OncoTargets and Therapy, Volume 15, Issue (2022)

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OncoTargets and Therapy, Volume 15, Issue (2022)

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Case Report

Case Report
Successful Treatment of Primary CNS Extranodal NK/T-Cell Lymphoma with Surgery and Chemotherapy Combined with Sintilimab: A Case Report and Literature Review
Liping Qin, Yajun Li, Yizi He, Ruolan Zeng, Tao Pan, Yilang Zuo, Ling Xiao & Hui Zhou
Pages: 1-11
Published online: 17 Sep 2022
AbstractforSuccessful Treatment of Primary CNS Extranodal NK/T-Cell Lymphoma with Surgery and Chemotherapy Combined with Sintilimab: A Case Report and Literature Review | Full Text | References | PDF (7 MB)
  • 182 Views
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Case Report
Multiple Primary Lung Tumors of Different Pathological Types Including Squamous Cell Carcinoma, Adenocarcinoma, and Mixed Squamous Cell and Glandular Papilloma: A Case Report
Xiaojing Wang, Haifeng Liu, Dongjie Zhai, Yanan Qin, Chuifeng Fan & Di Zhang
Pages: 13-19
Published online: 22 Sep 2022
AbstractforMultiple Primary Lung Tumors of Different Pathological Types Including Squamous Cell Carcinoma, Adenocarcinoma, and Mixed Squamous Cell and Glandular Papilloma: A Case Report | Full Text | References | PDF (2.1 MB)
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Corrigendum

Correction
Secondary Nasopharyngeal Mixed Adenoneuroendocrine Carcinoma After Radical Radiotherapy for Nasopharyngeal Carcinoma: A Rare Case and Literature Review [Corrigendum]
Pages: 21-22
Published online: 07 Jan 2022
CitationforSecondary Nasopharyngeal Mixed Adenoneuroendocrine Carcinoma After Radical Radiotherapy for Nasopharyngeal Carcinoma: A Rare Case and Literature Review [Corrigendum] | Full Text | PDF (2.3 MB)
  • 73 Views
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Open Access

Review

Review Article
Role of Reactivating Mutant p53 Protein in Suppressing Growth and Metastasis of Triple-Negative Breast Cancer
Taylor P Berke, Simon H Slight & Salman M Hyder
Pages: 23-30
Published online: 17 Sep 2022
AbstractforRole of Reactivating Mutant p53 Protein in Suppressing Growth and Metastasis of Triple-Negative Breast Cancer | Full Text | References | PDF (978.8 KB)
  • 540 Views
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Open Access

Original Research

Article
Efficacy and Safety of Gefitinib Plus Pemetrexed/Platinum in Advanced EGFR-Mutated Lung Adenocarcinoma Patients: A Real-World Observational Study
Rui Wang & Qiang Wu
Pages: 31-39
Published online: 13 Jan 2022
AbstractforEfficacy and Safety of Gefitinib Plus Pemetrexed/Platinum in Advanced EGFR-Mutated Lung Adenocarcinoma Patients: A Real-World Observational Study | Full Text | References | PDF (5.4 MB)
  • 76 Views
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Open Access
Article
Prognostic Implications of Six Altered Genes in Asian Non-Surgical Esophageal Carcinoma Patients Treated with Chemoradiotherapy
Alei Feng, Ning Yang, Ruoying Yu, Jingwen Liu, Jiaohui Pang, Xue Wu, Yang Shao, Zhe Yang & Honghai Dai
Pages: 41-51
Published online: 17 Sep 2022
AbstractforPrognostic Implications of Six Altered Genes in Asian Non-Surgical Esophageal Carcinoma Patients Treated with Chemoradiotherapy | Full Text | References | PDF (2.4 MB)
  • 128 Views
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Open Access

Review

Review Article
Pexidartinib in the Management of Advanced Tenosynovial Giant Cell Tumor: Focus on Patient Selection and Special Considerations
Anna Vaynrub, John H Healey, William Tap & Max Vaynrub
Pages: 53-66
Published online: 13 Jan 2022
AbstractforPexidartinib in the Management of Advanced Tenosynovial Giant Cell Tumor: Focus on Patient Selection and Special Considerations | Full Text | References | PDF (406.4 KB)
  • 280 Views
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Open Access

Case Report

Case Report
Superselective Prostate Artery Embolization for Treatment of Severe Haematuria Secondary to Rapid Progression of Treatment-Induced Neuroendocrine Prostate Cancer: A Case Report
Liang Deng, Chao Li, Qiangrong He, Chenghui Huang, Qian Chen, Shengwang Zhang, Long Wang, Yu Gan & Zhi Long
Pages: 67-75
Published online: 17 Sep 2022
AbstractforSuperselective Prostate Artery Embolization for Treatment of Severe Haematuria Secondary to Rapid Progression of Treatment-Induced Neuroendocrine Prostate Cancer: A Case Report | Full Text | References | PDF (1.2 MB)
  • 125 Views
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Open Access

Corrigendum

Correction
Traditional Chinese Medicine Astragalus Polysaccharide Enhanced Antitumor Effects of the Angiogenesis Inhibitor Apatinib in Pancreatic Cancer Cells on Proliferation, Invasiveness, and Apoptosis [Corrigendum]
Pages: 77-79
Published online: 17 Sep 2022
First Page PreviewforTraditional Chinese Medicine Astragalus Polysaccharide Enhanced Antitumor Effects of the Angiogenesis Inhibitor Apatinib in Pancreatic Cancer Cells on Proliferation, Invasiveness, and Apoptosis [Corrigendum] | Full Text | PDF (2.9 MB)
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Open Access

