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Review

Modulation of neurotrophic signaling pathways by polyphenols

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Pages 23-42 | Published online: 21 Dec 2015

References

  • ManachCScalbertAMorandCRémésyCJiménezLPolyphenols: food sources and bioavailabilityAm J Clin Nutr200479572774715113710
  • LinkABalaguerFGoelACancer chemoprevention by dietary polyphenols: promising role for epigeneticsBiochem Pharmacol201080121771179220599773
  • WengCJYenGCChemopreventive effects of dietary phytochemicals against cancer invasion and metastasis: phenolic acids, monophenol, polyphenol, and their derivativesCancer Treat Rev2012381768721481535
  • DarveshASBishayeeAChemopreventive and therapeutic potential of tea polyphenols in hepatocellular cancerNutr Cancer201365332934423530632
  • AnnuzziGBozzettoLCostabileGDiets naturally rich in polyphenols improve fasting and postprandial dyslipidemia and reduce oxidative stress: a randomized controlled trialAm J Clin Nutr201499346347124368433
  • ShayJElbazHALeeIZielskeSPMalekMHHuttemannMMolecular mechanisms and therapeutic effects of (−)-epicatechin and other polyphenols in cancer, inflammation, diabetes, and neurodegenerationOxid Med Cell Longev2015201518126026180580
  • DaiJMumperRJPlant phenolics: extraction, analysis and their antioxidant and anticancer propertiesMolecules201015107313735220966876
  • PocernichCBLangeMLSultanaRButterfieldDANutritional approaches to modulate oxidative stress in Alzheimer’s diseaseCurr Alzheimer Res20118545246921605052
  • VauzourDVafeiadouKRodriguez-MateosARendeiroCSpencerJPThe neuroprotective potential of flavonoids: a multiplicity of effectsGenes Nutr200833–411512618937002
  • ScalbertAManachCMorandCRémésyCJiménezLDietary polyphenols and the prevention of diseasesCrit Rev Food Sci Nutr200545428730616047496
  • BhullarKSRupasingheHPolyphenols: multipotent therapeutic agents in neurodegenerative diseasesOxid Med Cell Longev20132013
  • EbrahimiASchluesenerHNatural polyphenols against neurodegenerative disorders: potentials and pitfallsAgeing Res Rev201211232934522336470
  • LiHZhangYCaoLCurcumin could reduce the monomer of TTR with Tyr114Cys mutation via autophagy in cell model of familial amyloid polyneuropathyDrug Des Devel Ther2014821212128
  • LarsonAJSymonsJDJaliliTTherapeutic potential of quercetin to decrease blood pressure: review of efficacy and mechanismsAdv Nutr201231394622332099
  • QuiñonesMMiguelMAleixandreABeneficial effects of polyphenols on cardiovascular diseasePharmacol Res201368112513123174266
  • FrescoPBorgesFMarquesMDinizCThe anticancer properties of dietary polyphenols and its relation with apoptosisCurr Pharm Des201016111413420214622
  • NishiumiSMiyamotoSKawabataKDietary flavonoids as cancer-preventive and therapeutic biofactorsFront Biosci2010313321362
  • MartinMAGoyaLRamosSPotential for preventive effects of cocoa and cocoa polyphenols in cancerFood Chem Toxicol20135633635123439478
  • ConteEFagoneEFrucianoMGiliEIemmoloMVancheriCAnti-inflammatory and antifibrotic effects of resveratrol in the lungHistol Histopathol201430552352925515609
  • GonzalezRBallesterILopez-PosadasREffects of flavonoids and other polyphenols on inflammationCrit Rev Food Sci Nutr201151433136221432698
  • BabuPVALiuDGilbertERRecent advances in understanding the anti-diabetic actions of dietary flavonoidsJ Nutr Biochem201324111777178924029069
  • AssiniJMMulvihillEEHuffMWCitrus flavonoids and lipid metabolismCurr Opin Lipidol2013241344023254473
  • YaoZZhangLJiGEfficacy of polyphenolic ingredients of Chinese herbs in treating dyslipidemia of metabolic syndromesEur J Integr Med2014123135146
  • IslamBSharmaCAdemAAburawiEOjhaSInsight into the mechanism of polyphenols on the activity of HMGR by molecular dockingDrug Des Devel Ther2015949434951
  • ChirumboloSDietary assumption of plant polyphenols and prevention of allergyCurr Pharm Des201420681183923701556
  • CuevasASaavedraNSalazarLAAbdallaDSModulation of immune function by polyphenols: possible contribution of epigenetic factorsNutrients2013572314233223812304
  • CiminoSSortinoGFavillaVPolyphenols: key issues involved in chemoprevention of prostate cancerOxid Med Cell Longev20122012
  • JinHLengQLiCDietary flavonoid for preventing colorectal neoplasmsCochrane Libr20128CD009350
