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Review

Selective use of sorafenib in the treatment of thyroid cancer

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Pages 1119-1131 | Published online: 11 Mar 2016

References

  • JemalABrayFCenterMMFerlayJWardEFormanDGlobal cancer statisticsCA Cancer J Clin2011612699021296855
  • HundahlSAFlemingIDFremgenAMMenckHRA National Cancer Data Base report on 53,856 cases of thyroid carcinoma treated in the U.S., 1985–1995Cancer19988312263826489874472
  • Eustatia-RuttenCFCorssmitEPBiermaszNRPereiraAMRomijnJASmitJWSurvival and death causes in differentiated thyroid carcinomaJ Clin Endocrinol Metab200691131331916263822
  • HaugenBRAlexanderEKBibleKC2015 American Thyroid Association Management Guidelines for adult patients with thyroid nodules and differentiated thyroid cancerThyroid201626113326462967
  • DuranteCHaddyNBaudinELong-term outcome of 444 patients with distant metastases from papillary and follicular thyroid carcinoma: benefits and limits of radioiodine therapyJ Clin Endocrinol Metab20069182892289916684830
  • HodakSPCartySERadioiodine-resistant differentiated thyroid cancer: hope for the futureOncology200923977577619777763
  • RobbinsRJWanQGrewalRKReal-time prognosis for metastatic thyroid carcinoma based on 2-[18F]fluoro-2-deoxyd-glucose-positron emission tomography scanningJ Clin Endocrinol Metab200691249850516303836
  • American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid CancerCooperDSDohertyGMRevised American Thyroid Association Management Guidelines for patients with thyroid nodules and differentiated thyroid cancerThyroid200919111167121419860577
  • PitoiaFWardLWohllkNRecommendations of the Latin American Thyroid Society on diagnosis and management of differentiated thyroid cancerArq Bras Endocrinol Metabol200953788488719942992
  • BroseMSSmitJCapdevilaJApproach to the patient with advanced differentiated thyroid cancerExpert Rev Anticancer Ther20121291137114723098114
  • SchlumbergerMBroseMEliseiRDefinition and management of radioactive iodine-refractory differentiated thyroid cancerLancet Diabetes Endocrinol20141327021570218
  • PaciniFItoYLusterMPitoiaFRobinsonBWirthLRadioactive iodine-refractory differentiated thyroid cancer: unmet needs and future directionsExpert Rev Endocrinol Metab201275541554
  • EisenhauerEATherassePBogaertsJNew response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1)Eur J Cancer200945222824719097774
  • KimABalisFMWidemannBCSorafenib and sunitinibOncologist200914880080519648603
  • MarottaVGuerraASapioMRVitaleMRET/PTC rearrangement in benign and malignant thyroid diseases: a clinical standpointEur J Endocrinol2011165449950721750045
  • FaginJAChallenging dogma in thyroid cancer molecular genetics – role of RET/PTC and BRAF in tumor initiationJ Clin Endocrinol Metab20048994264426615356019
  • SantoroMMelilloRMFuscoARET/PTC activation in papillary thyroid carcinoma: European Journal of Endocrinology Prize LectureEur J Endocrinol2006155564565317062879
  • XingMBRAF mutation and thyroid cancer recurrenceJ Clin Oncol201533222482248326124474
  • MinolettiFButtiMGCoronelliSThe two genes generating RET/PTC3 are localized in chromosomal band 10q11.2Genes Chromosomes Cancer199411151577529046
  • SuarezHGdu VillardJASeverinoMPresence of mutations in all three ras genes in human thyroid tumorsOncogene1990545655702183158
  • Garcia-RostanGZhaoHCampRLRas mutations are associated with aggressive tumor phenotypes and poor prognosis in thyroid cancerJ Clin Oncol200321173226323512947056
