Polyethylenimine-mediated gene delivery to the lung and therapeutic applications

References

• AbdallahBHassanABenoistC1996A powerful nonviral vector for In Vivo gene transfer into the adult mammalian brain: PolyethylenimineHum Gene Ther71947548930654
   PubMed Web of Science ®Google Scholar
• AhnCHChaeSYBaeYH2002Biodegradable poly(ethylenimine) for plasmid DNA deliveryJ Control Release802738211943404
   PubMed Web of Science ®Google Scholar
• AignerAFischerDMerdanT2002Delivery of unmodified bioactive ribozymes by an RNA-stabilizing polyethylenimine (LMW-PEI) efficiently down-regulates gene expressionGene Ther91700712457284
   PubMed Web of Science ®Google Scholar
• AnejaMKImkerRRudolphC2007Phage phiC31 integrase-mediated genomic integration and long-term gene expression in the lung after nonviral gene deliveryJ Gene Med99677517712864
   PubMed Web of Science ®Google Scholar
• AroteRKimTHKimYK2007A biodegradable poly(ester amine) based on polycaprolactone and polyethylenimine as a gene carrierBiomaterials287354417034844
   PubMed Web of Science ®Google Scholar
• BakerACottenM1997Delivery of bacterial artificial chromosomes into mammalian cells with psoralen-inactivated adenovirus carrierNucleic Acids Res25195069115362
   PubMed Web of Science ®Google Scholar
• BakerASaltikMLehrmannH1997Polyethylenimine (PEI) is a simple, inexpensive and effective reagent for condensing and linking plasmid DNA to adenovirus for gene deliveryGene Ther4773829338005
   PubMed Web of Science ®Google Scholar
• BehrJ-P1994Gene transfer with synthetic cationic amphiphiles: Propsects for gene therapyBioconjugate Chem53829
   PubMed Web of Science ®Google Scholar
• BelurLRFrandsenJLDupuyAJ2003Gene insertion and long-term expression in lung mediated by the Sleeping Beauty transposon systemMol Ther8501712946324
   PubMed Web of Science ®Google Scholar
• BertschingerMBackliwalGSchertenleibA2006Disassembly of polyethylenimine-DNA particles in vitro: Implications for polyethylenimine-mediated DNA deliveryJ Control Release1169610417079047
   PubMed Web of Science ®Google Scholar
• BieberTMeissnerWKostinS2002Intracellular route and transcriptional competence of polyethylenimine-DNA complexesJ Control Release824415412175756
   PubMed Web of Science ®Google Scholar
• BlenkinsoppWK1967Proliferation of respiratory tract epithelium in the ratExp Cell Res46144546025276
   PubMed Web of Science ®Google Scholar
• BlessingTKursaMHolzhauserR2001Different strategies for formation of pegylated EGF-conjugated PEI/DNA complexes for targeted gene deliveryBioconjug Chem125293711459457
   PubMed Web of Science ®Google Scholar
• BolettaABenigniALutzJ1997Nonviral gene delivery to the rat kidney with polyethylenimineHum Gene Ther81243519215741
   PubMed Web of Science ®Google Scholar
• BöttgerMZaitsevSVOttoA1998Acid nuclear extracts as mediators of gene transfer and expressionBiochim Biophys Acta139578879434155
   PubMed Web of Science ®Google Scholar
• BoussifOLezoualc’hFZantaMA1995A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: PolyethylenimineProc Natl Acad Sci U S A9272973017638184
   PubMed Web of Science ®Google Scholar
• BragonziABolettaABiffiA1999Comparison between cationic polymers and lipids in mediating systemic gene delivery to the lungsGene Therapy61995200410637451
   PubMed Web of Science ®Google Scholar
• BragonziAConeseM2002Non-viral approach toward gene therapy of cystic fibrosis lung diseaseCurr Gene Ther229530512189717
   PubMedGoogle Scholar
• BragonziADinaGVillaA2000Biodistribution and transgene expression with nonviral cationic vector/DNA complexes in the lungsGene Ther717536011083497
   PubMed Web of Science ®Google Scholar
• BrundaMJLuistroLWarrierRR1993Antitumor and antimeta-static activity of interleukin 12 against murine tumorsJ Exp Med1781223308104230
   PubMed Web of Science ®Google Scholar
• BrunnerSFurtbauerESauerT2002Overcoming the nuclear barrier: cell cycle independent nonviral gene transfer with linear polyethylenimine or electroporationMol Ther580611786049
   PubMed Web of Science ®Google Scholar
• BrunnerSSauerTCarottaS2000Cell cycle dependence of gene transfer by lipoplex, polyplex and recombinant adenovirusGene Ther7401710694822
   PubMed Web of Science ®Google Scholar
• BrusCKleemannEAignerA2004Stabilization of oligonucleotide-polyethylenimine complexes by freeze-drying: physicochemical and biological characterizationJ Control Release951193115013239