  • ZandHChemopreventive and chemosensitization potential of flavonoids in acute lymphoblastic leukemiaJ Pediatr Biochem2012211521
  • QuerfurthHWLaFerlaFMAlzheimer’s diseaseNew Engl J Med2010362432934420107219
  • CitronMAlzheimer’s disease: strategies for disease modificationNat Rev Drug Discov20109538739820431570
  • MangialascheFSolomonAWinbladBMecocciPKivipeltoMAlzheimer’s disease: clinical trials and drug developmentLancet Neurol20109770271620610346
  • ShayJElbazHALeeIZielskeSPMalekMHHüttemannMMolecular mechanisms and therapeutic effects of (−)-epicatechin and other polyphenols in cancer, inflammation, diabetes, and neurodegenerationOxid Med Cell Longev20152015
  • AlbarracinSLStabBCasasZEffects of natural antioxidants in neurodegenerative diseaseNutr Neurosci20121511922305647
  • KrikorianRBoespflugELFleckDEConcord grape juice supplementation and neurocognitive function in human agingJ Agric Food Chem201260235736574222468945
  • WitteAVKertiLMarguliesDSFlöelAEffects of resveratrol on memory performance, hippocampal functional connectivity, and glucose metab olism in healthy older adultsJ Neurosci201434237862787024899709
  • Kesse-GuyotEFezeuLAndreevaVATotal and specific polyphenol intakes in midlife are associated with cognitive function measured 13 years laterJ Nutr20121421768322090468
  • LetenneurLProust-LimaCLe GougeADartiguesJ-FBarberger-GateauPFlavonoid intake and cognitive decline over a 10-year periodAm J Epidemiol2007165121364137117369607
  • CimrováBBudáčSMelicherováUJergelováMJaglaFElectrophysiological evidence of the effect of natural polyphenols upon the human higher brain functionsNeuro Endocrinol Lett201132446446821876511
  • TorreRSolaSPonsMEpigallocatechin-3-gallate, a DYRK1A inhibitor, rescues cognitive deficits in Down syndrome mouse models and in humansMol Nutr Food Res201458227828824039182
  • GundimedaUMcNeillTHSchiffmanJEHintonDRGopalakrishnaRGreen tea polyphenols potentiate the action of nerve growth factor to induce neuritogenesis: possible role of reactive oxygen speciesJ Neurosci Res201088163644365520936703
  • SuganumaMOkabeSOniyamaMTadaYItoHFujikiHWide distribution of [3H](−)-epigallocatechin gallate, a cancer preventive tea polyphenol, in mouse tissueCarcinogenesis19981910177117769806157
  • El MohsenMMAKuhnleGRechnerARUptake and metabolism of epicatechin and its access to the brain after oral ingestionFree Radic Biol Med200233121693170212488137
  • RossiLMazzitelliSArcielloMCapoCRotilioGBenefits from dietary polyphenols for brain aging and Alzheimer’s diseaseNeurochem Res200833122390240018415677
  • VingtdeuxVGilibertoLZhaoHAMP-activated protein kinase signaling activation by resveratrol modulates amyloid-β peptide metabolismJ Biol Chem2010285129100911320080969
  • YoudimKAQaiserMZBegleyDJRice-EvansCAAbbottNJFlavonoid permeability across an in situ model of the blood–brain barrierFree Radic Biol Med200436559260414980703
  • YoudimKADobbieMSKuhnleGProteggenteARAbbottNJRice-EvansCInteraction between flavonoids and the blood–brain barrier: in vitro studiesJ Neurochem200385118019212641740
  • FiruziOLacannaAPetrucciRMarrosuGSasoLEvaluation of the antioxidant activity of flavonoids by “ferric reducing antioxidant power” assay and cyclic voltammetryBiochim Biophys Acta200517211–317418415652192
  • FiruziOMladěnkaPPetrucciRMarrosuGSasoLHypochlorite scavenging activity of flavonoidsJ Pharm Pharmacol200456680180715231046
  • DueñasMGonzález-ManzanoSGonzález-ParamásASantos- BuelgaCAntioxidant evaluation of O-methylated metabolites of catechin, epicatechin and quercetinJ Pharm Biomed Anal201051244344919442472
  • LemmensKJvan de WierBVaesNThe flavonoid 7-mono-O-(β-hydroxyethyl)-rutoside is able to protect endothelial cells by a direct antioxidant effectToxicol in Vitro201428453854324412621
  • MartínMÁFernández-MillánERamosSBravoLGoyaLCocoa flavonoid epicatechin protects pancreatic beta cell viability and function against oxidative stressMol Nutr Food Res201458344745624115486
  • GarridoJGasparAGarridoEMAlkyl esters of hydroxycinnamic acids with improved antioxidant activity and lipophilicity protect PC12 cells against oxidative stressBiochimie201294496196722210493
  • GasparAMartinsMSilvaPDietary phenolic acids and derivatives. Evaluation of the antioxidant activity of sinapic acid and its alkyl estersJ Agric Food Chem20105821112731128020949946
