An innovative approach to induce cross-protective immunity against porcine reproductive and respiratory syndrome virus in the lungs of pigs through adjuvanted nanotechnology-based vaccination

References

• HoltkampDKliebensteinJPRRS Costs Industry $664 Million Annually [webpage on the Internet]Pork Checkoff Study2011 Available from: http://www.pork.org/News/1265/PRRSCostsIndustry664Million.aspxAccessed January 26, 2014
   Google Scholar
• WangXEatonMMayerMPorcine reproductive and respiratory syndrome virus productively infects monocyte-derived dendritic cells and compromises their antigen-presenting abilityArch Virol2007152228930317031757
   PubMed Web of Science ®Google Scholar
• NielsenHSOleksiewiczMBForsbergRStadejekTBøtnerAStorgaardTReversion of a live porcine reproductive and respiratory syndrome virus vaccine investigated by parallel mutationsJ Gen Virol200182Pt 61263127211369869
   PubMedGoogle Scholar
• KimmanTGCornelissenLAMoormannRJRebelJMStockhofe-ZurwiedenNChallenges for porcine reproductive and respiratory syndrome virus (PRRSV) vaccinologyVaccine200927283704371819464553
   PubMed Web of Science ®Google Scholar
• ChadwickSKriegelCAmijiMNanotechnology solutions for mucosal immunizationAdv Drug Deliv Rev2010624–539440719931581
   PubMed Web of Science ®Google Scholar
• DevalapallyHChakilamAAmijiMMRole of nanotechnology in pharmaceutical product developmentJ Pharm Sci200796102547256517688284
   PubMed Web of Science ®Google Scholar
• UlmerJBValleyURappuoliRVaccine manufacturing: challenges and solutionsNat Biotechnol200624111377138317093488
   PubMed Web of Science ®Google Scholar
• MurtaughMPXiaoZZuckermannFImmunological responses of swine to porcine reproductive and respiratory syndrome virus infectionViral Immunol200215453354712513925
   PubMed Web of Science ®Google Scholar
• BhavsarMDAmijiMMPolymeric nano- and microparticle technologies for oral gene deliveryExpert Opin Drug Deliv20074319721317489649
   PubMed Web of Science ®Google Scholar
• GiriPKKhullerGKIs intranasal vaccination a feasible solution for tuberculosis?Expert Rev Vaccines2008791341135618980538
   PubMed Web of Science ®Google Scholar
• McNeilSENanotechnology for the biologistJ Leukoc Biol200578358559415923216
   PubMed Web of Science ®Google Scholar
• PanyamJLabhasetwarVBiodegradable nanoparticles for drug and gene delivery to cells and tissueAdv Drug Deliv Rev200355332934712628320
   PubMed Web of Science ®Google Scholar
• GargNKMangalSKhambeteHSharmaPKTyagiRKMucosal delivery of vaccines: role of mucoadhesive/biodegradable polymersRecent Pat Drug Deliv Formul20104211412820380624
   PubMedGoogle Scholar
• BinjawadagiBDwivediVManickam1CAdjuvanted poly(lactic-co-glycolic) acid nanoparticle-entrapped inactivated porcine reproductive and respiratory syndrome virus vaccine elicits cross-protective immune response in pigsInt J Nanomedicine2014967969424493925
   PubMed Web of Science ®Google Scholar
• DwivediVManickamCPattersonRCross-protective immunity to porcine reproductive and respiratory syndrome virus by intranasal delivery of a live virus vaccine with a potent adjuvantVaccine201129234058406621419162
   PubMed Web of Science ®Google Scholar
• DwivediVManickamCPattersonRDodsonKWeemanMRenukaradhyaGJIntranasal delivery of whole cell lysate of Mycobacterium tuberculosis induces protective immune responses to a modified live porcine reproductive and respiratory syndrome virus vaccine in pigsVaccine201129234067407621419164
   PubMed Web of Science ®Google Scholar
• RenukaradhyaGJDwivediVManickamCBinjawadagiBBenfieldDMucosal vaccines to prevent porcine reproductive and respiratory syndrome: a new perspectiveAnim Health Res Rev2012131213722717576
   PubMedGoogle Scholar
• SrivastavaPInteraction of heat shock proteins with peptides and antigen presenting cells: chaperoning of the innate and adaptive immune responsesAnnu Rev Immunol20022039542511861608
   PubMed Web of Science ®Google Scholar
• WernerGHMaralRFlochFMigliore-SamourDJollèsPAdjuvant and immunostimulating activities of water-soluble substances extracted from Mycobacterium tuberculosis (var. hominis)Biomedicine19752254404524166
   PubMedGoogle Scholar
