Targeting hedgehog signaling in cancer: research and clinical developments

References

• Nusslein-VolhardCWieschausEMutations affecting segment number and polarity in DrosophilaNature198028757857958016776413
   PubMed Web of Science ®Google Scholar
• KraussSConcordetJPInghamPWA functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryosCell1993757143114448269519
   PubMed Web of Science ®Google Scholar
• EchelardYEpsteinDJSt-JacquesBSonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarityCell1993757141714307916661
   PubMed Web of Science ®Google Scholar
• RiddleRDJohnsonRLLauferETabinCSonic hedgehog mediates the polarizing activity of the ZPACell1993757140114168269518
   PubMed Web of Science ®Google Scholar
• ChangDTLópezAvon KesslerDPProducts, genetic linkage and limb patterning activity of a murine hedgehog geneDevelopment199412011333933537720571
   PubMed Web of Science ®Google Scholar
• RoelinkHAugsburgerAHeemskerkJFloor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochordCell19947647617758124714
   PubMed Web of Science ®Google Scholar
• EpsteinEHBasal cell carcinomas: attack of the hedgehogNat Rev Cancer200881074375418813320
   PubMed Web of Science ®Google Scholar
• XieJHedgehog signaling in prostate cancerFuture Oncol20051333133816556007
   PubMedGoogle Scholar
• XieJHedgehog signaling pathway: development of antagonists for cancer therapyCurr Oncol Rep200810210711318377823
   PubMed Web of Science ®Google Scholar
• XieJMolecular biology of basal and squamous cell carcinomasAdv Exp Med Biol200862424125118348461
   PubMed Web of Science ®Google Scholar
• JiangJHuiCCHedgehog signaling in development and cancerDev Cell200815680181219081070
   PubMed Web of Science ®Google Scholar
• InghamPWPlaczekMOrchestrating ontogenesis: variations on a theme by sonic hedgehogNat Rev Genet200671184185017047684
   PubMed Web of Science ®Google Scholar
• SasakiHHuiCNakafukuMKondohHA binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitroDevelopment19971247131313229118802
   PubMed Web of Science ®Google Scholar
• KinzlerKWVogelsteinBThe Gli gene encodes a nuclear protein which binds specific sequences in the human genomeMol Cell Biol19901026346422105456
   PubMed Web of Science ®Google Scholar
• McMahonAPInghamPWTabinCJDevelopmental roles and clinical significance of hedgehog signalingCurr Top Dev Biol200353111412509125
   PubMed Web of Science ®Google Scholar
• InghamPWMcMahonAPHedgehog signaling in animal development: paradigms and principlesGenes Dev200115233059308711731473
   PubMed Web of Science ®Google Scholar
• TaipaleJBeachyPAThe hedgehog and Wnt signalling pathways in cancerNature2001411683534935411357142
   PubMed Web of Science ®Google Scholar
• LeeJJEkkerSCvon KesslerDPPorterJASunBIBeachyPAAutoproteolysis in hedgehog protein biogenesisScience19942665190152815377985023
   PubMed Web of Science ®Google Scholar
• PorterJAYoungKEBeachyPACholesterol modification of hedgehog signaling proteins in animal developmentScience199627452852552598824192
   PubMed Web of Science ®Google Scholar
• PorterJAvon KesslerDPEkkerSCThe product of hedgehog autoproteolytic cleavage active in local and long-range signallingNature199537465203633667885476
   PubMed Web of Science ®Google Scholar
• BuglinoJAReshMDHhat is a palmitoylacyltransferase with specificity for N-palmitoylation of sonic hedgehogJ Biol Chem200828332220762208818534984
   PubMed Web of Science ®Google Scholar
• KawakamiTKawcakTLiYJZhangWHuYChuangPTMouse dispatched mutants fail to distribute hedgehog proteins and are defective in hedgehog signalingDevelopment2002129245753576512421714
   PubMed Web of Science ®Google Scholar
• MaYErknerAGongRHedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatchedCell20021111637512372301
   PubMed Web of Science ®Google Scholar
• CasparyTGarcía-GarcíaMJHuangfuDMouse dispatched homolog1 is required for long-range, but not juxtacrine, Hh signalingCurr Biol200212181628163212372258
   PubMed Web of Science ®Google Scholar
• DierkerTDreierRPetersenABordychCGrobeKHeparan sulfate-modulated, metalloprotease-mediated sonic hedgehog release from producing cellsJ Biol Chem2009284128013802219176481
   PubMed Web of Science ®Google Scholar
• BeckettKFranch-MarroXVincentJPGlypican-mediated endocytosis of hedgehog has opposite effects in filies and miceTrends Cell Biol200818836036318603427
   PubMed Web of Science ®Google Scholar
• LumLYaoSMozerBIdentification of hedgehog pathway components by RNAi in Drosophila cultured cellsScience200329956152039204512663920
   PubMed Web of Science ®Google Scholar
• Baena-LopezLARodriguezIBaonzaAThe tumor suppressor genes dachsous and fat modulate different signalling pathways by regulating dally and dally-likeProc Natl Acad Sci U S A2008105289645965018621676
   PubMed Web of Science ®Google Scholar