Retraction

Retraction
Bone Marrow Mesenchymal Stem Cells-Derived Exosomal miR-425-5p Inhibits Acute Myeloid Leukemia Cell Proliferation, Apoptosis, Invasion and Migration by Targeting WTAP [Retraction]
Pages: 81-82
Published online: 17 Sep 2022
CitationforBone Marrow Mesenchymal Stem Cells-Derived Exosomal miR-425-5p Inhibits Acute Myeloid Leukemia Cell Proliferation, Apoptosis, Invasion and Migration by Targeting WTAP [Retraction] | Full Text | PDF (131.8 KB)
  • 95 Views
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Retraction
LncRNA GA-Binding Protein Transcription Factor Subunit Beta-1 Antisense RNA 1 Inhibits Renal Carcinoma Growth Through an MiR-1246/Phosphoenolpyruvate Carboxykinase 1 Pathway [Retraction]
Pages: 83-84
Published online: 17 Sep 2022
CitationforLncRNA GA-Binding Protein Transcription Factor Subunit Beta-1 Antisense RNA 1 Inhibits Renal Carcinoma Growth Through an MiR-1246/Phosphoenolpyruvate Carboxykinase 1 Pathway [Retraction] | Full Text | PDF (135.7 KB)
  • 76 Views
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Open Access
Retraction
Knockdown of Fibrous Sheath Interacting Protein 1 Expression Reduces Bladder Urothelial Carcinoma Cell Proliferation and Induces Apoptosis via Inhibition of the PI3K/AKT Pathway [Retraction]
Pages: 85-86
Published online: 17 Sep 2022
CitationforKnockdown of Fibrous Sheath Interacting Protein 1 Expression Reduces Bladder Urothelial Carcinoma Cell Proliferation and Induces Apoptosis via Inhibition of the PI3K/AKT Pathway [Retraction] | Full Text | PDF (133.6 KB)
  • 80 Views
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Open Access

Original Research

Article
Stichoposide C Exerts Anticancer Effects on Ovarian Cancer by Inducing Autophagy via Inhibiting AKT/mTOR Pathway
Fangfang Liu, Lumin Tang, Mengyu Tao, Chuang Cui, Di He, Longxia Li, Yahui Liao, Yamin Gao, Jing He, Fan Sun, Houwen Lin & He Li
Pages: 87-101
Published online: 17 Sep 2022
AbstractforStichoposide C Exerts Anticancer Effects on Ovarian Cancer by Inducing Autophagy via Inhibiting AKT/mTOR Pathway | Full Text | References | PDF (14.3 MB)
  • 198 Views
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Open Access

Review

Review Article
Overcoming Resistance to Kinase Inhibitors: The Paradigm of Chronic Myeloid Leukemia
Sara De Santis, Cecilia Monaldi, Manuela Mancini, Samantha Bruno, Michele Cavo & Simona Soverini
Pages: 103-116
Published online: 17 Sep 2022
AbstractforOvercoming Resistance to Kinase Inhibitors: The Paradigm of Chronic Myeloid Leukemia | Full Text | References | PDF (1.5 MB)
  • 236 Views
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Open Access

Retraction

Retraction
Long Noncoding RNA UCA1 Accelerates Nasopharyngeal Carcinoma Cell Progression by Modulating miR-124-3p/ITGB1 Axis [Retraction]
Pages: 117-118
Published online: 17 Sep 2022
CitationforLong Noncoding RNA UCA1 Accelerates Nasopharyngeal Carcinoma Cell Progression by Modulating miR-124-3p/ITGB1 Axis [Retraction] | Full Text | PDF (129.8 KB)
  • 87 Views
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Open Access
Retraction
Knockdown of Long Noncoding RNA 00152 (LINC00152) Inhibits Human Retinoblastoma Progression [Retraction]
Pages: 119-120
Published online: 17 Sep 2022
CitationforKnockdown of Long Noncoding RNA 00152 (LINC00152) Inhibits Human Retinoblastoma Progression [Retraction] | Full Text | PDF (135.2 KB)
  • 96 Views
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Open Access

Original Research

Article
Aberrant miR-362-3p is Associated with EBV-Infection and Prognosis in Nasopharyngeal Carcinoma and Involved in Tumor Progression by Targeting JMJD2A
Xiangyun Wang & Ping Chen
Pages: 121-131
Published online: 17 Sep 2022
AbstractforAberrant miR-362-3p is Associated with EBV-Infection and Prognosis in Nasopharyngeal Carcinoma and Involved in Tumor Progression by Targeting JMJD2A | Full Text | References | PDF (4.5 MB)
  • 132 Views
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Open Access

Retraction

Retraction
lncRNA HAND2-AS1 Regulates Prostate Cancer Cell Growth Through Targeting the miR-106a-5p/RBM24 Axis [Retraction]
Pages: 133-134
Published online: 17 Sep 2022
CitationforlncRNA HAND2-AS1 Regulates Prostate Cancer Cell Growth Through Targeting the miR-106a-5p/RBM24 Axis [Retraction] | Full Text | PDF (131.6 KB)
  • 77 Views
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Open Access

Original Research

Article
Treatment Patterns and Outcomes Among Elderly Glioblastoma Patients in Riyadh, Saudi Arabia
Amal Marie, Ahmed Maklad, Abdullah AlTwairgi, Moemen Aly, Ashraf Elyamany, Wafaa AlShaqweer, Mohamed Senosy & Ali Balbaid
Pages: 135-144
Published online: 17 Sep 2022
AbstractforTreatment Patterns and Outcomes Among Elderly Glioblastoma Patients in Riyadh, Saudi Arabia | Full Text | References | PDF (3.4 MB)
  • 149 Views
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Open Access

Retraction

Retraction
LINC02476 Promotes the Malignant Phenotype of Hepatocellular Carcinoma by Sponging miR-497 and Increasing HMGA2 Expression [Retraction]
Pages: 145-146
Published online: 17 Sep 2022
CitationforLINC02476 Promotes the Malignant Phenotype of Hepatocellular Carcinoma by Sponging miR-497 and Increasing HMGA2 Expression [Retraction] | Full Text | PDF (132 KB)
  • 75 Views
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Open Access

Original Research

Article
Genetic and Clinicopathologic Characteristics of Papillary Thyroid Carcinoma in the Chinese Population: High BRAF Mutation Allele Frequency, Multiple Driver Gene Mutations, and RET Fusion May Indicate More Advanced TN Stage
Zhihong Wang, Peng Tang, Surong Hua, Junyi Gao, Bin Zhang, Hua Wan, Qixi Wu, Jiaxin Zhang & Ge Chen
Pages: 147-157
Published online: 17 Sep 2022
AbstractforGenetic and Clinicopathologic Characteristics of Papillary Thyroid Carcinoma in the Chinese Population: High BRAF Mutation Allele Frequency, Multiple Driver Gene Mutations, and RET Fusion May Indicate More Advanced TN Stage | Full Text | References | PDF (1.6 MB)
  • 203 Views
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Open Access

