Lactobacillus fermentum ZS09 Mediates Epithelial–Mesenchymal Transition (EMT) by Regulating the Transcriptional Activity of the Wnt/β-Catenin Signalling Pathway to Inhibit Colon Cancer Activity

References

• Clerici SP, Peppelenbosch M, Fuhler G, Sílvio RC, Carmen VFH. Colorectal cancer cell-derived small extracellular vesicles educate human fibroblasts to stimulate migratory capacity. Front Cell Dev Biol. 2021;9:696373. doi:10.3389/fcell.2021.696373
   PubMed Web of Science ®Google Scholar
• Yamada N, Kuranaga Y, Kumazaki M, et al. Colorectal cancer cell-derived extracellular vesicles induce phenotypic alteration of t cells into tumor-growth supporting cells with transforming growth factor-β1-mediated suppression. Oncotarget. 2016;7:27033–27043. doi:10.18632/oncotarget.7041
   PubMedGoogle Scholar
• Girardin M, Seidman EG. Indications for the use of probiotics in gastrointestinal diseases. Digest Dis. 2011;29:574–587. doi:10.1159/000332980
   PubMed Web of Science ®Google Scholar
• Wang F, Qin HL. Changes of intestinal flora after gastrointestinal surgery: clinical significance of intestinal environment reconstruction. Chin J Gastrointest Surg. 2020;23:27–31. doi:10.3760/cma.j.cn.441530-20200416-00220
   Google Scholar
• He JD, Kong C, Gao RY, Yin F, Zhang Y, Qin HL. Effects of probiotics on the intestinal microecological abnormalities and colorectal cancer of mice induced by high-fat diet. Chin J Gastrointest Surg. 2020;23:77–85. doi:10.3760/cma.j.cn.441530-20200417-00223
   Google Scholar
• Yang L, Guo H, Shen YL, et al. Analysis of the influence of probiotics on intestinal micro-ecology and related diseases. J Integrat Nurs. 2019;1:163–169. doi:10.35437/intnur.issn.2663-4481.2019.01.03.07
   Google Scholar
• Adnan A, Motevaseli E, Sadroddiny E. The effects lactobacillus crispatus probiotics on proliferation and metastasis of cervical cancer cell line using 3D cell culture. Indian J Public Health Res Dev. 2018;9:401. doi:10.5958/0976-5506.2018.01870.3
   Google Scholar
• Escamilla J, Lane MA, Maitin V. Cell-free supernatants from probiotic lactobacillus casei and lactobacillus rhamnosus GG decrease colon cancer cell invasion in vitro. Nutr Cancer. 2012;64:871–878. doi:10.1080/01635581.2012.700758
   PubMed Web of Science ®Google Scholar
• Yuan L, Zhou M, Huang D, et al. Resveratrol inhibits the invasion and metastasis of colon cancer through reversal of epithelial mesenchymal transition via the akt/gsk3β/snail signaling pathway. Mol Med Rep. 2019;20:2783–2795. doi:10.3892/mmr.2019.10528
   PubMed Web of Science ®Google Scholar
• Guarino M, Rubino B, Ballabio G. The role of epithelial-mesenchymal transition in cancer pathology. Pathologe. 2007;39:305–318.
   Google Scholar
• Radisky DC. Epithelial-mesenchymal transition. Cancer Res. 2008;68:9574. doi:10.1158/0008-5472.CAN-08-2316
   PubMed Web of Science ®Google Scholar
• Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition. J Clin Invest. 2015;119:1420–1428. doi:10.1172/JCI39104
   Google Scholar
• Ekem B, Gong W, Han L, et al. Involvement of wnt/β-catenin pathway in the inhibition of invasion and epithelial-mesenchymal transition in ovarian cancer cells. Trop J Pharm Res. 2020;19:1365–1370. doi:10.4314/tjpr.v19i7.4
   Web of Science ®Google Scholar
• Gu J, Cui CF, Yang L, Wang L, Jiang XH. Emodin inhibits colon cancer cell invasion and migration by suppressing epithelialmesenchymal transition via the wnt/β-catenin pathway. Oncol Res. 2018;27:193–202. doi:10.3727/096504018X15150662230295
   PubMed Web of Science ®Google Scholar
• Drisko JA, Giles CK, Bischoff BJ. Probiotics in health maintenance and disease prevention. Altern Med Rev. 2003;8:143–155.
