Aberrant Fluid Shear Stress Contributes to Articular Cartilage Pathogenesis via Epigenetic Regulation of ZBTB20 by H3K4me3

References

• Englund M, Roemer FW, Hayashi D, Crema MD, Guermazi A. Meniscus pathology, osteoarthritis and the treatment controversy. Nat Rev Rheumatol. 2012;8(7):412–419. doi:10.1038/nrrheum.2012.69
   PubMed Web of Science ®Google Scholar
• Martel-Pelletier J, Barr AJ, Cicuttini FM, et al. Osteoarthritis. Nat Rev Dis Primers. 2016;2:16072. doi:10.1038/nrdp.2016.72
   PubMed Web of Science ®Google Scholar
• Hunter DJ, Schofield D, Callander E. The individual and socioeconomic impact of osteoarthritis. Nat Rev Rheumatol. 2014;10(7):437–441. doi:10.1038/nrrheum.2014.44
   PubMed Web of Science ®Google Scholar
• Guilak F. Biomechanical factors in osteoarthritis. Best Pract Res Clin Rheumatol. 2011;25(6):815–823. doi:10.1016/j.berh.2011.11.013
   PubMed Web of Science ®Google Scholar
• Yokota H, Goldring MB, Sun HB. CITED2-mediated regulation of MMP-1 and MMP-13 in human chondrocytes under flow shear. J Biol Chem. 2003;278(47):47275–47280. doi:10.1074/jbc.M304652200
   PubMed Web of Science ®Google Scholar
• Buckwalter JA, Martin JA, Brown TD. Perspectives on chondrocyte mechanobiology and osteoarthritis. Biorheology. 2006;43(3–4):603–609.
   PubMed Web of Science ®Google Scholar
• Kerin A, Patwari P, Kuettner K, Cole A, Grodzinsky A. Molecular basis of osteoarthritis: biomechanical aspects. Cell Mol Life Sci. 2002;59(1):27–35. doi:10.1007/s00018-002-8402-1
   PubMed Web of Science ®Google Scholar
• Healy ZR, Lee NH, Gao X, et al. Divergent responses of chondrocytes and endothelial cells to shear stress: cross-talk among COX-2, the Phase 2 response, and apoptosis. Proc Natl Acad Sci USA. 2005;102(39):14010–14015. doi:10.1073/pnas.0506620102
   PubMed Web of Science ®Google Scholar
• Carter DR, Wong M. Modelling cartilage mechanobiology. Philos Trans R Soc Lond B Biol Sci. 2003;358(1437):1461–1471. doi:10.1098/rstb.2003.1346
   PubMed Web of Science ®Google Scholar
• Carter DR, Beaupre GS, Wong M, Smith RL, Andriacchi TP, Schurman DJ. The mechanobiology of articular cartilage development and degeneration. Clin Orthop Relat Res. 2004;427(427 Suppl):S69–77. doi:10.1097/01.blo.0000144970.05107.7e
   Google Scholar
• Wang P, Guan PP, Guo C, Zhu F, Konstantopoulos K, Wang ZY. Fluid shear stress-induced osteoarthritis: roles of cyclooxygenase-2 and its metabolic products in inducing the expression of proinflammatory cytokines and matrix metalloproteinases. FASEB J. 2013;27(12):4664–4677. doi:10.1096/fj.13-234542
   PubMed Web of Science ®Google Scholar
• Hunziker EB. Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects. Osteoarthritis Cartilage. 2002;10(6):432–463.
   PubMed Web of Science ®Google Scholar
• Kan RL, Chen J, Sallam T. Crosstalk between epitranscriptomic and epigenetic mechanisms in gene regulation. Trends Genet. 2021. doi:10.1016/j.tig.2021.06.014
   PubMed Web of Science ®Google Scholar
• Yuan G, Flores NM, Hausmann S, et al. Elevated NSD3 histone methylation activity drives squamous cell lung cancer. Nature. 2021;590(7846):504–508. doi:10.1038/s41586-020-03170-y
   PubMed Web of Science ®Google Scholar
• Zhang H, Ji L, Yang Y, Zhang X, Gang Y, Bai L. The role of HDACs and HDACi in cartilage and osteoarthritis. Front Cell Dev Biol. 2020;8:560117. doi:10.3389/fcell.2020.560117
   PubMed Web of Science ®Google Scholar
• Wen ZH, Huang JS, Lin YY, et al. Chondroprotective effects of a histone deacetylase inhibitor, panobinostat, on pain behavior and cartilage degradation in anterior cruciate ligament transection-induced experimental osteoarthritic rats. Int J Mol Sci. 2021;22:14. doi:10.3390/ijms22147290
