Lipocalin-2 Alleviates LPS-Induced Inflammation Through Alteration of Macrophage Properties

References

• Lin WW, Karin M. A cytokine-mediated link between innate immunity, inflammation, and cancer. J Clin Invest. 2007;117:1175–1183. doi:10.1172/JCI31537
   PubMed Web of Science ®Google Scholar
• Kolb R, Sutterwala FS, Zhang W. Obesity and cancer: inflammation bridges the two. Curr Opin Pharmacol. 2016;29:77–89. doi:10.1016/j.coph.2016.07.005
   PubMed Web of Science ®Google Scholar
• Hotamisligil GS. Inflammation and metabolic disorders. Nature. 2006;444:860–867. doi:10.1038/nature05485
   PubMed Web of Science ®Google Scholar
• Okin D, Medzhitov R. Evolution of inflammatory diseases. Curr Biol. 2012;22:R733–R740. doi:10.1016/j.cub.2012.07.029
   PubMed Web of Science ®Google Scholar
• Gordon S. Phagocytosis: an immunobiologic process. Immunity. 2016;44:463–475. doi:10.1016/j.immuni.2016.02.026
   PubMed Web of Science ®Google Scholar
• Epelman S, Lavine KJ, Randolph GJ. Origin and functions of tissue macrophages. Immunity. 2014;41:21–35. doi:10.1016/j.immuni.2014.06.013
   PubMed Web of Science ®Google Scholar
• Kjeldsen L, Johnsen AH, Sengeløv H, et al. Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase. J Biol Chem. 1993;268:10425–10432. doi:10.1016/S0021-9258(18)82217-7
   PubMed Web of Science ®Google Scholar
• Flower DR, North AC, Sansom CE. The lipocalin protein family: structural and sequence overview. Biochim Biophys Acta. 2000;1482:9–24. doi:10.1016/S0167-4838(00)00148-5
   PubMed Web of Science ®Google Scholar
• Goetz DH, Holmes MA, Borregaard N, et al. The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition. Mol Cell. 2002;10:1033–1043. doi:10.1016/S1097-2765(02)00708-6
   PubMed Web of Science ®Google Scholar
• Devireddy LR, Gazin C, Zhu X, et al. A cell-surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake. Cell. 2005;123:1293–1305. doi:10.1016/j.cell.2005.10.027
   PubMed Web of Science ®Google Scholar
• Mishra J, Dent C, Tarabishi R, et al. Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery. Lancet. 2005;365:1231–1238. doi:10.1016/S0140-6736(05)74811-X
   PubMed Web of Science ®Google Scholar
• Liu Z, Petersen R, Devireddy L. Impaired neutrophil function in 24p3 null mice contributes to enhanced susceptibility to bacterial infections. J Immunol. 2013;190:4692–4706. doi:10.4049/jimmunol.1202411
   PubMed Web of Science ®Google Scholar
• Flo TH, Smith KD, Sato S, et al. Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron. Nature. 2004;432:917–921. doi:10.1038/nature03104
   PubMed Web of Science ®Google Scholar
• Singh V, Yeoh BS, Chassaing B, et al. Microbiota-inducible innate immune, siderophore binding protein lipocalin 2 is critical for intestinal homeostasis. Cell Mol Gastroenterol Hepatol. 2016;2:482–498. doi:10.1016/j.jcmgh.2016.03.007
   PubMedGoogle Scholar
• Dittrich AM, Krokowski M, Meyer HA, et al. Lipocalin 2 protects against airway inflammation and hyperresponsiveness in a murine model of allergic airway disease. Clin Exp Allergy. 2010;40:1689–1700. doi:10.1111/j.1365-2222.2010.03508.x
   PubMed Web of Science ®Google Scholar
• Kang SS, Ren Y, Liu CC, et al. Lipocalin-2 protects the brain during inflammatory conditions. Mol Psychiatry. 2018;23:344–350. doi:10.1038/mp.2016.243
   PubMed Web of Science ®Google Scholar
• Nam Y, Kim JH, Seo M, et al. Lipocalin-2 protein deficiency ameliorates experimental autoimmune encephalomyelitis: the pathogenic role of lipocalin-2 in the central nervous system and peripheral lymphoid tissues. J Biol Chem. 2014;289:16773–16789. doi:10.1074/jbc.M113.542282
   PubMed Web of Science ®Google Scholar
• Jang E, Lee S, Kim JH, et al. Secreted protein lipocalin-2 promotes microglial M1 polarization. FASEB J. 2013;27:1176–1190. doi:10.1096/fj.12-222257
