104
Views
3
CrossRef citations to date
0
Altmetric
Original Research

IKBKB rs2272736 is Associated with Gastric Cancer Survival

, , , ORCID Icon, , , , & ORCID Icon show all
Pages 345-352 | Published online: 19 Aug 2020

References

  • Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424. doi:10.3322/caac.2149230207593
  • Ferlay J, Shin H-R, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 2010;127(12):2893–2917. doi:10.1002/ijc.2551621351269
  • Tian J, Wang X-D, Chen Z-C. Survival of patients with stomach cancer in Changle city of China. World J Gastroenterol. 2004;10(11):1543–1546. doi:10.3748/wjg.v10.i11.154315162521
  • Fu Z, Lin L, Liu S, et al. Ginkgo biloba extract inhibits metastasis and ERK/nuclear factor kappa B (NF-κB) signaling pathway in gastric cancer. Med Sci Monit. 2019;25:6836–6845. doi:10.12659/MSM.91514631509521
  • Li W, Li Q, Wei L, et al. Rosmarinic acid analogue-11 induces apoptosis of human gastric cancer SGC-7901 cells via the epidermal growth factor receptor (EGFR)/Akt/nuclear factor kappa B (NF-κB) pathway. Med Sci Monit Basic Res. 2019;25:63–75. doi:10.12659/MSMBR.91333130799435
  • Jiang Z, Wu W, Qian M-L. Cellular damage and apoptosis along with changes in NF-kappa B expression were induced with contrast agent enhanced ultrasound in gastric cancer cells and hepatoma cells. Cancer Cell Int. 2012;12(1):8. doi:10.1186/1475-2867-12-822417534
  • Barcellos-Hoff MH, Lyden D, Wang TC. The evolution of the cancer niche during multistage carcinogenesis. Nat Rev Cancer. 2013;13(7):511–518. doi:10.1038/nrc353623760023
  • Taniguchi K, Karin M. NF-κB, inflammation, immunity and cancer: coming of age. Nat Rev Immunol. 2018;18(5):309–324. doi:10.1038/nri.2017.14229379212
  • Park MH, Hong JT. Roles of NF-κB in cancer and inflammatory diseases and their therapeutic approaches. Cells. 2016;5(2):15. doi:10.3390/cells5020015
  • Zhang Y, Zhou H, Tao Y, Liu X, Yuan Z, Nie C. ARD1 contributes to IKKβ-mediated breast cancer tumorigenesis. Cell Death Dis. 2018;9(9):860. doi:10.1038/s41419-018-0921-230154412
  • Page A, Bravo A, Suarez-Cabrera C, et al. IKKβ-mediated resistance to skin cancer development is dependent. Mol Cancer Res. 2017;15(9):1255–1264. doi:10.1158/1541-7786.MCR-17-015728584022
  • Sakamoto K, Hikiba Y, Nakagawa H, et al. Inhibitor of kappaB kinase beta regulates gastric carcinogenesis via interleukin-1alpha expression. Gastroenterology. 2010;139(1):226–238.e6. doi:10.1053/j.gastro.2010.03.04720347815
  • Shi Y, Hu Z, Wu C, et al. A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13.31 and 5p13.1. Nat Genet. 2011;43(12):1215–1218. doi:10.1038/ng.97822037551
  • Tanikawa C, Kamatani Y, Toyoshima O, et al. Genome-wide association study identifies gastric cancer susceptibility loci at 12q24.11-12 and 20q11.21. Cancer Sci. 2018;109(12):4015–4024. doi:10.1111/cas.1381530281874
  • Wang W, Du M, Li Z, et al. A genetic variant located in promoter region is associated with prognosis of gastric cancer. Cancer Epidemiol Biomarkers Prev. 2018;27(7):822–828. doi:10.1158/1055-9965.EPI-17-105429685895
  • Gonzalez-Hormazabal P, Romero S, Musleh M, et al. -251T>A (rs4073) polymorphism is associated with prognosis in gastric cancer patients. Anticancer Res. 2018;38(10):5703–5708. doi:10.21873/anticanres.1290730275190
  • Brookes AJ. The essence of SNPs. Gene. 1999;234(2):177–186. doi:10.1016/S0378-1119(99)00219-X10395891
  • Espinosa-Parrilla Y, Muñoz X, Bonet C, et al. Genetic association of gastric cancer with miRNA clusters including the cancer-related genes MIR29, MIR25, MIR93 and MIR106: results from the EPIC-EURGAST study. Int J Cancer. 2014;135(9):2065–2076. doi:10.1002/ijc.2885024643999
  • Pan W, Liu L, Wei J, et al. A functional lncRNA HOTAIR genetic variant contributes to gastric cancer susceptibility. Mol Carcinog. 2016;55(1):90–96. doi:10.1002/mc.2226125640751
  • Sun Q, Gu H, Zeng Y, et al. Hsa-mir-27a genetic variant contributes to gastric cancer susceptibility through affecting miR-27a and target gene expression. Cancer Sci. 2010;101(10):2241–2247. doi:10.1111/j.1349-7006.2010.01667.x20666778
  • Ju H, Lim B, Kim M, et al. A regulatory polymorphism at position −309 in PTPRCAP is associated with susceptibility to diffuse-type gastric cancer and gene expression. Neoplasia. 2009;11(12):1340–1347. doi:10.1593/neo.9113220019842
  • Fan H, Liu D, Qiu X, et al. A functional polymorphism in the DNA methyltransferase-3A promoter modifies the susceptibility in gastric cancer but not in esophageal carcinoma. BMC Med. 2010;8:12. doi:10.1186/1741-7015-8-1220128888