• ToyodaHKinoshita-ToyodaAFoxBSelleckSBStructural analysis of glycosaminoglycans in animals bearing mutations in sugarless, sulfateless, and tout-velu. Drosophila homologues of vertebrate genes encoding glycosaminoglycan biosynthetic enzymesJ Biol Chem200027529218562186110806213
   PubMed Web of Science ®Google Scholar
• BellaicheYTheIPerrimonNTout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusionNature1998394668885889665133
   PubMed Web of Science ®Google Scholar
• KozielLKunathMKellyOGVortkampAExt1-dependent heparan sulfate regulates the range of Ihh signaling during endochondral ossificationDev Cell20046680181315177029
   PubMed Web of Science ®Google Scholar
• StoneDMHynesMArmaniniMThe tumour-suppressor gene patched encodes a candidate receptor for sonic hedgehogNature199638466051291348906787
   PubMed Web of Science ®Google Scholar
• TaipaleJCooperMKMaitiTBeachyPAPatched acts catalytically to suppress the activity of smoothenedNature2002418690089289712192414
   PubMed Web of Science ®Google Scholar
• ChuangPTMcMahonAPVertebrate hedgehog signalling modulated by induction of a hedgehog-binding proteinNature1999397672061762110050855
   PubMed Web of Science ®Google Scholar
• MartinelliDCFanCMGas1 extends the range of hedgehog action by facilitating its signalingGenes Dev200721101231124317504940
   PubMed Web of Science ®Google Scholar
• SeppalaMDepewMJMartinelliDCFanCMSharpePTCobourneMTGas1 is a modifier for holoprosencephaly and genetically interacts with sonic hedgehogJ Clin Invest200711761575158417525797
   PubMed Web of Science ®Google Scholar
• AllenBLTenzenTMcMahonAPThe hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse developmentGenes Dev200721101244125717504941
   PubMed Web of Science ®Google Scholar
• OkadaACharronFMorinSBoc is a receptor for sonic hedgehog in the guidance of commissural axonsNature2006444711736937317086203
   PubMed Web of Science ®Google Scholar
• TenzenTAllenBLColeFKangJSKraussRSMcMahonAPThe cell surface membrane proteins Cdo and Boc are components and targets of the hedgehog signaling pathway and feedback network in miceDev Cell200610564765616647304
   PubMed Web of Science ®Google Scholar
• ZhangWKangJSColeFYiMJKraussRSCdo functions at multiple points in the sonic hedgehog pathway, and Cdo-deficient mice accurately model human holoprosencephalyDev Cell200610565766516647303
   PubMed Web of Science ®Google Scholar
• YaoSLumLBeachyPThe ihog cell-surface proteins bind hedgehog and mediate pathway activationCell2006125234335716630821
   PubMed Web of Science ®Google Scholar
• CapurroMIXuPShiWLiFJiaAFilmusJGlypican-3 inhibits hedgehog signaling during development by competing with patched for hedgehog bindingDev Cell200814570071118477453
   PubMed Web of Science ®Google Scholar
• LiFShiWCapurroMFilmusJGlypican-5 stimulates rhabdomyosarcoma cell proliferation by activating hedgehog signalingJ Cell Biol2011192469170421339334
   PubMed Web of Science ®Google Scholar
• WittRMHechtMLPazyra-MurphyMFHeparan sulfate proteoglycans containing a glypican 5 core and 2-O-sulfo-iduronic acid function as sonic hedgehog co-receptors to promote proliferationJ Biol Chem201328836262752628823867465
   PubMed Web of Science ®Google Scholar
• Sanchez-HernandezDSierraJOrtigao-FariasJRGuerreroIThe WIF domain of the human and Drosophila Wif-1 secreted factors confers specificity for Wnt or hedgehogDevelopment2012139203849385822951645
   PubMed Web of Science ®Google Scholar
• AvanesovAHoneyagerSMMalickiJBlairSSThe role of glypicans in Wnt inhibitory factor-1 activity and the structural basis of Wif1’s effects on Wnt and hedgehog signalingPLoS Genetics201282e100250322383891
   PubMed Web of Science ®Google Scholar
• YavariANagarajROwusu-AnsahERole of lipid metabolism in smoothened derepression in hedgehog signalingDev Cell2010191546520643350
   PubMed Web of Science ®Google Scholar
• KhaliullinaHPanakovaDEugsterCRiedelFCarvalhoMEatonSPatched regulates smoothened trafficking using lipoprotein-derived lipidsDevelopment2009136244111412119906846
   PubMed Web of Science ®Google Scholar
• CallejoACuliJGuerreroIPatched, the receptor of hedgehog, is a lipoprotein receptorProc Natl Acad Sci U S A2008105391291718198278
   PubMed Web of Science ®Google Scholar
• BijlsmaMFSpekCAZivkovicDvan de WaterSRezaeeFPeppelenboschMPRepression of smoothened by patched-dependent (pro-)vitamin D3 secretionPLoS Biol200648e23216895439
   PubMed Web of Science ®Google Scholar
• WangYDavidowLArvanitesACGlucocorticoid compounds modify smoothened localization and hedgehog pathway activityChem Bio201219897298222921064
   PubMed Web of Science ®Google Scholar
• PhilippMFralishGBMeloniARSmoothened signaling in vertebrates is facilitated by a G protein-coupled receptor kinaseMol Biol Cell200819125478548918815277
   PubMed Web of Science ®Google Scholar