   PubMed Web of Science ®Google Scholar
• CarrabinoSDi GioiaSCopreniE2005Serum albumin enhances polyethylenimine-mediated gene delivery to human respiratory epithelial cellsJ Gene Med715556416028303
   PubMed Web of Science ®Google Scholar
• Cavazzana-CalvoMFischerA2007Gene therapy for severe combined immunodeficiency: are we there yet?J Clin Invest11714566517549248
   PubMed Web of Science ®Google Scholar
• CheminIMoradpourDWielandS1998Liver-directed gene transfer: a linear polyethlenimine derivative mediates highly efficient DNA delivery to primary hepatocytes in vitro and in vivoJ Viral Hepat5369759857346
   PubMed Web of Science ®Google Scholar
• ChenJLWangHGaoJQ2007Liposomes modified with polycation used for gene delivery: preparation, characterization and transfection in vitroInt J Pharm3432556117624698
   PubMed Web of Science ®Google Scholar
• CholletPFavrotMCHurbinA2002Side-effects of a systemic injection of linear polyethylenimine-DNA complexesJ Gene Med4849111828391
   PubMed Web of Science ®Google Scholar
• ChoosakoonkriangSLoboBKoeG2003Biophysical characterization of PEI/DNA complexesJ Pharm Sci9217102212884257
   PubMed Web of Science ®Google Scholar
• ClammeJPAzoulayJMelyY2003aMonitoring of the formation and dissociation of polyethylenimine/DNA complexes by two photon fluorescence correlation spectroscopyBiophys J841960812609898
   PubMed Web of Science ®Google Scholar
• ClammeJPKrishnamoorthyGMélyY2003bIntracellular dynamics of the gene delivery vehicle polyethylenimine during transfection: investigation by two-photon fluorescence correlation spectroscopyBiochim Biophys Acta1617526114637019
   PubMed Web of Science ®Google Scholar
• ConeseMCopreniEPiroD2007Gene and Cell Therapy for the Treatment of Cystic FibrosisAdv Gene Mol Cell Ther199119
   Google Scholar
• DamesPOrtizASchillingerU2006Aerosol gene delivery to the murine lung is mouse strain dependentJ Mol Med
   PubMed Web of Science ®Google Scholar
• DaviesLASeguelaCVarathalingamA2007Identification of transfected cell types following non-viral gene transfer to the murine lungJ Gene Med91849617351986
   PubMed Web of Science ®Google Scholar
• de FougerollesAVornlocherHPMaraganoreJ2007Interfering with disease: a progress report on siRNA-based therapeuticsNat Rev Drug Discov64435317541417
   PubMed Web of Science ®Google Scholar
• Del VecchioMBajettaECanovaS2007Interleukin-12: biological properties and clinical applicationClin Cancer Res1346778517699845
   PubMed Web of Science ®Google Scholar
• DensmoreCL2006Advances in noninvasive pulmonary gene therapyCurr Drug Deliv3556316472094
   PubMedGoogle Scholar
• DensmoreCLKleinermanESGautamA2001Growth suppression of established human osteosarcoma lung metastases in mice by aerosol gene therapy with PEI-p53 complexesCancer Gene Ther86192711593330
   PubMed Web of Science ®Google Scholar
• DheurSDiasNvan AerschotA1999Polyethylenimine but not cationic lipid improves antisense activity of 3′-capped phosphodiester oligonucleotidesAntisense Nucleic Acid Drug Dev95152510645777
   PubMedGoogle Scholar
• Di GioiaSRejmanJCarrabinoS2008Role of biophysical parameters on ex vivo and in vivo gene transfer to the airway epithelium by polyethylenimine/albumin complexesBiomacromolecules
   PubMed Web of Science ®Google Scholar
• DifFDjediatCAlegriaO2006Transfection of multiple pulmonary cell types following intravenous injection of PEI-DNA in normal and CFTR mutant miceJ Gene Med882916142827
   PubMed Web of Science ®Google Scholar
• DingWHattoriYHigashiyamaK2007Hydroxyethylated cationic cholesterol derivatives in liposome vectors promote gene expression in the lungInt J Pharm
   Google Scholar
• DrapkinPTO’RiordanCRYiSM2000Targeting the urokinase plasminogen activator receptor enhances gene transfer to human airway epitheliaJ Clin Invest1055899610712430
   PubMed Web of Science ®Google Scholar
• DriskellRAEngelhardtJF2003Current status of gene therapy for inherited lung diseasesAnnu Rev Physiol6558561212524461
   PubMed Web of Science ®Google Scholar
• DuanXJiaSFKoshkinaN2006Intranasal interleukin-12 gene therapy enhanced the activity of ifosfamide against osteosarcoma lung metastasesCancer1061382816453328
   PubMed Web of Science ®Google Scholar
• DunlapDDMaggiASoriaMR1997Nanoscopic structure of DNA condensed for gene deliveryNucleic Acids Res2530951019224610
