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Original Research

SPINDOC is Highly Expressed in Pan-Cancer Samples and Can Promote the Proliferation, Invasion and Migration of Hepatocellular Carcinoma Cells by Activating Wnt/β-Catenin Signaling Pathway

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Pages 555-570 | Published online: 18 May 2022

References

  • Villanueva A. Hepatocellular Carcinoma. N Engl J Med. 2019;380:1450–1462. doi:10.1056/NEJMra1713263
  • Forner A, Reig M, Bruix J. Hepatocellular carcinoma. Lancet. 2018;391(10127):1301–1314. doi:10.1016/S0140-6736(18)30010-2
  • Chen W, Zheng R, Baade PD, et al. Cancer statistics in China, 2015. CA Cancer J Clin. 2016;66:115–132. doi:10.3322/caac.21338
  • Noonan A, Pawlik TM. Hepatocellular carcinoma: an update on investigational drugs in Phase I and II clinical trials. Expert Opin Investig Drugs. 2019;28(11):941–949. doi:10.1080/13543784.2019.1677606
  • Gao Y, Yue W, Zhang P, et al. Spindlin1, a novel nuclear protein with a role in the transformation of NIH3T3 cells. Biochem Biophys Res Commun. 2005;335(2):343–350. doi:10.1016/j.bbrc.2005.07.087
  • Chen X, Wang YW, Xing AY, et al. Suppression of SPIN1-mediated PI3K-Akt pathway by miR-489 increases chemosensitivity in breast cancer. J Pathol. 2016;239:459–472. doi:10.1002/path.4743
  • Song Q, Ji Q, Xiao J, et al. miR-409 inhibits human non-small-cell lung cancer progression by directly targeting SPIN1. Mol Ther Nucleic Acids. 2018;13:154–163. doi:10.1016/j.omtn.2018.08.020
  • Li Y, Ma X, Wang Y, Li G. miR-489 inhibits proliferation, cell cycle progression and induces apoptosis of glioma cells via targeting SPIN1-mediated PI3K/AKT pathway. Biomed Pharmacother. 2017;93:435–443. doi:10.1016/j.biopha.2017.06.058
  • Chen X, Wang YW, Gao P. SPIN1, negatively regulated by miR-148/152, enhances Adriamycin resistance via upregulating drug metabolizing enzymes and transporter in breast cancer. J Exp Clin Cancer Res. 2018;37:100. doi:10.1186/s13046-018-0748-9
  • Lv BB, Ma RR, Chen X, et al. E2F1-activated SPIN1 promotes tumor growth via a MDM2-p21-E2F1 feedback loop in gastric cancer. Mol Oncol. 2020;14:2629–2645. doi:10.1002/1878-0261.12778
  • Zhao M, Bu Y, Feng J, et al. SPIN1 triggers abnormal lipid metabolism and enhances tumor growth in liver cancer. Cancer Lett. 2020;470:54–63. doi:10.1016/j.canlet.2019.11.032
  • Bae N, Gao M, Li X, et al. A transcriptional coregulator, SPIN.DOC, attenuates the coactivator activity of Spindlin1. J Biol Chem. 2017;292:20808–20817. doi:10.1074/jbc.M117.814913
  • Devi MS, Meiguilungpou R, Sharma AL, et al. Spindlin docking protein (SPIN.DOC) interaction with SPIN1 (a histone code reader) regulates Wnt signaling. Biochem Biophys Res Commun. 2019;511(3):498–503. doi:10.1016/j.bbrc.2019.02.096
  • Gao J, Aksoy BA, Dogrusoz U, et al. Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal. 2013;6:l1. doi:10.1126/scisignal.2004088
  • Cerami E, Gao J, Dogrusoz U, et al. The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov. 2012;2:401–404. doi:10.1158/2159-8290.CD-12-0095
  • Xie J, Chen L, Cao Y, et al. Single-cell sequencing analysis and weighted co-expression network analysis based on public databases identified that TNC is a novel biomarker for keloid. Front Immunol. 2021;12:783907. doi:10.3389/fimmu.2021.783907
  • Xie J, Zhang X, Zhang K, et al. Construction and validation of the diagnostic model of keloid based on weighted gene co-expression network analysis (WGCNA) and differential expression analysis. J Plast Surg Hand Surg;2022. 1–9. doi:10.1080/2000656X.2021.2024557
  • Staub E, Mennerich D, Rosenthal A. The Spin/Ssty repeat: a new motif identified in proteins involved in vertebrate development from gamete to embryo. Genome Biol. 2002;3:H3.
  • Wang W, Chen Z, Mao Z, et al. Nucleolar protein Spindlin1 recognizes H3K4 methylation and stimulates the expression of rRNA genes. EMBO Rep. 2011;12:1160–1166. doi:10.1038/embor.2011.184
  • Su X, Zhu G, Ding X, et al. Molecular basis underlying histone H3 lysine-arginine methylation pattern readout by Spin/Ssty repeats of Spindlin1. Genes Dev. 2014;28:622–636. doi:10.1101/gad.233239.113
  • Wang JX, Zeng Q, Chen L, et al. SPINDLIN1 promotes cancer cell proliferation through activation of WNT/TCF-4 signaling. Mol Cancer Res. 2012;10:326–335. doi:10.1158/1541-7786.MCR-11-0440
  • Urrutia E, Chen H, Zhou Z, Zhang NR, Jiang Y. Integrative pipeline for profiling DNA copy number and inferring tumor phylogeny. Bioinformatics. 2018;34:2126–2128. doi:10.1093/bioinformatics/bty057
  • He S, Tang S. WNT/beta-catenin signaling in the development of liver cancers. Biomed Pharmacother. 2020;132:110851. doi:10.1016/j.biopha.2020.110851
  • Zhang Y, Wang X. Targeting the Wnt/beta-catenin signaling pathway in cancer. J Hematol Oncol. 2020;13:165. doi:10.1186/s13045-020-00990-3
  • Nusse R, Clevers H. Wnt/beta-catenin signaling, disease, and emerging therapeutic modalities. Cell. 2017;169:985–999. doi:10.1016/j.cell.2017.05.016