubMed Web of Science ®Google Scholar
• Bach EC, Morgan JW, Ewin SE, Barth SH, Raab-Graham KF, Weiner JL. Chronic ethanol exposures leads to a negative affective state in female rats that is accompanied by a paradoxical decrease in ventral hippocampus excitability. Frontiers Neurosci. 2021;15:458. doi:10.3389/fnins.2021.669075
   Web of Science ®Google Scholar
• Uniyal A, Kotiyal A, Gadepalli A, Ummadisetty O, Tiwari V. Epigallocatechin-3-gallate improves chronic alcohol induced cognitive dysfunction in rats by interfering with the neuro-inflammatory, cell death and oxido-nitrosative stress pathways; 2021.
   Google Scholar
• Zhang X, Lian S, Zhang Y, Zhao Q. efficacy and safety of donepezil for mild cognitive impairment: a systematic review and meta-analysis. Clinic Neurol Neurosurg. 2022;213:107134. doi:10.1016/j.clineuro.2022.107134
   PubMed Web of Science ®Google Scholar
• Li Y, Sun X, Zhuang J, Wang J, Yang C. Donepezil ameliorates oxygen‑glucose deprivation/reoxygenation‑induced cardiac microvascular endothelial cell dysfunction through PARP1/NF‑κB signaling. Mol Medi Rep. 2022;25(4):1–9.
   PubMed Web of Science ®Google Scholar
• Getachew B, Hudson T, Heinbockel T, Csoka AB, Tizabi Y. Protective effects of donepezil against alcohol-induced toxicity in cell culture: role of caspase-3. Neurotox Res. 2018;34(3):757–762. doi:10.1007/s12640-018-9913-3
   PubMed Web of Science ®Google Scholar
• Panche A, Diwan A, Chandra S. Flavonoids: an overview. J Nutr Sci. 2016;5:e47.
   PubMed Web of Science ®Google Scholar
• Rendeiro C, Rhodes JS, Spencer JP. The mechanisms of action of flavonoids in the brain: direct versus indirect effects. Neurochemi Int. 2015;89:126–139.
   PubMed Web of Science ®Google Scholar
• Heim KE, Tagliaferro AR, Bobilya DJ. Flavonoid antioxidants: chemistry, metabolism and structure-activity relationships. J Nutri Biochem. 2002;13(10):572–584. doi:10.1016/S0955-2863(02)00208-5
   PubMed Web of Science ®Google Scholar
• Dong W, Wei T, Guang-Ming Y, Bao-Chang C. Anti-inflammatory, antioxidant and cytotoxic activities of flavonoids from Oxytropis falcata Bunge. J Nat Medi. 2010;8(6):461–465.
   Google Scholar
• Ognibene E, Bovicelli P, Adriani W, Saso L, Laviola G. Behavioral effects of 6-bromoflavanone and 5-methoxy-6, 8-dibromoflavanone as anxiolytic compounds. Prog Neuro Psychopharmacol Biol Psychiatry. 2008;32(1):128–134. doi:10.1016/j.pnpbp.2007.07.023
   PubMed Web of Science ®Google Scholar
• Cho N, Lee KY, Huh J, et al. Cognitive-enhancing effects of Rhus verniciflua bark extract and its active flavonoids with neuroprotective and anti-inflammatory activities. Food Chemi Toxicol. 2013;58:355–361. doi:10.1016/j.fct.2013.05.007
   PubMed Web of Science ®Google Scholar
• Spencer JP. Food for thought: the role of dietary flavonoids in enhancing human memory, learning and neuro-cognitive performance: symposium on ‘diet and mental health’. Proc Nutri Soci. 2008;67(2):238–252. doi:10.1017/S0029665108007088
   PubMed Web of Science ®Google Scholar
• Pu F, Mishima K, Irie K, et al. Neuroprotective effects of quercetin and rutin on spatial memory impairment in an 8-arm radial maze task and neuronal death induced by repeated cerebral ischemia in rats. J Pharmacol Sci. 2007;104:0707310004.