   PubMed Web of Science ®Google Scholar
• ElfingerMMauckschCRudolphC2007Characterization of lactoferrin as a targeting ligand for nonviral gene delivery to airway epithelial cellsBiomaterials2834485517475321
   PubMed Web of Science ®Google Scholar
• EngelhardtJFYankaskasJRErnstSA1992Submucosal glands are the predominant site of CFTR expression in the human bronchusNat Genet2240471285365
   PubMed Web of Science ®Google Scholar
• EpsteinSLTumpeyTMMisplonJA2002DNA vaccine expressing conserved influenza virus proteins protective against H5N1 challenge infection in miceEmerg Infect Dis879680112141964
   PubMed Web of Science ®Google Scholar
• ErnstNUlrichskotterSScmalixWA1999Interaction of liposomal and polycationic transfection complexes with pulmonary surfactantJ Gene Med13314010738550
   PubMed Web of Science ®Google Scholar
• FajacIThevenotGBedouetL2003Uptake of plasmid/glycosylated polymer complexes and gene transfer efficiency in differentiated airway epithelial cellsJ Gene Med5384812516050
   PubMed Web of Science ®Google Scholar
• FerkolTCohnLAPhillipsTE2003Targeted delivery of antiprotease to the epithelial surface of human tracheal xenograftsAm J Respir Crit Care Med1671374912615618
   PubMed Web of Science ®Google Scholar
• FerkolTPeralesJCEckmanE1995Gene transfer into airway epithelim of animals by targeting the polymeric immunoglobulin receptorJ Clin Invest954935027860731
   PubMed Web of Science ®Google Scholar
• FerrariSGeddesDMAltonEW2002Barriers to and new approaches for gene therapy and gene delivery in cystic fibrosisAdv Drug Deliv Rev5413739312458150
   PubMed Web of Science ®Google Scholar
• FerrariSKitsonCFarleyR2001Mucus altering agents as adjunct for nonviral gene transfer to airway epitheliumGene Ther813808611571577
   PubMed Web of Science ®Google Scholar
• FerrariSMoroEPettenazzoA1997ExGen 500 is an efficient vector for gene delivery to lung epithelial cells in vitro and in vivoGene Ther4110069415317
   PubMed Web of Science ®Google Scholar
• FerrariSPettenazzoAGarbatiN1999Polyethylenimine shows properties of interest for cystic fibrosis gene therapyBiochim Biophys Acta14472192510542318
   PubMed Web of Science ®Google Scholar
• FischerDBieberTLiY1999A novel non-viral vector for DNA delivery based on low molecular weight, branched polyethylenimine: effect of molecular weight on transfection efficiency and cytotoxicityPharm Res161273910468031
   PubMed Web of Science ®Google Scholar
• FischerDvon HarpeAKunathK2002Copolymers of ethylene imine and N-(2-hydroxyethyl)-ethylene imine as tools to study effects of polymer structure on physicochemical and biological properties of DNA complexesBioconjug Chem1311243312236795
   PubMed Web of Science ®Google Scholar
• FishRJKruithofEK2004Short-term cytotoxic effects and long-term instability of RNAi delivered using lentiviral vectorsBMC Mol Biol5915291968
   PubMed Web of Science ®Google Scholar
• FloreaBMeaneyCJungingerH2002Transfection efficiency and toxicity of polyethylenimine in differentiated Calu-3 and nondifferentiated COS-1 cell culturesAAPS Pharm Sci4E12
   PubMed Web of Science ®Google Scholar
• FloreaBIMolenaarTJBotI2003Identification of an internalising peptide in differentiated Calu-3 cells by phage display technology; application to gene delivery to the airwaysJ Drug Target113839015203927
   PubMed Web of Science ®Google Scholar
• ForrestMLPackDW2002On the kinetics of polyplex endocytic trafficking: implications for gene delivery vector designMol Ther6576612095304
   PubMed Web of Science ®Google Scholar
• GautamADensmoreCLGolunskiE2001aTransgene expression in mouse airway epithelium by aerosol gene therapy with PEI-DNA complexesMol Ther3551611319917
   PubMed Web of Science ®Google Scholar
• GautamADensmoreCLWaldrepJC2000Inhibition of experimental lung metastasis by aerosol delivery of PEI-p53 complexesMol Ther23182311020346
   PubMed Web of Science ®Google Scholar
• GautamADensmoreCLWaldrepJC2001bPulmonary cytokine response associated with PEI-DNA aerosol gene therapyGene Ther82545711313798
   PubMed Web of Science ®Google Scholar
• GeQFilipLBaiA2004Inhibition of influenza virus production in virus-infected mice by RNA interferenceProc Natl Acad Sci U S A10186768115173599
   PubMed Web of Science ®Google Scholar