  • ChenJChuaK-WChuaCCAntioxidant activity of 7,8-dihydroxyflavone provides neuroprotection against glutamate-induced toxicityNeurosci Lett2011499318118521651962
  • VauzourDDietary polyphenols as modulators of brain functions: biological actions and molecular mechanisms underpinning their beneficial effectsOxid Med Cell Longev2012201291427322701758
  • Gutierrez-MerinoCLopez-SanchezCLagoaRSamhan-AriasAKBuenoCGarcia-MartinezVNeuroprotective actions of flavonoidsCurr Med Chem20111881195121221291366
  • HwangS-LShihP-HYenG-CNeuroprotective effects of citrus flavonoidsJ Agric Food Chem201260487788522224368
  • VenkatesanRJiEKimSYPhytochemicals that regulate neurode-generative disease by targeting neurotrophins: a comprehensive reviewBiomed Res Int2015201581406826075266
  • SilvaTBravoJSummavielleTBiology-oriented development of novel lipophilic antioxidants with neuroprotective activityRSC Adv20155211580015811
  • DarveshASCarrollRTBishayeeAGeldenhuysWJVan der SchyfCJOxidative stress and Alzheimer’s disease: dietary polyphenols as potential therapeutic agentsExpert Rev Neurother201010572974520420493
  • FiruziOMiriRTavakkoliMSasoLAntioxidant therapy: current status and future prospectsCurr Med Chem201118253871388821824100
  • YuanJYanknerBAApoptosis in the nervous systemNature2000407680580280911048732
  • LinC-WWuM-JLiuIY-CSuJ-DYenJ-HNeurotrophic and cytoprotective action of luteolin in PC12 cells through ERK-dependent induction of Nrf2-driven HO-1 expressionJ Agric Food Chem20105874477448620302373
  • LiaoK-KWuM-JChenP-YCurcuminoids promote neurite outgrowth in PC12 cells through MAPK/ERK-and PKC-dependent pathwaysJ Agric Food Chem201160143344322145830
  • ReznichenkoLAmitTYoudimMMandelSGreen tea polyphenol (−)-epigallocatechin-3-gallate induces neurorescue of long-term serum-deprived PC12 cells and promotes neurite outgrowthJ Neurochem20059351157116715934936
  • dos SantosNAGMartinsNMde Barros SilvaRFerreiraRSSistiFMdos SantosACCaffeic acid phenethyl ester (CAPE) protects PC12 cells from MPP+ toxicity by inducing the expression of neuron-typical proteinsNeuroToxicology20144513113825454720
  • LaiH-CWuM-JChenP-YNeurotrophic effect of citrus 5-hydroxy-3, 6, 7, 8, 3′, 4′-hexamethoxyflavone: promotion of neurite outgrowth via cAMP/PKA/CREB pathway in PC12 cellsPLoS One2011611e2828022140566
  • YangS-HLiaoC-CChenYSyuJ-PJengC-JWangS-MDaidzein induces neuritogenesis in DRG neuronal culturesJ Biomed Sci2012198022931352
  • TsaiTKlausmeyerAConradR7,8-Dihydroxyflavone leads to survival of cultured embryonic motoneurons by activating intracellular signaling pathwaysMol Cell Neurosci201356182823500004
  • TangsaengvitNKitphatiWTadtongSBunyapraphatsaraNNukoolkarnVNeurite outgrowth and neuroprotective effects of quercetin from Caesalpinia mimosoides Lamk. on cultured P19-derived neuronsEvid Based Complement Alternat Med2013201383805123840266
  • YabeTHiraharaHHaradaNFerulic acid induces neural progenitor cell proliferation in vitro and in vivoNeuroscience2010165251552419837139
  • TangBLProtein trafficking mechanisms associated with neurite outgrowth and polarized sorting in neuronsJ Neurochem200179592393011739603
  • DasKPFreudenrichTMMundyWRAssessment of PC12 cell differentiation and neurite growth: a comparison of morphological and neurochemical measuresNeurotoxicol Teratol200426339740615113601
  • NakajimaK-INiisatoNMarunakaYGenistein enhances the NGF-induced neurite outgrowthBiomed Res201132535135622033305
  • ChenZ-AWangJ-LLiuR-TLiquiritin potentiate neurite outgrowth induced by nerve growth factor in PC12 cellsCytotechnology2009601–312513219789989
  • XuSLChoiRCZhuKYIsorhamnetin, a flavonol aglycone from Ginkgo biloba L., induces neuronal differentiation of cultured PC12 cells: potentiating the effect of nerve growth factorEvid Based Complement Alternat Med2012201227827322761636
  • LiYChenXSatakeMOshimaYOhizumiYAcetylated flavonoid glycosides potentiating NGF action from scoparia dulcisJ Nat Prod200467472572715104516
  • ZhangFWangY-YLiuHResveratrol produces neurotrophic effects on cultured dopaminergic neurons through prompting astroglial BDNF and GDNF releaseEvid Based Complement Alternat Med2012201293760523304227
  • WangPJengC-JChienC-LWangS-MSignaling mechanisms of daidzein-induced axonal outgrowth in hippocampal neuronsBiochem Biophys Res Commun2008366239340018062921
