References
- VinkemeierUCohenSLMoarefiIChaitBTKuriyanJDarnellJEJrDNA binding of in vitro activated Stat1 alpha, Stat1 beta and truncated Stat1: interaction between NH2-terminal domains stabilizes binding of two dimers to tandem DNA sitesEMBO J19961520561656268896455
- WojciakJMMartinez-YamoutMADysonHJWrightPEStructural basis for recruitment of CBP/p300 coactivators by STAT1 and STAT2 transactivation domainsEMBO J200928794895819214187
- ZhongZWenZDarnellJEJrStat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6Science1994264515595988140422
- AkiraSNishioYInoueMMolecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathwayCell199477163717512451
- HartKCRobertsonSCKanemitsuMYMeyerANTynanJADonoghueDJTransformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4Oncogene200019293309332010918587
- CirriPChiarugiPMarraFc-Src activates both STAT1 and STAT3 in PDGF-stimulated NIH3T3 cellsBiochem Biophys Res Commun199723924934979344858
- EhretGBReichenbachPSchindlerUDNA binding specificity of different STAT proteins. Comparison of in vitro specificity with natural target sitesJ Biol Chem200127696675668811053426
- XuXSunYLHoeyTCooperative DNA binding and sequence-selective recognition conferred by the STAT amino-terminal domainScience199627352767947978670419
- AndrésRMHaldAJohansenCKragballeKIversenLStudies of Jak/STAT3 expression and signalling in psoriasis identifies STAT3-Ser727 phosphorylation as a modulator of transcriptional activityExp Dermatol201322532332823614738
- WakaharaRKunimotoHTaninoKPhospho-Ser727 of STAT3 regulates STAT3 activity by enhancing dephosphorylation of phospho-Tyr705 largely through TC45Genes Cells201217213214522233524
- WangRCherukuriPLuoJActivation of Stat3 sequence-specific DNA binding and transcription by p300/CREB-binding protein-mediated acetylationJ Biol Chem200528012115281153415649887
- YuanZLGuanYJChatterjeeDChinYEStat3 dimerization regulated by reversible acetylation of a single lysine residueScience2005307570726927315653507
- SasakiAYasukawaHSuzukiACytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domainGenes Cells19994633935110421843
- YasukawaHMisawaHSakamotoHThe JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loopEMBO J19991851309132010064597
- ChungCDLiaoJLiuBSpecific inhibition of Stat3 signal transduction by PIAS3Science19972785344180318059388184
- NallarSCKalakondaSLindnerDJTumor-derived mutations in the gene associated with retinoid interferon-induced mortality (GRIM-19) disrupt its anti-signal transducer and activator of transcription 3 (STAT3) activity and promote oncogenesisJ Biol Chem2013288117930794123386605
- ZhangXGuoAYuJIdentification of STAT3 as a substrate of receptor protein tyrosine phosphatase TProc Natl Acad Sci USA2007104104060406417360477
- VeeriahSBrennanCMengSThe tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancersProc Natl Acad Sci USA2009106239435944019478061
- YamamotoTSekineYKashimaKThe nuclear isoform of protein-tyrosine phosphatase TC-PTP regulates interleukin-6-mediated signaling pathway through STAT3 dephosphorylationBiochem Biophys Res Commun2002297481181712359225
- ZhangWChanRJChenHNegative regulation of Stat3 by activating PTPN11 mutants contributes to the pathogenesis of Noonan syndrome and juvenile myelomonocytic leukemiaJ Biol Chem200928433223532236319509418
- NieYErionDMYuanZSTAT3 inhibition of gluconeogenesis is downregulated by SirT1Nat Cell Biol200911449250019295512
- BernierMPaulRKMartin-MontalvoANegative regulation of STAT3 protein-mediated cellular respiration by SIRT1 proteinJ Biol Chem201128622192701927921467030