• GhioAJCarterJDDaileyLA1999Respiratory epithelial cells demonstrate lactoferrin receptors that increase after metal exposureAm J Physiol276L9334010362717
   PubMed Web of Science ®Google Scholar
• GillDRSmythSEGoddardCA2001Increased persistence of lung gene expression using plasmids containing the ubiquitin elongation factor 1alpha promoterGene Ther815394611704814
   PubMed Web of Science ®Google Scholar
• GodbeyWTWuKKMikosAG1999aSize matters: molecular weight affects the efficiency of poly(ethylenimine) as a gene delivery vehicleJ Biomed Mater Res452687510397985
   PubMed Web of Science ®Google Scholar
• GodbeyWTWuKKMikosAG1999bTracking the intracellular path of poly(ethylenimine)/DNA complexes for gene deliveryProc Natl Acad Sci U S A9651778110220439
   PubMed Web of Science ®Google Scholar
• GodbeyWTWuKKMikosAG2001Poly(ethylenimine)-mediated gene delivery affects endothelial cell function and viabilityBiomaterials224718011214758
   PubMed Web of Science ®Google Scholar
• GosselinMAGuoWLeeRJ2001Efficient gene transfer using reversibly cross-linked low molecular weight polyethylenimineBioconjug Chem129899411716690
   PubMed Web of Science ®Google Scholar
• GottschalkSSparrowJTHauerJ1996A novel DNA-peptide complex for efficient gene transfer and expression in mammalian cellsGene Ther3448579156807
   PubMed Web of Science ®Google Scholar
• GoulaDBeckerNLemkineG2000Rapid crossing of the pulmonary endothelial barrier by polyethylenimine/DNA complexesGene Ther749950410757023
   PubMed Web of Science ®Google Scholar
• GoulaDBenoistCManteroS1998aPolyethylenimine-based intravenous delivery of transgenes to mouse lungGene Ther5129159930332
   PubMed Web of Science ®Google Scholar
• GoulaDRemyJSErbacherP1998bSize, diffusibility and transfection performance of linear PEI/DNA complexes in the mouse central nervous systemGene Ther571279797878
   PubMed Web of Science ®Google Scholar
• GraysonACDoodyAMPutnamD2006Biophysical and structural characterization of polyethylenimine-mediated siRNA delivery in vitroPharm Res2318687616845585
   PubMed Web of Science ®Google Scholar
• GrosseSAronYHonoreI2004Lactosylated polyethylenimine for gene transfer into airway epithelial cells: role of the sugar moiety in cell delivery and intracellular trafficking of the complexesJ Gene Med63455615026996
   PubMed Web of Science ®Google Scholar
• GrosseSAronYThevenotG2005Potocytosis and cellular exit of complexes as cellular pathways for gene delivery by polycationsJ Gene Med712758615906406
   PubMed Web of Science ®Google Scholar
• GrosseSThevenotGMonsignyM2006Which mechanism for nuclear import of plasmid DNA complexed with polyethylenimine derivatives?J Gene Med88455116685744
   PubMed Web of Science ®Google Scholar
• GrzelinskiMUrban-KleinBMartensT2006RNA interference-mediated gene silencing of pleiotrophin through polyethylenimine-complexed small interfering RNAs in vivo exerts antitumoral effects in glioblastoma xenograftsHum Gene Ther177516616839274
   PubMed Web of Science ®Google Scholar
• HanSMahatoRIKimSW2001Water-soluble lipopolymer for gene deliveryBioconjug Chem123374511353530
   PubMed Web of Science ®Google Scholar
• HonoréIGrosseSFrisonN2005Transcription of plasmid DNA: Influence of plasmid DNA/polyethylenimine complex formationJ Control Release1075374616087268
   PubMed Web of Science ®Google Scholar
• HuhSHDoHJLimHY2007Optimization of 25 kDa linear polyethylenimine for efficient gene deliveryBiologicals351657117084092
   PubMed Web of Science ®Google Scholar
• HuthSHoffmanFvon GersdorffK2006Interaction of polyamine gene vectors with RNA leads to the dissociation of plasmid DNA-carrier complexesJ Gene Med814162417029296
   PubMed Web of Science ®Google Scholar
• HwangSKJinHKwonJT2007Aerosol-delivered programmed cell death 4 enhanced apoptosis, controlled cell cycle and suppressed AP-1 activity in the lungs of AP-1 luciferase reporter miceGene Ther1413536117611588
   PubMed Web of Science ®Google Scholar
• ItakaKHaradaAYamasakiY2004In situ single cell observation by fluorescence resonance energy transfer reveals fast intra-cytoplasmic delivery and easy release of plasmid DNA complexed with linear polyethylenimineJ Gene Med6768414716679
   PubMed Web of Science ®Google Scholar
• JeongGJByunHMKimJM2007Biodistribution and tissue expression kinetics of plasmid DNA complexed with polyethylenimines of different molecular weight and structureJ Control Release1181182517250923
