The Effects of Adoptively Transferred IL-23/IL-18-Polarized Neutrophils on Tumor and Collagen-Induced Arthritis in Mice

References

• Galli SJ, Borregaard N, Wynn TA. Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils. Nat Immunol. 2011;12(11):1035–1044. doi:10.1038/ni.2109
   PubMed Web of Science ®Google Scholar
• Li Y, Wang W, Yang F, Xu Y, Feng C, Zhao Y. The regulatory roles of neutrophils in adaptive immunity. Cell Commun Signal. 2019;17(1):147. doi:10.1186/s12964-019-0471-y
   PubMed Web of Science ®Google Scholar
• Xu Y, Zhang Q, Zhao Y. The functional diversity of neutrophils and clustered polarization of immunity. Cell Mol Immunol. 2020;17(11):1212–1214. doi:10.1038/s41423-020-0378-y
   PubMed Web of Science ®Google Scholar
• Tsuda Y, Takahashi H, Kobayashi M, Hanafusa T, Herndon DN, Suzuki F. Three different neutrophil subsets exhibited in mice with different susceptibilities to infection by methicillin-resistant Staphylococcus aureus. Immunity. 2004;21(2):215–226. doi:10.1016/j.immuni.2004.07.006
   PubMed Web of Science ®Google Scholar
• Chen F, Wu W, Millman A, et al. Neutrophils prime a long-lived effector macrophage phenotype that mediates accelerated helminth expulsion. Nat Immunol. 2014;15(10):938–946. doi:10.1038/ni.2984
   PubMed Web of Science ®Google Scholar
• Puga I, Cols M, Barra CM, et al. B cell-helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen. Nat Immunol. 2011;13(2):170–180. doi:10.1038/ni.2194
   PubMed Web of Science ®Google Scholar
• Deniset JF, Surewaard BG, Lee WY, Kubes P. Splenic Ly6G(high) mature and Ly6G(int) immature neutrophils contribute to eradication of S. pneumoniae. J Exp Med. 2017;214(5):1333–1350. doi:10.1084/jem.20161621
   PubMed Web of Science ®Google Scholar
• Tamassia N, Bianchetto-Aguilera F, Arruda-Silva F, et al. Cytokine production by human neutrophils: revisiting the “dark side of the moon”. Eur J Clin Invest. 2018;48(Suppl 2):e12952. doi:10.1111/eci.12952
   PubMedGoogle Scholar
• Sun B, Zhu L, Tao Y, et al. Characterization and allergic role of IL-33-induced neutrophil polarization. Cell Mol Immunol. 2018;15(8):782–793. doi:10.1038/cmi.2017.163
   PubMed Web of Science ®Google Scholar
• Taylor PR, Roy S, Leal SM Jr., et al. Activation of neutrophils by autocrine IL-17A-IL-17RC interactions during fungal infection is regulated by IL-6, IL-23, RORgammat and dectin-2. Nat Immunol. 2014;15(2):143–151. doi:10.1038/ni.2797
   PubMed Web of Science ®Google Scholar
• Ramirez-Velazquez CCE, Guido-Bayardo L, Ortiz-Navarrete V. IL-17-producing peripheral blood CD177+ neutrophils increase in allergic asthmatic subjects. Allergy Asthma Clin Immunol. 2013;9(1):23. doi:10.1186/1710-1492-9-23
   PubMed Web of Science ®Google Scholar
• Velden J, Paust HJ, Hoxha E, et al. Renal IL-17 expression in human ANCA-associated glomerulonephritis. Am J Physiol Renal Physiol. 2012;302(12):F1663–1673. doi:10.1152/ajprenal.00683.2011
   PubMed Web of Science ®Google Scholar
• Hu S, He W, Du X, et al. IL-17 production of neutrophils enhances antibacteria ability but promotes arthritis development during mycobacterium tuberculosis infection. EBioMedicine. 2017;23:88–99. doi:10.1016/j.ebiom.2017.08.001
   PubMed Web of Science ®Google Scholar
• Cai S, Batra S, Langohr I, Iwakura Y, Jeyaseelan S. IFN-gamma induction by neutrophil-derived IL-17A homodimer augments pulmonary antibacterial defense. Mucosal Immunol. 2016;9(3):718–729. doi:10.1038/mi.2015.95
   PubMed Web of Science ®Google Scholar
• Li Y, Zhu L, Chu Z, et al. Characterization and biological significance of IL-23-induced neutrophil polarization. Cell Mol Immunol. 2018;15(5):518–530. doi:10.1038/cmi.2017.39
   PubMed Web of Science ®Google Scholar
• Hu X, Wang P, Du J, et al. Phosphatase Wip1 masters IL-17-producing neutrophil-mediated colitis in mice. Inflamm Bowel Dis. 2016;22(6):1316–1325. doi:10.1097/MIB.0000000000000751
