Madecassic Acid Ameliorates the Progression of Osteoarthritis: An in vitro and in vivo Study

References

• Wolf J, Franca EB, Assuncao AA. The burden of low back pain, rheumatoid arthritis, osteoarthritis, and gout and their respective attributable risk factors in Brazil: results of the GBD 2017 study. Rev Soc Bras Med Trop. 2022;55(suppl 1):e0285. doi:10.1590/0037-8682-0285-2021
   Web of Science ®Google Scholar
• Mahmoudian A, Lohmander LS, Mobasheri A, et al. Early-stage symptomatic osteoarthritis of the knee - time for action. Nat Rev Rheumatol. 2021;17(10):621–632. doi:10.1038/s41584-021-00673-4
   Web of Science ®Google Scholar
• Molfetta L, Casabella A, Rosini S, et al. Role of the Osteochondral Unit in the Pathogenesis of Osteoarthritis: focus on the Potential Use of Clodronate. Curr Rheumatol Rev. 2022;18(1):2–11. doi:10.2174/1573397117666211006094117
   Web of Science ®Google Scholar
• Goldring SR, Goldring MB. Changes in the osteochondral unit during osteoarthritis: structure, function and cartilage-bone crosstalk. Nat Rev Rheumatol. 2016;12(11):632–644. doi:10.1038/nrrheum.2016.148
   PubMed Web of Science ®Google Scholar
• Krishnan Y, Grodzinsky AJ. Cartilage diseases. Matrix Biol. 2018;71-72:51–69. doi:10.1016/j.matbio.2018.05.005
   PubMed Web of Science ®Google Scholar
• Palazzo C, Nguyen C, Lefevre-Colau -M-M, et al. Risk factors and burden of osteoarthritis. Ann Phys Rehabil Med. 2016;59(3):134–138. doi:10.1016/j.rehab.2016.01.006
   PubMed Web of Science ®Google Scholar
• Goldring MB, Otero M. Inflammation in osteoarthritis. Curr Opin Rheumatol. 2011;23(5):471–478. doi:10.1097/BOR.0b013e328349c2b1
   PubMed Web of Science ®Google Scholar
• Berenbaum F, Walker C. Osteoarthritis and inflammation: a serious disease with overlapping phenotypic patterns. Postgrad Med. 2020;132(4):377–384. doi:10.1080/00325481.2020.1730669
   PubMed Web of Science ®Google Scholar
• He J, Cao W, Azeem I, et al. Epigenetics of osteoarthritis: histones and TGF-beta1. Clin Chim Acta. 2020;510:593–598. doi:10.1016/j.cca.2020.08.011
   Web of Science ®Google Scholar
• Rezus E, Burlui A, Cardoneanu A, et al. From Pathogenesis to Therapy in Knee Osteoarthritis: bench-to-Bedside. Int J Mol Sci. 2021;22(5):2697. doi:10.3390/ijms22052697
   PubMed Web of Science ®Google Scholar
• Heinegard D, Saxne T. The role of the cartilage matrix in osteoarthritis. Nat Rev Rheumatol. 2011;7(1):50–56. doi:10.1038/nrrheum.2010.198
   PubMed Web of Science ®Google Scholar
• Whittaker JL, Truong LK, Dhiman K, et al. Osteoarthritis year in review 2020: rehabilitation and outcomes. Osteoarthritis Cartilage. 2021;29(2):190–207. doi:10.1016/j.joca.2020.10.005
   PubMed Web of Science ®Google Scholar
• Thielen N, Neefjes M, Wiegertjes R, et al. Osteoarthritis-Related Inflammation Blocks TGF-beta’s Protective Effect on Chondrocyte Hypertrophy via (de)Phosphorylation of the SMAD2/3 Linker Region. Int J Mol Sci. 2021;22(15):8124. doi:10.3390/ijms22158124
   Web of Science ®Google Scholar
• Barison MJ, Nogoceke R, Josino R, et al. Functionalized Hydrogels for Cartilage Repair: the Value of Secretome-Instructive Signaling. Int J Mol Sci. 2022;23(11):6010. doi:10.3390/ijms23116010