• OgdenSKFeiDLSchillingNSAhmedYFHwaJRobbinsDJG protein Galphai functions immediately downstream of smoothened in hedgehog signallingNature2008456722496797018987629
   PubMed Web of Science ®Google Scholar
• MolnarCHolguinHMayorFJrRuiz-GomezAde CelisJFThe G protein-coupled receptor regulatory kinase GPRK2 participates in hedgehog signaling in DrosophilaProc Natl Acad Sci U S A2007104197963796817483466
   PubMed Web of Science ®Google Scholar
• RioboNASaucyBDilizioCManningDRActivation of heterotrimeric G proteins by smoothenedProc Natl Acad Sci U S A200610333126071261216885213
   PubMed Web of Science ®Google Scholar
• DouglasAEHeimJAShenFThe alpha subunit of the G protein G13 regulates activity of one or more Gli transcription factors independently of smoothenedJ Biol Chem201128635307143072221757753
   PubMed Web of Science ®Google Scholar
• ZhaoYTongCJiangJHedgehog regulates smoothened activity by inducing a conformational switchNature2007450716725225817960137
   PubMed Web of Science ®Google Scholar
• CorbitKCAanstadPSinglaVNormanARStainierDYReiterJFVertebrate smoothened functions at the primary ciliumNature200543770611018102116136078
   PubMed Web of Science ®Google Scholar
• HuangfuDLiuARakemanASMurciaNSNiswanderLAndersonKVHedgehog signalling in the mouse requires intrafagellar transport proteinsNature20034266962838714603322
   PubMed Web of Science ®Google Scholar
• MaySRAshiqueAMKarlenMLoss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of GliDev Biol2005287237838916229832
   PubMed Web of Science ®Google Scholar
• HuangfuDAndersonKVCilia and hedgehog responsiveness in the mouseProc Natl Acad Sci U S A200510232113251133016061793
   PubMed Web of Science ®Google Scholar
• ZhangQDavenportJRCroyleMJHaycraftCJYoderBKDisruption of IFT results in both exocrine and endocrine abnormalities in the pancreas of Tg737(orpk) mutant miceLab Invest2005851456415580285
   PubMed Web of Science ®Google Scholar
• HooverANWynkoopAZengHJiaJNiswanderLALiuAC2cd3 is required for cilia formation and hedgehog signaling in mouseDevelopment2008135244049405819004860
   PubMed Web of Science ®Google Scholar
• HillmanRTFengBYNiJNeuropilins are positive regulators of hedgehog signal transductionGenes Dev201125222333234622051878
   PubMed Web of Science ®Google Scholar
• SnuderlMBatistaAKirkpatrickNDTargeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastomaCell201315251065107623452854
   PubMed Web of Science ®Google Scholar
• CaoYWangLNandyDNeuropilin-1 upholds dedifferentiation and propagation phenotypes of renal cell carcinoma cells by activating Akt and sonic hedgehog axesCancer Res200868218667867218974107
   PubMed Web of Science ®Google Scholar
• ParraLMZouYSonic hedgehog induces response of commissural axons to Semaphorin repulsion during midline crossingNat Neurosci2010131293519946319
   PubMed Web of Science ®Google Scholar
• CheungHOZhangXRibeiroAThe kinesin protein Kif7 is a critical regulator of Gli transcription factors in mammalian hedgehog signalingSci Signal2009276ra2919549984
   PubMed Web of Science ®Google Scholar
• Endoh-YamagamiSEvangelistaMWilsonDThe mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during developmentCurr Biol200919151320132619592253
   PubMed Web of Science ®Google Scholar
• LawKKMakinoSMoRZhangXPuviindranVHuiCCAntagonistic and cooperative actions of Kif7 and Sufu define graded intracellular Gli activities in hedgehog signalingPLoS One2012711e5019323166838
   PubMed Web of Science ®Google Scholar
• LiZJNieuwenhuisENienWKif7 regulates Gli2 through Sufu-dependent and -independent functions during skin development and tumorigenesisDevelopment2012139224152416123034632
   PubMed Web of Science ®Google Scholar
• HsuSHZhangXYuCKif7 promotes hedgehog signaling in growth plate chondrocytes by restricting the inhibitory function of SufuDevelopment2011138173791380121795282
   PubMed Web of Science ®Google Scholar
• WilsonCWNguyenCTChenMHFused has evolved divergent roles in vertebrate hedgehog signalling and motile ciliogenesisNature200945972439810219305393
   PubMed Web of Science ®Google Scholar
• MerchantMEvangelistaMLuohSMLoss of the serine/threonine kinase fused results in postnatal growth defects and lethality due to progressive hydrocephalusMol Cell Biol200525167054706816055717
   PubMed Web of Science ®Google Scholar
• ChenMHGaoNKawakamiTChuangPTMice deficient in the fused homolog do not exhibit phenotypes indicative of perturbed hedgehog signaling during embryonic developmentMol Cell Biol200525167042705316055716
   PubMed Web of Science ®Google Scholar
• EggenschwilerJTEspinozaEAndersonKVRab23 is an essential negative regulator of the mouse sonic hedgehog signalling pathwayNature2001412684319419811449277
   PubMed Web of Science ®Google Scholar
• ReiterJFSkarnesWCTectonic, a novel regulator of the hedgehog pathway required for both activation and inhibitionGenes Dev2006201222716357211
