114
Views
5
CrossRef citations to date
0
Altmetric
Original Research

Precision medicine approaches for the management of Ewing sarcoma: current perspectives

, &
Pages 9-14 | Published online: 17 Jan 2019

References

  • FletcherCDMBridgeJAHogendoornPMertensFWHO Classification of Tumours of Soft Tissue and BoneLyonIARC Press2013
  • SiegelRLMillerKDJemalAStatisticsCCancer statistics, 2018CA Cancer J Clin201868173029313949
  • SubbiahVProspects and pitfalls of personalizing therapies for sarcomas: from children, adolescents, and young adults to the elderlyCurr Oncol Rep201416940125030655
  • BrohlASSolomonDAChangWThe genomic landscape of the Ewing Sarcoma family of tumors reveals recurrent STAG2 mutationPLoS Genet2014107e100447525010205
  • CromptonBDStewartCTaylor-WeinerAThe genomic landscape of pediatric Ewing sarcomaCancer Discov20144111326134125186949
  • TirodeFSurdezDMaXGenomic landscape of Ewing sarcoma defines an aggressive subtype with co-association of STAG2 and TP53 mutationsCancer Discov20144111342135325223734
  • DelattreOZucmanJMelotTThe Ewing family of tumors – a subgroup of small-round-cell tumors defined by specific chimeric transcriptsN Engl J Med199433152942998022439
  • ShernJFChenLChmieleckiJComprehensive genomic analysis of rhabdomyosarcoma reveals a landscape of alterations affecting a common genetic axis in fusion-positive and fusion-negative tumorsCancer Discov20144221623124436047
  • SandLGSzuhaiKHogendoornPCSequencing overview of Ewing sarcoma: a journey across genomic, epigenomic and transcriptomic landscapesInt J Mol Sci2015167161761621526193259
  • KovarHBlocking the road, stopping the engine or killing the driver? Advances in targeting EWS/FLI-1 fusion in Ewing sarcoma as novel therapyExpert Opin Ther Targets201418111315132825162919
  • BallingerMLGoodeDLRay-CoquardIMonogenic and poly-genic determinants of sarcoma risk: an international genetic studyLancet Oncol20161791261127127498913
  • BrohlASPatidarRTurnerCEFrequent inactivating germline mutations in DNA repair genes in patients with Ewing sarcomaGenet Med201719895595828125078
  • ZhangJWalshMFWuGGermline mutations in predisposition genes in pediatric cancerN Engl J Med2015373242336234626580448
  • LeeJMLedermannJAKohnECPARP inhibitors for BRCA1/2 mutation-associated and BRCA-like malignanciesAnn Oncol2014251324024225019
  • DelattreOZucmanJPlougastelBGene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumoursNature199235963911621651522903
  • SankarSLessnickSLPromiscuous partnerships in Ewing’s sarcomaCancer Genet2011204735136521872822
  • Kawamura-SaitoMYamazakiYKanekoKFusion between CIC and DUX4 up-regulates PEA3 family genes in Ewing-like sarcomas with t(4;19)(q35;q13) translocationHum Mol Genet200615132125213716717057
  • SolomonDABrohlASKhanJMiettinenMClinicopathologic features of a second patient with Ewing-like sarcoma harboring CIC– FOXO4 gene fusionAm J Surg Pathol201438121724172525321332
  • PierronGTirodeFLucchesiCA new subtype of bone sarcoma defined by BCOR–CCNB3 gene fusionNat Genet201244446146622387997
  • Kousar JahanSKMayannaMKavithaBLPatilAKumariPJahanSKA rare case of translocation (12;22) (p13;Q) in Ewing’s sarcomaIndian J Med Paediatr Oncol2014351899225006293
  • ShuklaNEwing sarcoma: a tough road to clinically relevant biomarkersPediatr Blood Cancer201562574174225586427
  • ArnaldezFIHelmanLJNew strategies in Ewing sarcoma: lost in translation?Clin Cancer Res201420123050305624756371
  • CotterillSJAhrensSPaulussenMPrognostic factors in Ewing’s tumor of bone: analysis of 975 patients from the European Intergroup Cooperative Ewing’s Sarcoma Study GroupJ Clin Oncol200018173108311410963639