   Web of Science ®Google Scholar
• Cho J-S, Han C-K, Lee Y-S, Jin C-B. Neuroprotective and antioxidant effects of the butanol fraction prepared from opuntia ficus-indica var. Saboten Biomol Thera. 2007;15(4):205–211. doi:10.4062/biomolther.2007.15.4.205
   Google Scholar
• Hwang S-L, Shih P-H, Yen G-C. Neuroprotective effects of citrus flavonoids. J Agri Food Chemi. 2012;60(4):877–885. doi:10.1021/jf204452y
   PubMed Web of Science ®Google Scholar
• Devore EE, Kang JH, Breteler MM, Grodstein F. Dietary intakes of berries and flavonoids in relation to cognitive decline. Annals Neurol. 2012;72(1):135–143. doi:10.1002/ana.23594
   PubMed Web of Science ®Google Scholar
• Johnston GA. Flavonoid nutraceuticals and ionotropic receptors for the inhibitory neurotransmitter GABA. Neurochem Int. 2015;89:120–125. doi:10.1016/j.neuint.2015.07.013
   PubMed Web of Science ®Google Scholar
• Ulubelen A, Mabry T, Aynehchi Y. Flavonoids of Anvillea garcini. J Nat Prod. 1979;42(6):624–626. doi:10.1021/np50006a007
   Web of Science ®Google Scholar
• Shahid M, Subhan F, Ahmad N, Sewell RD. The flavonoid 6-methoxyflavone allays cisplatin-induced neuropathic allodynia and hypoalgesia. Biomedi Pharmacothera. 2017;95:1725–1733. doi:10.1016/j.biopha.2017.09.108
   PubMed Web of Science ®Google Scholar
• Hall BJ, Karim N, Chebib M, Johnston GA, Hanrahan JR. Modulation of ionotropic GABA receptors by 6-methoxyflavanone and 6-methoxyflavone. Neurochemi Res. 2014;39(6):1068–1078. doi:10.1007/s11064-013-1157-2
   PubMed Web of Science ®Google Scholar
• So J-S, Kim G-C, Song M, et al. 6-Methoxyflavone inhibits NFAT translocation into the nucleus and suppresses T cell activation. J Immunol. 2014;193(6):2772–2783. doi:10.4049/jimmunol.1400285
   PubMed Web of Science ®Google Scholar
• Raghavendra V, Kulkarni SK. Possible antioxidant mechanism in melatonin reversal of aging and chronic ethanol-induced amnesia in plus-maze and passive avoidance memory tasks. Free Radical Biol Medi. 2001;30(6):595–602. doi:10.1016/S0891-5849(00)00447-0
   PubMed Web of Science ®Google Scholar
• Umukoro S, Adewole F, Eduviere A, Aderibigbe A, Onwuchekwa C. Free radical scavenging effect of donepezil as the possible contribution to its memory enhancing activity in mice. Drug Res. 2014;64(05):236–239.
   Google Scholar
• Wang D-H, Li W, Liu X-F, Zhang J-M, Wang S-M. Chinese medicine formula “Jian-Pi-Zhi-Dong Decoction” attenuates Tourette Syndrome via downregulating the expression of dopamine transporter in mice. Evidence Based Comp Alter Medi. 2013;2013. doi:10.1155/2013/385685
   Web of Science ®Google Scholar
• Napier TC, Istre ED. Methamphetamine induced sensitization includes a functional upregulation of ventral pallidal 5 HT2A/2C receptors. Synapse. 2008;62(1):14–21. doi:10.1002/syn.20460
   PubMed Web of Science ®Google Scholar
• Rehman NU, Abbas M, Al-Rashida M, et al. Effect of 4-Fluoro-N-(4-Sulfamoylbenzyl) benzene sulfonamide on acquisition and expression of nicotine-induced behavioral sensitization and striatal adenosine levels. Drug Design Develop Thera. 2020;14:3777. doi:10.2147/DDDT.S270025
   PubMed Web of Science ®Google Scholar
• Egashira N, Kubota N, Goto Y, et al. The antipsychotic trifluoperazine reduces marble-burying behavior in mice via D2 and 5-HT2A receptors: implications for obsessive–compulsive disorder. Pharmacol Biochem Behav. 2018;165:9–13. doi:10.1016/j.pbb.2017.12.006
   PubMed Web of Science ®Google Scholar
• Golub HM, Zhou QG, Zucker H, et al. Chronic alcohol exposure is associated with decreased neurogenesis, aberrant integration of newborn neurons, and cognitive dysfunction in female mice. Clin Exp Res. 2015;39(10):1967–1977. doi:10.1111/acer.12843
   PubMed Web of Science ®Google Scholar
• Weitzner DS, Engler-Chiurazzi EB, Kotilinek LA, Ashe KH, Reed MN. Morris water maze test: optimization for mouse strain and testing environment. Jove J Visualized Exp. 2015;2015(100):e52706.