   PubMed Web of Science ®Google Scholar
• LiCChiSXieJHedgehog signaling in skin cancersCell Signal20112381235124321397013
   PubMed Web of Science ®Google Scholar
• HuangSYangLAnYExpression of hedgehog signaling molecules in lung cancerActa Histochem2011113556456920656337
   PubMed Web of Science ®Google Scholar
• KinzlerKWRuppertJMBignerSHVogelsteinBThe Gli gene is a member of the Kruppel family of zinc finger proteinsNature198833261623713742832761
   PubMed Web of Science ®Google Scholar
• RuppertJMKinzlerKWWongAJThe Gli-Kruppel family of human genesMol Cell Biol198888310431132850480
   PubMed Web of Science ®Google Scholar
• BarnfieldPCZhangXThanabalasinghamVYoshidaMHuiCCNegative regulation of Gli1 and Gli2 activator function by suppressor of fused through multiple mechanismsDifferentiation200573839740516316410
   PubMed Web of Science ®Google Scholar
• ShengTChiSZhangXXieJRegulation of Gli1 localization by the cAMP/protein kinase A signaling axis through a site near the nuclear localization signalJ Biol Chem2006281191216293631
   PubMed Web of Science ®Google Scholar
• KogermanPGrimmTKogermanLMammalian suppressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1Nat Cell Biol19991531231910559945
   PubMed Web of Science ®Google Scholar
• SteccaBMasCClementVMelanomas require hedghog-Gli signaling regulated by interactions between Gli1 and the RAS-MEK/AKT pathwaysProc Natl Acad Sci U S A2007104145895590017392427
   PubMed Web of Science ®Google Scholar
• PanYBaiCBJoynerALWangBSonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradationMol Cell Biol20062693365337716611981
   PubMed Web of Science ®Google Scholar
• HuntzickerEGEstayISZhenHLoktevaLAJacksonPKOroAEDual degradation signals control Gli protein stability and tumor formationGenes Dev200620327628116421275
   PubMed Web of Science ®Google Scholar
• WangBLiYEvidence for the direct involvement of βTrCP in Gli3 protein processingProc Natl Acad Sci U S A20061031333816371461
   PubMed Web of Science ®Google Scholar
• Di MarcotullioLFerrettiEGrecoANumb is a suppressor of hedgehog signalling and targets Gli1 for Itch-dependent ubiquitinationNat Cell Biol20068121415142317115028
   PubMed Web of Science ®Google Scholar
• JiangJRegulation of Hh/Gli signaling by dual ubiquitin pathwaysCell Cycle20065212457246317102630
   PubMed Web of Science ®Google Scholar
• CanettieriGDi MarcotullioLGrecoAHistone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates hedgehog signalling through Gli acetylationNat Cell Biol201012213214220081843
   PubMed Web of Science ®Google Scholar
• ConiSAntonucciLD’AmicoDGli2 acetylation at lysine 757 regulates hedgehog-dependent transcriptional output by preventing its promoter occupancyPLoS One201386e6571823762415
   PubMed Web of Science ®Google Scholar
• HanLPanYWangBSmall ubiquitin-like modifier (SUMO) modification inhibits Gli2 protein transcriptional activity in vitro and in vivoJ Biol Chem201228724204832048922549777
   PubMed Web of Science ®Google Scholar
• ZhangQShiQChenYMultiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligaseProc Natl Acad Sci U S A200910650211912119619955409
   PubMed Web of Science ®Google Scholar
• ChengSYBishopJMSuppressor of fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complexProc Natl Acad Sci U S A20029985442544711960000
   PubMed Web of Science ®Google Scholar
• WangCPanYWangBSuppressor of fused and Spop regulate the stability, processing and function of Gli2 and Gli3 full-length activators but not their repressorsDevelopment2010137122001200920463034
   PubMed Web of Science ®Google Scholar
• LiZJMackSCMakTHAngersSTaylorMDHuiCCEvasion of p53 and G/M checkpoints are characteristic of Hh-driven basal cell carcinomaOncogene Epub June 10, 2013
   Web of Science ®Google Scholar
• JaganiZMora-BlancoELSansamCGLoss of the tumor suppressor Snf5 leads to aberrant activation of the hedgehog-Gli pathwayNat Med201016121429143321076395
   PubMed Web of Science ®Google Scholar
• AtwoodSXLiMLeeATangJYOroAEGli activation by atypical protein kinase C iota/lambda regulates the growth of basal cell carcinomasNature2013494743848448823446420
   PubMed Web of Science ®Google Scholar
• YangLXieGFanQXieJActivation of the hedgehog-signaling pathway in human cancer and the clinical implicationsOncogene201029446948119935712
   PubMed Web of Science ®Google Scholar
• HahnHWickingCZaphiropoulousPGMutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndromeCell19968568418518681379
   PubMed Web of Science ®Google Scholar
• JohnsonRLRothmanALXieJHuman homolog of patched, a candidate gene for the basal cell nevus syndromeScience19962725268166816718658145
   PubMed Web of Science ®Google Scholar
• EpsteinEJrGenetic determinants of basal cell carcinoma riskMed Pediatr Oncol200136555555811340611