- GaoHGuoR-FSpeyerCStat3 activation in acute lung injuryJ Immunol2004172127703771215187153
- BraunDAFribourgMSealfonSCCytokine response is determined by duration of receptor and signal transducers and activators of transcription 3 (STAT3) activationJ Biol Chem201328852986299323166328
- DauerDJFerraroBSongLStat3 regulates genes common to both wound healing and cancerOncogene200524213397340815735721
- GallucciRMSimeonovaPPMathesonJMImpaired cutaneous wound healing in interleukin-6-deficient and immunosuppressed miceFASEB J200014152525253111099471
- SanoSItamiSTakedaKKeratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesisEMBO J199918174657466810469645
- PickertGNeufertCLeppkesMSTAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healingJ Exp Med200920671465147219564350
- CofferPJvan PuijenbroekABurgeringBMInsulin activates Stat3 independently of p21ras-ERK and PI-3 K signal transductionOncogene19971521252925399399641
- CarvalheiraJBSilotoRMIgnacchittiIInsulin modulates leptin-induced STAT3 activation in rat hypothalamusFEBS Lett2001500311912411445068
- InoueHOgawaWAsakawaARole of hepatic STAT3 in brain-insulin action on hepatic glucose productionCell Metab20063426727516581004
- ZongCSChanJLevyDEHorvathCSadowskiHBWangLHMechanism of STAT3 activation by insulin-like growth factor I receptorJ Biol Chem200027520150991510510747872
- Niso-SantanoMShenSAdjemianSDirect interaction between STAT3 and EIF2AK2 controls fatty acid-induced autophagyAutophagy20139341541723221979
- TakedaKNoguchiKShiWTargeted disruption of the mouse Stat3 gene leads to early embryonic lethalityProc Natl Acad Sci USA1997948380138049108058
- SanoSTakahamaYSugawaraTStat3 in thymic epithelial cells is essential for postnatal maintenance of thymic architecture and thymocyte survivalImmunity200115226127311520461
- ChapmanRSLourencoPCTonnerESuppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3Genes Dev199913192604261610521404
- YuHJoveRThe STATs of cancer – new molecular targets come of ageNat Rev Cancer2004429710514964307
- CeramiEGaoJDogrusozUThe cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics dataCancer Discov20122540140422588877
- WangZZhuSShenMSTAT3 is involved in esophageal carcinogenesis through regulation of Oct-1Carcinogenesis201334367868823172665
- SenMJoyceSPanahandehMTargeting Stat3 abrogates EGFR inhibitor resistance in cancerClin Cancer Res201218184986499622825581
- CaoXTayAGuyGRTanYHActivation and association of Stat3 with Src in v-Src-transformed cell linesMol Cell Biol1996164159516038657134
- BrombergJFHorvathCMBesserDLathemWWDarnellJEStat3 activation is required for cellular transformation by v-srcMol Cell Biol1998185255325589566875
- TurksonJBowmanTGarciaRCaldenhovenEDe GrootRPJoveRStat3 activation by Src induces specific gene regulation and is required for cell transformationMol Cell Biol1998185254525529566874
- PedranziniLLeitchABrombergJStat3 is required for the development of skin cancerJ Clin Invest2004114561962215343379
- BowmanTBroomeMASinibaldiDStat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesisProc Natl Acad Sci USA200198137319732411404481
- YuCYWangLKhaletskiyASTAT3 activation is required for interleukin-6 induced transformation in tumor-promotion sensitive mouse skin epithelial cellsOncogene200221253949396012037677
- ChiarleRSimmonsWJCaiHStat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic targetNat Med200511662362915895073
- VulturAArulanandamRTurksonJNiuGJoveRRaptisLStat3 is required for full neoplastic transformation by the Simian Virus 40 large tumor antigenMol Biol Cell20051683832384615917293