  • EzzatSZhengLKolendaJSafarianAFreemanJLAsaSLPrevalence of activating ras mutations in morphologically characterized thyroid nodulesThyroid1996654094168936664
  • VaskoVVGaudartJAllasiaCThyroid follicular adenomas may display features of follicular carcinoma and follicular variant of papillary carcinomaEur J Endocrinol2004151677978615588246
  • SabraMMDominguezJMGrewalRKClinical outcomes and molecular profile of differentiated thyroid cancers with radioiodine-avid distant metastasesJ Clin Endocrinol Metab2013985E829E83623533233
  • HoALGrewalRKLeboeufRSelumetinib-enhanced radioiodine uptake in advanced thyroid cancerN Engl J Med2013368762363223406027
  • HowellGMHodakSPYipLRAS mutations in thyroid cancerOncologist201318892693223873720
  • KimuraETNikiforovaMNZhuZKnaufJANikiforovYEFaginJAHigh prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinomaCancer Res20036371454145712670889
  • XingMBRAF mutation in thyroid cancerEndocr Relat Cancer200512224526215947100
  • XingMWestraWHTufanoRPBRAF mutation predicts a poorer clinical prognosis for papillary thyroid cancerJ Clin Endocrinol Metab200590126373637916174717
  • XingMBRAF mutation in papillary thyroid cancer: pathogenic role, molecular bases, and clinical implicationsEndocr Rev200728774276217940185
  • O’NeillCJBullockMChouABRAF(V600E) mutation is associated with an increased risk of nodal recurrence requiring reoperative surgery in patients with papillary thyroid cancerSurgery201014861139114521134544
  • WangWZhaoWWangHPoorer prognosis and higher prevalence of BRAF (V600E) mutation in synchronous bilateral papillary thyroid carcinomaAnn Surg Oncol2012191313622033631
  • GrabellusFWormKSchmidKWSheuSYThe BRAF V600E mutation in papillary thyroid carcinoma is associated with glucose transporter 1 overexpressionThyroid201222437738222376167
  • JooJYParkJYYoonYHPrediction of occult central lymph node metastasis in papillary thyroid carcinoma by preoperative BRAF analysis using fine-needle aspiration biopsy: a prospective studyJ Clin Endocrinol Metab201297113996400322930785
  • XingMBRAFV600E mutation and papillary thyroid cancer: chicken or egg?J Clin Endocrinol Metab20129772295229822774213
  • GuerraASapioMRMarottaVThe primary occurrence of BRAF(V600E) is a rare clonal event in papillary thyroid carcinomaJ Clin Endocrinol Metab201297251752422170714
  • GuerraAFugazzolaLMarottaVA high percentage of BRAFV600E alleles in papillary thyroid carcinoma predicts a poorer outcomeJ Clin Endocrinol Metab20129772333234022508706
  • de BiaseDCesariVVisaniMHigh-sensitivity BRAF mutation analysis: BRAF V600E is acquired early during tumor development but is heterogeneously distributed in a subset of papillary thyroid carcinomasJ Clin Endocrinol Metab2014998E1530E153824780046
  • SajiMRingelMDThe PI3K-Akt-mTOR pathway in initiation and progression of thyroid tumorsMol Cell Endocrinol20103211202819897009
  • Ricarte-FilhoJCRyderMChitaleDAMutational profile of advanced primary and metastatic radioactive iodine-refractory thyroid cancers reveals distinct pathogenetic roles for BRAF, PIK3CA, and AKT1Cancer Res200969114885489319487299
  • LandaIGanlyIChanTAFrequent somatic TERT promoter mutations in thyroid cancer: higher prevalence in advanced forms of the diseaseJ Clin Endocrinol Metab2013989E1562E156623833040
  • LiuXQuSLiuRTERT promoter mutations and their association with BRAF V600E mutation and aggressive clinicopathological characteristics of thyroid cancerJ Clin Endocrinol Metab2014996E1130E113624617711