   PubMedGoogle Scholar
• GorlinRJNevoid basal-cell carcinoma syndromeMedicine1987662981133547011
   PubMed Web of Science ®Google Scholar
• XieJMuroneMLuohSMActivating smoothened mutations in sporadic basal-cell carcinomaNature1998391666290929422511
   PubMed Web of Science ®Google Scholar
• LamCWXieJToKFA frequent activated smoothened mutation in sporadic basal cell carcinomasOncogene19991838338369989836
   PubMed Web of Science ®Google Scholar
• ReifenbergerJWolterMKnobbeCBSomatic mutations in the PTCH, SMOH, SUFUH and TP53 genes in sporadic basal cell carcinomasBr J Dermatol20051521435115656799
   PubMed Web of Science ®Google Scholar
• ReifenbergerJWolterMWeberRGMissense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous systemCancer Res1998589179818039581815
   PubMed Web of Science ®Google Scholar
• Couve-PrivatSBouadjarBAvrilMFSarasinADaya-GrosjeanLSignificantly high levels of ultraviolet-specific mutations in the smoothened gene in basal cell carcinomas from DNA repair-deficient xeroderma pigmentosum patientsCancer Res200262247186718912499255
   PubMed Web of Science ®Google Scholar
• TostarUMalmCJMeis-KindblomJMKindblomLGToftgardRUndenABDeregulation of the hedgehog signalling pathway: a possible role for the PTCH and SUFU genes in human rhabdomyoma and rhabdomyosarcoma developmentJ Pathol20062081172516294371
   PubMed Web of Science ®Google Scholar
• PresseyJGAndersonJRCrossmanDKLynchJCBarrFGHedgehog pathway activity in pediatric embryonal rhabdomyosarcoma and undifferentiated sarcoma: a report from the Children’s Oncology GroupPediatr Blood Cancer201157693093821618411
   PubMed Web of Science ®Google Scholar
• ClarkVEErson-OmayEZSerinAGenomic analysis of non-NF2 meningiomas reveals mutations in TRAF7, KLF4, AKT1, and SMOScience201333961231077108023348505
   PubMed Web of Science ®Google Scholar
• AavikkoMLiSPSaarinenSLoss of SUFU function in familial multiple meningiomaAm J Hum Genet201291352052622958902
   PubMed Web of Science ®Google Scholar
• KijimaCMiyashitaTSuzukiMOkaHFujiiKTwo cases of nevoid basal cell carcinoma syndrome associated with meningioma caused by a PTCH1 or SUFU germline mutationFam Cancer201211456557022829011
   PubMed Web of Science ®Google Scholar
• FeiDLSanchez-MejiasAWangZHedgehog signaling regulates bladder cancer growth and tumorigenicityCancer Res201272174449445822815529
   PubMed Web of Science ®Google Scholar
• Rodriguez-BlancoJSchillingNSTokhuntsRThe hedgehog processing pathway is required for NSCLC growth and survivalOncogene201332182335234522733134
   PubMed Web of Science ®Google Scholar
• ShinKLeeJGuoNHedgehog/Wnt feedback supports regenerative proliferation of epithelial stem cells in bladderNature2011472734111011421389986
   PubMed Web of Science ®Google Scholar
• HahnHWojnowskiLZimmerAMHallJMillerGZimmerARhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndromeNat Med1998456196229585239
   PubMed Web of Science ®Google Scholar
• HatleyMETangWGarciaMRA mouse model of rhabdomyosarcoma originating from the adipocyte lineageCancer Cell201222453654623079662
   PubMed Web of Science ®Google Scholar
• IgnatiusMSChenEElpekNMIn vivo imaging of tumor-propagating cells, regional tumor heterogeneity, and dynamic cell movements in embryonal rhabdomyosarcomaCancer Cell201221568069322624717
   PubMed Web of Science ®Google Scholar
• NitzkiFZibatAFrommholdAUncommitted precursor cells might contribute to increased incidence of embryonal rhabdomyosarcoma in heterozygous patched1-mutant miceOncogene201130434428443621602886
   PubMed Web of Science ®Google Scholar
• PelczarPZibatAvan DopWAInactivation of patched1 in mice leads to development of gastrointestinal stromal-like tumors that express PDGFRα but not kitGastroenterology2013144113414423041331
   PubMed Web of Science ®Google Scholar
• ParkKSMartelottoLGPeiferMA crucial requirement for hedgehog signaling in small cell lung cancerNat Med201117111504150821983857
   PubMed Web of Science ®Google Scholar
• WangDHClemonsNJMiyashitaTAberrant epithelial-mesenchymal hedgehog signaling characterizes Barrett’s metaplasiaGastroenterology201013851810182220138038
   PubMed Web of Science ®Google Scholar
• YangLWangLSChenXLHedgehog signaling activation in the development of squamous cell carcinoma and adenocarcinoma of esophagusInt J Biochem Mol Biol201231465722509480
   PubMedGoogle Scholar
• TianHCallahanCADuPreeKJHedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesisProc Natl Acad Sci U S A2009106114254425919246386
   PubMed Web of Science ®Google Scholar
• MaoJLigonKLRakhlinEYA novel somatic mouse model to survey tumorigenic potential applied to the hedgehog pathwayCancer Res20066620101711017817047082
   PubMed Web of Science ®Google Scholar
• AszterbaumMEpsteinJOroAUltraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout miceNat Med19995111285129110545995