Case Series

Case Report
Rapid and Efficient Response to Gilteritinib and Venetoclax-Based Therapy in Two AML Patients with FLT3-ITD Mutation Unresponsive to Venetoclax Plus Azacitidine
Lei-Si Zhang, Jun Wang, Ming-Zhu Xu, Tian-Mei Wu, Si-Man Huang, Han-Yu Cao, Ai-Ning Sun, Song-Bai Liu & Sheng-Li Xue
Pages: 159-164
Published online: 11 Oct 2022
AbstractforRapid and Efficient Response to Gilteritinib and Venetoclax-Based Therapy in Two AML Patients with FLT3-ITD Mutation Unresponsive to Venetoclax Plus Azacitidine | Full Text | References | PDF (1.9 MB)
  • 144 Views
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Open Access

Review

Review Article
PARP Inhibitor Applicability: Detailed Assays for Homologous Recombination Repair Pathway Components
Geraldine O’Sullivan Coyne, Chris Karlovich, Deborah Wilsker, Andrea Regier Voth, Ralph E Parchment, Alice P Chen & James H Doroshow
Pages: 165-180
Published online: 17 Sep 2022
AbstractforPARP Inhibitor Applicability: Detailed Assays for Homologous Recombination Repair Pathway Components | Full Text | References | PDF (2.5 MB)
  • 319 Views
  • 4 CrossRef citations
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Open Access

Original Research

Article
Expression and Prognostic Value of Glucose Transporter 3 in Diffuse Large B Cell Lymphoma
Yongpeng Xu, Xinglu Zhou, Shuai Zhang, Abiyasi Nanding & Qijia Xuan
Pages: 181-191
Published online: 17 Sep 2022
AbstractforExpression and Prognostic Value of Glucose Transporter 3 in Diffuse Large B Cell Lymphoma | Full Text | References | PDF (2 MB)
  • 138 Views
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Open Access

Review

Review Article
Targeted Therapy for Relapsed/Refractory Follicular Lymphoma: Focus on Clinical Utility of Tazemetostat
Ruben Raychaudhuri & Chaitra Ujjani
Pages: 193-199
Published online: 17 Sep 2022
AbstractforTargeted Therapy for Relapsed/Refractory Follicular Lymphoma: Focus on Clinical Utility of Tazemetostat | Full Text | References | PDF (253 KB)
  • 249 Views
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Original Research

Article
Airway Fusobacterium is Associated with Poor Response to Immunotherapy in Lung Cancer
Shujuan Chu, Zaixing Cheng, Zhongyuan Yin, Juanjuan Xu, Feng Wu, Yang Jin & Guanghai Yang
Pages: 201-213
Published online: 17 Sep 2022
AbstractforAirway Fusobacterium is Associated with Poor Response to Immunotherapy in Lung Cancer | Full Text | References | PDF (8 MB)
  • 166 Views
  • 7 CrossRef citations
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Open Access

Retraction

Retraction
miR-132 Can Inhibit Glioma Cells Invasion and Migration by Target MMP16 in vitro [Retraction]
Pages: 215-216
Published online: 17 Sep 2022
CitationformiR-132 Can Inhibit Glioma Cells Invasion and Migration by Target MMP16 in vitro [Retraction] | Full Text | PDF (137.6 KB)
  • 90 Views
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Open Access

Corrigendum

Correction
HMGB1/RAGE Axis Mediates the Apoptosis, Invasion, Autophay, and Angiogenesis of the Renal Cell Carcinoma [Corrigendum]
Pages: 217-218
Published online: 17 Sep 2022
CitationforHMGB1/RAGE Axis Mediates the Apoptosis, Invasion, Autophay, and Angiogenesis of the Renal Cell Carcinoma [Corrigendum] | Full Text | PDF (2.7 MB)
  • 87 Views
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Original Research

Article
Epigenetic Activation of lncRNA MIR155HG Mediated by Promoter Hypomethylation and SP1 is Correlated with Immune Infiltration in Glioma
Xuechao Wu, Quan Wan, Jing Wang, Peng Hou, Qijian Zhang, Qing Wang & Xiaojie Lu
Pages: 219-235
Published online: 17 Sep 2022
AbstractforEpigenetic Activation of lncRNA MIR155HG Mediated by Promoter Hypomethylation and SP1 is Correlated with Immune Infiltration in Glioma | Full Text | References | PDF (15.1 MB)
  • 120 Views
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Case Series

Case Report
Undifferentiated Large Cell Carcinoma of the Thymus Associated with Plasma-Cell Type Castleman Disease-Like Reaction: A Case Series
Lihua Han, En-Hua Wang & Liang Wang
Pages: 237-242
Published online: 20 Sep 2022
AbstractforUndifferentiated Large Cell Carcinoma of the Thymus Associated with Plasma-Cell Type Castleman Disease-Like Reaction: A Case Series | Full Text | References | PDF (2.1 MB)
  • 103 Views
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Open Access
Case Report
Selinexor, Bortezomib and Dexamethasone: An Effective Salvage Regimen for Heavily Pretreated Myeloma Patients
Michel Delforge, Jolien Raddoux, Corine Antonis, Céline Clement, Nicolas Kint, Anneleen Vanhellemont, Julie Bravetti & Peter Vandenberghe
Pages: 243-250
Published online: 20 Sep 2022
AbstractforSelinexor, Bortezomib and Dexamethasone: An Effective Salvage Regimen for Heavily Pretreated Myeloma Patients | Full Text | References | PDF (714.3 KB)
  • 123 Views
  • 1 CrossRef citations
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Case Report