  • OberlinODeleyMCBuiBNPrognostic factors in localized Ewing’s tumours and peripheral neuroectodermal tumours: the third study of the French Society of Paediatric Oncology (EW88 study)Br J Cancer200185111646165411742482
  • OwenLAKowalewskiAALessnickSLEWS/FLI mediates transcriptional repression via NKX2.2 during oncogenic transformation in Ewing’s sarcomaPLoS One200834e196518414662
  • NickersonTChangFLorimerDSmeekensSPSawyersCLPollakMIn vivo progression of LAPC-9 and LNCaP prostate cancer models to androgen independence is associated with increased expression of insulin-like growth factor I (IGF-I) and IGF-I receptor (IGF-IR)Cancer Res200161166276628011507082
  • CullenKJYeeDSlyWSInsulin-like growth factor receptor expression and function in human breast cancerCancer Res199050148532152773
  • GoochJLvan den BergCLYeeDInsulin-like growth factor (IGF)-I rescues breast cancer cells from chemotherapy-induced cell death – proliferative and anti-apoptotic effectsBreast Cancer Res Treat199956111010517338
  • HassanABMacaulayVMThe insulin-like growth factor system as a therapeutic target in colorectal cancerAnn Oncol200213334935611996463
  • OlmosDPostel-VinaySMolifeLRSafety, pharmacokinetics, and preliminary activity of the anti-IGF-1R antibody figitumumab (CP-751,871) in patients with sarcoma and Ewing’s sarcoma: a Phase 1 expansion cohort studyLancet Oncol201011212913520036194
  • TolcherAWRothenbergMLRodonJA Phase I pharmacokinetic and pharmacodynamic study of AMG 479, a fully human monoclonal antibody against insulin-like growth factor type 1 receptor (IGF-1R), in advanced solid tumorsJ Clin Oncol20072518 Suppl3002
  • KurzrockRPatnaikAAisnerJA Phase I study of weekly R1507, a human monoclonal antibody insulin-like growth factor-I receptor antagonist, in patients with advanced solid tumorsClin Cancer Res20101682458246520371689
  • van MaldegemAMBovéeJVPeterseEFHogendoornPCGelderblomHEwing sarcoma: the clinical relevance of the insulin-like growth factor 1 and the poly-ADP-ribose-polymerase pathwayEur J Cancer20165317118026765686
  • MalempatiSWeigelBIngleAMPhase I/II trial and pharmacokinetic study of cixutumumab in pediatric patients with refractory solid tumors and Ewing sarcoma: a report from the Children’s Oncology GroupJ Clin Oncol201230325626222184397
  • TapWDDemetriGBarnettePPhase II study of ganitumab, a fully human anti-type-1 insulin-like growth factor receptor antibody, in patients with metastatic Ewing family tumors or desmoplastic small round cell tumorsJ Clin Oncol201230151849185622508822
  • SchwartzGKTapWDQinLXCixutumumab and temsirolimus for patients with bone and soft-tissue sarcoma: a multicentre, open-label, Phase 2 trialLancet Oncol201314437138223477833
  • WagnerLMFouladiMAhmedAPhase II study of cixutumumab in combination with temsirolimus in pediatric patients and young adults with recurrent or refractory sarcoma: a report from the Children’s Oncology GroupPediatr Blood Cancer201562344044425446280
  • GarnettMJEdelmanEJHeidornSJSystematic identification of genomic markers of drug sensitivity in cancer cellsNature2012483739157057522460902
  • StewartEGoshornRBradleyCTargeting the DNA repair pathway in Ewing sarcomaCell Rep20149382984025437539
  • ChoyEButrynskiJEHarmonDCPhase II study of olaparib in patients with refractory Ewing sarcoma following failure of standard chemotherapyBMC Cancer201414181325374341
  • SankarSBellRStephensBMechanism and relevance of EWS/FLI-mediated transcriptional repression in Ewing sarcomaOncogene201332425089510023178492