- DasguptaARaychaudhuriBHaqqiTStat3 activation is required for the growth of U87 cell-derived tumours in miceEur J Cancer200945467768419121577
- GeorgeRESandaTHannaMActivating mutations in ALK provide a therapeutic target in neuroblastomaNature2008455721597597818923525
- AnandMLaiRGelebartPβ-catenin is constitutively active and increases STAT3 expression/activation in anaplastic lymphoma kinase-positive anaplastic large cell lymphomaHaematologica201196225326120971814
- JonesAVKreilSZoiKWidespread occurrence of the JAK2 V617F mutation in chronic myeloproliferative disordersBlood200510662162216815920007
- ScottLMCampbellPJBaxterEJThe V617F JAK2 mutation is uncommon in cancers and in myeloid malignancies other than the classic myeloproliferative disordersBlood200510682920292116204151
- CampbellPJGriesshammerMDöhnerKV617F mutation in JAK2 is associated with poorer survival in idiopathic myelofibrosisBlood200610752098210016293597
- OkuSTakenakaKKuriyamaTJAK2 V617F uses distinct signalling pathways to induce cell proliferation and neutrophil activationBr J Haematol2010150333434420553273
- FlemingTPSaxenaAClarkWCAmplification and/or overexpression of platelet-derived growth factor receptors and epidermal growth factor receptor in human glial tumorsCancer Res19925216455045531322795
- YehHHLaiWWChenHHLiuHSSuWCAutocrine IL-6-induced Stat3 activation contributes to the pathogenesis of lung adenocarcinoma and malignant pleural effusionOncogene200625314300430916518408
- GrandisJRDrenningSDChakrabortyARequirement of Stat3 but not Stat1 activation for epidermal growth factor receptor- mediated cell growth In vitroJ Clin Invest19981027138513929769331
- BatraSKCastelino-PrabhuSWikstrandCJEpidermal growth factor ligand-independent, unregulated, cell-transforming potential of a naturally occurring human mutant EGFRvIII geneCell Growth Differ1995610125112598845302
- LoHWCaoXZhuHAli-OsmanFCyclooxygenase-2 is a novel transcriptional target of the nuclear EGFR-STAT3 and EGFRvIII-STAT3 signaling axesMol Cancer Res20108223224520145033
- HeBYouLUematsuKSOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancerProc Natl Acad Sci USA200310024141331413814617776
- IwamotoTSengaTNaitoYThe JAK-inhibitor, JAB/SOCS-1 selectively inhibits cytokine-induced, but not v-Src induced JAK-STAT activationOncogene200019414795480111032030
- CapelloDGloghiniABaldanziGAlterations of negative regulators of cytokine signalling in immunodeficiency-related non-Hodgkin lymphomaHematol Oncol2013311222822488585
- LaczmanskaIKarpinskiPBebenekMProtein tyrosine phosphatase receptor-like genes are frequently hypermethylated in sporadic colorectal cancerJ Hum Genet2013581111523096495
- KouXChenNFengZLuoLYinZGSTP1 negatively regulates Stat3 activation in epidermal growth factor signalingOncol Lett2013531053105723426146
- ZhongSTangMWYeoWLiuCLoYMJohnsonPJSilencing of GSTP1 gene by CpG island DNA hypermethylation in HBV-associated hepatocellular carcinomasClin Cancer Res2002841087109211948118
- LinXAsgariKPutziMJReversal of GSTP1 CpG island hypermethylation and reactivation of pi-class glutathione S-transferase (GSTP1) expression in human prostate cancer cells by treatment with procainamideCancer Res200161248611861611751372
- SchlessingerKLevyDEMalignant transformation but not normal cell growth depends on signal transducer and activator of transcription 3Cancer Res200565135828583415994959
- CorvinusFMOrthCMorigglRPersistent STAT3 activation in colon cancer is associated with enhanced cell proliferation and tumor growthNeoplasia20057654555516036105
- NiuGBowmanTHuangMRoles of activated Src and Stat3 signaling in melanoma tumor cell growthOncogene200221467001701012370822
