429
Views
13
CrossRef citations to date
0
Altmetric
Original Research

The Use of a New Food-Grade Lecithin Formulation of Highly Standardized Ginger (Zingiber officinale) and Acmella oleracea Extracts for the Treatment of Pain and Inflammation in a Group of Subjects with Moderate Knee Osteoarthritis

, ORCID Icon, ORCID Icon, , , ORCID Icon, , , ORCID Icon, , ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon show all
Pages 761-770 | Published online: 21 Apr 2020

References

  • Cross M, Smith E, Hoy D, et al. The global burden of hip and knee osteoarthritis: estimates from the Global Burden of Disease 2010 study. Ann Rheum Dis. 2014;73(7):1323–1330. doi:10.1136/annrheumdis-2013-204763
  • Helmick CG, Felson DT, Lawrence RC, et al. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States: part I. Arthritis Rheum. 2008;58(1):15–25. doi:10.1002/art.23177
  • Paoloni M, Bernetti A, Belelli A, et al. Appropriateness of clinical and organizational criteria for intra-articular injection therapies in osteoarthritis. A delphi method consensus initiative among experts in Italy. Ann Ist Super Sanita. 2015;51(2):131–138. doi:10.4415/ANN_15_02_11
  • De Filippis L, Gulli S, Caliri A, et al. [Epidemiology and risk factors in osteoarthritis: literature review data from “OASIS” study]. Reumatismo. 2014;56(3):169–184.
  • Yong-liang JIA, Jun-ming Z, Lin-hui Z, Bao-shan SUN, Meng-jing BAO, Fen-fen LI. Analgesic and anti-inflammatory effects of ginger oil. Chin Herbal Med. 2011;3(2):150–155. doi:10.3969/j.issn.1674-6384.2011.02.011
  • Prachayasittikul V, Prachayasittikul S, Ruchirawat S, Prachayasittikul V. High therapeutic potential of Spilanthes acmella: a review. EXCLI J. 2013;12:291–312.
  • Boonen J, Baert B, Burvenich C, Blondeel P, De Saeger S, De Spiegeleer B. LC–MS profiling of N-alkylamides in Spilanthes acmella extract and the transmucosal behaviour of its main bio-active spilanthol. J Pharm Biomed Anal. 2010;53(3):243–249. doi:10.1016/j.jpba.2010.02.010
  • Ratnasooriya WD, Pieris KPP, Samaratunga U, Jayakody JRAC. Diuretic activity of Spilanthes acmella flowers in rats. J Ethnopharmacol. 2004;91(2–3):317–320. doi:10.1016/j.jep.2004.01.006
  • Ong HM, Mohamad AS, Adilah MN, et al. Antinociceptive activity of methanolic extract of Acmella uliginosa (Sw.) cass. J Ethnopharmacol. 2011;133(1):227–233. doi:10.1016/j.jep.2010.09.030
  • Acosta-García J, Hernández-Chan N, Paz-Bermúdez F, et al. D4 and D1 dopamine receptors modulate [3H]GABA release in the substantia nigra pars reticulata of the rat. Neuropharmacology. 2009;57(7–8):725–730. doi:10.1016/j.neuropharm.2009.08.010
  • Chakraborty A, Devi BRK, Sanjebam R, Khumbong S, Thokchom IS. Preliminary studies on local anesthetic and antipyretic activities of Spilanthes acmella Murr. in experimental animal models. Indian J Pharmacol. 2010;42(5):277–279. doi:10.4103/0253-7613.70106
  • Wu L-C, Fan N-C, Lin M-H, et al. Anti-inflammatory effect of spilanthol from Spilanthes acmella on murine macrophage by down-regulating LPS-induced inflammatory mediators. J Agric Food Chem. 2008;56(7):2341–2349. doi:10.1021/jf073057e
  • Dedov VN, Tran VH, Duke CC, et al. Gingerols: a novel class of vanilloid receptor (VR1) agonists. Br J Pharmacol. 2002;137(6):793–798. doi:10.1038/sj.bjp.0704925
  • Vennekens R, Vriens J, Nilius B. Herbal compounds and toxins modulating TRP channels. Curr Neuropharmacol. 2008;6(1):79–96. doi:10.2174/157015908783769644
  • Semwal RB, Semwal DK, Combrinck S, Viljoen AM. Gingerols and shogaols: important nutraceutical principles from ginger. Phytochemistry. 2015;117:554–568. doi:10.1016/j.phytochem.2015.07.012
  • Salaffi F, Blasetti P, Del Medico P, Stancati A, Carotti M. Affidabilità e validità della versione italiana del WOMAC nella valutazione della gonartrosi sintomatica. Reumatismo. 2000;52(Suppl 2):602.:.
  • Lysholm J, Gillquist J. Evaluation of knee ligament surgery results with special emphasis on use of a scoring scale. Am J Sports Med. 1982;10(3):150–154. doi:10.1177/036354658201000306
  • Bellamy N, Buchanan WW, Goldsmith CH, Campbell J, Stitt LW. Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. J Rheumatol. 1988;15(12):1833–1840.