  • SankarSTheisenERBearssJReversible LSD1 inhibition interferes with global EWS/ETS transcriptional activity and impedes Ewing sarcoma tumor growthClin Cancer Res201420174584459724963049
  • TawbiHABurgessMBolejackVPembrolizumab in advanced soft-tissue sarcoma and bone sarcoma (SARC028): a multicentre, two-cohort, single-arm, open-label, Phase 2 trialLancet Oncol201718111493150128988646
  • SpurnyCKailayangiriSJamitzkySProgrammed cell death ligand 1 (PD-L1) expression is not a predominant feature in Ewing sarcomasPediatr Blood Cancer2018651e26719
  • RossigCCellular immunotherapy strategies for Ewing sarcomaImmunotherapy20146561162124896629
  • GhisoliMBarveMMennelRThree-year follow up of GMCSF/bi-shRNA (furin) DNA-transfected autologous tumor immunotherapy (Vigil) in metastatic advanced Ewing’s sarcomaMol Ther20162481478148327109631
  • ThielUSchoberSJEinspielerIEwing sarcoma partial regression without GvHD by chondromodulin-I/HLA-A*02:01-specific allorestricted T cell receptor transgenic T cellsOncoimmunology201765e131223928638739
  • HuangXParkHGreeneJIGF1R- and ROR1-specific CAR T cells as a potential therapy for high risk sarcomasPLoS One2015107e013315226173023
  • BahramiAWuJDyerMADelattreOPappoASLoss of STAG2 expression and prognosis in Ewing sarcoma family of tumorsJ Clin Oncol20153315 Suppl10024
  • HonokiKStojanovskiEMcEvoyMPrognostic significance ofp16INK4a alteration for Ewing sarcomaCancer200711061351136017661343
  • LermanDMMonumentMJMcIlvaineETumoral TP53 and/or CDKN2A alterations are not reliable prognostic biomarkers in patients with localized Ewing sarcoma: a report from the Children’s Oncology GroupPediatr Blood Cancer201562575976525464386
  • FagnouCMichonJPeterMPresence of tumor cells in bone marrow but not in blood is associated with adverse prognosis in patients with Ewing’s tumor. Société Française d’Oncologie PédiatriqueJ Clin Oncol1998165170717119586882
  • de AlavaELozanoMDPatiñoASierrasesúmagaLPardo-MindánFJEwing family tumors: potential prognostic value of reverse-transcriptase polymerase chain reaction detection of minimal residual disease in peripheral blood samplesDiagn Mol Pathol1998731521579836070
  • WestDCGrierHESwallowMMDemetriGDGranowetterLSklarJDetection of circulating tumor cells in patients with Ewing’s sarcoma and peripheral primitive neuroectodermal tumorJ Clin Oncol19971525835889053480
  • AthaleUHShurtleffSAJenkinsJJUse of reverse transcriptase polymerase chain reaction for diagnosis and staging of alveolar rhabdomyosarcoma, Ewing sarcoma family of tumors, and desmoplastic small round cell tumorJ Pediatr Hematol Oncol20012329910411216714
  • ZoubekALadensteinRWindhagerRPredictive potential of testing for bone marrow involvement in Ewing tumor patients by RT-PCR: a preliminary evaluationInt J Cancer199879156609495359
  • ShulmanDSKlegaKImamovic-TucoADetection of circulating tumour DNA is associated with inferior outcomes in Ewing sarcoma and osteosarcoma: a report from the Children’s Oncology GroupBr J Cancer2018119561562130131550
  • HayashiMChuDMeyerCFHighly personalized detection of minimal Ewing sarcoma disease burden from plasma tumor DNACancer2016122193015302327351911
  • ShuklaNNPatelJAMagnanHPlasma DNA-based molecular diagnosis, prognostication, and monitoring of patients with EWSR1 fusion-positive sarcomasJCO Precis Oncol20171111
  • KrumbholzMHellbergJSteifBGenomic EWSR1 fusion sequence as highly sensitive and dynamic plasma tumor marker in Ewing sarcomaClin Cancer Res201622174356436527283964