  • AgrawalRNobleETyagiEZhuangYYingZGomez-PinillaFFlavonoid derivative 7,8-DHF attenuates TBI pathology via TrkB activationBiochim Biophys Acta20151852586287225661191
  • ZhaoJChengYYFanWBotanical drug puerarin coordinates with nerve growth factor in the regulation of neuronal survival and neuritogenesis via activating ERK1/2 and PI3K/Akt signaling pathways in the neurite extension processCNS Neurosci Ther2015211617025310912
  • TaLEEspesetLPodratzJWindebankAJNeurotoxicity of oxaliplatin and cisplatin for dorsal root ganglion neurons correlates with platinum–DNA bindingNeurotoxicology2006276992100216797073
  • QuasthoffSHartungHPChemotherapy-induced peripheral neuropathyJ Neurol2002249191711954874
  • KleinRBrownDTurnleyAMPhenoxodiol protects against Cisplatin induced neurite toxicity in a PC-12 cell modelBMC Neurosci2007816117672914
  • KamsteegMRutherfordTSapiEPhenoxodiol – an isoflavone analog – induces apoptosis in chemoresistant ovarian cancer cellsOncogene200322172611262012730675
  • DikshitPGoswamiAMishraACatterjeeMJanaNRCurcumin induces stress response, neurite outgrowth and prevent NF-κB activation by inhibiting the proteasome functionNeurotox Res200691293716464750
  • LevyYSGilgun-SherkiYMelamedEOffenDTherapeutic potential of neurotrophic factors in neurodegenerative diseasesBio Drugs200519297127
  • HymanCHoferMBardeYABDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigraNature199135063152302322005978
  • MaisonpierrePCBelluscioLFriedmanBNT-3, BDNF, and NGF in the developing rat nervous system: parallel as well as reciprocal patterns of expressionNeuron1990545015091688327
  • SchindowskiKBelarbiKBueeLNeurotrophic factors in Alzheimer’s disease: role of axonal transportGenes Brain Behav20087s1435618184369
  • LongoFMMassaSMSmall-molecule modulation of neurotrophin receptors: a strategy for the treatment of neurological diseaseNat Rev Drug Discov201312750752523977697
  • NagaharaAHTuszynskiMHPotential therapeutic uses of BDNF in neurological and psychiatric disordersNat Rev Drug Discov201110320921921358740
  • AllenSJWatsonJJShoemarkDKBaruaNUPatelNKGDNF, NGF and BDNF as therapeutic options for neurodegenerationPharmacol Ther2013138215517523348013
  • HuangEJReichardtLFTrk receptors: Roles in neuronal signal transductionAnnu Rev Biochem2012722003609642
  • WebsterNJPirrungMCSmall molecule activators of the Trk receptors for neuroprotectionBMC Neuroscience20089Suppl 2S119090982
  • ChaoMVNeurotrophins and their receptors: a convergence point for many signalling pathwaysNat Rev Neurosci20034429930912671646
  • UltschMHWiesmannCSimmonsLCCrystal structures of the neurotrophin-binding domain of TrkA, TrkB and TrkCJ Mol Biol1999290114915910388563
  • HuangEJReichardtLFTrk receptors: roles in neuronal signal transductionAnnu Rev Biochem200372160964212676795
  • KaplanDRMillerFDNeurotrophin signal transduction in the nervous systemCurr Opin Neurobiol200010338139110851172
  • PatapoutianAReichardtLFTrk receptors: mediators of neurotrophin actionCurr Opin Neurobiol200111327228011399424
  • JangS-WLiuXYepesMA selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavoneProc Natl Acad Sci U S A201010762687269220133810
  • GuptaVKYouYLiJCKlistornerAGrahamSLProtective effects of 7,8-dihydroxyflavone on retinal ganglion and RGC-5 cells against excitotoxic and oxidative stressJ Mol Neurosci20134919610423054592
  • YuQChangQLiuXProtection of spiral ganglion neurons from degeneration using small-molecule TrkB receptor agonistsJ Neurosci20133332130421305223926258
  • Al-GayyarMMatragoonSPillaiBAliTAbdelsaidMEl-RemessyAEpicatechin blocks pro-nerve growth factor (proNGF)-mediated retinal neurodegeneration via inhibition of p75 neurotrophin receptor proNGF expression in a rat model of diabetesDiabetologia201154366968021136036
  • ChaiLGuoHLiHScutellarin and caffeic acid ester fraction, active components of Dengzhanxixin injection, upregulate neurotrophins synthesis and release in hypoxia/reoxygenation rat astrocytesJ Ethnopharmacol2013150110010724012966
  • XuSLBiCWChoiRCFlavonoids induce the synthesis and secretion of neurotrophic factors in cultured rat astrocytes: a signaling response mediated by estrogen receptorEvid Based Complement Alternat Med2013201312707523878590
