Safety evaluation of poly(lactic-co-glycolic acid)/poly(lactic-acid) microspheres through intravitreal injection in rabbits

Xianfang Rong1 Department of Ophthalmology and Vision Science, Eye and ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China

Weien Yuan2 School of Pharmacy, Shanghai Jiao Tong University, Shanghai, People’s Republic of China

Yi Lu1 Department of Ophthalmology and Vision Science, Eye and ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of ChinaCorrespondence[email protected]

Xiaofen Mo1 Department of Ophthalmology and Vision Science, Eye and ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of ChinaCorrespondence[email protected]

Pages 3057-3068 | Published online: 24 Jun 2014

Cite this article
CrossMark

Full Article
Figures & data
References
Citations
Metrics
Licensing
Reprints & Permissions
View PDF PDF

References

FouldsWMoseleyHEadieAMcNaughtEVitreal, retinal, and pigment epithelial contribution to the posterior blood–ocular barrierTrans Ophthalmol Soc UK198010033413426946627
PubMedGoogle Scholar
GhateDEdelhauserHFOcular drug deliveryExpert Opin Drug Deliv20063227528716506953
PubMedGoogle Scholar
Cunha-VazJGThe blood–ocular barriers: past, present, and futureDoc Ophthalmol1997931–21491579476613
PubMed Web of Science ®Google Scholar
KearnsVRWilliamsRLDrug delivery systems for the eyeExpert Rev Med Devices20096327729019419285
PubMed Web of Science ®Google Scholar
TanitoMLiFElliottMHDittmarMAndersonREProtective effect of TEMPOL derivatives against light-induced retinal damage in ratsInvest Ophth Vis Sci200748419001905
PubMed Web of Science ®Google Scholar
RongXMoXRenTNeuroprotective effect of erythropoietin-loaded composite microspheres on retinal ganglion cells in ratsEur J Pharm Sci201143433434221621611
PubMed Web of Science ®Google Scholar
FrogerNCadettiLLorachHTaurine provides neuroprotection against retinal ganglion cell degenerationPLoS ONE2012710e4201723115615
PubMed Web of Science ®Google Scholar
GhateDEdelhauserHFBarriers to glaucoma drug deliveryJ Glaucoma200817214715618344762
PubMed Web of Science ®Google Scholar
PrasadAGSchadluRApteRSIntravitreal pharmacotherapy: applications in retinal diseaseCompr Ophthalmol Update20078525926918201513
PubMedGoogle Scholar
WadhwaSPaliwalRPaliwalSRVyasSNanocarriers in ocular drug delivery: an update reviewCurr Pharm Design2009152327242750
PubMed Web of Science ®Google Scholar
YasukawaTOguraYKimuraHSakuraiETabataYDrug delivery from ocular implantsExpert Opin Drug Deliv20063226127316506952
PubMedGoogle Scholar
SinhaVTrehanABiodegradable microspheres for protein deliveryJ Control Release200390326128012880694
PubMed Web of Science ®Google Scholar
SoppimathKSAminabhaviTMKulkarniARRudzinskiWEBiodegradable polymeric nanoparticles as drug delivery devicesJ Control Release200170112011166403
PubMed Web of Science ®Google Scholar
KreuterJNanoparticulate systems in drug delivery and targetingJ Drug Target1995331711738705247
PubMed Web of Science ®Google Scholar
RongXYangSMiaoHEffects of erythropoietin–dextran microparticle-based PLGA/PLA microspheres on RGCsInvest Ophth Vis Sci2012531060256034
PubMed Web of Science ®Google Scholar
GengYYuanWWuFChenJHeMJinTFormulating erythropoietin-loaded sustained-release PLGA microspheres without protein aggregationJ Control Release2008130325926518620011
PubMed Web of Science ®Google Scholar
Andrieu-SolerCAubert-PouësselADoatMIntravitreous injection of PLGA microspheres encapsulating GDNF promotes the survival of photoreceptors in the rd1/rd1 mouseMol Vis2005111002101116319820
PubMed Web of Science ®Google Scholar
ShmueliRBOhnakaMMikiALong-term suppression of ocular neovascularization by intraocular injection of biodegradable polymeric particles containing a serpin-derived peptideBiomaterials201334307544755123849876