   Google Scholar
• Hendrickx JO, De Moudt S, Calus E, De Deyn PP, Van Dam D, De Meyer GR. Age-related cognitive decline in spatial learning and memory of C57BL/6J mice. Behav Brain Res. 2022;418:113649. doi:10.1016/j.bbr.2021.113649
   PubMed Web of Science ®Google Scholar
• Prieur EA, Jadavji NM. Assessing spatial working memory using the spontaneous alternation Y-maze test in aged male mice. Bio Pro. 2019;9:3.
   Web of Science ®Google Scholar
• Lueptow LM. Novel object recognition test for the investigation of learning and memory in mice. J Visualized Exp. 2017;2017(126):e55718.
   Google Scholar
• Chiang M-C, Huang AJ, Wintzer ME, Ohshima T, McHugh TJ. A role for CA3 in social recognition memory. Behav Brain Res. 2018;354:22–30. doi:10.1016/j.bbr.2018.01.019
   PubMed Web of Science ®Google Scholar
• Kraeuter A-K, Guest PC, Sarnyai Z. The nest building test in mice for assessment of general well-being. In: Pre-Clinical Models. Springer; 2019:87–91.
   Google Scholar
• Hou X, Huang W, Tong Y, Tian M. Hollow dummy template imprinted boronate-modified polymers for extraction of norepinephrine, epinephrine and dopamine prior to quantitation by HPLC. Microchimica Acta. 2019;186(11):1–9. doi:10.1007/s00604-019-3801-2
   Web of Science ®Google Scholar
• Rubio J, Yucra S, Gasco M, Gonzales GF. Dose–response effect of black maca (Lepidium meyenii) in mice with memory impairment induced by ethanol. Toxicol Mecha Meth. 2011;21(8):628–634. doi:10.3109/15376516.2011.583294
   PubMed Web of Science ®Google Scholar
• Pinto LS, Gualberto FA, Pereira SR, Barros PA, Franco GC, Ribeiro AM. Dietary restriction protects against chronic-ethanol-induced changes in exploratory behavior in Wistar rats. Brain Res. 2006;1078(1):171–181. doi:10.1016/j.brainres.2005.12.092
   PubMed Web of Science ®Google Scholar
• Mansouri A, Demeilliers C, Amsellem S, Pessayre D, Fromenty B. Acute ethanol administration oxidatively damages and depletes mitochondrial DNA in mouse liver, brain, heart, and skeletal muscles: protective effects of antioxidants. J Pharmacol Exp Thera. 2001;298(2):737–743.
   PubMed Web of Science ®Google Scholar
• Steigerwald ES, Miller MW. Performance by adult rats in sensory‐mediated radial arm maze tasks is not impaired and may be transiently enhanced by chronic exposure to ethanol. Clin Exp Res. 1997;21(9):1553–1559. doi:10.1111/j.1530-0277.1997.tb04489.x
   PubMed Web of Science ®Google Scholar
• Lukoyanov NV, Madeira MD, Paula–Barbosa MM. Behavioral and neuroanatomical consequences of chronic ethanol intake and withdrawal. Physiol and Behavior. 1999;66(2):337–346. doi:10.1016/S0031-9384(98)00301-1
   PubMed Web of Science ®Google Scholar
• Ferreira SEM, Soares LM, Lira CR, et al. Ethanol-induced locomotor sensitization: neuronal activation in the nucleus accumbens and medial prefrontal cortex. Neurosci Letters. 2021;749:135745. doi:10.1016/j.neulet.2021.135745
   PubMed Web of Science ®Google Scholar
• Kliethermes CL. Anxiety-like behaviors following chronic ethanol exposure. Neurosci Biobehav Rev. 2005;28(8):837–850. doi:10.1016/j.neubiorev.2004.11.001
   PubMed Web of Science ®Google Scholar
• Ibos KE, Bodnár É, Bagosi Z, et al. Kisspeptin-8 induces anxiety-like behavior and hypolocomotion by activating the HPA axis and increasing GABA release in the nucleus accumbens in rats. Biomedi. 2021;9(2):112.