   PubMedGoogle Scholar
• Bubnov RV, Spivak MY, Lazarenko LM, Bomba A, Boyko NV. Probiotics and immunity: provisional role for personalized diets and disease prevention. EPMA J. 2015;6:14–25. doi:10.1186/s13167-015-0036-0
   PubMed Web of Science ®Google Scholar
• Hwang S, Jo M, Hong JE, Park CO, Lee CG, Rhee KJ. Protective effects of zerumbone on colonic tumorigenesis in enterotoxigenic bacteroides fragilis (ETBF)-colonized AOM/DSS balb/c mice. Int J Mol Sci. 2020;21:857–870. doi:10.3390/ijms21030857
   PubMed Web of Science ®Google Scholar
• Fazio VM, Robertis MD, Massi E, et al. The AOM/DSS murine model for the study of colon carcinogenesis: from pathways to diagnosis and therapy studies. J Carcinog. 2011;10:9–12. doi:10.4103/1477-3163.78279
   PubMedGoogle Scholar
• Liu ZL, Li LF, Xia SS, et al. Chondroitin sulfate modification enhances the targeting and therapeutic effect of nanomedicine on aom/dss-induced mouse colon cancer. J Drug Deliv Sci Technol. 2019;52:1–7. doi:10.1016/j.jddst.2019.04.010
   Web of Science ®Google Scholar
• Yan S, Wang H, Chen X, Liang C, Shang W. Mir-182-5p inhibits colon cancer tumorigenesis, angiogenesis, and lymphangiogenesis by directly downregulating VEGF-C. Cancer Lett. 2020;488:18–26. doi:10.1016/j.canlet.2020.04.021
   PubMed Web of Science ®Google Scholar
• Liu ZY, Qi LS, Li YX, Zhao XL, Sun BC. Vegfr2 regulates endothelial differentiation of colon cancer cells. BMC Cancer. 2017;17:593–604. doi:10.1186/s12885-017-3578-9
   PubMed Web of Science ®Google Scholar
• Wang RH, Xie JG, Chen H, Ren TT, Zhang YC. [Expression of angiopoietin-2 and vascular endothelial growth factor in human colon cancer]. Nan Fang Yi Ke Da Xue Xue Bao = Journal of Southern Medical University. 2013;33(8):1236–1239. Chinese.
   PubMedGoogle Scholar
• Claesson‐Welsh L, Welsh M. Vegfa and tumour angiogenesis. J Intern Med. 2013;273:114–127. doi:10.1111/joim.12019
   PubMed Web of Science ®Google Scholar
• Zucker S, Vacirca J. Role of matrix metalloproteinases (MMPs) in colorectal cancer. Cancer Metastasis Rev. 2004;23(1/2):101–117. doi:10.1023/A:1025867130437
   PubMed Web of Science ®Google Scholar
• Gallego-Fabrega C, Cullell N, Soriano-Tárraga C, et al. DNA methylation of mmps and timps in atherothrombosis process in carotid plaques and blood tissues. Oncotarget. 2020;11(10):905–912. doi:10.18632/oncotarget.27469
   PubMedGoogle Scholar
• Sun P, Sun D, Wang X. Effects of scutellaria barbata polysaccharide on the proliferation, apoptosis and emt of human colon cancer HT29 cells. Carbohydrate Polymers Scientific & Technological Aspects of Industrially Important Polysaccharides. 2017;167:90–96.
   PubMed Web of Science ®Google Scholar
• Wang J, Cai H, Liu Q, et al. Cinobufacini inhibits colon cancer invasion and metastasis via suppressing wnt/β-catenin signaling pathway and EMT. Am J Chin Med. 2020;48:703–718. doi:10.1142/S0192415X20500354
   PubMed Web of Science ®Google Scholar
• Li R, Xu J, Wong D, Li J, Zhao P, Bian L. Self-assembled n-cadherin mimetic peptide hydrogels promote the chondrogenesis of mesenchymal stem cells through inhibition of canonical wnt/β-catenin signaling. Biomaterials. 2017;145:33–43. doi:10.1016/j.biomaterials.2017.08.031
   PubMed Web of Science ®Google Scholar
• Ivanova K, Ananiev J, Aleksandrova E, Ignatova MM, Gulubova M. Expression of e-cadherin/beta-catenin in epithelial carcinomas of the thyroid gland. Open Access Maced J Med Sci. 2017;5:155–159. doi:10.3889/oamjms.2017.043
   PubMedGoogle Scholar
• Singh A, Settleman J. Emt, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer. Oncogene. 2010;29(34):4741–4751. doi:10.1038/onc.2010.215
   PubMed Web of Science ®Google Scholar
• Nusse R, Clevers H. Wnt/β-catenin signaling, disease, and emerging therapeutic modalities. Cell. 2017;169:985–999. doi:10.1016/j.cell.2017.05.016
   PubMed Web of Science ®Google Scholar
• Bahrami A, Amerizadeh F, ShahidSales S, et al. Therapeutic potential of targeting Wnt/β-catenin pathway in treatment of colorectal cancer: rational and progress. J Cell Biochem. 2017;118(8):1979–1983. doi:10.1002/jcb.25903
   PubMed Web of Science ®Google Scholar
• Kobayashi PE, Fonseca-Alves CE, Rivera-Calderón LG, et al. Deregulation of e-cadherin, β-catenin, apc and caveolin-1 expression occurs in canine prostate cancer and metastatic processes. Res Vet Sci. 2018;118:254–261. doi:10.1016/j.rvsc.2018.03.004
   PubMed Web of Science ®Google Scholar