   PubMed Web of Science ®Google Scholar
• Ichii M, Oritani K, Toda J, et al. Signal-transducing adaptor protein-2 delays recovery of B lineage lymphocytes during hematopoietic stress. Haematologica. 2021;106(2):424–436. doi:10.3324/haematol.2019.225573
   PubMed Web of Science ®Google Scholar
• Chandrasekar B, Patel DN, Mummidi S, Kim JW, Clark RA, Valente AJ. Interleukin-18 suppresses adiponectin expression in 3T3-L1 adipocytes via a novel signal transduction pathway involving ERK1/2-dependent NFATc4 phosphorylation. J Biol Chem. 2008;283(7):4200–4209. doi:10.1074/jbc.M708142200
   PubMed Web of Science ®Google Scholar
• Singh A, Dashnyam M, Chim B, et al. Anxiolytic drug FGIN-1-27 ameliorates autoimmunity by metabolic reprogramming of pathogenic Th17 cells. Sci Rep. 2020;10(1):3766. doi:10.1038/s41598-020-60610-5
   PubMed Web of Science ®Google Scholar
• Shi H, Sun L, Wang Y, et al. N4BP1 negatively regulates NF-κB by binding and inhibiting NEMO oligomerization. Nat Commun. 2021;12(1):1379. doi:10.1038/s41467-021-21711-5
   PubMed Web of Science ®Google Scholar
• Lu Z, Miao Y, Muhammad I, et al. Colistin-induced autophagy and apoptosis involves the JNK-Bcl2-Bax signaling pathway and JNK-p53-ROS positive feedback loop in PC-12 cells. Chem Biol Interact. 2017;277:62–73. doi:10.1016/j.cbi.2017.08.011
   PubMed Web of Science ®Google Scholar
• Kong X, Chen Z, Xia Y, et al. Dehydrocorydaline accounts the majority of anti-inflammatory property of corydalis rhizoma in cultured macrophage. Evid Based Complement Alternat Med. 2020;2020:4181696. doi:10.1155/2020/4181696
   PubMed Web of Science ®Google Scholar
• Davies SP, Reddy H, Caivano M, Cohen P. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000;351(Pt 1):95–105. doi:10.1042/bj3510095
   PubMedGoogle Scholar
• Kim JA, Lee J, Margolis RL, Fotedar R. SP600125 suppresses Cdk1 and induces endoreplication directly from G2 phase, independent of JNK inhibition. Oncogene. 2010;29(11):1702–1716. doi:10.1038/onc.2009.464
   PubMed Web of Science ®Google Scholar
• Shi L, Tian H, Wang P, et al. Spaceflight and simulated microgravity suppresses macrophage development via altered RAS/ERK/NFkappaB and metabolic pathways. Cell Mol Immunol. 2021;18(6):1489–1502. doi:10.1038/s41423-019-0346-6
   PubMed Web of Science ®Google Scholar
• Pertea M, Kim D, Pertea GM, Leek JT, Salzberg SL. Transcript-level expression analysis of RNA-seq experiments with HISAT, StringTie and Ballgown. Nat Protoc. 2016;11(9):1650–1667. doi:10.1038/nprot.2016.095
   PubMed Web of Science ®Google Scholar
• Love MI, Huber W, Anders S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 2014;15(12):550. doi:10.1186/s13059-014-0550-8
   PubMed Web of Science ®Google Scholar
• Wu J, Mao X, Cai T, Luo J, Wei L. KOBAS server: a web-based platform for automated annotation and pathway identification. Nucleic Acids Res. 2006;34(WebServer issue):W720–724. doi:10.1093/nar/gkl167
   PubMed Web of Science ®Google Scholar
• Shannon P, Markiel A, Ozier O, et al. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 2003;13(11):2498–2504. doi:10.1101/gr.1239303
   PubMed Web of Science ®Google Scholar
• Chu Z, Sun C, Sun L, et al. Primed macrophages directly and specifically reject allografts. Cell Mol Immunol. 2020;17(3):237–246. doi:10.1038/s41423-019-0226-0
   PubMed Web of Science ®Google Scholar
• Wu T, Zhao Y, Wang H, et al. mTOR masters monocytic myeloid-derived suppressor cells in mice with allografts or tumors. Sci Rep. 2016;6(1):20250. doi:10.1038/srep20250
   PubMedGoogle Scholar
• Hou Y, Lin H, Zhu L, et al. Lipopolysaccharide increases the incidence of collagen-induced arthritis in mice through induction of protease HTRA-1 expression. Arthritis Rheum. 2013;65(11):2835–2846. doi:10.1002/art.38124
   PubMedGoogle Scholar