   PubMed Web of Science ®Google Scholar
• Zhang J, Wu Y, Zhang Y, et al. The role of lipocalin 2 in the regulation of inflammation in adipocytes and macrophages. Mol Endocrinol. 2008;22:1416–1426. doi:10.1210/me.2007-0420
   PubMedGoogle Scholar
• Moschen AR, Adolph TE, Gerner RR, et al. Lipocalin-2: a master mediator of intestinal and metabolic inflammation. Trends Endocrinol Metab. 2017;28:388–397. doi:10.1016/j.tem.2017.01.003
   PubMed Web of Science ®Google Scholar
• Wang Q, Li S, Tang X, et al. Lipocalin 2 protects against Escherichia coli infection by modulating neutrophil and macrophage function. Front Immunol. 2019;10:2594. doi:10.3389/fimmu.2019.02594
   PubMed Web of Science ®Google Scholar
• Tang W, Ma J, Gu R, et al. Lipocalin 2 suppressed ocular inflammation by inhibiting the activation of NF-κB pathway in endotoxin-induced uveitis. Cell Physiol Biochem. 2018;46:375–388. doi:10.1159/000488472
   PubMedGoogle Scholar
• Shi C, Pamer EG. Monocyte recruitment during infection and inflammation. Nat Rev Immunol. 2011;11:762–774. doi:10.1038/nri3070
   PubMed Web of Science ®Google Scholar
• Ginhoux F, Jung S. Monocytes and macrophages: developmental pathways and tissue homeostasis. Nat Rev Immunol. 2014;14:392–404. doi:10.1038/nri3671
   PubMed Web of Science ®Google Scholar
• Warszawska JM, Gawish R, Sharif O, et al. Lipocalin 2 deactivates macrophages and worsens pneumococcal pneumonia outcomes. J Clin Invest. 2013;123:3363–3372. doi:10.1172/JCI67911
   PubMed Web of Science ®Google Scholar
• Guo H, Jin D, Chen X. Lipocalin 2 is a regulator of macrophage polarization and NF-κB/STAT3 pathway activation. Mol Endocrinol. 2014;28:1616–1628. doi:10.1210/me.2014-1092
   PubMed Web of Science ®Google Scholar
• Hoh BL, Hosaka K, Downes DP, et al. Monocyte chemotactic protein-1 promotes inflammatory vascular repair of murine carotid aneurysms via a macrophage inflammatory protein-1α and macrophage inflammatory protein-2-dependent pathway. Circulation. 2011;124:2243–2252. doi:10.1161/CIRCULATIONAHA.111.036061
   PubMed Web of Science ®Google Scholar
• Han CZ, Juncadella IJ, Kinchen JM, et al. Macrophages redirect phagocytosis by non-professional phagocytes and influence inflammation. Nature. 2016;539:570–574. doi:10.1038/nature20141
   PubMed Web of Science ®Google Scholar
• Kourtzelis I, Hajishengallis G, Chavakis T. Phagocytosis of apoptotic cells in resolution of inflammation. Front Immunol. 2020;11:553. doi:10.3389/fimmu.2020.00553
   PubMed Web of Science ®Google Scholar
• Ravichandran KS. Find-me and eat-me signals in apoptotic cell clearance: progress and conundrums. J Exp Med. 2010;207:1807–1817. doi:10.1084/jem.20101157
   PubMed Web of Science ®Google Scholar
• Hanayama R, Tanaka M, Miwa K, et al. Identification of a factor that links apoptotic cells to phagocytes. Nature. 2002;417:182–187. doi:10.1038/417182a
   PubMed Web of Science ®Google Scholar
• Levine B, Mizushima N, Virgin HW. Autophagy in immunity and inflammation. Nature. 2011;469:323–335. doi:10.1038/nature09782
   PubMed Web of Science ®Google Scholar
• Deretic V, Klionsky DJ. Autophagy and inflammation: a special review issue. Autophagy. 2018;14:179–180. doi:10.1080/15548627.2017.1412229
   PubMed Web of Science ®Google Scholar
• Schroder K, Kanneganti TD, Shao F, et al. Mechanisms and consequences of inflammasome activation. J Mol Biol. 2018;430:131–132. doi:10.1016/j.jmb.2017.12.005
   PubMed Web of Science ®Google Scholar
• Singh SB, Davis AS, Taylor GA, et al. Human IRGM induces autophagy to eliminate intracellular mycobacteria. Science. 2006;313:1438–1441. doi:10.1126/science.1129577
   PubMed Web of Science ®Google Scholar