  • MalaguarneraRChenKYKimTYSwitch in signaling control of mTORC1 activity after oncoprotein expression in thyroid cancer cell linesJ Clin Endocrinol Metab20149910E1976E198725029414
  • BunoneGVigneriPMarianiLExpression of angiogenesis stimulators and inhibitors in human thyroid tumors and correlation with clinical pathological featuresAm J Pathol19991551967197610595926
  • EscudierBEisenTStadlerWMSorafenib for treatment of renal cell carcinoma: final efficacy and safety results of the phase III treatment approaches in renal cancer global evaluation trialJ Clin Oncol200927203312331819451442
  • LlovetJMRicciSMazzaferroVSHARP Investigators Study GroupSorafenib in advanced hepatocellular carcinomaN Engl J Med2008359437839018650514
  • BroseMSNuttingCMJarzabBDECISION investigatorsSorafenib in radioactive iodine-refractory, locally advanced or metastatic differentiated thyroid cancer: a randomised, double-blind, phase 3 trialLancet2014384994031932824768112
  • AdnaneLTrailPATaylorIWilhelmSMSorafenib (BAY 43-9006, Nexavar), a dual-action inhibitor that targets RAF/MEK/ERK pathway in tumor cells and tyrosine kinases VEGFR/PDGFR in tumor vasculatureMethods Enzymol200640759761216757355
  • WilhelmSMCarterCTangLBAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesisCancer Res200464197099710915466206
  • Bayer HealthCare Pharmaceuticals Inc [webpage on the Internet]Prescribing Information for Sorafenib (Nexavar)USABayer HealthCare Pharmaceuticals Inc2011 Available from: http://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021923s016lbl.pdfAccessed September 14, 2015
  • European Medicines Agency [homepage on the internet]Nexavar (Sorafenib): Summary of Product CharacteristicsUnited KingdomEuropean Medicines Agency2014 Available from: http://www.ema.europa.euAccessed September 14, 2015
  • StrumbergDRichlyHHilgerRAPhase I clinical and phar-macokinetic study of the novel Raf kinase and vascular endothelial growth factor receptor inhibitor BAY 43-9006 in patients with advanced refractory solid tumorsJ Clin Oncol200523596597215613696
  • FallahiPFerrariSMSantiniFSorafenib and thyroid cancerBioDrugs201327661562823818056
  • BastholtLBroseMSJarzabBPopulation PK modeling and exposure-response analyses of sorafenib in patients with radioactive iodine-refractory differentiated thyroid cancer (RAI-rDTC) in the phase III DECISION trialJ Clin Oncol201432suppl 56061
  • KloosRMRKnoppMHeverhagenJSignificant clinical and biologic activity of RAF/VEGF-R kinase inhibitor BAY 43-9006 in patients with metastatic papillary thyroid carcinoma (PTC): updated results of a phase II studyJ Clin Oncol200624suppl 2885534
  • Gupta-AbramsonVTroxelABNelloreAPhase II trial of sorafenib in advanced thyroid cancerJ Clin Oncol200826294714471918541894
  • KloosRTRingelMDKnoppMVPhase II trial of sorafenib in metastatic thyroid cancerJ Clin Oncol200927101675168419255327
  • BroseMSTroxelABRedlingerMEffect of BRAFV600E on response to sorafenib in advanced thyroid cancer patientsJ Clin Oncol200927suppl 156002
  • HoftijzerHHeemstraKAMorreauHBeneficial effects of sorafenib on tumor progression, but not on radioiodine uptake, in patients with differentiated thyroid carcinomaEur J Endocrinol2009161692393119773371
  • CabanillasMEWaguespackSGBronsteinYTreatment with tyrosine kinase inhibitors for patients with differentiated thyroid cancer: the M.D. Anderson experienceJ Clin Endocrinol Metab20109562588259520392874