Case Report
A Novel LOC101927967 Intergenic Region ALK Fusion Identified by NGS and Validated by IHC and FISH in a Patient with Early Stage Adenocarcinoma of Lung
Xiaojing Jia, Qianru He, Xiaodan Xing, Yanming Yang & Yan Ma
Pages: 251-254
Published online: 14 Mar 2022
AbstractforA Novel LOC101927967 Intergenic Region ALK Fusion Identified by NGS and Validated by IHC and FISH in a Patient with Early Stage Adenocarcinoma of Lung | Full Text | References | PDF (1.9 MB)
  • 112 Views
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Case Report
Progression-Free Survival of a Patient with Advanced Hepatocellular Carcinoma Treated with Adoptive Cell Therapy Using Natural Killer Cells: A Case Report
Guodai Hong, Silun Xie, Zikuan Guo, Diping Zhang, Sihai Ge, Suqin Zhang & Wenbin Gao
Pages: 255-266
Published online: 15 Mar 2022
AbstractforProgression-Free Survival of a Patient with Advanced Hepatocellular Carcinoma Treated with Adoptive Cell Therapy Using Natural Killer Cells: A Case Report | Full Text | References | PDF (10.4 MB)
  • 150 Views
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Open Access
Case Report
Efficacy of Disitamab Vedotin in Treating HER2 2+/FISH- Gastric Cancer
Li Dai, Xiangren Jin, Liuxing Wang, Haibin Wang, Zhiqiang Yan, Guanghai Wang, Baichuang Liang, Fu Huang, Yuling Luo, Taichun Chen & Qian Wang
Pages: 267-275
Published online: 16 Mar 2022
AbstractforEfficacy of Disitamab Vedotin in Treating HER2 2+/FISH- Gastric Cancer | Full Text | References | PDF (3.3 MB)
  • 204 Views
  • 1 CrossRef citations
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Open Access

Review

Review Article
Exploring the Role of Transglutaminase in Patients with Glioblastoma: Current Perspectives
William P Katt, Cody Aplin & Richard A Cerione
Pages: 277-290
Published online: 17 Sep 2022
AbstractforExploring the Role of Transglutaminase in Patients with Glioblastoma: Current Perspectives | Full Text | References | PDF (4.6 MB)
  • 201 Views
  • 3 CrossRef citations
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Open Access
Review Article
The Research Progress of Bufalin in the Treatment of Hepatocellular Carcinoma
Han-yu Jiang, Hui-min Zheng, Cheng Xia, Xiang Li, Gang Wang, Tong Zhao, Xiao-nan Cui, Ruo-yu Wang & Ying Liu
Pages: 291-298
Published online: 17 Sep 2022
AbstractforThe Research Progress of Bufalin in the Treatment of Hepatocellular Carcinoma | Full Text | References | PDF (1.5 MB)
  • 104 Views
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Original Research

Article
CDKN3 Overcomes Bladder Cancer Cisplatin Resistance via LDHA-Dependent Glycolysis Reprogramming
Mengxuan Li, Nan Che, Yu Jin, Jinhua Li & Wanshan Yang
Pages: 299-311
Published online: 26 Mar 2022
AbstractforCDKN3 Overcomes Bladder Cancer Cisplatin Resistance via LDHA-Dependent Glycolysis Reprogramming | Full Text | References | PDF (9.8 MB)
  • 117 Views
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Open Access

Case Report

Case Report
Genetic Testing and Immunotherapy for Intracranial Inflammatory Myofibroblastic Tumor: A Case Report
Xiangji Meng, Lei Zhang, Qi Wang, Jimin Chen, Chunmei Zhang, Rongjie Tao & Yong Wang
Pages: 313-321
Published online: 01 Apr 2022
AbstractforGenetic Testing and Immunotherapy for Intracranial Inflammatory Myofibroblastic Tumor: A Case Report | Full Text | References | PDF (3.1 MB)
  • 193 Views
  • 1 CrossRef citations
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Open Access
Case Report
Remarkable Response to the Triplet Combination of Olaparib with Pembrolizumab and Bevacizumab in the Third-Line Treatment of an Ovarian Clear Cell Carcinoma Patient with an ARID1A Mutation: A Case Report
Yingchao Zhao & Yao Jiang
Pages: 323-328
Published online: 02 Apr 2022
AbstractforRemarkable Response to the Triplet Combination of Olaparib with Pembrolizumab and Bevacizumab in the Third-Line Treatment of an Ovarian Clear Cell Carcinoma Patient with an ARID1A Mutation: A Case Report | Full Text | References | PDF (807.9 KB)
  • 168 Views
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Open Access

Retraction

Retraction
The Silencing of LncRNA-H19 Decreases Chemoresistance of Human Glioma Cells to Temozolomide by Suppressing Epithelial-Mesenchymal Transition via the Wnt/β-Catenin Pathway [Retraction]
Pages: 329-330
Published online: 07 Apr 2022
CitationforThe Silencing of LncRNA-H19 Decreases Chemoresistance of Human Glioma Cells to Temozolomide by Suppressing Epithelial-Mesenchymal Transition via the Wnt/β-Catenin Pathway [Retraction] | Full Text | PDF (252.4 KB)
  • 70 Views
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Open Access

Original Research

Article
An Innovative Site-Specific Anti-HER2 Antibody-Drug Conjugate with High Homogeneity and Improved Therapeutic Index
Xiwu Hui, Can Yuan, Weirong Cao, Wenli Ge, Di Zhang, Mo Dan, Qian Zhao, Boning Liu & Bing Yao
Pages: 331-343
Published online: 17 Sep 2022
AbstractforAn Innovative Site-Specific Anti-HER2 Antibody-Drug Conjugate with High Homogeneity and Improved Therapeutic Index | Full Text | References | PDF (4.8 MB)
  • 551 Views
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Case Report

Case Report
Treatment of PD-1 Inhibitor-Associated Toxic Epidermal Necrolysis: A Case Report and Brief Review
Yidong Zhao, Yuzhen Cao, Xiuyu Wang & Tianyi Qian
Pages: 345-351
Published online: 17 Sep 2022
AbstractforTreatment of PD-1 Inhibitor-Associated Toxic Epidermal Necrolysis: A Case Report and Brief Review | Full Text | References | PDF (1.6 MB)
  • 165 Views
  • 5 CrossRef citations
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Case Series