  • SohrabjiFMirandaRToran-AllerandCDIdentification of a putative estrogen response element in the gene encoding brain-derived neurotrophic factorProc Natl Acad Sci U S A1995922411110111147479947
  • ParkSJKimDHKimJMMismatch between changes in baicalein-induced memory-related biochemical parameters and behavioral consequences in mouseBrain Res2010135514115020691671
  • ChoNLeeKYHuhJCognitive-enhancing effects of Rhus verniciflua bark extract and its active flavonoids with neuroprotective and anti-inflammatory activitiesFood Chem Toxicol20135835536123688860
  • SouzaLCAntunesMSBorges FilhoCFlavonoid Chrysin prevents age-related cognitive decline via attenuation of oxidative stress and modulation of BDNF levels in aged mouse brainPharmacol Biochem Behav2015134223025931267
  • PanMHanHZhongCGengQEffects of genistein and daidzein on hippocampus neuronal cell proliferation and BDNF expression in H19-7 neural cell lineJ Nutr Health Aging201216438939422499464
  • OkuyamaSShimadaNKajiMHeptamethoxyflavone, a citrus flavonoid, enhances brain-derived neurotrophic factor production and neurogenesis in the hippocampus following cerebral global ischemia in miceNeurosci Lett2012528219019522985518
  • JeonSJBakHSeoJOroxylin A induces BDNF expression on cortical neurons through adenosine A2A receptor stimulation: a possible role in neuroprotectionBiomol Ther201220127
  • LiRLiangTXuLZhengNZhangKDuanXPuerarin attenuates neuronal degeneration in the substantia nigra of 6-OHDA-lesioned rats through regulating BDNF expression and activating the Nrf2/ARE signaling pathwayBrain Res201315231923747813
  • LiuPZouDYiLQuercetin ameliorates hypobaric hypoxia-induced memory impairment through mitochondrial and neuron function adaptation via the PGC-1α pathwayRestor Neurol Neurosci201533214315725588463
  • KurauchiYHisatsuneAIsohamaYMishimaSKatsukiHCaffeic acid phenethyl ester protects nigral dopaminergic neurons via dual mechanisms involving haem oxygenase-1 and brain-derived neurotrophic factorBr J Pharmacol201216631151116822224485
  • HoppeJBCoradiniKFrozzaRLFree and nanoencapsulated curcumin suppress β-amyloid-induced cognitive impairments in rats: involvement of BDNF and Akt/GSK-3β signaling pathwayNeurobiol Learn Mem201310613414423954730
  • ZhangFLuY-FWuQLiuJShiJ-SResveratrol promotes neurotrophic factor release from astrogliaExp Biol Med20122378943948
  • RahvarMNiksereshtMShafieeSMEffect of oral resveratrol on the BDNF gene expression in the hippocampus of the rat brainNeurochem Res201136576176521221775
  • YuanHZhangJLiuHLiZThe protective effects of resveratrol on Schwann cells with toxicity induced by ethanol in vitroNeurochem Int201363314615323770283
  • MoriyaJChenRYamakawaJ-ISasakiKIshigakiYTakahashiTResveratrol improves hippocampal atrophy in chronic fatigue mice by enhancing neurogenesis and inhibiting apoptosis of granular cellsBiol Pharm Bull201134335435921372384
  • LiuRGaoMQiangG-FThe anti-amnesic effects of luteolin against amyloid β 25–35 peptide-induced toxicity in mice involve the protection of neurovascular unitNeuroscience200916241232124319442706
  • LeeYWKimDHJeonSJNeuroprotective effects of salvianolic acid B on an Aβ 25–35 peptide-induced mouse model of Alzheimer’s diseaseEur J Pharmacol20137041707723461850
  • DonatoFde GomesMGGoesATRHesperidin exerts antidepressant-like effects in acute and chronic treatments in mice: Possible role of L-arginine-NO-cGMP pathway and BDNF levelsBrain Res Bull2014104192624709058
  • WangZGuJWangXAntidepressant-like activity of resveratrol treatment in the forced swim test and tail suspension test in mice: the HPA axis, BDNF expression and phosphorylation of ERKPharmacol Biochem Behav201311210411024125781
  • SuGYYangJYWangFAntidepressant-like effects of Xiaochaihutang in a rat model of chronic unpredictable mild stressJ Ethnopharmacol2014152121722624440317
  • LvQ-QWuW-JGuoX-LAntidepressant activity of astilbin: involvement of monoaminergic neurotransmitters and BDNF signal pathwayBiol Pharm Bull201437698799524681540
  • XiongZJiangBWuP-FAntidepressant effects of a plant-derived flavonoid baicalein involving extracellular signal-regulated kinases cascadeBiol Pharm Bull201134225325921415537
  • LiuDXieKYangXResveratrol reverses the effects of chronic unpredictable mild stress on behavior, serum corticosterone levels and BDNF expression in ratsBehav Brain Res201426491624503118