• LarsonCLBellJFListRHRibiEWichtWCSymposium on relationship of structure of microorganisms to their immunological properties. ii. host-reactive properties of cell walls and protoplasm from mycobacteriaBacteriol Rev19632734135114097344
   PubMedGoogle Scholar
• WhiteRGBernstockLJohnsRGLedererEThe influence of components of M. tuberculosis and other Mycobacteria upon antibody production to ovalbuminImmunology195811546613513142
   PubMed Web of Science ®Google Scholar
• DwivediVManickamCBinjawadagiBJoyappaDRenukaradhyaGJBiodegradable nanoparticle-entrapped vaccine induces cross-protective immune response against a virulent heterologous respiratory viral infection in pigsPLoS One2012712e5179423240064
   PubMed Web of Science ®Google Scholar
• DwivediVManickamCBinjawadagiBRenukaradhyaGJPLGA nanoparticle entrapped killed porcine reproductive and respiratory syndrome virus vaccine helps in viral clearance in pigsVet Microbiol20131661–2475823764272
   PubMed Web of Science ®Google Scholar
• KimWILeeDSJohnsonWRoofMChaSHYoonKJEffect of genotypic and biotypic differences among PRRS viruses on the serologic assessment of pigs for virus infectionVet Microbiol20071231–311417467931
   PubMed Web of Science ®Google Scholar
• TakayamaKSchnoesHKArmstrongELBoyleRWSite of inhibitory action of isoniazid in the synthesis of mycolic acids in Mycobacterium tuberculosisJ Lipid Res1975164308317806645
   PubMed Web of Science ®Google Scholar
• JungKAlekseevKPZhangXCheonDSVlasovaANSaifLJAltered pathogenesis of porcine respiratory coronavirus in pigs due to immunosuppressive effects of dexamethasone: implications for corticosteroid use in treatment of severe acute respiratory syndrome coronavirusJ Virol20078124136811369317942563
   PubMed Web of Science ®Google Scholar
• RenukaradhyaGJAlekseevKJungKFangYSaifLJPorcine reproductive and respiratory syndrome virus-induced immunosuppression exacerbates the inflammatory response to porcine respiratory coronavirus in pigsViral Immunol201023545746620883160
   PubMed Web of Science ®Google Scholar
• KaiserTJChristopher-HenningsJNelsonEAMeasurement of immunoglobulin G, A and M concentrations in boar seminal plasmaTheriogenology20005471171118411131334
   PubMed Web of Science ®Google Scholar
• ZhangLTianXZhouFIntranasal administration of CpG oligonucleotides induces mucosal and systemic Type 1 immune responses and adjuvant activity to porcine reproductive and respiratory syndrome killed virus vaccine in piglets in vivoInt Immunopharmacol20077131732174017996683
   PubMed Web of Science ®Google Scholar
• MulupuriPZimmermanJJHermannJAntigen-specific B-cell responses to porcine reproductive and respiratory syndrome virus infectionJ Virol200882135837017942527
   PubMed Web of Science ®Google Scholar
• ThompsonALJohnsonBTSempowskiGDMaximal adjuvant activity of nasally delivered IL-1α requires adjuvant-responsive CD11c(+) cells and does not correlate with adjuvant-induced in vivo cytokine productionJ Immunol201218862834284622345651
   PubMed Web of Science ®Google Scholar
• FerreiraMUKatzinAMThe assessment of antibody affinity distribution by thiocyanate elution: a simple dose-response approachJ Immunol Methods199518722973057499889
   PubMed Web of Science ®Google Scholar
• GuoYJSunSHZhangYProtection of pigs against Taenia solium cysticercosis using recombinant antigen or in combination with DNA vaccineVaccine20042229–303841384715364430
   PubMed Web of Science ®Google Scholar
• AdamACiorbaruRPetitJFLedererEIsolation and properties of a macromolecular, water-soluble, immuno-adjuvant fraction from the cell wall of Mycobacterium smegmatisProc Natl Acad Sci U S A19726948518544502937
   PubMed Web of Science ®Google Scholar
• AzevedoMSYuanLPoulySCytokine responses in gnotobiotic pigs after infection with virulent or attenuated human rotavirusJ Virol200680137238216352562
   PubMed Web of Science ®Google Scholar
• Christopher-HenningsJHollerLDBenfieldDANelsonEADetection and duration of porcine reproductive and respiratory syndrome virus in semen, serum, peripheral blood mononuclear cells, and tissues from Yorkshire, Hampshire, and Landrace boarsJ Vet Diagn Invest200113213314211289209
   PubMed Web of Science ®Google Scholar
• CaiHYAlexanderHCarmanSLloydDJosephsonGMaxieMGRestriction fragment length polymorphism of porcine reproductive and respiratory syndrome viruses recovered from Ontario farms, 1998–2000J Vet Diagn Invest200214434334712152819