Case Report
Clinical Response to Neoadjuvant Immunotherapy Combined with Targeted Therapy and Chemotherapy in Oral Squamous Cell Carcinoma: Experience in Three Patients
Yu Tian, Lei Zhang, Nenghao Jin, Zhiyi Wan, Henghui Zhang, Haizhong Zhang & Lei Zhang
Pages: 353-359
Published online: 08 Apr 2022
AbstractforClinical Response to Neoadjuvant Immunotherapy Combined with Targeted Therapy and Chemotherapy in Oral Squamous Cell Carcinoma: Experience in Three Patients | Full Text | References | PDF (4.7 MB)
  • 213 Views
  • 3 CrossRef citations
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Case Report

Case Report
CAR T-Cell Therapy for Relapsed/Refractory Diffuse Large B-Cell Lymphoma with Progressive Muscular Dystrophy: A Case Report
Liting Chen, Bin Xu, Wanying Liu, Di Wang, Jinhuan Xu, Xia Mao, Min Xiao, Jianfeng Zhou & Yi Xiao
Pages: 361-366
Published online: 08 Apr 2022
AbstractforCAR T-Cell Therapy for Relapsed/Refractory Diffuse Large B-Cell Lymphoma with Progressive Muscular Dystrophy: A Case Report | Full Text | References | PDF (2.9 MB)
  • 135 Views
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Case Series

Case Report
Genomic Analysis of Tumors from Patients with Glioblastoma with Long-Term Response to Afatinib
Scott Owen, Scheryll Alken, Jad Alshami, Marie-Christine Guiot, Petr Kavan, David A Reardon, Thierry Muanza, Neil Gibson, Karine Pemberton, Flavio Solca, Agnieszka Cseh & Frank Saran
Pages: 367-380
Published online: 08 Apr 2022
AbstractforGenomic Analysis of Tumors from Patients with Glioblastoma with Long-Term Response to Afatinib | Full Text | References | PDF (5.7 MB)
  • 218 Views
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Open Access

Review

Review Article
Hereditary Gynecologic Cancer Syndromes – A Narrative Review
Stoyan Kostov, Rafał Watrowski, Yavor Kornovski, Deyan Dzhenkov, Stanislav Slavchev, Yonka Ivanova & Angel Yordanov
Pages: 381-405
Published online: 08 Apr 2022
AbstractforHereditary Gynecologic Cancer Syndromes – A Narrative Review | Full Text | References | PDF (4.6 MB)
  • 361 Views
  • 3 CrossRef citations
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Open Access

Case Report

Case Report
Pancytopenia During Osimertinib Treatment in a Patient with EGFR-Mutated Non-Small Cell Lung Cancer
Pietro Di Marino, Cosima Chiapperino, Francesca Chiara Primavera, Maria Teresa Martino, Davide Brocco, Consiglia Carella, Antonino Grassadonia, Nicola Tinari & Michele De Tursi
Pages: 407-410
Published online: 11 Apr 2022
AbstractforPancytopenia During Osimertinib Treatment in a Patient with EGFR-Mutated Non-Small Cell Lung Cancer | Full Text | References | PDF (303.4 KB)
  • 188 Views
  • 1 CrossRef citations
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Open Access

Review

Review Article
Migfilin: Cell Adhesion Effect and Comorbidities
Baoyu Duan, Ziyao Qin, Xuefeng Gu & Yanfei Li
Pages: 411-422
Published online: 19 Apr 2022
AbstractforMigfilin: Cell Adhesion Effect and Comorbidities | Full Text | References | PDF (2.3 MB)
  • 151 Views
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Open Access
Review Article
Targeting TP53-Mutated Acute Myeloid Leukemia: Research and Clinical Developments
Eric M Granowicz & Brian A Jonas
Pages: 423-436
Published online: 21 Apr 2022
AbstractforTargeting TP53-Mutated Acute Myeloid Leukemia: Research and Clinical Developments | Full Text | References | PDF (494.5 KB)
  • 328 Views
  • 8 CrossRef citations
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Review Article
Glioblastoma: Pitfalls and Opportunities of Immunotherapeutic Combinations
Marcin Niedbała, Katarzyna Malarz, Gitanjali Sharma, Gabriela Kramer-Marek & Wojciech Kaspera
Pages: 437-468
Published online: 28 Apr 2022
AbstractforGlioblastoma: Pitfalls and Opportunities of Immunotherapeutic Combinations | Full Text | References | PDF (2.8 MB)
  • 472 Views
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Open Access

Retraction

Retraction
MicroRNA-423 Drug Resistance and Proliferation of Breast Cancer Cells by Targeting ZFP36 [Retraction]
Pages: 469-470
Published online: 02 May 2022
CitationforMicroRNA-423 Drug Resistance and Proliferation of Breast Cancer Cells by Targeting ZFP36 [Retraction] | Full Text | PDF (237.6 KB)
  • 113 Views
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Review

Review Article
Profile of Margetuximab: Evidence to Date in the Targeted Treatment of Metastatic HER2-positive Breast Cancer
Ilana Schlam, Raquel Nunes & Filipa Lynce
Pages: 471-478
Published online: 28 Apr 2022
AbstractforProfile of Margetuximab: Evidence to Date in the Targeted Treatment of Metastatic HER2-positive Breast Cancer | Full Text | References | PDF (1.6 MB)
  • 189 Views
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Original Research

Article
Identification of 1,2,4-Oxadiazoles-Based Novel EGFR Inhibitors: Molecular Dynamics Simulation-Guided Identification and in vitro ADME Studies
Vishal Unadkat, Shishir Rohit, Paranjay Parikh, Kaushal Patel, Vinod Sanna & Sanjay Singh
Pages: 479-495
Published online: 11 Oct 2022
AbstractforIdentification of 1,2,4-Oxadiazoles-Based Novel EGFR Inhibitors: Molecular Dynamics Simulation-Guided Identification and in vitro ADME Studies | Full Text | References | PDF (6.4 MB)
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Review

Review Article
The Development of Non-Invasive Diagnostic Tools in Bladder Cancer
Alison Schulz, Justin Loloi, Luis Pina Martina & Alexander Sankin
Pages: 497-507
Published online: 17 Sep 2022
AbstractforThe Development of Non-Invasive Diagnostic Tools in Bladder Cancer | Full Text | References | PDF (433.7 KB)
  • 392 Views
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Original Research