   Web of Science ®Google Scholar
• Wang J, Wang X, Ding X, Huang T, Song D, Tao H. EZH2 is associated with cartilage degeneration in osteoarthritis by promoting SDC1 expression via histone methylation of the microRNA-138 promoter. Lab Invest. 2021;101(5):600–611. doi:10.1038/s41374-021-00532-6
   PubMed Web of Science ®Google Scholar
• Yang D, Okamura H, Nakashima Y, Haneji T. Histone demethylase Jmjd3 regulates osteoblast differentiation via transcription factors Runx2 and osterix. J Biol Chem. 2013;288(47):33530–33541. doi:10.1074/jbc.M113.497040
   PubMed Web of Science ®Google Scholar
• Ye L, Fan Z, Yu B, et al. Histone demethylases KDM4B and KDM6B promote osteogenic differentiation of human MSCs. Cell Stem Cell. 2018;23(6):898–899. doi:10.1016/j.stem.2018.11.002
   PubMed Web of Science ®Google Scholar
• Kaya-Okur HS, Wu SJ, Codomo CA, et al. CUT&Tag for efficient epigenomic profiling of small samples and single cells. Nat Commun. 2019;10(1):1930. doi:10.1038/s41467-019-09982-5
   PubMed Web of Science ®Google Scholar
• Lu L, Zhang X, Zhang M, et al. RANTES and SDF-1 are keys in cell-based therapy of TMJ osteoarthritis. J Dent Res. 2015;94(11):1601–1609. doi:10.1177/0022034515604621
   PubMed Web of Science ®Google Scholar
• Liu YD, Liao LF, Zhang HY, et al. Reducing dietary loading decreases mouse temporomandibular joint degradation induced by anterior crossbite prosthesis. Osteoarthritis Cartilage. 2014;22(2):302–312. doi:10.1016/j.joca.2013.11.014
   PubMed Web of Science ®Google Scholar
• Weng Y, Liu Y, Du H, et al. Glycosylation of DMP1 is essential for chondrogenesis of Condylar cartilage. J Dent Res. 2017;96(13):1535–1545. doi:10.1177/0022034517717485
   PubMed Web of Science ®Google Scholar
• Bernstein BE, Kamal M, Lindblad-Toh K, et al. Genomic maps and comparative analysis of histone modifications in human and mouse. Cell. 2005;120(2):169–181. doi:10.1016/j.cell.2005.01.001
   PubMed Web of Science ®Google Scholar
• Cherifi C, Monteagudo S, Lories RJ. Promising targets for therapy of osteoarthritis: a review on the Wnt and TGF-beta signalling pathways. Ther Adv Musculoskelet Dis. 2021;13:1759720X211006959. doi:10.1177/1759720X211006959
   PubMed Web of Science ®Google Scholar
• Lories RJ, Monteagudo S. Review article: is Wnt signaling an attractive target for the treatment of osteoarthritis? Rheumatol Ther. 2020;7(2):259–270. doi:10.1007/s40744-020-00205-8
   PubMed Web of Science ®Google Scholar
• Sun JL, Yan JF, Yu SB, Zhao J, Lin QQ, Jiao K. MicroRNA-29b promotes subchondral bone loss in TMJ osteoarthritis. J Dent Res. 2020;99(13):1469–1477. doi:10.1177/0022034520937617
   PubMed Web of Science ®Google Scholar
• Zhang J, Liao L, Zhu J, et al. Osteochondral interface stiffening in mandibular Condylar osteoarthritis. J Dent Res. 2018;97(5):563–570. doi:10.1177/0022034517748562
   PubMed Web of Science ®Google Scholar
• Mathiessen A, Conaghan PG. Synovitis in osteoarthritis: current understanding with therapeutic implications. Arthritis Res Ther. 2017;19(1):18. doi:10.1186/s13075-017-1229-9
   PubMed Web of Science ®Google Scholar
• Belluzzi E, Macchi V, Fontanella CG, et al. Infrapatellar fat pad gene expression and protein production in patients with and without osteoarthritis. Int J Mol Sci. 2020;21:17. doi:10.3390/ijms21176016
   Web of Science ®Google Scholar
• Donell S. Subchondral bone remodelling in osteoarthritis. EFORT Open Rev. 2019;4(6):221–229. doi:10.1302/2058-5241.4.180102
   PubMed Web of Science ®Google Scholar
• Adams MA. The mechanical environment of chondrocytes in articular cartilage. Biorheology. 2006;43(3–4):537–545.