   PubMed Web of Science ®Google Scholar
• FangYKimDYRoppSHeterogeneity in Nsp2 of European-like porcine reproductive and respiratory syndrome viruses isolated in the United StatesVirus Res2004100222923515019241
   PubMed Web of Science ®Google Scholar
• ManickamCDwivediVPattersonRPapenfussTRenukaradhyaGJPorcine reproductive and respiratory syndrome virus induces pronounced immune modulatory responses at mucosal tissues in the parental vaccine strain VR2332 infected pigsVet Microbiol20131621687722995873
   PubMed Web of Science ®Google Scholar
• DarwichLDíazIMateuECertainties, doubts and hypotheses in porcine reproductive and respiratory syndrome virus immunobiologyVirus Res20101541–212313220659507
   PubMed Web of Science ®Google Scholar
• KamijukuHNagataYJiangXMechanism of NKT cell activation by intranasal coadministration of alpha-galactosylceramide, which can induce cross-protection against influenza virusesMucosal Immunol20081320821819079180
   PubMed Web of Science ®Google Scholar
• GuillonneauCMinternJDHubertFXCombined NKT cell activation and influenza virus vaccination boosts memory CTL generation and protective immunityProc Natl Acad Sci U S A200910693330333519211791
   PubMed Web of Science ®Google Scholar
• OgraPLMucosal immune response to poliovirus vaccines in childhoodRev Infect Dis19846Suppl 2S361S3686740074
   PubMedGoogle Scholar
• SchmidtACWenzkeDRMcAuliffeJMMucosal immunization of rhesus monkeys against respiratory syncytial virus subgroups A and B and human parainfluenza virus type 3 by using a live cDNA-derived vaccine based on a host range-attenuated bovine parainfluenza virus type 3 vector backboneJ Virol20027631089109911773385
   PubMed Web of Science ®Google Scholar
• ImaokaKMillerCJKubotaMNasal immunization of nonhuman primates with simian immunodeficiency virus p55gag and cholera toxin adjuvant induces Th1/Th2 help for virus-specific immune responses in reproductive tissuesJ Immunol199816111595259589834076
   PubMed Web of Science ®Google Scholar
• ManochaMPalPCChitralekhaKTEnhanced mucosal and systemic immune response with intranasal immunization of mice with HIV peptides entrapped in PLG microparticles in combination with Ulex Europaeus-I lectin as M cell targetVaccine20052348–495599561716099080
   PubMed Web of Science ®Google Scholar
• RossowKDBenfieldDAGoyalSMNelsonEAChristopher- HenningsJCollinsJEChronological immunohistochemical detection and localization of porcine reproductive and respiratory syndrome virus in gnotobiotic pigsVet Pathol19963355515568885182
   PubMed Web of Science ®Google Scholar
• GanterMHenselACellular variables in bronchoalveolar lavage fluids (BALF) in selected healthy pigsRes Vet Sci19976332152179491446
   PubMed Web of Science ®Google Scholar
• KugathasanKRoedigerEKSmallCLMcCormickSYangPXingZCD11c+ antigen presenting cells from the alveolar space, lung parenchyma and spleen differ in their phenotype and capabilities to activate naïve and antigen-primed T cellsBMC Immunol200894818700962
   PubMed Web of Science ®Google Scholar
• PlagemannPGRowlandRRCafrunyWAPolyclonal hypergammaglobulinemia and formation of hydrophobic immune complexes in porcine reproductive and respiratory syndrome virus-infected and uninfected pigsViral Immunol200518113814715802958
   PubMed Web of Science ®Google Scholar
• ButlerJEWertzNWeberPLagerKMPorcine reproductive and respiratory syndrome virus subverts repertoire development by proliferation of germline-encoded B cells of all isotypes bearing hydrophobic heavy chain CDR3J Immunol200818042347235618250444
   PubMed Web of Science ®Google Scholar
• KimHKimHKJungJHThe assessment of efficacy of porcine reproductive respiratory syndrome virus inactivated vaccine based on the viral quantity and inactivation methodsVirol J2011832321703032
   PubMed Web of Science ®Google Scholar
• VanheeMDelputtePLDelrueIGeldhofMFNauwynckHJDevelopment of an experimental inactivated PRRSV vaccine that induces virus-neutralizing antibodiesVet Res20094066319674539
   PubMed Web of Science ®Google Scholar
• RajapaksaTEBennettKMHamerMLytleCRodgersVGLoDDIntranasal M cell uptake of nanoparticles is independently influenced by targeting ligands and buffer ionic strengthJ Biol Chem201028531237392374620511224