   PubMed Web of Science ®Google Scholar
• GoodrichLVMilenkovicLHigginsKMScottMPAltered neural cell fates and medulloblastoma in mouse patched mutantsScience19972775329110911139262482
   PubMed Web of Science ®Google Scholar
• FeldmannGDharaSFendrichVBlockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancersCancer Res20076752187219617332349
   PubMed Web of Science ®Google Scholar
• BaileyJMSwansonBJHamadaTSonic hedgehog promotes desmoplasia in pancreatic cancerClin Cancer Res200814195995600418829478
   PubMed Web of Science ®Google Scholar
• ChangQFoltzWDChaudaryNHillRPHedleyDWTumor-stroma interaction in orthotopic primary pancreatic cancer xenografts during hedgehog pathway inhibitionInt J Cancer2013133122523423280784
   PubMed Web of Science ®Google Scholar
• TangSNFuJNallDRodovaMShankarSSrivastavaRKInhibition of sonic hedgehog pathway and pluripotency maintaining factors regulate human pancreatic cancer stem cell characteristicsInt J Cancer20121311304021796625
   PubMed Web of Science ®Google Scholar
• FeldmannGFendrichVMcGovernKAn orally bioavailable small-molecule inhibitor of hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancerMol Cancer Ther2008792725273518790753
   PubMed Web of Science ®Google Scholar
• GuDLiuHSuGHCombining hedgehog signaling inhibition with focal irradiation on reduction of pancreatic cancer metastasisMol Cancer Ther20131261038104823468532
   PubMed Web of Science ®Google Scholar
• BaileyJMMohrAMHollingsworthMASonic hedgehog paracrine signaling regulates metastasis and lymphangiogenesis in pancreatic cancerOncogene200928403513352519633682
   PubMed Web of Science ®Google Scholar
• OliveKPJacobetzMADavidsonCJInhibition of hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancerScience200932459331457146119460966
   PubMed Web of Science ®Google Scholar
• ZhaoCChenAJamiesonCHHedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemiaNature2009458723977677919169242
   PubMed Web of Science ®Google Scholar
• BoydALSalciKRShapovalovaZMcIntyreBABhatiaMNonhematopoietic cells represent a more rational target of in vivo hedgehog signaling affecting normal or acute myeloid leukemia progenitorsExp Hematol Epub June 6, 2013
   Web of Science ®Google Scholar
• RomerJTKimuraHMagdalenoSSuppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/−)p53(−/−) miceCancer Cell20046322924015380514
   PubMed Web of Science ®Google Scholar
• GuDFanQZhangXXieJA role for transcription factor STAT3 signaling in oncogene smoothened-driven carcinogenesisJ Biol Chem201228745383563836622992748
   PubMed Web of Science ®Google Scholar
• XieJAszterbaumMZhangXA role of PDGFRalpha in basal cell carcinoma proliferationProc Natl Acad Sci U S A200198169255925911481486
   PubMed Web of Science ®Google Scholar
• JohnsonRWNguyenMPPadaleckiSSTGF-beta promotion of Gli2-induced expression of parathyroid hormone-related protein, an important osteolytic factor in bone metastasis, is independent of canonical hedgehog signalingCancer Res201171382283121189326
   PubMed Web of Science ®Google Scholar
• KeysarSBLePNAndersonRTHedgehog signaling alters reliance on EGF receptor signaling and mediates anti-EGFR therapeutic resistance in head and neck cancerCancer Res201373113381339223576557
   PubMed Web of Science ®Google Scholar
• EberlMKlinglerSMangelbergerDHedgehog-EGFR cooperation response genes determine the oncogenic phenotype of basal cell carcinoma and tumour-initiating pancreatic cancer cellsEMBO Mol Med20124321823322294553
   PubMed Web of Science ®Google Scholar
• FanQHeMShengTRequirement of TGFbeta signaling for SMO-mediated carcinogenesisJ Biol Chem201028547365703657620858897
   PubMed Web of Science ®Google Scholar
• WangYDingQYenCJThe crosstalk of mTOR/S6K1 and hedgehog pathwaysCancer Cell201221337438722439934
   PubMed Web of Science ®Google Scholar
• ShiSDengYZZhaoJSRACK1 promotes non-small-cell lung cancer tumorigenicity through activating sonic hedgehog signaling pathwayJ Biol Chem2012287117845785822262830
   PubMed Web of Science ®Google Scholar
• HsiehAEllsworthRHsiehDHedgehog/Gli1 regulates IGF dependent malignant behaviors in glioma stem cellsJ Cell Physiol201122641118112720857406
   PubMed Web of Science ®Google Scholar
• MainwaringLAKenneyAMDivergent functions for eIF4E and S6 kinase by sonic hedgehog mitogenic signaling in the developing cerebellumOncogene201130151784179721339731
   PubMed Web of Science ®Google Scholar
• FernandezLASquatritoMNorthcottPOncogenic YAP promotes radioresistance and genomic instability in medulloblastoma through IGF2-mediated Akt activationOncogene201231151923193721874045
   PubMed Web of Science ®Google Scholar
• HellerEHurchlaMAXiangJHedgehog signaling inhibition blocks growth of resistant tumors through effects on tumor microenvironmentCancer Res201272489790722186138