   PubMed Web of Science ®Google Scholar
• Jin J, Jaspers RT, Wu G, Korfage JAM, Klein-Nulend J, Bakker AD. Shear stress modulates osteoblast cell and nucleus morphology and volume. Int J Mol Sci. 2020;21:21. doi:10.3390/ijms21218361
   Web of Science ®Google Scholar
• Ye X, Zhao Q, Sun X, Li H. Enhancement of mesenchymal stem cell attachment to decellularized porcine aortic valve scaffold by in vitro coating with antibody against CD90: a preliminary study on antibody-modified tissue-engineered heart valve. Tissue Eng Part A. 2009;15(1):1–11. doi:10.1089/ten.tea.2008.0001
   PubMed Web of Science ®Google Scholar
• Maleszewska M, Vanchin B, Harmsen MC, Krenning G. The decrease in histone methyltransferase EZH2 in response to fluid shear stress alters endothelial gene expression and promotes quiescence. Angiogenesis. 2016;19(1):9–24. doi:10.1007/s10456-015-9485-2
   PubMed Web of Science ®Google Scholar
• Chang SF, Huang KC, Chang HI, Lee KC, Su YP, Chen CN. 2 dyn/cm(2) shear force upregulates kruppel-like factor 4 expression in human chondrocytes to inhibit the interleukin-1beta-activated nuclear factor-kappaB. J Cell Physiol. 2018;234(1):958–968. doi:10.1002/jcp.26924
   PubMed Web of Science ®Google Scholar
• Guan PP, Ding WY, Wang P. The roles of prostaglandin F2 in regulating the expression of matrix metalloproteinase-12 via an insulin growth factor-2-dependent mechanism in sheared chondrocytes. Signal Transduct Target Ther. 2018;3:27. doi:10.1038/s41392-018-0029-2
   PubMed Web of Science ®Google Scholar
• Wang P, Zhu F, Konstantopoulos K. The antagonistic actions of endogenous interleukin-1beta and 15-deoxy-Delta12,14-prostaglandin J2 regulate the temporal synthesis of matrix metalloproteinase-9 in sheared chondrocytes. J Biol Chem. 2012;287(38):31877–31893. doi:10.1074/jbc.M112.362731
   PubMed Web of Science ®Google Scholar
• Wang P, Zhu F, Tong Z, Konstantopoulos K. Response of chondrocytes to shear stress: antagonistic effects of the binding partners Toll-like receptor 4 and caveolin-1. FASEB J. 2011;25(10):3401–3415. doi:10.1096/fj.11-184861
   PubMed Web of Science ®Google Scholar
• Grandi FC, Bhutani N. Epigenetic Therapies for Osteoarthritis. Trends Pharmacol Sci. 2020;41(8):557–569. doi:10.1016/j.tips.2020.05.008
   PubMed Web of Science ®Google Scholar
• Fujita N, Matsushita T, Ishida K, et al. Potential involvement of SIRT1 in the pathogenesis of osteoarthritis through the modulation of chondrocyte gene expressions. J Orthop Res. 2011;29(4):511–515. doi:10.1002/jor.21284
   PubMed Web of Science ®Google Scholar
• Sun Y, Preiss NK, Valenteros KB, et al. Zbtb20 restrains CD8 T cell immunometabolism and restricts memory differentiation and antitumor immunity. J Immunol. 2020;205(10):2649–2666. doi:10.4049/jimmunol.2000459
   PubMed Web of Science ®Google Scholar
• Ren AJ, Wang K, Zhang H, et al. ZBTB20 regulates nociception and pain sensation by modulating TRP channel expression in nociceptive sensory neurons. Nat Commun. 2014;5:4984. doi:10.1038/ncomms5984
   PubMed Web of Science ®Google Scholar
• Nagao M, Ogata T, Sawada Y, Gotoh Y. Zbtb20 promotes astrocytogenesis during neocortical development. Nat Commun. 2016;7:11102. doi:10.1038/ncomms11102
   PubMed Web of Science ®Google Scholar
• Liu X, Zhang P, Bao Y, et al. Zinc finger protein ZBTB20 promotes toll-like receptor-triggered innate immune responses by repressing IkappaBalpha gene transcription. Proc Natl Acad Sci U S A. 2013;110(27):11097–11102. doi:10.1073/pnas.1301257110
   PubMed Web of Science ®Google Scholar
• Zhou G, Jiang X, Zhang H, et al. Zbtb20 regulates the terminal differentiation of hypertrophic chondrocytes via repression of Sox9. Development. 2015;142(2):385–393. doi:10.1242/dev.108530
   PubMed Web of Science ®Google Scholar
• Lories RJ, Peeters J, Bakker A, et al. Articular cartilage and biomechanical properties of the long bones in Frzb-knockout mice. Arthritis Rheum. 2007;56(12):4095–4103. doi:10.1002/art.23137
   PubMedGoogle Scholar
• Zhu M, Tang D, Wu Q, et al. Activation of beta-catenin signaling in articular chondrocytes leads to osteoarthritis-like phenotype in adult beta-catenin conditional activation mice. J Bone Miner Res. 2009;24(1):12–21. doi:10.1359/jbmr.080901
   PubMed Web of Science ®Google Scholar
• Sun JL, Yan JF, Li J, et al. Conditional deletion of Adrb2 in mesenchymal stem cells attenuates osteoarthritis-like defects in temporomandibular joint. Bone. 2020;133:115229. doi:10.1016/j.bone.2020.115229
   PubMed Web of Science ®Google Scholar
• Liu Q, Yang H, Zhang M, et al. Initiation and progression of dental-stimulated temporomandibular joints osteoarthritis. Osteoarthritis Cartilage. 2021;29(5):633–642. doi:10.1016/j.joca.2020.12.016
   PubMed Web of Science ®Google Scholar