Article
TROP2 as Patient-Tailoring but Not Prognostic Biomarker for Breast Cancer
Xiaoyue Liu, Tianhao Zhou, Yongmei Wang, Min Pei, Guifeng Wang, Wendi Chu, Qi Wang, Shaoqian Du, Hongxia Wang & Chunhe Wang
Pages: 509-520
Published online: 03 May 2022
AbstractforTROP2 as Patient-Tailoring but Not Prognostic Biomarker for Breast Cancer | Full Text | References | PDF (4.1 MB)
  • 272 Views
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Corrigendum

Correction
A Hybrid Glioma Tumor Cell Lysate Immunotherapy Vaccine Demonstrates Good Clinical Efficacy in the Rat Model [Corrigendum]
Pages: 521-522
Published online: 06 May 2022
CitationforA Hybrid Glioma Tumor Cell Lysate Immunotherapy Vaccine Demonstrates Good Clinical Efficacy in the Rat Model [Corrigendum] | Full Text | PDF (1.7 MB)
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Correction
Inhibition of Migration, Invasion and Drug Resistance of Pancreatic Adenocarcinoma Cells – Role of Snail, Slug and Twist and Small Molecule Inhibitors [Corrigendum]
Pages: 523-526
Published online: 11 May 2022
First Page PreviewforInhibition of Migration, Invasion and Drug Resistance of Pancreatic Adenocarcinoma Cells – Role of Snail, Slug and Twist and Small Molecule Inhibitors [Corrigendum] | Full Text | PDF (7.9 MB)
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Correction
Gastric H+/K+-ATPase Expression in Normal Laryngeal Tissue and Laryngeal Carcinoma [Corrigendum]
Pages: 527-528
Published online: 12 May 2022
CitationforGastric H+/K+-ATPase Expression in Normal Laryngeal Tissue and Laryngeal Carcinoma [Corrigendum] | Full Text | PDF (1.2 MB)
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Correction
RANKL/RANK Pathway Abrogates Cetuximab Sensitivity in Gastric Cancer Cells via Activation of EGFR and c-Src [Corrigendum]
Pages: 529-530
Published online: 13 May 2022
CitationforRANKL/RANK Pathway Abrogates Cetuximab Sensitivity in Gastric Cancer Cells via Activation of EGFR and c-Src [Corrigendum] | Full Text | PDF (2 MB)
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Original Research

Article
Protein Expression of Folate Receptor Alpha in Adenoid Cystic Carcinoma of the Head and Neck
Julia Schnoell, Bernhard J Jank, Lorenz Kadletz-Wanke, Stefan Stoiber, Elisabeth Gurnhofer, Michaela Schlederer, Gregor Heiduschka & Lukas Kenner
Pages: 531-538
Published online: 17 Sep 2022
AbstractforProtein Expression of Folate Receptor Alpha in Adenoid Cystic Carcinoma of the Head and Neck | Full Text | References | PDF (2.4 MB)
  • 141 Views
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Retraction

Retraction
Silencing circZFR Inhibits the Proliferation, Migration and Invasion of Human Renal Carcinoma Cells by Regulating miR-206 [Retraction]
Pages: 539-540
Published online: 18 May 2022
CitationforSilencing circZFR Inhibits the Proliferation, Migration and Invasion of Human Renal Carcinoma Cells by Regulating miR-206 [Retraction] | Full Text | PDF (241.7 KB)
  • 79 Views
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Original Research

Article
Circular RNA circLRCH3 Inhibits Proliferation, Migration, and Invasion of Colorectal Cancer Cells Through miRNA-223/LPP Axis
Yiming Yang, Di Wang, Kaixiong Tao & Guobin Wang
Pages: 541-554
Published online: 18 May 2022
AbstractforCircular RNA circLRCH3 Inhibits Proliferation, Migration, and Invasion of Colorectal Cancer Cells Through miRNA-223/LPP Axis | Full Text | References | PDF (11.2 MB)
  • 123 Views
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Article
SPINDOC is Highly Expressed in Pan-Cancer Samples and Can Promote the Proliferation, Invasion and Migration of Hepatocellular Carcinoma Cells by Activating Wnt/β-Catenin Signaling Pathway
Wangxia Tong, Lilan Yang, Li Liu, Xudong Liu & Ning Luo
Pages: 555-570
Published online: 18 May 2022
AbstractforSPINDOC is Highly Expressed in Pan-Cancer Samples and Can Promote the Proliferation, Invasion and Migration of Hepatocellular Carcinoma Cells by Activating Wnt/β-Catenin Signaling Pathway | Full Text | References | PDF (12.7 MB)
  • 147 Views
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Article
Genomic Alteration Spectrum of Non-Small Cell Lung Cancer Patients in East-China Characterized by Tumor Tissue DNA and Cell-Free DNA
Jie Li, Siwen Chen, Hui Xue, Haoyi Wang, Tianwei Huang, Hongya Xie, Jiang He, Cai Ke, Zhaonan Yu & Bin Ni
Pages: 571-584
Published online: 17 Sep 2022
AbstractforGenomic Alteration Spectrum of Non-Small Cell Lung Cancer Patients in East-China Characterized by Tumor Tissue DNA and Cell-Free DNA | Full Text | References | PDF (5.7 MB)
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Retraction

Retraction
Upregulated RACK1 Attenuates Gastric Cancer Cell Growth and Epithelial–Mesenchymal Transition via Suppressing Wnt/β-Catenin Signaling [Retraction]
Pages: 585-586
Published online: 20 May 2022
CitationforUpregulated RACK1 Attenuates Gastric Cancer Cell Growth and Epithelial–Mesenchymal Transition via Suppressing Wnt/β-Catenin Signaling [Retraction] | Full Text | PDF (235.4 KB)
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Case Report

Case Report
Clinical and Pathological Features of Primary Renal Well-Differentiated Neuroendocrine Tumor
Hua Jiang & He Zhang
Pages: 587-596
Published online: 17 Sep 2022
AbstractforClinical and Pathological Features of Primary Renal Well-Differentiated Neuroendocrine Tumor | Full Text | References | PDF (722.2 KB)
  • 219 Views
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Original Research