  • JinXLiuPYangFZhangY-HMiaoDRosmarinic acid ameliorates depressive-like behaviors in a rat model of CUS and up-regulates BDNF levels in the hippocampus and hippocampal-derived astrocytesNeurochem Res20133891828183723756732
  • HetmanMGozdzARole of extracellular signal regulated kinases 1 and 2 in neuronal survivalEur J Biochem2004271112050205515153093
  • HetmanMXiaZSignaling pathways mediating anti-apoptotic action of neurotrophinsActa Neurobiol Exp2000604531546
  • SatohYKobayashiYTakeuchiAPagèsGPouysségurJKazamaTDeletion of ERK1 and ERK2 in the CNS causes cortical abnormalities and neonatal lethality: Erk1 deficiency enhances the impairment of neurogenesis in Erk2-deficient miceJ Neurosci20113131149115521248139
  • ParmarMSJaumotteJDWyrostekSLZigmondMJCavanaughJEThe role of ERK1, 2, and 5 in dopamine neuron survival during agingNeurobiol Aging201435366967924411019
  • LiZTheusMHWeiLRole of ERK 1/2 signaling in neuronal differentiation of cultured embryonic stem cellsDev Growth Differ200648851352317026715
  • LiQChenMLiuHYangLYangTHeGThe dual role of ERK signaling in the apoptosis of neuronsFront Biosci20131914111417
  • MunshiARameshRMitogen-activated protein kinases and their role in radiation responseGenes Cancer201349–1040140824349638
  • MoustafaKAbuQamarSJarrarMAl-RajabAJTrémouillaux-GuillerJMAPK cascades and major abiotic stressesPlant Cell Rep20143381217122524832772
  • KomisGIllésPBeckMŠamajJMicrotubules and mitogen-activated protein kinase signallingCurr Opin Plant Biol201114665065721839668
  • YangYBianGLuQNeuroprotection and neurotrophism effects of liquiritin on primary cultured hippocampal cellsJ Chin Mater Med2008338931935
  • WangZZhangXWangHQiLLouYNeuroprotective effects of icaritin against beta amyloid-induced neurotoxicity in primary cultured rat neuronal cells via estrogen-dependent pathwayNeuroscience2007145391192217321691
  • MoghbelinejadSNassiri-AslMFarivarTNRutin activates the MAPK pathway and BDNF gene expression on beta-amyloid induced neurotoxicity in ratsToxicol Lett2014224110811324148604
  • LinL-FChiuS-PWuM-JChenP-YYenJ-HLuteolin induces microRNA-132 expression and modulates neurite outgrowth in PC12 cellsPloS One201278e4330422916239
  • KanoYHorieNDoiSArtepillin C derived from propolis induces neurite outgrowth in PC12m3 cells via ERK and p38 MAPK pathwaysNeurochem Res20083391795180318338254
  • SagaraYVanhnasyJMaherPInduction of PC12 cell differentiation by flavonoids is dependent upon extracellular signal-regulated kinase activationJ Neurochem20049051144115515312169
  • ZhangZCaiLZhouXMethyl 3, 4-dihydroxybenzoate promote rat cortical neurons survival and neurite outgrowth through the adenosine A2a receptor/PI3K/Akt signaling pathwayNeuroReport201526636737325807175
  • LonzeBEGintyDDFunction and regulation of CREB family transcription factors in the nervous systemNeuron200235460562312194863
  • BossVRobackJDYoungANNerve growth factor, but not epidermal growth factor, increases Fra-2 expression and alters Fra-2/JunD binding to AP-1 and CREB binding elements in pheochromocytoma (PC12) cellsJ Neurosci2001211182611150315
  • MantamadiotisTLembergerTBleckmannSCDisruption of CREB function in brain leads to neurodegenerationNat Genet2002311475411967539
  • FurukawaYWatanabeSOkuyamaSNakajimaMNeurotrophic effect of Citrus auraptene: neuritogenic activity in PC12 cellsInt J Mol Sci20121355338534722754300
  • NagaseHOmaeNOmoriANobiletin and its related flavonoids with CRE-dependent transcription-stimulating and neuritegenic activitiesBiochem Biophys Res Commun200533741330133616253614
  • HwangS-LLinJ-AShihP-HYehC-TYenG-CPro-cellular survival and neuroprotection of citrus flavonoid: the actions of hesperetin in PC12 cellsFood Funct20123101082109022767158
  • LiQZhaoHZhangZLong-term administration of green tea catechins prevents age-related spatial learning and memory decline in C57BL/6 J mice by regulating hippocampal cyclic amp-response element binding protein signaling cascadeNeuroscience200915941208121519409206
  • OhSBParkHRJangYJChoiSYSonTGLeeJBaicalein attenuates impaired hippocampal neurogenesis and the neurocognitive deficits induced by γ-ray radiationBr J Pharmacol2013168242143122891631
  • LeeBSurBShimILeeHHahmD-HBaicalin improves chronic corticosterone-induced learning and memory deficits via the enhancement of impaired hippocampal brain-derived neurotrophic factor and cAMP response element-binding protein expression in the ratJ Nat Med201468113214323749289