- RahamanSOHarborPCChernovaOBarnettGHVogelbaumMAHaqueSJInhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cellsOncogene200221558404841312466961
- BhardwajASethiGVadhan-RajSResveratrol inhibits proliferation, induces apoptosis, and overcomes chemoresistance through down-regulation of STAT3 and nuclear factor-kappaB-regulated antiapoptotic and cell survival gene products in human multiple myeloma cellsBlood200710962293230217164350
- WeerasinghePGarciaGEZhuQInhibition of Stat3 activation and tumor growth suppression of non-small cell lung cancer by G-quartet oligonucleotidesInt J Oncol200731112913617549413
- LeslieKLangCDevganGCyclin D1 is transcriptionally regulated by and required for transformation by activated signal transducer and activator of transcription 3Cancer Res20066652544255216510571
- EwenMELambJThe activities of cyclin D1 that drive tumorigenesisTrends Mol Med200410415816215059606
- CaoXLiuDYanXStat3 inhibits WTX expression through up-regulation of microRNA-370 in Wilms tumorFEBS Lett2013587663964423333300
- ZhuangLLeeCSScolyerRAMcl-1, Bcl-XL and Stat3 expression are associated with progression of melanoma whereas Bcl-2, AP-2 and MITF levels decrease during progression of melanomaMod Pathol200720441642617384650
- Catlett-FalconeRLandowskiTHOshiroMMConstitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cellsImmunity199910110511510023775
- ZushiSShinomuraYKiyoharaTSTAT3 mediates the survival signal in oncogenic ras-transfected intestinal epithelial cellsInt J Cancer19987833263309766567
- RealPJSierraADe JuanASegoviaJCLopez-VegaJMFernandez-LunaJLResistance to chemotherapy via Stat3-dependent overexpression of Bcl-2 in metastatic breast cancer cellsOncogene200221507611761812400004
- TimofeevaOATarasovaNIZhangXSTAT3 suppresses transcription of proapoptotic genes in cancer cells with the involvement of its N-terminal domainProc Natl Acad Sci USA201311041267127223288901
- XieTXHuangFJAldapeKDActivation of stat3 in human melanoma promotes brain metastasisCancer Res20066663188319616540670
- ItohMMurataTSuzukiTRequirement of STAT3 activation for maximal collagenase-1 (MMP-1) induction by epidermal growth factor and malignant characteristics in T24 bladder cancer cellsOncogene20062581195120416205632
- FujiiMHonmaMTakahashiHIshida-YamamotoAIizukaHIntercellular contact augments epidermal growth factor receptor (EGFR) and signal transducer and activator of transcription 3 (STAT3)-activation which increases podoplanin-expression in order to promote squamous cell carcinoma motilityCell Signal201325476076523266472
- ZhouWGrandisJRWellsASTAT3 is required but not sufficient for EGF receptor-mediated migration and invasion of human prostate carcinoma cell linesBr J Cancer200695216417116804520
- PriesterMCopanakiEVafaizadehVSTAT3 silencing inhibits glioma single cell infiltration and tumor growthNeuro-oncology201315784085223486688
- CascioSFerlaRD’AndreaAExpression of angiogenic regulators, VEGF and leptin, is regulated by the EGF/PI3K/STAT3 pathway in colorectal cancer cellsJ Cell Physiol2009221118919419492417
- WeiLHKuoMLChenCAInterleukin-6 promotes cervical tumor growth by VEGF-dependent angiogenesis via a STAT3 pathwayOncogene200322101517152712629515
- ValdembriDSeriniGVaccaARibattiDBussolinoFIn vivo activation of JAK2/STAT-3 pathway during angiogenesis induced by GM-CSFFASEB J200216222522711744626
- ZhaoMGaoFHWangJYJAK2/STAT3 signaling pathway activation mediates tumor angiogenesis by upregulation of VEGF and bFGF in non-small-cell lung cancerLung Cancer201173336637421333372