   Google Scholar
• Heinz A, Beck A, Wrase J, et al. Neurotransmitter systems in alcohol dependence. Pharmacopsy. 2009;42(S 01):S95–S101. doi:10.1055/s-0029-1214395
   PubMed Web of Science ®Google Scholar
• Suwabe A, Kubota M, Niwa M, Kobayashi K, Kanba S. Effect of a 5-HT1A receptor agonist, flesinoxan, on the extracellular noradrenaline level in the hippocampus and on the locomotor activity of rats. Brain Res. 2000;858(2):393–401. doi:10.1016/S0006-8993(00)01941-7
   PubMed Web of Science ®Google Scholar
• Ongnok B, Khuanjing T, Chunchai T, et al. Donepezil provides neuroprotective effects against brain injury and Alzheimer’s pathology under conditions of cardiac ischemia/reperfusion injury. Biochimica et Biophysica Acta. 2021;1867(1):165975. doi:10.1016/j.bbadis.2020.165975
   PubMed Web of Science ®Google Scholar
• Ongnok B, Khuanjing T, Chunchai T, et al. Donepezil protects against doxorubicin-induced chemobrain in rats via attenuation of inflammation and oxidative stress without interfering with doxorubicin efficacy. Neurotherapeutics. 2021;18(3):2107–2125. doi:10.1007/s13311-021-01092-9
   PubMed Web of Science ®Google Scholar
• Garcı́a-Moreno LM, Conejo NM, Capilla A, Garcı́a-Sánchez O, Senderek K, Arias JL. Chronic ethanol intake and object recognition in young and adult rats. Progress Neuro Psychopharmacol Biol Psy. 2002;26(5):831–837. doi:10.1016/S0278-5846(01)00327-X
   PubMed Web of Science ®Google Scholar
• Morrisett R, Swartzwelder HS. Attenuation of hippocampal long-term potentiation by ethanol: a patch-clamp analysis of glutamatergic and GABAergic mechanisms. J Neurosci. 1993;13(5):2264–2272. doi:10.1523/JNEUROSCI.13-05-02264.1993
   PubMed Web of Science ®Google Scholar
• Antunes M, Biala G. The novel object recognition memory: neurobiology, test procedure, and its modifications. Cog Proc. 2012;13(2):93–110. doi:10.1007/s10339-011-0430-z
   PubMed Web of Science ®Google Scholar
• Barker GR, Warburton EC. When is the hippocampus involved in recognition memory? J Neurosci. 2011;31(29):10721–10731. doi:10.1523/JNEUROSCI.6413-10.2011
   PubMed Web of Science ®Google Scholar
• Spanswick SC, Dyck RH. Object/context specific memory deficits following medial frontal cortex damage in mice. PLoS One. 2012;7(8):e43698. doi:10.1371/journal.pone.0043698
   PubMed Web of Science ®Google Scholar
• Chastain G. Alcohol, neurotransmitter systems, and behavior. J General Psychol. 2006;133(4):329–335. doi:10.3200/GENP.133.4.329-335
   PubMed Web of Science ®Google Scholar
• Sakai R, Ukai W, Sohma H, et al. Attenuation of brain derived neurotrophic factor (BDNF) by ethanol and cytoprotective effect of exogenous BDNF against ethanol damage in neuronal cells. J Neural Trans. 2005;112(8):1005–1013. doi:10.1007/s00702-004-0246-4
   PubMed Web of Science ®Google Scholar
• Pereira DB, Rebola N, Rodrigues RJ, Cunha RA, Carvalho AP, Duarte CB. Trkb receptors modulation of glutamate release is limited to a subset of nerve terminals in the adult rat hippocampus. J Neurosci Res. 2006;83(5):832–844. doi:10.1002/jnr.20784
   PubMed Web of Science ®Google Scholar
• Cunha C, Brambilla R, Thomas KL. A simple role for BDNF in learning and memory? Frontiers Mol Neurosci. 2010;3:1.