  • ZhaoLWangJ-LLiuRLiX-XLiJ-FZhangLNeuroprotective, anti-amyloidogenic and neurotrophic effects of apigenin in an Alzheimer’s disease mouse modelMolecules20131889949996523966081
  • LiuRLiJ-ZSongJ-KPinocembrin improves cognition and protects the neurovascular unit in Alzheimer related deficitsNeurobiol Aging20143561275128524468471
  • JinCHShinEJParkJBFustin flavonoid attenuates β-amyloid (1–42)-induced learning impairmentJ Neurosci Res200987163658367019533734
  • BasliASouletSChaherNWine polyphenols: potential agents in neuroprotectionOxid Med Cell Longev20122012
  • SasoLFiruziOPharmacological applications of antioxidants: lights and shadowsCurr Drug Targets201415131177119925341421
  • AmaraFBerbenniMFragniMNeuroprotection by cocktails of dietary antioxidants under conditions of nerve growth factor deprivationOxid Med Cell Longev2015201521725826236423
  • PanickarKSAndersonRAEffect of polyphenols on oxidative stress and mitochondrial dysfunction in neuronal death and brain edema in cerebral ischemiaInt J Mol Sci201112118181820722174658
  • Razzaghi-AslNGarridoJKhazraeiHBorgesFFiruziOAntioxidant properties of hydroxycinnamic acids: A review of structure-activity relationshipsCurr Med Chem201320364436445023834166
  • WeinrebOAmitTYoudimMBA novel approach of proteomics and transcriptomics to study the mechanism of action of the antioxidant–iron chelator green tea polyphenol (−)-epigallocatechin-3-gallateFree Radic Biol Med200743454655617640565
  • HarikumarKBAggarwalBBResveratrol: a multitargeted agent for age-associated chronic diseasesCell Cycle2008781020103518414053
  • Campos-EsparzaMRSanchez-GomezMVMatuteCMolecular mechanisms of neuroprotection by two natural antioxidant polyphenolsCell Calcium200945435836819201465
  • SelkoeDJClearing the brain’s amyloid cobwebsNeuron200132217718011683988
  • VillemagneVLBurnhamSBourgeatPAmyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer’s disease: a prospective cohort studyLancet Neurol201312435736723477989
  • UshikuboHWatanabeSTanimotoY3,3′,4′,5, 5′-Pentahydroxyflavone is a potent inhibitor of amyloid β fibril formationNeurosci Lett20125131515622343025
  • HongS-YJeongW-SJunMProtective effects of the key compounds isolated from Corni fructus against β-amyloid-induced neurotoxicity in PC12 cellsMolecules2012179108311084522964500
  • HeoHJLeeCYEpicatechin and catechin in cocoa inhibit amyloid β protein induced apoptosisJ Agric Food Chem20055351445144815740021
  • MengPYoshidaHTanjiKCarnosic acid attenuates apoptosis induced by amyloid-1–42 or 1–43 in SH-SY5Y human neuroblastoma cellsNeurosci Res2015941925510380
  • MuXHeGChengYLiXXuBDuGBaicalein exerts neuroprotective effects in 6-hydroxydopamine-induced experimental parkinsonism in vivo and in vitroPharmacol Biochem Behav200992464264819327378
  • TavakkoliMMiriRJassbiARCarthamus, Salvia and Stachys species protect neuronal cells against oxidative stress-induced apoptosisPharm Biol201452121550155725243877
  • SajadMZarganJZargarMAQuercetin prevents protein nitration and glycolytic block of proliferation in hydrogen peroxide insulted cultured neuronal precursor cells (NPCs): Implications on CNS regenerationNeurotoxicology201336243323396185
  • LiuBZhangHXuCNeuroprotective effects of icariin on corticosterone-induced apoptosis in primary cultured rat hippocampal neuronsBrain Res20111375596721182828
  • KenslerTWWakabayashiNBiswalSCell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathwayAnnu Rev Pharmacol Toxicol2007478911616968214
  • ChungSWLiuXMaciasAABaronRMPerrellaMAHeme oxygenase-1–derived carbon monoxide enhances the host defense response to microbial sepsis in miceJ Clin Invest2008118123918060048
  • ZhangDDMechanistic studies of the Nrf2-Keap1 signaling pathwayDrug Metab Rev200638476978917145701
  • ZhangMAnCGaoYLeakRKChenJZhangFEmerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotectionProg Neurobiol2013100304723025925
  • ChoH-YJedlickaAEReddySPRole of NRF2 in protection against hyperoxic lung injury in miceAm J Respir Cell Mol Biol200226217518211804867
  • RomeoLIntrieriMD’AgataVThe major green tea poly-phenol, (−)-epigallocatechin-3-gallate, induces heme oxygenase in rat neurons and acts as an effective neuroprotective agent against oxidative stressJ Am Coll Nutr200928sup4492S499S20234037