• Yoo JK, Kwon H, Khil LY, Zhang L, Jun HS, Yoon JW. IL-18 induces monocyte chemotactic protein-1 production in macrophages through the phosphatidylinositol 3-kinase/Akt and MEK/ERK1/2 pathways. J Immunol. 2005;175(12):8280–8286. doi:10.4049/jimmunol.175.12.8280
   PubMed Web of Science ®Google Scholar
• Furumaya C, Martinez-Sanz P, Bouti P, Kuijpers TW, Matlung HL. Plasticity in pro- and anti-tumor activity of neutrophils: shifting the balance. Front Immunol. 2020;11:2100. doi:10.3389/fimmu.2020.02100
   PubMed Web of Science ®Google Scholar
• Lubberts E. The IL-23-IL-17 axis in inflammatory arthritis. Nat Rev Rheumatol. 2015;11(7):415–429. doi:10.1038/nrrheum.2015.53
   PubMed Web of Science ®Google Scholar
• Vecellio M, Hake VX, Davidson C, Carena MC, Wordsworth BP, Selmi C. The IL-17/IL-23 axis and its genetic contribution to psoriatic arthritis. Front Immunol. 2020;11:596086. doi:10.3389/fimmu.2020.596086
   PubMed Web of Science ®Google Scholar
• Astry B, Venkatesha SH, Moudgil KD. Involvement of the IL-23/IL-17 axis and the Th17/Treg balance in the pathogenesis and control of autoimmune arthritis. Cytokine. 2015;74(1):54–61. doi:10.1016/j.cyto.2014.11.020
   PubMed Web of Science ®Google Scholar
• Ratsimandresy RA, Indramohan M, Dorfleutner A, Stehlik C. The AIM2 inflammasome is a central regulator of intestinal homeostasis through the IL-18/IL-22/STAT3 pathway. Cell Mol Immunol. 2017;14(1):127–142. doi:10.1038/cmi.2016.35
   PubMed Web of Science ®Google Scholar
• Hou Y, Zhu L, Tian H, et al. IL-23-induced macrophage polarization and its pathological roles in mice with imiquimod-induced psoriasis. Protein Cell. 2018;9(12):1027–1038. doi:10.1007/s13238-018-0505-z
   PubMed Web of Science ®Google Scholar
• Venken K, Jacques P, Mortier C, et al. RORgammat inhibition selectively targets IL-17 producing iNKT and gammadelta-T cells enriched in Spondyloarthritis patients. Nat Commun. 2019;10(1):9. doi:10.1038/s41467-018-07911-6
   PubMedGoogle Scholar
• Mangan PR, Harrington LE, O’Quinn DB, et al. Transforming growth factor-beta induces development of the T(H)17 lineage. Nature. 2006;441(7090):231–234. doi:10.1038/nature04754
   PubMed Web of Science ®Google Scholar
• Hasan Z, Koizumi SI, Sasaki D, et al. JunB is essential for IL-23-dependent pathogenicity of Th17 cells. Nat Commun. 2017;8(1):15628. doi:10.1038/ncomms15628
   PubMedGoogle Scholar
• Durant L, Watford WT, Ramos HL, et al. Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis. Immunity. 2010;32(5):605–615. doi:10.1016/j.immuni.2010.05.003
   PubMed Web of Science ®Google Scholar
• Honorati MC, Neri S, Cattini L, Facchini A. Interleukin-17, a regulator of angiogenic factor release by synovial fibroblasts. Osteoarthritis Cartilage. 2006;14(4):345–352. doi:10.1016/j.joca.2005.10.004
   PubMed Web of Science ®Google Scholar
• Li X, Bechara R, Zhao J, McGeachy MJ, Gaffen SL. IL-17 receptor-based signaling and implications for disease. Nat Immunol. 2019;20(12):1594–1602. doi:10.1038/s41590-019-0514-y
   PubMed Web of Science ®Google Scholar
• Li S, Cong X, Gao H, et al. Tumor-associated neutrophils induce EMT by IL-17a to promote migration and invasion in gastric cancer cells. J Exp Clin Cancer Res. 2019;38(1):6. doi:10.1186/s13046-018-1003-0
   PubMed Web of Science ®Google Scholar
• Jungnickel C, Schmidt LH, Bittigkoffer L, et al. IL-17C mediates the recruitment of tumor-associated neutrophils and lung tumor growth. Oncogene. 2017;36(29):4182–4190. doi:10.1038/onc.2017.28
   PubMed Web of Science ®Google Scholar
• Waugh DJ, Wilson C. The interleukin-8 pathway in cancer. Clin Cancer Res. 2008;14(21):6735–6741. doi:10.1158/1078-0432.CCR-07-4843
   PubMed Web of Science ®Google Scholar
• Lee JW, Wang P, Kattah MG, et al. Differential regulation of chemokines by IL-17 in colonic epithelial cells. J Immunol. 2008;181(9):6536–6545. doi:10.4049/jimmunol.181.9.6536
   PubMed Web of Science ®Google Scholar