Article
EGFR Mutation Status and Subtypes Predicted by CT-Based 3D Radiomic Features in Lung Adenocarcinoma
Quan Chen, Yan Li, Qiguang Cheng, Juno Van Valkenburgh, Xiaotian Sun, Chuansheng Zheng, Ruiguang Zhang & Rong Yuan
Pages: 597-608
Published online: 30 May 2022
AbstractforEGFR Mutation Status and Subtypes Predicted by CT-Based 3D Radiomic Features in Lung Adenocarcinoma | Full Text | References | PDF (6 MB)
  • 126 Views
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Case Report

Case Report
Primary Hepatoid Adenocarcinoma of the Lung: A Systematic Literature Review
Zhitao Chen, Chenchen Ding, Ting Zhang, Yahui He & Guoping Jiang
Pages: 609-627
Published online: 17 Sep 2022
AbstractforPrimary Hepatoid Adenocarcinoma of the Lung: A Systematic Literature Review | Full Text | References | PDF (13 MB)
  • 166 Views
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Case Report
Successful Treatment of Metastatic Gallbladder Carcinoma with PD-L1 Expression by the Combination of PD-1 Inhibitor Plus Bevacizumab with Chemotherapy: A Case Report
Lihong Guo, Jie Zhang, Xueqin Liu, Haocong Liu, Yamin Zhang & Jinpeng Liu
Pages: 629-636
Published online: 07 Jun 2022
AbstractforSuccessful Treatment of Metastatic Gallbladder Carcinoma with PD-L1 Expression by the Combination of PD-1 Inhibitor Plus Bevacizumab with Chemotherapy: A Case Report | Full Text | References | PDF (3.6 MB)
  • 273 Views
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Case Report
Successful Treatment with Short-Term Steroid Against Severe Hepatitis Confirmed by Liver Biopsy in a Patient with Advanced Squamous-Cell Lung Cancer Receiving a Combination of Pembrolizumab, Carboplatin, and Nab-Paclitaxel: A Case Report
Anna Hayashi, Shinji Nakamichi, Yukako Nakayama, Atsuhiro Nagano, Erika Mikami, Natsuki Takano, Takehiro Tozuka, Masaru Matsumoto, Akihiko Miyanaga, Rintaro Noro, Yasuhiro Terasaki, Kaoru Kubota, Masahiro Seike & Akihiko Gemma
Pages: 637-642
Published online: 07 Jun 2022
AbstractforSuccessful Treatment with Short-Term Steroid Against Severe Hepatitis Confirmed by Liver Biopsy in a Patient with Advanced Squamous-Cell Lung Cancer Receiving a Combination of Pembrolizumab, Carboplatin, and Nab-Paclitaxel: A Case Report | Full Text | References | PDF (1.2 MB)
  • 137 Views
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Case Report
An Effective Hormonal Therapy for a Patient with Estrogen Receptor 1 (ESR1)-Amplified Metastatic Ovarian Cancer: A Case Report
Yue Wang, Shuang Tan, Evenki Pan, Yutong Ma, Xue Wu, Zhe Yu & Kui Jiang
Pages: 643-649
Published online: 09 Jun 2022
AbstractforAn Effective Hormonal Therapy for a Patient with Estrogen Receptor 1 (ESR1)-Amplified Metastatic Ovarian Cancer: A Case Report | Full Text | References | PDF (3.5 MB)
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Case Report
FGFR2-ERC1: A Subtype of FGFR2 Oncogenic Fusion Variant in Lung Adenocarcinoma and the Response to Anlotinib
Chen Hong, Jianping Wei, Tao Zhou, Xia Wang & Jing Cai
Pages: 651-657
Published online: 10 Jun 2022
AbstractforFGFR2-ERC1: A Subtype of FGFR2 Oncogenic Fusion Variant in Lung Adenocarcinoma and the Response to Anlotinib | Full Text | References | PDF (4.8 MB)
  • 104 Views
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Case Report
Leptomeningeal Metastatic L858R EGFR-mutant Lung Cancer: Prompt Response to Osimertinib in the Absence of T790M-mutation and Effective Subsequent Pulsed Erlotinib
Aladdin Kanbour, Faroug Salih, Wafa Abualainin, Mohamed Abdelrazek, Lajos Szabados, Issam Al-Bozom & Nabil E Omar
Pages: 659-667
Published online: 14 Jun 2022
AbstractforLeptomeningeal Metastatic L858R EGFR-mutant Lung Cancer: Prompt Response to Osimertinib in the Absence of T790M-mutation and Effective Subsequent Pulsed Erlotinib | Full Text | References | PDF (3.3 MB)
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Original Research

Article
Long-Term Efficacy and Safety of Anlotinib as a Monotherapy and Combined Therapy for Advanced Sarcoma
Weitao Yao, Xinhui Du, Jiaqiang Wang, Xin Wang, Peng Zhang & Xiaohui Niu
Pages: 669-679
Published online: 14 Jun 2022
AbstractforLong-Term Efficacy and Safety of Anlotinib as a Monotherapy and Combined Therapy for Advanced Sarcoma | Full Text | References | PDF (4.1 MB)
  • 159 Views
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Retraction

Retraction
LncRNA RNF144A-AS1 Promotes Bladder Cancer Progression via RNF144A-AS1/miR-455-5p/SOX11 Axis [Retraction]
Pages: 681-682
Published online: 15 Jun 2022
CitationforLncRNA RNF144A-AS1 Promotes Bladder Cancer Progression via RNF144A-AS1/miR-455-5p/SOX11 Axis [Retraction] | Full Text | PDF (235.2 KB)
  • 84 Views
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Original Research

Article
Development and Characterization of 3D Hybrid Spheroids for the Investigation of the Crosstalk Between B-Cell Non-Hodgkin Lymphomas and Mesenchymal Stromal Cells
Kamila Duś-Szachniewicz, Katarzyna Gdesz-Birula & Grzegorz Rymkiewicz
Pages: 683-697
Published online: 17 Jun 2022
AbstractforDevelopment and Characterization of 3D Hybrid Spheroids for the Investigation of the Crosstalk Between B-Cell Non-Hodgkin Lymphomas and Mesenchymal Stromal Cells | Full Text | References | PDF (7.3 MB)
  • 324 Views
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Retraction