  • Wewers ME, Lowe NK. A critical review of visual analogue scales in the measurement of clinical phenomena. Res Nurs Health. 1990;13(4):227–236. doi: 10.1002/nur.4770130405
  • Ware JE, Sherbourne CD. The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care. 1992;30(6):473–483. doi: 10.1097/00005650-199206000-00002
  • Pinheiro J, Bates D. Mixed-Effects Models in S and S-Plus. New York: Springer; 2000. Available from: https://scholar.google.it/scholar?q=Mixed-Effects+Models+in+S+and+S-PLUS+2000&hl=it≈sdt=0%2C5≈ylo=2000≈yhi=2001. Accessed July 10, 2018.
  • R Core Team. R: A Language and Environment for Statistical Computing. Austria: R Foundation for Statistical Computing; 2017. doi:10.1038/sj.hdy.6800737
  • Agresti A. Modelling ordered categorical data: recent advances and future challenges. Stat Med. 1999;18(17–18):2191–2207. doi:10.1002/(SICI)1097-0258(19990915/30)18:17/18<2191::AID-SIM249>3.0.CO;2-M
  • Molenberghs G, Verbeke G. A review on linear mixed models for longitudinal data, possibly subject to dropout. Stat Model an Int J. 2001;1(4):235–269. doi:10.1177/1471082X0100100402
  • Molenberghs G, Verbeke G. Linear Mixed Models for Longitudinal Data. New York: Springer New York; 2000. doi:10.1007/978-1-4419-0300-6
  • Harvey WF, Hunter DJ. The role of analgesics and intra-articular injections in disease management. Med Clin North Am. 2009;93(1):201–211. doi:10.1016/j.mcna.2008.07.010
  • Bjordal J, Ljunggren A, Klovning LS. Non-steroidal anti-inflammatory drugs, including cyclo-oxygenase-2 inhibitors, in osteoarthritic knee pain: meta-analysis of randomised placebo controlled trials. BMJ. 2004;4(4):1317.
  • Zhang L, min LY, mao YS, yun DX. [Mechanism of exacerbation of colonic damage in experimental colitis treated with celecoxib]. Beijing Da Xue Xue Bao. 2008;40(2):195–199.
  • De Spiegeleer B, Boonen J, Malysheva SV, et al. Skin penetration enhancing properties of the plant N-alkylamide spilanthol. J Ethnopharmacol. 2013;148(1):117–125. doi:10.1016/j.jep.2013.03.076
  • Paulraj J, Govindarajan R, Palpu P. The genus Spilanthes ethnopharmacology, phytochemistry, and pharmacological properties: a review. Adv Pharmacol Sci. 2013;2013:510298. doi:10.1155/2013/510298
  • Rios MY, Olivo HF. Natural and synthetic alkamides: applications in pain therapy. Stud Nat Prod Chem. 2014;43:79–121. doi:10.1016/B978-0-444-63430-6.00003-5
  • Molina-Torres J, Salazar-Cabrera CJ, Armenta-Salinas C, Ramírez-Chávez E. Fungistatic and bacteriostatic activities of alkamides from Heliopsis longipes roots: affinin and reduced amides. J Agric Food Chem. 2004;52(15):4700–4704. doi:10.1021/jf034374y
  • Hind N, Biggs N. Plate 460. Acmella oleracea compositae. Curtis’s Bot Mag. 2003;20(1):31–39. doi:10.1111/1467-8748.00368
  • Cilia-López VG, Juárez-Flores BI, Aguirre-Rivera JR, Reyes-Agüero JA. Analgesic activity of Heliopsis longipes and its effect on the nervous system. Pharm Biol. 2010;48(2):195–200. doi:10.3109/13880200903078495
  • Tiwari KL, Jadhav SK, Joshi V. An updated review on medicinal herb genus Spilanthes. Zhong Xi Yi Jie He Xue Bao. 2011;9(11):1170–1178. doi: 10.3736/jcim20111103
  • Abeysiri GRPI, Dharmadasa RM, Abeysinghe DC, et al. Screening of phytochemical, physico-chemical and bioactivity of different parts of Acmella oleraceae Murr. (Asteraceae), a natural remedy for toothache. Ind Crops Prod. 2013;50:852–856. doi:10.1016/j.indcrop.2013.08.043
  • Dias AMA, Santos P, Seabra IJ, RNC J, Braga MEM, de Sousa HC. Spilanthol from Spilanthes acmella flowers, leaves and stems obtained by selective supercritical carbon dioxide extraction. J Supercrit Fluids. 2012;61:62–70. doi:10.1016/J.SUPFLU.2011.09.020
  • Sharma V, Boonen J, Chauhan NS, Thakur M, De Spiegeleer B, Dixit VK. Spilanthes acmella ethanolic flower extract: LC–MS alkylamide profiling and its effects on sexual behavior in male rats. Phytomedicine. 2011;18(13):1161–1169. doi:10.1016/J.PHYMED.2011.06.001