- SriuranpongVParkJIAmornphimolthamPPatelVNelkinBDGutkindJSEpidermal growth factor receptor-independent constitutive activation of STAT3 in head and neck squamous cell carcinoma is mediated by the autocrine/paracrine stimulation of the interleukin 6/gp130 cytokine systemCancer Res200363112948295612782602
- NiuGWrightKLHuangMConstitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesisOncogene200221132000200811960372
- MasudaMRuanHYItoASignal transducers and activators of transcription 3 up-regulates vascular endothelial growth factor production and tumor angiogenesis in head and neck squamous cell carcinomaOral Oncol200743878579017169602
- GrivennikovSKarinETerzicJIL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancerCancer Cell200915210311319185845
- LiangJNagahashiMKimEYSphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancerCancer Cell201323110712023273921
- BurdelyaLKujawskiMNiuGStat3 activity in melanoma cells affects migration of immune effector cells and nitric oxide-mediated antitumor effectsJ Immunol200517473925393115778348
- SeeAPHanJEPhallenJThe role of STAT3 activation in modulating the immune microenvironment of GBMJ Neurooncol2012110335936823096132
- SherryMMReevesAWuJKCochranBHSTAT3 is required for proliferation and maintenance of multipotency in glioblastoma stem cellsStem Cells200927102383239219658181
- KimYHsuJZhouTPotent in vivo pharmacology of AZD9150, a next-generation, constrained ethyl-modified antisense oligonucleotide targeting STAT3 in multiple preclinical cancer models [abstract]Proceedings of the 104th Annual Meeting of the American Association for Cancer Research2013 Apr 6–10Washington, DC. Philadelphia (PA) AACR; 2013. Abstract nr LB-317
- SenMThomasSMKimSFirst-in-human trial of a STAT3 decoy oligonucleotide in head and neck tumors: implications for cancer therapyCancer Discov20122869470522719020
- SchustJSperlBHollisAMayerTUBergTStattic: a small-molecule inhibitor of STAT3 activation and dimerizationChem Biol200613111235124217114005
- RenZCabellLASchaeferTSMcMurrayJSIdentification of a high-affinity phosphopeptide inhibitor of Stat3Bioorg Med Chem Lett200313463363612639546
- ZhangXYuePFletcherSZhaoWGunningPTTurksonJA novel small-molecule disrupts Stat3 SH2 domain-phosphotyrosine interactions and Stat3-dependent tumor processesBiochem Pharmacol201079101398140920067773
- GomezCBaiLZhangJDesign, synthesis, and evaluation of peptidomimetics containing Freidinger lactams as STAT3 inhibitorsBioorg Med Chem Lett20091961733173619243938
- Epling-BurnettePKLiuJHCatlett-FalconeRInhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expressionJ Clin Invest2001107335136211160159
- SongHWangRWangSLinJA low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cellsProc Natl Acad Sci USA2005102134700470515781862
- SenMToscaPJZwayerCLack of toxicity of a STAT3 decoy oligonucleotideCancer Chemother Pharmacol200963698399518766340
- LooyengaBDHutchingsDCherniIKingsleyCWeissGJMackeiganJSTAT3 is activated by JAK2 independent of key oncogenic driver mutations in non-small cell lung carcinomaPLoS ONE201272e3082022319590
- KorkayaHKimGIDavisAActivation of an IL6 inflammatory loop mediates trastuzumab resistance in HER2+ breast cancer by expanding the cancer stem cell populationMol Cell201247457058422819326
- BewryNNNairRREmmonsMFBoulwareDPinilla-IbarzJHazlehurstLAStat3 contributes to resistance toward BCR-ABL inhibitors in a bone marrow microenvironment model of drug resistanceMol Cancer Ther20087103169317518852120
- Marcher-BauerALuSAndersonJBCDD: a Conserved Domain Database for the functional annotation of proteinsNuclieic Acids Res201139225229