   Web of Science ®Google Scholar
• Li MH, Xiao R, Li JB, et al. Regenerative approaches for cartilage repair in the treatment of osteoarthritis. Osteoarthritis Cartilage. 2017;25(10):1577–1587. doi:10.1016/j.joca.2017.07.004
   PubMed Web of Science ®Google Scholar
• Xu X, Wang Y, Wei Z, et al. Madecassic acid, the contributor to the anti-colitis effect of madecassoside, enhances the shift of Th17 toward Treg cells via the PPARgamma/AMPK/ACC1 pathway. Cell Death Dis. 2017;8(3):e2723. doi:10.1038/cddis.2017.150
   Web of Science ®Google Scholar
• Won JH, Shin J-S, Park H-J, et al. Anti-inflammatory Effects of Madecassic Acid via the Suppression of NF- κ B Pathway in LPS-Induced RAW 264.7 Macrophage Cells. Planta Med. 2010;76(3):251–257. doi:10.1055/s-0029-1186142
   Web of Science ®Google Scholar
• Hsu YM, Hung Y-C, Hu L, et al. Anti-Diabetic Effects of Madecassic Acid and Rotundic Acid. Nutrients. 2015;7(12):10065–10075. doi:10.3390/nu7125512
   PubMed Web of Science ®Google Scholar
• Arancibia-Radich J, González-Blázquez R, Alcalá M, et al. Beneficial effects of murtilla extract and madecassic acid on insulin sensitivity and endothelial function in a model of diet-induced obesity. Sci Rep. 2019;9(1):599. doi:10.1038/s41598-018-36555-1
   Web of Science ®Google Scholar
• Tabassum R, Vaibhav K, Shrivastava P, et al. Centella asiatica attenuates the neurobehavioral, neurochemical and histological changes in transient focal middle cerebral artery occlusion rats. Neurol Sci. 2013;34(6):925–933. doi:10.1007/s10072-012-1163-1
   PubMed Web of Science ®Google Scholar
• Siddiqui S, Khan F, Jamali KS, et al. Madecassic Acid Reduces Fast Transient Potassium Channels and Promotes Neurite Elongation in Hippocampal CA1 Neurons. CNS Neurol Disord Drug Targets. 2020;19(1):12–26. doi:10.2174/1871527318666191111105508
   Web of Science ®Google Scholar
• Zhang H, Zhang M, Tao Y, et al. Madecassic acid inhibits the mouse colon cancer growth by inducing apoptosis and immunomodulation. J BUON. 2014;19(2):372–376.
   Web of Science ®Google Scholar
• Valdeira ASC, Darvishi E, Woldemichael GM, et al. Madecassic Acid Derivatives as Potential Anticancer Agents: synthesis and Cytotoxic Evaluation. J Nat Prod. 2019;82(8):2094–2105. doi:10.1021/acs.jnatprod.8b00864
   Web of Science ®Google Scholar
• Chen H, Qin J, Shi H, et al. Rhoifolin ameliorates osteoarthritis via the Nrf2/NF-kappaB axis: in vitro and in vivo experiments. Osteoarthritis Cartilage. 2022;30(5):735–745. doi:10.1016/j.joca.2022.01.009
   Web of Science ®Google Scholar
• Wang C, Gao Y, Zhang Z, et al. Safflower yellow alleviates osteoarthritis and prevents inflammation by inhibiting PGE2 release and regulating NF-kappaB/SIRT1/AMPK signaling pathways. Phytomedicine. 2020;78:153305. doi:10.1016/j.phymed.2020.153305
   PubMed Web of Science ®Google Scholar
• Xia T, Zhao R, Liu W, et al. Effect of substrate stiffness on hepatocyte migration and cellular Young’s modulus. J Cell Physiol. 2018;233(9):6996–7006. doi:10.1002/jcp.26491
   Web of Science ®Google Scholar
• Chow YY, Chin KY. The Role of Inflammation in the Pathogenesis of Osteoarthritis. Mediators Inflamm. 2020;2020:8293921. doi:10.1155/2020/8293921