   PubMed Web of Science ®Google Scholar
• JiaSFWorthLLDensmoreCL2003Aerosol gene therapy with PEI: IL-12 eradicates osteosarcoma lung metastasesClin Cancer Res93462812960138
   PubMed Web of Science ®Google Scholar
• JiaSFWorthLLDensmoreCL2002Eradication of osteosarcoma lung metastases following intranasal interleukin-12 gene therapy using a nonviral polyethylenimine vectorCancer Gene Ther9260611896442
   PubMed Web of Science ®Google Scholar
• JonesAT2007Macropinocytosis: searching for an endocytic identity and role in the uptake of cell penetrating peptidesJ Cell Mol Med116708417760832
   PubMed Web of Science ®Google Scholar
• JostPJHarbottleRPKnightA2001A novel peptide, THALWHT, for the targeting of human airway epitheliaFEBS Lett489263911165262
   PubMed Web of Science ®Google Scholar
• KawakamiSItoYCharoensitP2006Evaluation of proinflammatory cytokine production induced by linear and branched polyethylenimine/plasmid DNA complexes in miceJ Pharmacol Exp Ther31713829016522808
   PubMed Web of Science ®Google Scholar
• KhalilIAKogureKAkitaH2006Uptake pathways and subsequent intracellular trafficking in nonviral gene deliveryPharmacol Rev58324516507881
   PubMed Web of Science ®Google Scholar
• KichlerA2004Gene transfer with modified polyethyleniminesJ Gene Med6S3S1014978746
   PubMed Web of Science ®Google Scholar
• KichlerAChillonMLeborgneC2002Intranasal gene delivery with a polyethylenimine-PEG conjugateJ Control Release813798812044576
   PubMed Web of Science ®Google Scholar
• KichlerALeborgneCCoetynauxE2001Polyethylenimine-mediated gene delivery: a mechanistic studyJ Gene Med31354411318112
   PubMed Web of Science ®Google Scholar
• KimSHJeongJHLeeSH2006aPEG conjugated VEGF siRNA for anti-angiogenic gene therapyJ Control Release116123916831481
   PubMed Web of Science ®Google Scholar
• KimWJYockmanJWJeongJH2006bAnti-angiogenic inhibition of tumor growth by systemic delivery of PEI-g-PEG-RGD/pCMV-sFlt-1 complexes in tumor-bearing miceJ Control Release114381816884805
   PubMed Web of Science ®Google Scholar
• KircheisRKichlerAWallnerM1997Coupling of cell-binding ligands to polyethylenimine for targeted gene deliveryGene Ther4409189274717
   PubMed Web of Science ®Google Scholar
• KircheisRWightmanLWagnerE2001Design and gene delivery activity of modified polyethyleniminesAdv Drug Deliv Rev533415811744176
   PubMed Web of Science ®Google Scholar
• KleemannENeuMJekelN2005Nano-carriers for DNA delivery to the lung based upon a TAT-derived peptide covalently coupled to PEG-PEIJ Control Release10929931616298009
   PubMed Web of Science ®Google Scholar
• KlemmARYoungDLloydJB1998Effects of polyethyleneimine on endocytosis and lysosome stabilityBiochem Pharmacol564169698087
   PubMed Web of Science ®Google Scholar
• KolbMMartinGMedinaM2006Gene therapy for pulmonary diseasesChest1308798416963689
   PubMed Web of Science ®Google Scholar
• KopatzIRemyJSBehrJP2004A model for non-viral gene delivery: through syndecan adhesion molecules and powered by actinJ Gene Med67697615241784
   PubMed Web of Science ®Google Scholar
• KramerKLYostHJ2003Heparan sulfate core proteins in cell-cell signalingAnnu Rev Genet374618414616070
   PubMed Web of Science ®Google Scholar
• KreissPCameronBRangaraR1999Plasmid DNA size does not affect the physicochemical properties of lipoplexes but modulates gene transfer efficiencyNucleic Acids Res273792810481017
   PubMed Web of Science ®Google Scholar
• Labat-MoleurFSteffanA-MBrissonC1996An electron microscopy study into the mechanism of gene transfer with lipopolyaminesGene Ther3101079044741
   PubMed Web of Science ®Google Scholar
• LearJDDeGradoWF1987Membrane binding and conformational properties of peptides representing the NH2 terminus of influenza HA-2J Biol Chem262650053571268
   PubMed Web of Science ®Google Scholar
• LechardeurDSohnKJHaardtM1999Metabolic instability of plasmid DNA in the cytosol: a potential barrier to gene transferGene Ther64829710476208
   PubMed Web of Science ®Google Scholar
• LeeHJeongJHParkTG2001A new gene delivery formulation of polyethylenimine/DNA complexes coated with PEG conjugated fusogenic peptideJ Control Release761839211532323
   PubMed Web of Science ®Google Scholar
• LehrmanS1999Virus treatment questioned after gene therapy deathNature401517810524611
   PubMed Web of Science ®Google Scholar
• LemkineGFDemeneixBA2001Polyethylenimines for in vivo gene deliveryCurr Opin Mol Ther31788211338931