PubMed Web of Science ®Google Scholar
JiangCMooreMJZhangXKlassenHLangerRYoungMIntravitreal injections of GDNF-loaded biodegradable microspheres are neuroprotective in a rat model of glaucomaMol Vis2007131783179217960131
PubMed Web of Science ®Google Scholar
O’CallaghanJAssessment of neurotoxicity: use of glial fibrillary acidic protein as a biomarkerBiomedical and environmental sciences: BES199141–21972061910596
PubMedGoogle Scholar
PengYAngMFooSBiocompatibility and biodegradation studies of subconjunctival implants in rabbit eyesPLoS ONE201167e2250721799878
PubMed Web of Science ®Google Scholar
GiarmoukakisALabirisGSideroudiHBiodegradable nanoparticles for controlled subconjunctival delivery of latanoprost acid: In vitro and in vivo evaluation. Preliminary resultsExp Eye Res2013112293623603320
PubMed Web of Science ®Google Scholar
DuvvuriSJanoriaKGPalDMitraAKControlled delivery of ganciclovir to the retina with drug-loaded poly(d,L-lactide-co-glycolide) (PLGA) microspheres dispersed in PLGA-PEG-PLGA gel: a novel intravitreal delivery system for the treatment of cytomegalovirus retinitisJ Ocul Pharmacol Th2007233264274
Web of Science ®Google Scholar
MoriteraTOguraYYoshimuraNBiodegradable microspheres containing adriamycin in the treatment of proliferative vitreoretinopathyInvest Ophth Vis Sci1992331131253130
Web of Science ®Google Scholar
WoldemussieEWijonoMRuizGMüller cell response to laser-induced increase in intraocular pressure in ratsGlia200447210911915185390
PubMed Web of Science ®Google Scholar
KaplanHJStreileinJWStevensTRTransplantation immunology of the anterior chamber of the eye II. Immune response to allogeneic cellsJ Immunol19751153805810239065
PubMed Web of Science ®Google Scholar
StreileinJWOcular immune privilege: therapeutic opportunities from an experiment of natureNat Rev Immunol200331187988914668804
PubMed Web of Science ®Google Scholar
NiederkornJYSee no evil, hear no evil, do no evil: the lessons of immune privilegeNat Immunol20067435435916550198
PubMed Web of Science ®Google Scholar
Schewitz-BowersLPLeeRWDickADImmune mechanisms of intraocular inflammationExpert Rev Ophthalmol2010514358
Google Scholar
ZhouRHoraiRSilverPBThe living eye “diarms” uncommitted autoreactive T cells by converting them to Foxp3+ regulatory cells following local antigen recognitionJ Immunol201218841742175022238462
PubMed Web of Science ®Google Scholar
RosolenSGKolomietsBVarelaOPicaudSRetinal electrophysiology for toxicology studies: applications and limits of ERG in animals and ex vivo recordingsExp Toxicol Pathol2008601173218294830
PubMedGoogle Scholar

Share icon
Back to Top

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.

People also read
Recommended articles
Cited by

To cite this article:

Reference style: APA Chicago Harvard

Citation copied to clipboard

Reference styles above use APA (6th edition), Chicago (16th edition) & Harvard (10th edition)

Download citation

Download a citation file in RIS format that can be imported by citation management software including EndNote, ProCite, RefWorks and Reference Manager.

Choose format: RIS BibTex RefWorks Direct Export

Choose options: Citation Citation & abstract Citation & references

Safety evaluation of poly(lactic-co-glycolic acid)/poly(lactic-acid) microspheres through intravitreal injection in rabbits

References

Information for

Open access

Opportunities

Help and information

Your download is now in progress and you may close this window

Login or register to access this feature

Safety evaluation of poly(lactic-co-glycolic acid)/poly(lactic-acid) microspheres through intravitreal injection in rabbits

References

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date