   PubMed Web of Science ®Google Scholar
• AbbruzzeseJLNational Institutes of Health (US)Are there new targets for pancreatic cancer therapeutics?2007 Available from: http://videocast.nih.gov/launch.asp?13834Accessed September 10, 2013
   Google Scholar
• InagumaSKasaiKIkedaHGli1 facilitates the migration and invasion of pancreatic cancer cells through MUC5AC-mediated attenuation of E-cadherinOncogene201130671472320972463
   PubMed Web of Science ®Google Scholar
• JoostSAlmadaLLRohnalterVGli1 inhibition promotes epithelial-to-mesenchymal transition in pancreatic cancer cellsCancer Res2012721889922086851
   PubMed Web of Science ®Google Scholar
• LiXDengWLobo-RuppertSMRuppertJMGli1 acts through snail and E-cadherin to promote nuclear signaling by beta-cateninOncogene200726314489449817297467
   PubMed Web of Science ®Google Scholar
• JavelaudDPierratMJMauvielACrosstalk between TGF-beta and hedgehog signaling in cancerFEBS Lett2012586142016202522609357
   PubMed Web of Science ®Google Scholar
• Von HoffDDLoRussoPMRudinCMInhibition of the hedgehog pathway in advanced basal-cell carcinomaN Engl J Med9172009361121164117219726763
   PubMed Web of Science ®Google Scholar
• GrahamRALumBLCheetiSPharmacokinetics of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with locally advanced or metastatic solid tumors: the role of alpha-1-acid glycoprotein bindingClin Cancer Res20111782512252021300760
   PubMed Web of Science ®Google Scholar
• LoRussoPMRudinCMReddyJCPhase I trial of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with refractory, locally advanced or metastatic solid tumorsClin Cancer Res20111782502251121300762
   PubMed Web of Science ®Google Scholar
• LorussoPMJimenoADyGPharmacokinetic dose-scheduling study of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with locally advanced or metastatic solid tumorsClin Cancer Res201117175774578221753154
   PubMed Web of Science ®Google Scholar
• MetcalfeCde SauvageFJHedgehog fights back: mechanisms of acquired resistance against smoothened antagonistsCancer Res201171155057506121771911
   PubMed Web of Science ®Google Scholar
• TangTTangJYLiDTargeting superficial or nodular basal cell carcinoma with topically formulated small molecule inhibitor of smoothenedClin Cancer Res201117103378338721558397
   PubMed Web of Science ®Google Scholar
• SkvaraHKalthoffFMeingassnerJGTopical treatment of basal cell carcinomas in nevoid basal cell carcinoma syndrome with a smoothened inhibitorJ Invest Dermatol201113181735174421430703
   PubMed Web of Science ®Google Scholar
• BuonamiciSWilliamsJMorrisseyMInterfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastomaSci Transl Med201025151ra70
   PubMed Web of Science ®Google Scholar
• DijkgraafGJAlickeBWeinmannLSmall molecule inhibition of GDC-0449 refractory smoothened mutants and downstream mechanisms of drug resistanceCancer Res201171243544421123452
   PubMed Web of Science ®Google Scholar
• KimJAftabBTTangJYItraconazole and arsenic trioxide inhibit hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonistsCancer Cell2013231233423291299
   PubMed Web of Science ®Google Scholar
• KimJTangJYGongRItraconazole, a commonly used anti-fungal that inhibits hedgehog pathway activity and cancer growthCancer Cell201017438839920385363
   PubMed Web of Science ®Google Scholar
• TangJYXiaoTZOdaYVitamin D3 inhibits hedgehog signaling and proliferation in murine basal cell carcinomasCancer Prev Res (Phila)20114574475121436386
   PubMed Web of Science ®Google Scholar
• ChennaVHuCPramanikDA polymeric nanoparticle encapsulated small-molecule inhibitor of hedgehog signaling (NanoHHI) bypasses secondary mutational resistance to smoothened antagonistsMol Cancer Ther201211116517322027695
   PubMed Web of Science ®Google Scholar
• RohnerASpilkerMELamJLEffective targeting of hedgehog signaling in a medulloblastoma model with PF-5274857, a potent and selective smoothened antagonist that penetrates the blood-brain barrierMol Cancer Ther2012111576522084163
   PubMed Web of Science ®Google Scholar
• LeeMJHattonBAVillavicencioEHHedgehog pathway inhibitor saridegib (IPI-926) increases lifespan in a mouse medulloblastoma modelProc Natl Acad Sci U S A2012109207859786422550175
   PubMed Web of Science ®Google Scholar
• RudinCMHannCLLaterraJTreatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449N Engl J Med2009361121173117819726761
   PubMed Web of Science ®Google Scholar
• FuldaSMolecular targeted therapies for rhabdomyosarcoma: focus on hedgehog and apoptosis signalingKlinische Padiatrie2013225311511923625685
   PubMed Web of Science ®Google Scholar
• DierksCBeigiRGuoGRExpansion of Bcr-Abl-positive leukemic stem cells is dependent on hedgehog pathway activationCancer Cell200814323824918772113
   PubMed Web of Science ®Google Scholar