• Numasaki M, Watanabe M, Suzuki T, et al. IL-17 enhances the net angiogenic activity and in vivo growth of human non-small cell lung cancer in SCID mice through promoting CXCR-2-dependent angiogenesis. J Immunol. 2005;175(9):6177–6189. doi:10.4049/jimmunol.175.9.6177
   PubMed Web of Science ®Google Scholar
• Li TJ, Jiang YM, Hu YF, et al. Interleukin-17-producing neutrophils link inflammatory stimuli to disease progression by promoting angiogenesis in gastric cancer. Clin Cancer Res. 2017;23(6):1575–1585. doi:10.1158/1078-0432.CCR-16-0617
   PubMed Web of Science ®Google Scholar
• Fabrice Benchetrit AC, Vives V, Warnier G, Gey A. Interleukin-17 inhibits tumor cell growth by means of a T-cell-dependent mechanism. Blood. 2002;99(6):2114–2121. doi:10.1182/blood.V99.6.2114
   PubMed Web of Science ®Google Scholar
• Moran EM, Mullan R, McCormick J, et al. Human rheumatoid arthritis tissue production of IL-17A drives matrix and cartilage degradation: synergy with tumour necrosis factor-alpha, Oncostatin M and response to biologic therapies. Arthritis Res Ther. 2009;11(4):R113. doi:10.1186/ar2772
   PubMed Web of Science ®Google Scholar
• Rosu AMC, Stepan A, Musetescu A, Ene M. IL-17 patterns in synovium, serum and synovial fluid from treatment-naive, early rheumatoid arthritis patients. Rom J Morphol Embryol. 2012;53(1):73–80.
   PubMed Web of Science ®Google Scholar
• Pickens SR, Volin MV, Mandelin AM 2nd, Kolls JK, Pope RM, Shahrara S. IL-17 contributes to angiogenesis in rheumatoid arthritis. J Immunol. 2010;184(6):3233–3241. doi:10.4049/jimmunol.0903271
   PubMed Web of Science ®Google Scholar
• Chabaud MLE, Joosten L, van Den Berg W, Miossec P. IL-17 derived from juxta-articular bone and synovium contributes to joint degradation in rheumatoid arthritis. Arthritis Res. 2001;3(3):168–177. doi:10.1186/ar294
   PubMedGoogle Scholar
• Dudler J, Renggli-Zulliger N, Busso N, Lotz M, So A. Effect of interleukin 17 on proteoglycan degradation in murine knee joints. Ann Rheum Dis. 2000;59(7):529–532. doi:10.1136/ard.59.7.529
   PubMed Web of Science ®Google Scholar
• Nakae SSS, Horai R, Sudo K, Mori S, Iwakura Y. IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist. Proc Natl Acad Sci U S A. 2003;100(10):5986–5990. doi:10.1073/pnas.1035999100
   PubMed Web of Science ®Google Scholar
• Liang SC, Tan XY, Luxenberg DP, et al. Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. J Exp Med. 2006;203(10):2271–2279. doi:10.1084/jem.20061308
   PubMed Web of Science ®Google Scholar
• Zheng Y, Valdez PA, Danilenko DM, et al. Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens. Nat Med. 2008;14(3):282–289. doi:10.1038/nm1720
   PubMed Web of Science ®Google Scholar
• Miyazaki Y, Nakayamada S, Kubo S, et al. Th22 cells promote osteoclast differentiation via production of IL-22 in rheumatoid arthritis. Front Immunol. 2018;9:2901. doi:10.3389/fimmu.2018.02901
   PubMed Web of Science ®Google Scholar
• Zhao LJZ, Jiang Y, Ma N, Zhang Y, Feng L, Wang K. IL-22+CD4+T cells in patients with rheumatoid arthritis. Int J Rheum Dis. 2013;16(5):518–526. doi:10.1111/1756-185X.12099
   PubMed Web of Science ®Google Scholar
• Leipe J, Schramm MA, Grunke M, et al. Interleukin 22 serum levels are associated with radiographic progression in rheumatoid arthritis. Ann Rheum Dis. 2011;70(8):1453–1457. doi:10.1136/ard.2011.152074
   PubMed Web of Science ®Google Scholar
• Corneth OBJ, Reijmers RM, Mus AMC, et al. Loss of IL-22 inhibits autoantibody formation in collagen-induced arthritis in mice. Eur J Immunol. 2016;46(6):1404–1414. doi:10.1002/eji.201546241
   PubMed Web of Science ®Google Scholar
• van Hamburg JP, Corneth OB, Paulissen SM, et al. IL-17/Th17 mediated synovial inflammation is IL-22 independent. Ann Rheum Dis. 2013;72(10):1700–1707. doi:10.1136/annrheumdis-2012-202373
   PubMed Web of Science ®Google Scholar