   PubMed Web of Science ®Google Scholar
• van Doormaal MCM, Meerhoff GA, Vliet Vlieland TPM, et al. A clinical practice guideline for physical therapy in patients with Hip or knee osteoarthritis. Musculoskeletal Care. 2020;18(4):575–595. doi:10.1002/msc.1492
   PubMed Web of Science ®Google Scholar
• Goh SL, Persson MSM, Stocks J, et al. Relative Efficacy of Different Exercises for Pain, Function, Performance and Quality of Life in Knee and Hip Osteoarthritis: systematic Review and Network Meta-Analysis. Sports Med. 2019;49(5):743–761. doi:10.1007/s40279-019-01082-0
   PubMed Web of Science ®Google Scholar
• Katz JN, Arant KR, Loeser RF. Diagnosis and Treatment of Hip and Knee Osteoarthritis: a Review. JAMA. 2021;325(6):568–578. doi:10.1001/jama.2020.22171
   PubMed Web of Science ®Google Scholar
• Yun X, Fang Y, Lv C, et al. Inhibition of the activation of gammadeltaT17 cells through PPARgamma-PTEN/Akt/GSK3beta/NFAT pathway contributes to the anti-colitis effect of madecassic acid. Cell Death Dis. 2020;11(9):752. doi:10.1038/s41419-020-02969-x
   Web of Science ®Google Scholar
• Robinson WH, Lepus CM, Wang Q, et al. Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis. Nat Rev Rheumatol. 2016;12(10):580–592. doi:10.1038/nrrheum.2016.136
   PubMed Web of Science ®Google Scholar
• Zhen G, Guo Q, Li Y, et al. Mechanical stress determines the configuration of TGFbeta activation in articular cartilage. Nat Commun. 2021;12(1):1706. doi:10.1038/s41467-021-21948-0
   Web of Science ®Google Scholar
• Martel-Pelletier J, Barr AJ, Cicuttini FM, et al. Osteoarthritis. Nat Rev Dis Primers. 2016;2:16072. doi:10.1038/nrdp.2016.72
   PubMed Web of Science ®Google Scholar
• Hou CH, Tang C-H, Chen P-C, et al. Thrombospondin 2 Promotes IL-6 Production in Osteoarthritis Synovial Fibroblasts via the PI3K/AKT/NF-kappaB Pathway. J Inflamm Res. 2021;14:5955–5967. doi:10.2147/JIR.S314747
   PubMed Web of Science ®Google Scholar
• Kapoor M, Martel-Pelletier J, Lajeunesse D, et al. Role of proinflammatory cytokines in the pathophysiology of osteoarthritis. Nat Rev Rheumatol. 2011;7(1):33–42. doi:10.1038/nrrheum.2010.196
   PubMed Web of Science ®Google Scholar
• Wen ZH, Lin -Y-Y, Chang Y-C, et al. The COX-2 inhibitor etoricoxib reduces experimental osteoarthritis and nociception in rats: the roles of TGF-beta1 and NGF expressions in chondrocytes. Eur J Pain. 2020;24(1):209–222. doi:10.1002/ejp.1478
   Web of Science ®Google Scholar
• Ahmad N, Ansari MY, Haqqi TM. Role of iNOS in osteoarthritis: pathological and therapeutic aspects. J Cell Physiol. 2020;235(10):6366–6376. doi:10.1002/jcp.29607
   PubMed Web of Science ®Google Scholar
• Lai WF, Wong WT. Roles of the actin cytoskeleton in aging and age-associated diseases. Ageing Res Rev. 2020;58:101021. doi:10.1016/j.arr.2020.101021
   PubMed Web of Science ®Google Scholar
• Gentili C, Cancedda R. Cartilage and bone extracellular matrix. Curr Pharm Des. 2009;15(12):1334–1348. doi:10.2174/138161209787846739
   PubMed Web of Science ®Google Scholar
• Guilak F, Nims RJ, Dicks A, et al. Osteoarthritis as a disease of the cartilage pericellular matrix. Matrix Biol. 2018;71-72:40–50. doi:10.1016/j.matbio.2018.05.008