  • KeefeSMTroxelABRheeSPhase II trial of sorafenib in patients with advanced thyroid cancerJ Clin Oncol201129suppl 155562
  • MarottaVRamandoVCameraLSorafenib in advanced iodine-refractory differentiated thyroid cancer: efficacy, safety and exploratory analysis of role of serum thyroglobulin and FDG-PETClin Endocrinol (Oxf)201278576076723009688
  • SchneiderTCAbdulrahmanRMCorssmitEPMorreauHSmitJWKapiteijnELong-term analysis of the efficacy and tolerability of sorafenib in advanced radio-iodine refractory differentiated thyroid carcinoma: final results of a phase II trialEur J Endocrinol2012167564365022918300
  • LamETRingelMDKloosRTPhase II clinical trial of sorafenib in metastatic medullary thyroid cancerJ Clin Oncol201028142323233020368568
  • AhmedMBarbachanoYRiddellAAnalysis of the efficacy and toxicity of sorafenib in thyroid cancer: a phase II study in a UK based populationEur J Endocrinol2011165231532221566072
  • CapdevilaJIglesiasLHalperinISorafenib in metastatic thyroid cancerEndocr Relat Cancer201219220921622285864
  • DaduRWaguespackSGShermanSIEfficacy and tolerability of different starting doses of sorafenib in patients with differentiated thyroid cancerOncologist201419547748224733667
  • ChenLShenYLuoQYuYLuHZhuRResponse to sorafenib at a low dose in patients with radioiodine-refractory pulmonary metastases from papillary thyroid carcinomaThyroid201121211912421186953
  • ShenCTQiuZLLuoQYSorafenib in the treatment of radioiodine-refractory differentiated thyroid cancer: a meta-analysisEndocr Relat Cancer201421225326124302666
  • Klein HesselinkENSteenvoordenDKapiteijnETherapy of endocrine disease: response and toxicity of small-molecule tyrosine kinase inhibitors in patients with thyroid carcinoma: a systematic review and meta-analysisEur J Endocrinol20151725R215R22525572389
  • MassicotteMHBrassardMClaude-DesrochesMTyrosine kinase inhibitor treatments in patients with metastatic thyroid carcinomas: a retrospective study of the TUTHYREF networkEur J Endocrinol2014170457558224424318
  • GalloMMichelonFCastiglioneASorafenib treatment of radioiodine-refractory advanced thyroid cancer in daily clinical practice: a cohort study from a single centerEndocrine201549372673425414068
  • PitoiaFResponse to sorafenib treatment in advanced metastatic thyroid cancerArq Bras Endocrinol Metabol2014581374124728162
  • Clinicaltrials.gov [webpage on the Internet]Nexavar® versus Placebo in Locally Advanced/Metastatic RAI-Refractory Differentiated Thyroid CancerUSANational Institutes of Health2015 Available from: https://clinicaltrials.gov/ct2/show/NCT00984282?term=NCT00984282&rank=1Accessed October 14, 2015
  • TuttleRMHaddadRIBallDWThyroid carcinoma, version 2.2014J Natl Compr Canc Netw201412121671168025505208
  • CabanillasMEKurzrockRShermanSIPhase I trial of combination sorafenib and tipifarnib: the experience of advanced differentiated thyroid cancer (DTC) and medullary thyroid cancer (MTC)J Clin Oncol201028suppl 155586
  • HongDSCabanillasMEWhelerJInhibition of the Ras/Raf/MEK/ERK and RET kinase pathways with the combination of the multikinase inhibitor sorafenib and the farnesyltransferase inhibitor tipifarnib in medullary and differentiated thyroid malignanciesJ Clin Endocrinol Metab2011964997100521289252
  • ShermanEJHoALFuryMGA phase II study of temsirolimus/sorafenib in patients with radioactive iodine (RAI)-refractory thyroid carcinomaJ Clin Oncol201230suppl 155514
  • ShermanEJHoALFuryMGPhase II study of everolimus and sorafenib for the treatment of metastatic thyroid cancerJ Clin Oncol201331suppl6024