  • KosakaKMimuraJItohKRole of Nrf2 and p62/ZIP in the neurite outgrowth by carnosic acid in PC12h cellsJ Biochem20101471738119762340
  • RussellJMSodium-potassium-chloride cotransportPhysiol Rev200080121127610617769
  • NakajimaK-IMiyazakiHNiisatoNMarunakaYEssential role of NKCC1 in NGF-induced neurite outgrowthBiochem Biophys Res Commun2007359360461017548052
  • NakajimaK-INiisatoNMarunakaYQuercetin stimulates NGF-induced neurite outgrowth in PC12 cells via activation of Na+/K+/2Cl-cotransporterCell Physiol Biochem201128114715621865857
  • DiógenesMJFernandesCCSebastiaoAMRibeiroJAActivation of adenosine A2A receptor facilitates brain-derived neurotrophic factor modulation of synaptic transmission in hippocampal slicesJ Neurosci200424122905291315044529
  • TebanoMMartireAPotenzaRAdenosine A2A receptors are required for normal BDNF levels and BDNF-induced potentiation of synaptic transmission in the mouse hippocampusJ Neurochem2008104127928618005343
  • WieseSJablonkaSHoltmannBAdenosine receptor A2A-R contributes to motoneuron survival by transactivating the tyrosine kinase receptor TrkBProc Natl Acad Sci U S A200710443172101721517940030
  • ChengH-CShihH-MChernYEssential role of cAMP-response element-binding protein activation by A2A adenosine receptors in rescuing the nerve growth factor-induced neurite outgrowth impaired by blockage of the MAPK cascadeJ Biol Chem200227737339303394212114502
  • FlajoletMWangZFutterMFGF acts as a co-transmitter through adenosine A2A receptor to regulate synaptic plasticityNat Neurosci200811121402140918953346
  • PalazzoloGHorvathPZenobi-WongMThe flavonoid isoquercitrin promotes neurite elongation by reducing RhoA activityPLoS One2012711e4997923209630
  • Bora-TatarGErdem-YurterHInvestigations of curcumin and resveratrol on neurite outgrowth: perspectives on spinal muscular atrophyBiomed Res Int2014201470910825105137
  • DasguptaBMilbrandtJResveratrol stimulates AMP kinase activity in neuronsProc Natl Acad Sci U S A2007104177217722217438283
  • LiMTsangKSChoiSTLiKShawPCLauKFNeuronal differentiation of C17. 2 neural stem cells induced by a natural flavonoid, baicalinChembiochem201112344945621290546
  • WooKWKwonOWKimSYPhenolic derivatives from the rhizomes of Dioscorea nipponica and their anti-neuroinflammatory and neuroprotective activitiesJ Ethnopharmacol201415521164117024973689
  • GuanSZhangX-LGeDLiuT-QMaX-HCuiZ-FProtocatechuic acid promotes the neuronal differentiation and facilitates survival of phenotypes differentiated from cultured neural stem and progenitor cellsEur J Pharmacol2011670247147821946114
  • LinC-YNiC-CYinM-CLiiC-KFlavonoids protect pancreatic beta-cells from cytokines mediated apoptosis through the activation of PI3-kinase pathwayCytokine2012591657122579112
  • El OmriAHanJYamadaPKawadaKAbdrabbahMBIsodaHRosmarinus officinalis polyphenols activate cholinergic activities in PC12 cells through phosphorylation of ERK1/2J Ethnopharmacol2010131245145820633629
  • NishinaAKimuraHTsukagoshiHNeurite outgrowth of PC12 cells by 4′-O-β-d-glucopyranosyl-3′,4-dimethoxychalcone from Brassica rapa L. ‘hidabeni’ was enhanced by pretreatment with p38MAPK inhibitorNeurochem Res201338112397240724057400
  • ZeniALBZomkowskiADEMaraschinMRodriguesALSTascaCIInvolvement of PKA, CaMKII, PKC, MAPK/ERK and PI3K in the acute antidepressant-like effect of ferulic acid in the tail suspension testPharmacol Biochem Behav2012103218118622960128
  • MaherPAkaishiTAbeKFlavonoid fisetin promotes ERK-dependent long-term potentiation and enhances memoryProc Natl Acad Sci U S A200610344165681657317050681
  • MendoncaLMda Silva MachadoCTeixeiraCCCde FreitasLAPBianchiMdLPAntunesLMGCurcumin reduces cisplatin-induced neurotoxicity in NGF-differentiated PC12 cellsNeurotoxicology20133420521123036615
  • LevitesYAmitTMandelSYoudimMBNeuroprotection and neurorescue against Aβ toxicity and PKC-dependent release of nonamyloidogenic soluble precursor protein by green tea polyphenol (−)-epigallocatechin-3-gallateFASEB J200317895295412670874
  • LevitesYAmitTYoudimMBMandelSInvolvement of protein kinase C activation and cell survival/cell cycle genes in green tea polyphenol (−)-epigallocatechin 3-gallate neuroprotective actionJ Biol Chem200227734305743058012058035