   PubMed Web of Science ®Google Scholar
• AraujoLLöbenbergRKreuterJInfluence of the surfactant concentration on the body distribution of nanoparticlesJ Drug Target19996537338510342385
   PubMed Web of Science ®Google Scholar
• HeegaardPMDedieuLJohnsonNAdjuvants and delivery systems in veterinary vaccinology: current state and future developmentsArch Virol2011156218320221170730
   PubMed Web of Science ®Google Scholar
• HarmalaLAIngulliEGCurtsingerJMThe adjuvant effects of Mycobacterium tuberculosis heat shock protein 70 result from the rapid and prolonged activation of antigen-specific CD8+ T cells in vivoJ Immunol2002169105622562912421941
   PubMed Web of Science ®Google Scholar
• BansalKElluruSRNarayanaYPE_PGRS antigens of Mycobacterium tuberculosis induce maturation and activation of human dendritic cellsJ Immunol201018473495350420176745
   PubMed Web of Science ®Google Scholar
• LyckeNRecent progress in mucosal vaccine development: potential and limitationsNat Rev Immunol201212859260522828912
   PubMed Web of Science ®Google Scholar
• BinjawadagiBDwivediVManickamCTorrellesJBRenukaradhyaGJIntranasal delivery of an adjuvanted modified live porcine reproductive and respiratory syndrome virus vaccine reduces ROS productionViral Immunol201124647548222111597
   PubMed Web of Science ®Google Scholar
• DwivediVManickamCBinjawadagiBLinharesDMurtaughMPRenukaradhyaGJEvaluation of immune responses to porcine reproductive and respiratory syndrome virus in pigs during early stage of infection under farm conditionsVirol J201294522340040
   PubMed Web of Science ®Google Scholar
• ManickamCDwivediVMillerJPapenfussTRenukaradhyaGJMycobacterium tuberculosis whole cell lysate enhances proliferation of CD8 positive lymphocytes and nitric oxide secretion in the lungs of live porcine respiratory and reproductive syndrome virus vaccinated pigsViral Immunol201326110210823308386
   PubMed Web of Science ®Google Scholar
• AmorijJPKerstenGFSalujaVTowards tailored vaccine delivery: needs, challenges and perspectivesJ Control Release2012161236337622245687
   PubMed Web of Science ®Google Scholar
• BachmannMFJenningsGTVaccine delivery: a matter of size, geometry, kinetics and molecular patternsNat Rev Immunol2010101178779620948547
   PubMed Web of Science ®Google Scholar
• LopezOJOsorioFARole of neutralizing antibodies in PRRSV protective immunityVet Immunol Immunopathol2004102315516315507302
   PubMed Web of Science ®Google Scholar
• SpellbergBEdwardsJEType 1/Type 2 immunity in infectious diseasesClin Infect Dis20013217610211118387
   PubMed Web of Science ®Google Scholar
• SchlieheCRedaelliCEngelhardtSCD8- dendritic cells and macrophages cross-present poly(D,L-lactate-co-glycolate) acid microsphere-encapsulated antigen in vivoJ Immunol201118752112212121795597
   PubMed Web of Science ®Google Scholar
• DementoSLCuiWCriscioneJMRole of sustained antigen release from nanoparticle vaccines in shaping the T cell memory phenotypeBiomaterials201233194957496422484047
   PubMed Web of Science ®Google Scholar
• MaWChenMKaushalSPLGA nanoparticle-mediated delivery of tumor antigenic peptides elicits effective immune responsesInt J Nanomedicine201271475148722619507
   PubMed Web of Science ®Google Scholar
• SansonettiPJDi SantoJPDebugging how bacteria manipulate the immune responseImmunity200726214916117307704
   PubMed Web of Science ®Google Scholar
• OlinMRBatistaLXiaoZGammadelta lymphocyte response to porcine reproductive and respiratory syndrome virusViral Immunol200518349049916212527
   PubMed Web of Science ®Google Scholar
• ChongCSCaoMWongWWEnhancement of T helper type 1 immune responses against hepatitis B virus core antigen by PLGA nanoparticle vaccine deliveryJ Control Release20051021859915653136
   PubMed Web of Science ®Google Scholar
• ZimmermanJJBenfieldDDeeSPorcine reproductive and respiratory syndrome virus (Porcine Arterivirus)ZimmermanJJKarrikerLARamirezASchwartzKJStevensonGWDiseases of Swine, Tenth EditionWiley-BlackwellHoboken, NJ, USA2012461486
   Google Scholar
• WillsRWZimmermanJJYoonKJPorcine reproductive and respiratory syndrome virus: a persistent infectionVet Microbiol1997551–42312409220618
   PubMed Web of Science ®Google Scholar