   PubMed Web of Science ®Google Scholar
• Seabold GK, Luo J, Miller MW. Effect of ethanol on neurotrophin-mediated cell survival and receptor expression in cultures of cortical neurons. Develop Brain Res. 1998;108(1–2):139–145. doi:10.1016/S0165-3806(98)00043-1
   PubMedGoogle Scholar
• Perez-Rando M, Castillo-Gomez E, Bueno-Fernandez C, Nacher J. The TrkB agonist 7, 8-dihydroxyflavone changes the structural dynamics of neocortical pyramidal neurons and improves object recognition in mice. Brain Struct Funct. 2018;223(5):2393–2408. doi:10.1007/s00429-018-1637-x
   PubMed Web of Science ®Google Scholar
• Kim HG, Oh MS. Memory-enhancing effect of Mori Fructus via induction of nerve growth factor. Brit J Nutri. 2013;110(1):86–94. doi:10.1017/S0007114512004710
   PubMed Web of Science ®Google Scholar
• Hamidkhaniha S, Bashiri H, Omidi A, et al. Effect of pretreatment with intracerebroventricular injection of minocycline on morphine‐induced memory impairment in passive avoidance test: role of P‐CREB and c‐Fos expression in the dorsal hippocampus and basolateral amygdala regions. Clin and Exp Pharmacol Physiol. 2019;46(8):711–722. doi:10.1111/1440-1681.13090
   PubMed Web of Science ®Google Scholar
• Assunção M, Santos-Marques M, De Freitas V, et al. Red wine antioxidants protect hippocampal neurons against ethanol-induced damage: a biochemical, morphological and behavioral study. Neurosci. 2007;146(4):1581–1592. doi:10.1016/j.neuroscience.2007.03.040
   Web of Science ®Google Scholar
• Alqudah MA, Alzoubi KH, Ma’abrih G, Khabour OF. Vitamin C prevents memory impairment induced by waterpipe smoke: role of oxidative stress. Inhalation Toxicol. 2018;30(4–5):141–148. doi:10.1080/08958378.2018.1474977
   PubMed Web of Science ®Google Scholar
• Rice ME. Ascorbate regulation and its neuroprotective role in the brain. Trends Neurosci. 2000;23(5):209–216. doi:10.1016/S0166-2236(99)01543-X
   PubMed Web of Science ®Google Scholar
• Ahmad A, Shah A, Badshah H, et al. Neuroprotection by vitamin C against ethanol-induced neuroinflammation associated neurodegeneration in developing rat brain. CNS Neurological Disorders Drug Tar. 2016;15(3):360–370. doi:10.2174/1871527315666151110130139
   PubMed Web of Science ®Google Scholar
• Othman MZ, Hassan Z, Has ATC. Morris water maze: a versatile and pertinent tool for assessing spatial learning and memory. Exp Animals. 2022;1:21–0120.