• ReadTAFogartyMPMarkantSLIdentification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastomaCancer Cell200915213514719185848
   PubMed Web of Science ®Google Scholar
• HofmannIStoverEHCullenDEHedgehog signaling is dispensable for adult murine hematopoietic stem cell function and hematopoiesisCell Stem Cell20094655956719497284
   PubMed Web of Science ®Google Scholar
• GaoJGravesSKochUHedgehog signaling is dispensable for adult hematopoietic stem cell functionCell Stem Cell20094654855819497283
   PubMed Web of Science ®Google Scholar
• SigginsSLNguyenNYMcCormackMPThe hedgehog receptor patched1 regulates myeloid and lymphoid progenitors by distinct cell-extrinsic mechanismsBlood20091145995100419483124
   PubMed Web of Science ®Google Scholar
• MerchantAJosephGWangQBrennanSMatsuiWGli1 regulates the proliferation and differentiation of HSCs and myeloid progenitorsBlood2010115122391239620107231
   PubMed Web of Science ®Google Scholar
• ReyaTMorrisonSJClarkeMFWeissmanILStem cells, cancer, and cancer stem cellsNature2001414685910511111689955
   PubMed Web of Science ®Google Scholar
• Sims-MourtadaJIzzoJGApisarnthanaraxSHedgehog: an attribute to tumor regrowth after chemoradiotherapy and a target to improve radiation responseClin Cancer Res200612216565657217085672
   PubMed Web of Science ®Google Scholar
• YoshikawaRNakanoYTaoLHedgehog signal activation in oesophageal cancer patients undergoing neoadjuvant chemoradiotherapyBr J Cancer200898101670167418475300
   PubMed Web of Science ®Google Scholar
• TakebeNHarrisPJWarrenRQIvySPTargeting cancer stem cells by inhibiting Wnt, notch, and hedgehog pathwaysNat Rev Clin Oncol2011829710621151206
   PubMed Web of Science ®Google Scholar
• SongZYueWWeiBSonic hedgehog pathway is essential for maintenance of cancer stem-like cells in human gastric cancerPLoS One201163e1768721394208
   PubMed Web of Science ®Google Scholar
• TanakaHNakamuraMKamedaCThe hedgehog signaling pathway plays an essential role in maintaining the CD44+CD24−/low subpopulation and the side population of breast cancer cellsAnticancer Res20092962147215719528475
   PubMed Web of Science ®Google Scholar
• LiuSDontuGMantleIDHedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cellsCancer Res200666126063607116778178
   PubMed Web of Science ®Google Scholar
• TakahashiTKawakamiKMishimaSCyclopamine induces eosinophilic differentiation and upregulates CD44 expression in myeloid leukemia cellsLeuk Res201135563864520971508
   PubMed Web of Science ®Google Scholar
• LiCHeidtDGDalerbaPIdentification of pancreatic cancer stem cellsCancer Res20076731030103717283135
   PubMed Web of Science ®Google Scholar
• VisbalAPLaMarcaHLVillanuevaHAltered differentiation and paracrine stimulation of mammary epithelial cell proliferation by conditionally activated smoothenedDev Biol2011352111612721276786
   PubMed Web of Science ®Google Scholar
• BarEEChaudhryALinACyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastomaStem Cells200725102524253317628016
   PubMed Web of Science ®Google Scholar
• ClementVSanchezPde TriboletNRadovanovicIRuiz i AltabaAHedgehog-Gli1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicityCurr Biol200717216517217196391
   PubMed Web of Science ®Google Scholar
• SuWMengFHuangLZhengMLiuWSunHSonic hedgehog maintains survival and growth of chronic myeloid leukemia progenitor cells through β-catenin signalingExp Hematol201240541842722240607
   PubMed Web of Science ®Google Scholar
• Domingo-DomenechJVidalSJRodriguez-BravoVSuppression of acquired docetaxel resistance in prostate cancer through depletion of notch- and hedgehog-dependent tumor-initiating cellsCancer Cell201222337338822975379
   PubMed Web of Science ®Google Scholar
• RamaswamyBLuYTengKYHedgehog signaling is a novel therapeutic target in tamoxifen-resistant breast cancer aberrantly activated by PI3K/AKT pathwayCancer Res201272195048505922875023
   PubMed Web of Science ®Google Scholar
• StegADBevisKSKatreAAStem cell pathways contribute to clinical chemoresistance in ovarian cancerClin Cancer Res201218386988122142828
   PubMed Web of Science ®Google Scholar
• ChaudaryNPintilieMHedleyDHedgehog pathway signaling in cervical carcinoma and outcome after chemoradiationCancer2012118123105311522028038
   PubMed Web of Science ®Google Scholar
• QueirozKCRuela-de-SousaRRFuhlerGMHedgehog signaling maintains chemoresistance in myeloid leukemic cellsOncogene201029486314632220802532
   PubMed Web of Science ®Google Scholar
• SinghRRKunkallaKQuCABCG2 is a direct transcriptional target of hedgehog signaling and involved in stroma-induced drug tolerance in diffuse large B-cell lymphomaOncogene201130494874488621625222
   PubMed Web of Science ®Google Scholar
• LinSHGeorgeTJBen-JosefEOpportunities and challenges in the era of molecularly targeted agents and radiation therapyJ Natl Cancer Inst20131051068669323503600
   PubMedGoogle Scholar