   PubMed Web of Science ®Google Scholar
• Malemud CJ. Inhibition of MMPs and ADAM/ADAMTS. Biochem Pharmacol. 2019;165:33–40. doi:10.1016/j.bcp.2019.02.033
   PubMed Web of Science ®Google Scholar
• Mehana EE, Khafaga AF, El-Blehi SS. The role of matrix metalloproteinases in osteoarthritis pathogenesis: an updated review. Life Sci. 2019;234:116786. doi:10.1016/j.lfs.2019.116786
   PubMed Web of Science ®Google Scholar
• Pengas I, Eldridge S, Assiotis A, et al. MMP-3 in the peripheral serum as a biomarker of knee osteoarthritis, 40 years after open total knee meniscectomy. J Exp Orthop. 2018;5(1):21. doi:10.1186/s40634-018-0132-x
   Google Scholar
• Knauper V, Will H, López-Otin C, et al. Cellular mechanisms for human procollagenase-3 (MMP-13) activation. Evidence that MT1-MMP (MMP-14) and gelatinase a (MMP-2) are able to generate active enzyme. J Biol Chem. 1996;271(29):17124–17131. doi:10.1074/jbc.271.29.17124
   PubMed Web of Science ®Google Scholar
• Tang Y, Mo Y, Xin D, et al. beta-ecdysterone alleviates osteoarthritis by activating autophagy in chondrocytes through regulating PI3K/AKT/mTOR signal pathway. Am J Transl Res. 2020;12(11):7174–7186.
   PubMed Web of Science ®Google Scholar
• Tewari D, Patni P, Bishayee A, et al. Natural products targeting the PI3K-Akt-mTOR signaling pathway in cancer: a novel therapeutic strategy. Semin Cancer Biol. 2022;80:1–17. doi:10.1016/j.semcancer.2019.12.008
   Web of Science ®Google Scholar
• Zhang F, Zhang -Y-Y, Sun Y-S, et al. Asparanin A from Asparagus officinalis L. Induces G0/G1 Cell Cycle Arrest and Apoptosis in Human Endometrial Carcinoma Ishikawa Cells via Mitochondrial and PI3K/AKT Signaling Pathways. J Agric Food Chem. 2020;68(1):213–224. doi:10.1021/acs.jafc.9b07103
   PubMed Web of Science ®Google Scholar
• Qi Y, Cheng X, Gong G, et al. Synergistic neuroprotective effect of schisandrin and nootkatone on regulating inflammation, apoptosis and autophagy via the PI3K/AKT pathway. Food Funct. 2020;11(3):2427–2438. doi:10.1039/C9FO02927C
   PubMed Web of Science ®Google Scholar
• Fisch KM, Gamini R, Alvarez-Garcia O, et al. Identification of transcription factors responsible for dysregulated networks in human osteoarthritis cartilage by global gene expression analysis. Osteoarthritis Cartilage. 2018;26(11):1531–1538. doi:10.1016/j.joca.2018.07.012
   PubMed Web of Science ®Google Scholar
• Greene MA, Loeser RF. Function of the chondrocyte PI-3 kinase-Akt signaling pathway is stimulus dependent. Osteoarthritis Cartilage. 2015;23(6):949–956. doi:10.1016/j.joca.2015.01.014
   Web of Science ®Google Scholar
• Han G, Zhang Y, Li H. The Combination Treatment of Curcumin and Probucol Protects Chondrocytes from TNF-alpha Induced Inflammation by Enhancing Autophagy and Reducing Apoptosis via the PI3K-Akt-mTOR Pathway. Oxid Med Cell Longev. 2021;2021:5558066. doi:10.1155/2021/5558066
   PubMed Web of Science ®Google Scholar
• Hui W, Litherland GJ, Elias MS, et al. Leptin produced by joint white adipose tissue induces cartilage degradation via upregulation and activation of matrix metalloproteinases. Ann Rheum Dis. 2012;71(3):455–462. doi:10.1136/annrheumdis-2011-200372
   PubMed Web of Science ®Google Scholar