   PubMed Web of Science ®Google Scholar
• LiSTanYViroonchatapanE2000Targeted gene delivery to pulmonary endothelium by anti-PECAM antibodyAm J Physiol Lung Cell Mol Physiol278L5041110710522
   PubMed Web of Science ®Google Scholar
• LiSTsengWCStolzDB1999aDynamic changes in the characteristics of cationic lipidic vectors after exposure to mouse serum: implications for intravenous lipofectionGene Ther65859410476218
   PubMed Web of Science ®Google Scholar
• LiSWuS-PWhitmoreM1999bEffect of immune response on gene transfer to the lung via systemic administration of cationic lipidic vectorsAm J Physiol (Lung Cell Mol Physiol)276L796L804
   PubMed Web of Science ®Google Scholar
• LiYWangJLeeCG2004CNS gene transfer mediated by a novel controlled release system based on DNA complexes of degradable polycation PPE-EA: a comparison with polyethylenimine/DNA complexesGene Ther111091414681704
   PubMed Web of Science ®Google Scholar
• LiuHLiuLFletcherBS2006Sleeping Beauty-based gene therapy with indoleamine 2,3-dioxygenase inhibits lung allograft fibrosisFaseb J202384617015408
   PubMed Web of Science ®Google Scholar
• LiuHLiuLVisnerGA2007Nonviral gene delivery with indoleamine 2,3-dioxygenase targeting pulmonary endothelium protects against ischemia-reperfusion injuryAm J Transplant7229130017711549
   PubMed Web of Science ®Google Scholar
• LiuQMuruveDA2003Molecular basis of the inflammatory response to adenovirus vectorsGene Ther109354012756413
   PubMed Web of Science ®Google Scholar
• LolloCPBanaszczykMGChiouHC2000Obstacles and advances in non-viral gene deliveryCurr Opin Mol Ther21364211249633
   PubMed Web of Science ®Google Scholar
• LukacsGLHaggiePSeksekO2000Size-dependent DNA mobility in cytoplasm and nucleusJ Biol Chem2751625910636854
   PubMed Web of Science ®Google Scholar
• LungwitzUBreunigMBlunkT2005Polyethylenimine-based non-viral gene delivery systemsEur J Pharm Biopharm602476615939236
   PubMed Web of Science ®Google Scholar
• MannistoMReinisaloMRuponenM2007Polyplex-mediated gene transfer and cell cycle: effect of carrier on cellular uptake and intracellular kinetics, and significance of glycosaminoglycansJ Gene Med94798717410614
   PubMed Web of Science ®Google Scholar
• MannistoMRonkkoSMattoM2005The role of cell cycle on polyplex-mediated gene transfer into a retinal pigment epithelial cell lineJ Gene Med74667615619286
   PubMed Web of Science ®Google Scholar
• MartinMERiceKG2007Peptide-guided gene deliveryAaps J9E182917408236
   PubMed Web of Science ®Google Scholar
• McLachlanGBakerATennantP2007Optimizing aerosol gene delivery and expression in the ovine lungMol Ther153485417235313
   PubMed Web of Science ®Google Scholar
• MengQ-HRobinsonDJenkinsGR2004Efficient transfection of non-proliferating human airway epithelial cells with a sytnthetic vector systemJ Gene Med62102114978774
   PubMed Web of Science ®Google Scholar
• MerdanTKunathKFischerD2002Intracellular processing of poly(ethylene imine)/ribozyme complexes can be observed in living cells by using confocal laser scanning microscopy and inhibitor experimentPharm Res19140611883640
   PubMed Web of Science ®Google Scholar
• Meunier-DurmortCGrimalHSachsLM1997Adenovirus enhancement of polyethylenimine-mediated transfer of regulated genes in differentiated cellsGene Ther4808149338009
   PubMed Web of Science ®Google Scholar
• MinSHLeeDCLimMJ2006A composite gene delivery system consisting of polyethylenimine and an amphipathic peptide KALAJ Gene Med814253417009340
   PubMed Web of Science ®Google Scholar
• MislickKABaldeschwielerJD1996Evidence for the role of proteoglycans in cation-mediated gene transferProc Natl Acad Sci U S A9312349548901584
   PubMed Web of Science ®Google Scholar
• MoffattSWiehleSCristianoRJ2005Tumor-specific gene delivery mediated by a novel peptide-polyethylenimine-DNA polyplex targeting aminopeptidase N/CD13Hum Gene Ther16576715703489
   PubMed Web of Science ®Google Scholar
• MoffattSWiehleSCristianoRJ2006A multifunctional PEI-based cationic polyplex for enhanced systemic p53-mediated gene therapyGene Ther1315122316763664
   PubMed Web of Science ®Google Scholar
• MoghimiSMSymondsPMurrayJC2005A two-stage poly(ethylenimine)-mediated cytotoxicity: implications for gene transfer/therapyMol Ther11990515922971
   PubMed Web of Science ®Google Scholar