  • Dubey S, Maity S, Singh M, Saraf SA, Saha S. Phytochemistry, pharmacology and toxicology of Spilanthes acmella: a review. Adv Pharmacol Sci. 2013;2013:1–9. doi:10.1155/2013/423750
  • Rios MY, Aguilar-Guadarrama AB, Gutiérrez M Del C. Analgesic activity of affinin, an alkamide from Heliopsis longipes (Compositae). J Ethnopharmacol. 2007;110(2):364–367. doi:10.1016/j.jep.2006.09.041
  • Déciga-Campos M, Arriaga-Alba M, Ventura-Martínez R, Aguilar-Guadarrama B, Rios MY. Pharmacological and toxicological profile of extract from heliopsislongipes and affinin. Drug Dev Res. 2012;73(3):130–137. doi:10.1002/ddr.21002
  • Nomura ECO, Rodrigues MRA, da Silva CF, et al. Antinociceptive effects of ethanolic extract from the flowers of Acmella oleracea (L.) R.K. Jansen in mice. J Ethnopharmacol. 2013;150(2):583–589. doi:10.1016/j.jep.2013.09.007
  • Philip J, Sperry M, Wilson A, Wilson AF. Dietary supplements for osteoarthritis. American family physician. [ Cited January 15, 2008]. Available from: https://www.aafp.org/afp/2008/0115/p177.html#afp20080115p177-b4. Accessed July 11, 2018.
  • Sang S, Hong J, Wu H, et al. Increased growth inhibitory effects on human cancer cells and anti-inflammatory potency of shogaols from Zingiber officinale relative to gingerols. J Agric Food Chem. 2009;57(22):10645–10650. doi:10.1021/jf9027443
  • Young H-Y, Luo Y-L, Cheng H-Y, Hsieh W-C, Liao J-C, Peng W-H. Analgesic and anti-inflammatory activities of [6]-gingerol. J Ethnopharmacol. 2005;96(1–2):207–210. doi:10.1016/j.jep.2004.09.009
  • Fouda A-M-M, Berika MY. Evaluation of the effect of hydroalcoholic extract of Zingiber officinale rhizomes in rat collagen-induced arthritis. Basic Clin Pharmacol Toxicol. 2009;104(3):262–271. doi:10.1111/j.1742-7843.2008.00363.x
  • Grzanna R, Lindmark L, Frondoza CG. Ginger–an herbal medicinal product with broad anti-inflammatory actions. J Med Food. 2005;8(2):125–132. doi:10.1089/jmf.2005.8.125
  • Ojewole JAO. Analgesic, antiinflammatory and hypoglycaemic effects of ethanol extract of Zingiber officinale (roscoe) rhizomes (zingiberaceae) in mice and rats. Phytother Res. 2006;20(9):764–772. doi:10.1002/ptr.1952
  • Wilson PB. Ginger (Zingiber officinale) as an analgesic and ergogenic aid in sport: a systemic review. J Strength Cond Res. 2015;29(10):2980–2995. doi:10.1519/JSC.0000000000001098
  • Sellami M, Slimeni O, Pokrywka A, et al. Herbal medicine for sports: a review. J Int Soc Sports Nutr. 2018;15(1):14. doi:10.1186/s12970-018-0218-y
  • Rahnama P, Montazeri A, Huseini HF, Kianbakht S, Naseri M. Effect of Zingiber officinale R. rhizomes (ginger) on pain relief in primary dysmenorrhea: a placebo randomized trial. BMC Complement Altern Med. 2012;12(1):92. doi:10.1186/1472-6882-12-92
  • Ozgoli G, Goli M, Moattar F. Comparison of effects of ginger, mefenamic acid, and ibuprofen on pain in women with primary dysmenorrhea. J Altern Complement Med. 2009;15(2):129–132. doi:10.1089/acm.2008.0311
  • Shirvani MA, Motahari-Tabari N, Alipour A. The effect of mefenamic acid and ginger on pain relief in primary dysmenorrhea: a randomized clinical trial. Arch Gynecol Obstet. 2015;291(6):1277–1281. doi:10.1007/s00404-014-3548-2
  • Schweizer ML, Braun BI, Milstone AM. Research methods in healthcare epidemiology and antimicrobial stewardship—quasi-experimental designs. Infect Control Hosp Epidemiol. 2016;37(10):1135–1140. doi:10.1017/ice.2016.117
  • Shadish WR, Cook TD, Campbell DT Experimental and quasi-experimental designs for generalized causal inference.jr-*”-** fr houghton mifflin company Boston New York; 2002. Available from: https://pdfs.semanticscholar.org/9453/f229a8f51f6a95232e42acfae9b3ae5345df.pdf. Accessed November 15, 2018.