  • Hyland PL, Lin S-W, Hu N, et al. Genetic variants in fas signaling pathway genes and risk of gastric cancer. Int J Cancer. 2014;134(4):822–831. doi:10.1002/ijc.2841523921907
  • Boyle AP, Hong EL, Hariharan M, et al. Annotation of functional variation in personal genomes using RegulomeDB. Genome Res. 2012;22(9):1790–1797. doi:10.1101/gr.137323.11222955989
  • Xu Z, Taylor JA. SNPinfo: integrating GWAS and candidate gene information into functional SNP selection for genetic association studies. Nucleic Acids Res. 2009;37(WebServer issue):W600–W605. doi:10.1093/nar/gkp29019417063
  • Chen X, Li S, Yang Y, et al. Genome-wide association study validation identifies novel loci for atherosclerotic cardiovascular disease. J Thromb Haemost. 2012;10(8):1508–1514. doi:10.1111/j.1538-7836.2012.04815.x22702842
  • Grambsch PM, Therneau TM. Proportional hazards tests and diagnostics based on weighted residuals. Biometrika. 1994;81(3):515–526. doi:10.1093/biomet/81.3.515
  • Adzhubei IA, Schmidt S, Peshkin L, et al. A method and server for predicting damaging missense mutations. Nat Methods. 2010;7(4):248–249. doi:10.1038/nmeth0410-24820354512
  • Sim N-L, Kumar P, Hu J, Henikoff S, Schneider G, Ng PC. SIFT web server: predicting effects of amino acid substitutions on proteins. Nucleic Acids Res. 2012;40(W1):W452–W457. doi:10.1093/nar/gks53922689647
  • Schwarz JM, Cooper DN, Schuelke M, Seelow D. MutationTaster2: mutation prediction for the deep-sequencing age. Nat Methods. 2014;11(4):361–362. doi:10.1038/nmeth.289024681721
  • Jian X, Boerwinkle E, Liu X. In silico prediction of splice-altering single nucleotide variants in the human genome. Nucleic Acids Res. 2014;42(22):13534–13544. doi:10.1093/nar/gku120625416802
  • Machiela MJ, Chanock SJ. LDlink: a web-based application for exploring population-specific haplotype structure and linking correlated alleles of possible functional variants. Bioinformatics. 2015;31(21):3555–3557. doi:10.1093/bioinformatics/btv40226139635
  • Shindo M, Nakano H, Sakon S, Yagita H, Mihara M, Okumura K. Assignment of IkappaB kinase beta (IKBKB) to human chromosome band 8p12–>p11 by in situ hybridization. Cytogenet Cell Genet. 1998;82(1–2):32–33. doi:10.1159/0000150589763654
  • Schmid JA, Birbach A. IkappaB kinase beta (IKKbeta/IKK2/IKBKB)–a key molecule in signaling to the transcription factor NF-kappaB. Cytokine Growth Factor Rev. 2008;19(2):157–165. doi:10.1016/j.cytogfr.2008.01.00618308615
  • Häcker H, Karin M. Regulation and function of IKK and IKK-related kinases. Sci STKE. 2006;2006(357):re13. doi:10.1126/stke.3572006re1317047224
  • Perkins ND. Integrating cell-signalling pathways with NF-kappaB and IKK function. Nat Rev Mol Cell Biol. 2007;8(1):49–62. doi:10.1038/nrm208317183360
  • Scheidereit C. IkappaB kinase complexes: gateways to NF-kappaB activation and transcription. Oncogene. 2006;25(51):6685–6705. doi:10.1038/sj.onc.120993417072322
  • Hayden MS, Ghosh S. Signaling to NF-kappaB. Genes Dev. 2004;18(18):2195–2224. doi:10.1101/gad.122870415371334
  • Karin M. NF-kappaB and cancer: mechanisms and targets. Mol Carcinog. 2006;45(6):355–361. doi:10.1002/mc.2021716673382
  • Cao H, Jiang S, Yuan R, et al. Inhibition of IκB kinase 2 attenuated the proliferation and induced apoptosis of gastric cancer. Dig Dis Sci. 2019;64(5):1204–1216. doi:10.1007/s10620-018-5414-830560335
  • Huan Y, Wu D, Zhou D, Sun B, Li G. DBC1 promotes anoikis resistance of gastric cancer cells by regulating NF-κB activity. Oncol Rep. 2015;34(2):843–849. doi:10.3892/or.2015.400726035299
  • Xin S, Zhao Y, Wang C, et al. Polymorphisms of NF-κB pathway genes influence adverse drug reactions of gefitinib in NSCLC patients. Pharmacogenomics J. 2020;20(2):285–293. doi:10.1038/s41397-019-0115-z31664190
  • Xian H, Feng W, Zhang J. Schizandrin A enhances the efficacy of gefitinib by suppressing IKKβ/NF-κB signaling in non-small cell lung cancer. Eur J Pharmacol. 2019;855:10–19. doi:10.1016/j.ejphar.2019.04.01631028739
  • Krazinski BE, Kowalczyk AE, Sliwinska-Jewsiewicka A, et al. IKBKB expression in clear cell renal cell carcinoma is associated with tumor grade and patient outcomes. Oncol Rep. 2019;41(2):1189–1197. doi:10.3892/or.2018.687230483769
  • AJCC 8th edition of the American Joint Commission on cancer staging manual. Available from: https://cancerstaging.org/references-tools/deskreferences/Pages/default.aspx. Accessed 522, 2018.