Retraction
The Coexpression and Clinical Significance of Costimulatory Molecules B7-H1, B7-H3, and B7-H4 in Human Pancreatic Cancer [Retraction]
Pages: 699-700
Published online: 23 Jun 2022
CitationforThe Coexpression and Clinical Significance of Costimulatory Molecules B7-H1, B7-H3, and B7-H4 in Human Pancreatic Cancer [Retraction] | Full Text | PDF (231.6 KB)
  • 76 Views
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Retraction
LINC01436 Promotes the Progression of Gastric Cancer via Regulating miR-513a-5p/APE1 Axis [Retraction]
Pages: 701-702
Published online: 17 Sep 2022
CitationforLINC01436 Promotes the Progression of Gastric Cancer via Regulating miR-513a-5p/APE1 Axis [Retraction] | Full Text | PDF (230.7 KB)
  • 88 Views
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Case Report

Case Report
Response of Scalp and Skull Metastasis to Anti-PD-1 Antibody Combined with Regorafenib Treatment in a Sorafenib-Resistant Hepatocellular Carcinoma Patient and a Literature Review
Xin Long, Lei Zhang, Wen-qiang Wang, Er-lei Zhang, Xing Lv & Zhi-yong Huang
Pages: 703-716
Published online: 11 Oct 2022
AbstractforResponse of Scalp and Skull Metastasis to Anti-PD-1 Antibody Combined with Regorafenib Treatment in a Sorafenib-Resistant Hepatocellular Carcinoma Patient and a Literature Review | Full Text | References | PDF (6.7 MB)
  • 145 Views
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Case Report
Genetic Analysis and Combined Therapy of Surgery and Chemotherapy for the Progression-Free Survival of a Patient with Ovarian Carcinosarcoma: A Case Report and Literature Review
Shanshan Guo, Xiaoyun Zhang, Qianjue Tang, Mengyun Zhou, Dan Jiang & Erkai Yu
Pages: 717-725
Published online: 29 Jun 2022
AbstractforGenetic Analysis and Combined Therapy of Surgery and Chemotherapy for the Progression-Free Survival of a Patient with Ovarian Carcinosarcoma: A Case Report and Literature Review | Full Text | References | PDF (2.4 MB)
  • 137 Views
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Original Research

Article
Upregulation of Cartilage Oligomeric Matrix Protein Predicts Poor Prognosis in Urothelial Carcinoma
Yu-Hsuan Kuo, Hong-Yue Lai, Ti-Chun Chan, Chung-Hsi Hsing, Steven K Huang, Kun-Lin Hsieh, Tzu-Ju Chen, Wan-Shan Li, Jhih-Cheng Lu & Chien-Feng Li
Pages: 727-740
Published online: 17 Sep 2022
AbstractforUpregulation of Cartilage Oligomeric Matrix Protein Predicts Poor Prognosis in Urothelial Carcinoma | Full Text | References | PDF (3.9 MB)
  • 141 Views
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Case Report

Case Report
A Case of Pneumonia Masking Pleural Malignancy
Qian Xu, Juanjuan Tian, Lin Huang, Qilin Zhong, Yulin Xu, Linlin Liu & Jian Shi
Pages: 741-746
Published online: 02 Jul 2022
AbstractforA Case of Pneumonia Masking Pleural Malignancy | Full Text | References | PDF (670.4 KB)
  • 96 Views
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Review

Review Article
Targeting KRASG12C-Mutated Advanced Colorectal Cancer: Research and Clinical Developments
Jingran Ji, Chongkai Wang & Marwan Fakih
Pages: 747-756
Published online: 07 Jul 2022
AbstractforTargeting KRASG12C-Mutated Advanced Colorectal Cancer: Research and Clinical Developments | Full Text | References | PDF (1.9 MB)
  • 627 Views
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Retraction

Retraction
MicroRNA-769-5p Promotes the Growth of Glioma Cells by Targeting Lysine Methyltransferase 2A [Retraction]
Pages: 757-758
Published online: 08 Jul 2022
CitationforMicroRNA-769-5p Promotes the Growth of Glioma Cells by Targeting Lysine Methyltransferase 2A [Retraction] | Full Text | PDF (231 KB)
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Retraction
Circular RNA circGSE1 Promotes Cervical Cancer Progression Through miR-138-5p/Vimentin [Retraction]
Pages: 759-760
Published online: 12 Jul 2022
CitationforCircular RNA circGSE1 Promotes Cervical Cancer Progression Through miR-138-5p/Vimentin [Retraction] | Full Text | PDF (231 KB)
  • 86 Views
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Original Research

Article
Association Mining Identifies MAL2 as a Novel Tumor Suppressor in Colorectal Cancer
Kailai Wang, Yanmei Yang, Shu Zheng & Wangxiong Hu
Pages: 761-769
Published online: 09 Jul 2022
AbstractforAssociation Mining Identifies MAL2 as a Novel Tumor Suppressor in Colorectal Cancer | Full Text | References | PDF (5.1 MB)
  • 139 Views
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Case Report

Case Report
Case Report: Targeted Therapy with Anlotinib for a Rare Case of Spinal Cord Glioblastoma with FGFR3 Mutation
Ruiqiong Liu, Wei Wei, Huaying Hou, Ping Cong, Yong Zhou & Xiaoming Yu
Pages: 771-776
Published online: 11 Jul 2022
AbstractforCase Report: Targeted Therapy with Anlotinib for a Rare Case of Spinal Cord Glioblastoma with FGFR3 Mutation | Full Text | References | PDF (4.4 MB)
  • 126 Views
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Retraction

Retraction
Meg3 Induces EMT and Invasion of Glioma Cells via Autophagy [Retraction]
Pages: 777-778
Published online: 14 Jul 2022
CitationforMeg3 Induces EMT and Invasion of Glioma Cells via Autophagy [Retraction] | Full Text | PDF (232.8 KB)
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