• MounkesLCZhongWCipres-PalacinG1998Proteoglycans mediate cationic liposome-DNA complex-base gene delivery in vitro and in vivoJ Biol Chem27326164709748298
   PubMed Web of Science ®Google Scholar
• NastalaCLEdingtonHDMcKinneyTG1994Recombinant IL-12 administration induces tumor regression in association with IFN-gamma productionJ Immunol15316977067913943
   PubMed Web of Science ®Google Scholar
• NeuMFischerDKisselT2005Recent advances in rational gene transfer vector design based on poly(ethylene imine) and its derivativesJ Gene Med7992100915920783
   PubMed Web of Science ®Google Scholar
• OgrisMSteinleinPCarottaS2001DNA/polyethylenimine transfection particles: influence of ligands, polymer size, and PEGylation on internalization and gene expressionAAPS Pharm Sci3E21
   PubMed Web of Science ®Google Scholar
• OgrisMSteinleinPKursaM1998The size of DNA/transferrin-PEI complexes is an important factor for gene expression in cultured cellsGene Ther51425339930349
   PubMed Web of Science ®Google Scholar
• OhYKKimJPYoonH2001Prolonged organ retention and safety of plasmid DNA administered in polyethylenimine complexesGene Ther815879211704820
   PubMed Web of Science ®Google Scholar
• OhYKSuhDKimJM2002Polyethylenimine-mediated cellular uptake, nucleus trafficking and expression of cytokine plasmid DNAGene Ther916273212424615
   PubMed Web of Science ®Google Scholar
• OkudaTNiidomeTAoyagiH2004Cytosolic soluble proteins induce DNA release from DNA – gene carrier complexesJ Control Release983253215262423
   PubMed Web of Science ®Google Scholar
• OrsonFMSongLGautamA2002Gene delivery to the lung using protein/polyethylenimine/plasmid complexesGene Ther94637111938461
   PubMed Web of Science ®Google Scholar
• ParenteRANadasdiLSubbaraoNK1990aAssociation of a pH-sensitive peptide with membrane vesicles: role of amino acid sequenceBiochemistry29871392271551
   PubMed Web of Science ®Google Scholar
• ParenteRANirSSzokaFCJr1990bMechanism of leakage of phospholipid vesicle contents induced by the peptide GALABiochemistry29872082271552
   PubMed Web of Science ®Google Scholar
• ParenteRANirSSzokaFCJ1988pH-dependent fusion of phosphatidylcholine small vesicles. Induction by a synthetic amphipathic peptideJ Biol Chem2634724302450874
   PubMed Web of Science ®Google Scholar
• ParkIKLasieneJChouSH2007Neuron-specific delivery of nucleic acids mediated by Tet1-modified poly(ethylenimine)J Gene Med969170217582226
   PubMed Web of Science ®Google Scholar
• ParkTGJeongJHKimSW2006Current status of polymeric gene delivery systemsAdv Drug Deliv Rev584678616781003
   PubMed Web of Science ®Google Scholar
• ParkesRJHartSL2000Adhesion molecules and gene transferAdv Drug Deliv Rev441355211072111
   PubMed Web of Science ®Google Scholar
• PasqualiniRKoivunenEKainR2000Aminopeptidase N is a receptor for tumor-homing peptides and a target for inhibiting angiogenesisCancer Res60722710676659
   PubMed Web of Science ®Google Scholar
• PetersenHFechnerPMMartinAL2002Polyethylenimine-graft-poly(ethylene glycol) copolymers: influence of copolymer block structure on DNA complexation and biological activities as gene delivery systemBioconjug Chem138455412121141
   PubMed Web of Science ®Google Scholar
• PilewskiJM2002Gene therapy for airway diseases: continued progress toward identifying and overcoming barriers to efficiencyAm J Respir Cell Mol Biol271172112151301
   PubMed Web of Science ®Google Scholar
• PlankC2008Nanomagnetosols: magnetism opens up new perspectives for targeted aerosol delivery to the lungTrends Biotechnol26596318191261
   PubMed Web of Science ®Google Scholar
• PlankCMechtlerKSzokaFC1996Activation of the complement system by synthetic DNA complexes: A potential barrier for intravenous gene deliveryHuman Gene Therapy71437468844203
   PubMed Web of Science ®Google Scholar
• PlankCOberhauserBMechtlerK1994The influence of endosome-disruptive peptides on gene transfer using synthetic virus-like gene transfer systemsJ Biol Chem26912918248175709
   PubMed Web of Science ®Google Scholar
• PollardHRemyJ-SLoussouarnG1998Polyethylenimine but not cationic lipids promotes transgene delivery to the nucleus in mammalian cellsJ Biol Chem2737507119516451
   PubMed Web of Science ®Google Scholar
• PollardHToumaniantzGAmosJL2001Ca2+– sensitive cytosolic nucleases prevent efficient delivery to the nucleus of injected plasmidsJ Gene Med31536411318114