  • BroseMSTroxelABYarchoanMA phase II study of everolimus (E) and sorafenib (S) in patients (PTS) with metastatic differentiated thyroid cancer who have progressed on sorafenib aloneJ Clin Oncol201533suppl6072
  • US Dept of Health and Human Services, National Institutes of Health, National Cancer Institute [webpage on the Internet]Common Terminology Criteria for Adverse Events v4.0 (CTCAE). US Dept of Health and Human Services, National Institutes of Health, National Cancer Institute2006 Available from: http://ctep.cancer.gov/protocolDevelopment/electronic_applications/ctc.htmAccessed September 25, 2015
  • SchutzFAJeYRichardsCJChoueiriTKMeta-analysis of random-ized controlled trials for the incidence and risk of treatment-related mortality in patients with cancer treated with vascular endothelial growth factor tyrosine kinase inhibitorsJ Clin Oncol201230887187722312105
  • WordenFFassnachtMShiYSafety and tolerability of sorafenib in patients with radioiodine-refractory thyroid cancerEndocr Relat Cancer201522687788726370187
  • LeeWJLeeJLChangSECutaneous adverse effects in patients treated with the multitargeted kinase inhibitors sorafenib and sunitinibBr J Dermatol200916151045105119558553
  • FlahertyKTBroseMSSorafenib-related hand-foot skin reaction improves, not worsens, with continued treatmentClin Cancer Res20091524774920008857
  • BroseMSFrenetteCTKeefeSMSteinSMManagement of sorafenib-related adverse events: a clinician’s perspectiveSemin Oncol201441suppl 2S1S1624576654
  • RobinsonESKhankinEVKarumanchiSAHumphreysBDHypertension induced by vascular endothelial growth factor signaling pathway inhibition: mechanisms and potential use as a biomarkerSemin Nephrol201030659160121146124
  • KambaTMcDonaldDMMechanisms of adverse effects of anti-VEGF therapy for cancerBr J Cancer200796121788179517519900
  • ZhangZFWangTLiuLHGuoHQRisks of proteinuria associated with vascular endothelial growth factor receptor tyrosine kinase inhibitors in cancer patients: a systematic review and meta-analysisPLoS One201493e9013524621598
  • QiWShenZTangLYaoYCongestive heart failure risk in cancer patients treated with VEGFR-MKIs: a systematic review and meta-analysis of 36 clinical trialsBr J Clin Pharmacol201478474876224661224
  • BraunDKimTDle CoutrePKöhrleJHershmanJMSchweizerUTyrosine kinase inhibitors noncompetitively inhibit MCT8-mediated iodothyronine transportJ Clin Endocrinol Metab2012971E100E10522031512
  • AbdulrahmanRMVerloopHHoftijzerHSorafenib-induced hypothyroidism is associated with increased type 3 deiodinationJ Clin Endocrinol Metab20109583758376220484486
  • VerloopHSmitJWDekkersOMSorafenib therapy decreases the clearance of thyrotropinEur J Endocrinol2013168216316723125304
  • IllouzFLaboureau-SoaresSDuboisSRohmerVRodienPTyrosine kinase inhibitors and modifications of thyroid function tests: a reviewEur J Endocrinol2009160333133619103722
  • SchutzFAJeYChoueiriTKHematologic toxicities in cancer patients treated with the multi-tyrosine kinase sorafenib: a meta-analysis of clinical trialsCrit Rev Oncol Hematol201180229130021339073
  • PitoiaFAbelleiraEJerkovichFUrciuoliCCrossGPartial response to sorafenib treatment associated with transient grade 3 thrombocytope-nia in a patient with locally advanced thyroid cancerArch Endocrinol Metab201559434735026331323
  • RothenbergSMMcFaddenDGPalmerELDanielsGHWirthLJRedifferentiation of iodine-refractory BRAF V600E-mutant metastatic papillary thyroid cancer with dabrafenibClin Cancer Res20152151028103525549723