   Google Scholar
• Miyoshi E, Wietzikoski EC, Bortolanza M, et al. Both the dorsal hippocampus and the dorsolateral striatum are needed for rat navigation in the Morris water maze. Behav Brain Res. 2012;226(1):171–178. doi:10.1016/j.bbr.2011.09.011
   PubMed Web of Science ®Google Scholar
• D’Hooge R, De Deyn PP. Applications of the Morris water maze in the study of learning and memory. Brain Res Rev. 2001;36(1):60–90. doi:10.1016/s0165-0173(01)00067-4
   PubMedGoogle Scholar
• Tiwari V, Kuhad A, Chopra K. Suppression of neuro-inflammatory signaling cascade by tocotrienol can prevent chronic alcohol-induced cognitive dysfunction in rats. Behav Brain Res. 2009;203(2):296–303. doi:10.1016/j.bbr.2009.05.016
   PubMed Web of Science ®Google Scholar
• Pickering C, Alsiö J, Morud J, Ericson M, Robbins TW, Söderpalm B. Ethanol impairment of spontaneous alternation behaviour and associated changes in medial prefrontal glutamatergic gene expression precede putative markers of dependence. Pharmacol Biochem Behav. 2015;132:63–70. doi:10.1016/j.pbb.2015.02.021
   PubMed Web of Science ®Google Scholar
• Götesson J, Ericson M, Söderpalm B, Pickering C. Repeated ethanol but not phencyclidine impairs spontaneous alternation behaviour in the Y Maze. Basic Clin Pharmacol Toxicol. 2012;110(4):347–352. doi:10.1111/j.1742-7843.2011.00819.x
   PubMed Web of Science ®Google Scholar
• Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutri. 2000;130(4):1007S–1015S. doi:10.1093/jn/130.4.1007S
   PubMed Web of Science ®Google Scholar
• Kalita J, Kumar V, Misra UK, Bora HK. Memory and learning dysfunction following copper toxicity: biochemical and immunohistochemical basis. Mol Neurobiol. 2018;55(5):3800–3811. doi:10.1007/s12035-017-0619-y
   PubMed Web of Science ®Google Scholar
• Faingold C, N’gouemo P, Riaz A. Ethanol and neurotransmitter interactions—from molecular to integrative effects. Prog Neurobiol. 1998;55(5):509–535.
   PubMed Web of Science ®Google Scholar
• Kozlov A, Druzin MY, Kurzina N, Malinina E. The role of D1-dependent dopaminergic mechanisms of the frontal cortex in delayed responding in rats. Neurosci Behav Physiol. 2001;31(4):405–411. doi:10.1023/A:1010488612338
   PubMedGoogle Scholar
• Ayabe T, Ano Y, Ohya R, Kitaoka S, Furuyashiki T. The lacto-tetrapeptide Gly–Thr–Trp–Tyr, β-lactolin, improves spatial memory functions via dopamine release and D1 receptor activation in the hippocampus. Nutrients. 2019;11(10):2469.
   PubMed Web of Science ®Google Scholar
• Chaurasiya ND, Midiwo J, Pandey P, et al. Selective Interactions of O-methylated flavonoid natural products with human monoamine oxidase-A and-B. Molecules. 2020;25(22):5358. doi:10.3390/molecules25225358
   PubMed Web of Science ®Google Scholar
• O’Callaghan C, Hezemans FH, Ye R, et al. Locus coeruleus integrity and the effect of atomoxetine on response inhibition in Parkinson’s disease. MedRxiv. 2020;144:2513–2526.
   Google Scholar
• Coradazzi M, Gulino R, Fieramosca F, Falzacappa LV, Riggi M, Leanza G. Selective noradrenaline depletion impairs working memory and hippocampal neurogenesis. Neurobiol Aging. 2016;48:93–102. doi:10.1016/j.neurobiolaging.2016.08.012
   PubMed Web of Science ®Google Scholar
• Vaghef L, Farajdokht F, Erfani M, et al. Cerebrolysin attenuates ethanol-induced spatial memory impairments through inhibition of hippocampal oxidative stress and apoptotic cell death in rats. Alcohol. 2019;79:127–135. doi:10.1016/j.alcohol.2019.03.005
   PubMed Web of Science ®Google Scholar
• Hatami S, Hatami H, Sheikhzade F, Dehghan G. Chronic administration of crystal meth in parallel with oxidative stress impaired spatial memory in prefrontal cortex of mail rats. J Sci. 2016;14(2):126.
   Google Scholar
• Davis CK, Vemuganti R. Antioxidant therapies in traumatic brain injury. Neurochem Int. 2022;152:105255. doi:10.1016/j.neuint.2021.105255
   PubMed Web of Science ®Google Scholar
• Manrique HM, Miquel M, Aragon CM. Brain catalase mediates potentiation of social recognition memory produced by ethanol in mice. Drug Alc Depend. 2005;79(3):343–350. doi:10.1016/j.drugalcdep.2005.02.007
   PubMed Web of Science ®Google Scholar
• Zinn CG, Clairis N, Cavalcante LES, Furini CRG, de Carvalho Myskiw J, Izquierdo I. Major neurotransmitter systems in dorsal hippocampus and basolateral amygdala control social recognition memory. Proc Nat Acad Sci. 2016;113(33):E4914–E4919.
   PubMed Web of Science ®Google Scholar
• Marquardt K, Brigman JL. The impact of prenatal alcohol exposure on social, cognitive and affective behavioral domains: insights from rodent models. Alcohol. 2016;51:1–15. doi:10.1016/j.alcohol.2015.12.002
   PubMed Web of Science ®Google Scholar
• Baroni L, Sarni AR, Zuliani C. Plant foods rich in antioxidants and human cognition: a systematic review. Antioxidants. 2021;10(5):714. doi:10.3390/antiox10050714
   Web of Science ®Google Scholar
• Greenberg GD, Phillips TJ, Crabbe JC. Effects of acute alcohol withdrawal on nest building in mice selectively bred for alcohol withdrawal severity. Physiol Behav. 2016;165:257–266. doi:10.1016/j.physbeh.2016.08.006
   PubMed Web of Science ®Google Scholar
• Deacon RM, Croucher A, Rawlins JNP. Hippocampal cytotoxic lesion effects on species-typical behaviours in mice. Behav Brain Res. 2002;132(2):203–213. doi:10.1016/S0166-4328(01)00401-6
   PubMed Web of Science ®Google Scholar
• Jedynak P, Jaholkowski P, Wozniak G, Sandi C, Kaczmarek L, Filipkowski RK. Lack of cyclin D2 impairing adult brain neurogenesis alters hippocampal-dependent behavioral tasks without reducing learning ability. Behav Brain Res. 2012;227(1):159–166. doi:10.1016/j.bbr.2011.11.007
   PubMed Web of Science ®Google Scholar
• Kondratiuk I, Devijver H, Lechat B, Van Leuven F, Kaczmarek L, Filipkowski RK. Glycogen synthase kinase-3beta affects size of dentate gyrus and species-typical behavioral tasks in transgenic and knockout mice. Behav Brain Res. 2013;248:46–50. doi:10.1016/j.bbr.2013.03.045
   PubMed Web of Science ®Google Scholar
• Greenberg GD, Huang L, Spence S, et al. Nest building is a novel method for indexing severity of alcohol withdrawal in mice. Behav Brain Res. 2016;302:182–190. doi:10.1016/j.bbr.2016.01.023
   PubMed Web of Science ®Google Scholar
• Sager TN, Kirchhoff J, Mørk A, et al. Nest building performance following MPTP toxicity in mice. Behav Brain Res. 2010;208(2):444–449. doi:10.1016/j.bbr.2009.12.014
   PubMed Web of Science ®Google Scholar
• Gildawie KR, Galli RL, Shukitt-Hale B, Carey AN. Protective effects of foods containing flavonoids on age-related cognitive decline. Current Nutri Rep. 2018;7(2):39–48. doi:10.1007/s13668-018-0227-0
   PubMedGoogle Scholar
• Spencer JP. The interactions of flavonoids within neuronal signalling pathways. Genes Nutri. 2007;2(3):257–273. doi:10.1007/s12263-007-0056-z
   PubMed Web of Science ®Google Scholar
• Chen W-F, Shih Y-H, Liu H-C, et al. 6-methoxyflavone suppresses neuroinflammation in lipopolysaccharide- stimulated microglia through the inhibition of TLR4/MyD88/p38 MAPK/NF-κB dependent pathways and the activation of HO-1/NQO-1 signaling. Phytomedicine. 2022;99:154025. doi:10.1016/j.phymed.2022.154025
   PubMed Web of Science ®Google Scholar
• Galati G. O’brien PJ. Potential toxicity of flavonoids and other dietary phenolics: significance for their chemopreventive and anticancer properties. Free Radical Biol Medi. 2004;37(3):287–303. doi:10.1016/j.freeradbiomed.2004.04.034
   PubMed Web of Science ®Google Scholar