   PubMed Web of Science ®Google Scholar
• PoutonCW1998Nuclear import of polypeptides, polynucleotides and supramolecular complexesAdv Drug Deliv Rev34516410837670
   PubMed Web of Science ®Google Scholar
• PutnamDGentryCAPackDW2001Polymer-based gene delivery with low cytotoxicity by a unique balance of side-chain terminiProc Natl Acad Sci U S A981200511158617
   PubMed Web of Science ®Google Scholar
• ReadMLSinghSAhmedZ2005A versatile reducible polycation-based system for efficient delivery of a broad range of nucleic acidsNucleic Acids Res33e8615914665
   PubMed Web of Science ®Google Scholar
• RegnstromKRagnarssonEGFryknasM2006Gene expression profiles in mouse lung tissue after administration of two cationic polymers used for nonviral gene deliveryPharm Res234758216463010
   PubMed Web of Science ®Google Scholar
• RegnstromKRagnarssonEGKoping-HoggardM2003PEI – a potent, but not harmless, mucosal immuno-stimulator of mixed T-helper cell response and FasL-mediated cell death in miceGene Ther1015758312907949
   PubMed Web of Science ®Google Scholar
• RejmanJBragonziAConeseM2005Role of clathrin- and caveolae-mediated endocytosis in gene transfer mediated by lipo- and polyplexesMol Ther124687415963763
   PubMed Web of Science ®Google Scholar
• RejmanJConeseMHoekstraD2006Gene transfer by means of lipo- and polyplexes: role of clathrin and caveolae-mediated endocytosisJ Liposome Res162374716952878
   PubMed Web of Science ®Google Scholar
• RejmanJDi GioiaSBragonziA2007Pseudomonas aeruginosa Infection Destroys the Barrier Function of Lung Epithelium and Enhances Polyplex-Mediated TransfectionHum Gene Ther186425217638571
   PubMed Web of Science ®Google Scholar
• Remy-KristensenAClammeJPVuilleumierC2001Role of endocytosis in the transfection of L929 fibroblasts by polyethylenimine/DNA complexesBiochim Biophys Acta1514213211513802
   PubMed Web of Science ®Google Scholar
• RomanczukHGalerCEZabnerJ1999Modification of an adenoviral vector with biologically selected peptides: a novel strategy for gene delivery to cells of choiceHum Gene Ther1026152610566889
   PubMed Web of Science ®Google Scholar
• RoseneckerJNaundorfSGerstingSW2003Interaction of bronchoalveolar lavage fluid with polyplexes and lipoplexes: analysing the role of proteins and glycoproteinsJ Gene Med5496012516051
   PubMed Web of Science ®Google Scholar
• RudolphCLausierJNaundorfS2000In vivo gene delivery to the lung using polyethylenimine and fracturated polyamidoamine dendrimersJ Gene Med22697810953918
   PubMed Web of Science ®Google Scholar
• RudolphCOrtizASchillingerU2005aMethodological optimization of polyethylenimine (PEI)-based gene delivery to the lungs of mice via aerosol applicationJ Gene Med7596615538727
   PubMed Web of Science ®Google Scholar
• RudolphCPlankCLausierJ2003Oligomers of the arginine-rich motif of the HIV-1 TAT peptide are capable of transferring plasmid DNA into cellsJ Biol Chem27811411812519756
   PubMed Web of Science ®Google Scholar
• RudolphCSchillingerUOrtizA2005bAerosolized nanogram quantities of plasmid DNA mediate highly efficient gene delivery to mouse airway epitheliumMol Ther1249350116099412
   PubMed Web of Science ®Google Scholar
• SchiffelersRMAnsariAXuJ2004Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticleNucleic Acids Res32e14915520458
   PubMed Web of Science ®Google Scholar
• SeongJHLeeKMKimST2006Polyethylenimine-based antisense oligodeoxynucleotides of IL-4 suppress the production of IL-4 in a murine model of airway inflammationJ Gene Med83142316292779
   PubMed Web of Science ®Google Scholar
• ShiLTangGPGaoSJ2003Repeated intrathecal administration of plasmid DNA complexed with polyethylene glycol-grafted polyethylenimine led to prolonged transgene expression in the spinal cordGene Ther1011798812833127
   PubMed Web of Science ®Google Scholar
• SonawaneNDSzokaFCJrVerkmanAS2003Chloride accumulation and swelling in endosomes enhances DNA transfer by polyamine-DNA polyplexesJ Biol Chem278448263112944394
   PubMed Web of Science ®Google Scholar
• SongYKLiuFLiuD1998Enhanced gene expression in mouse lung by prolonging the retention time of intravenously injected plasmid DNAGene Ther5153179930306
   PubMed Web of Science ®Google Scholar
• SparrowJTEdwardsVVTungC1998Synthetic peptide-based DNA complexes for nonviral gene deliveryAdv Drug Deliv Rev301153110837606
   PubMed Web of Science ®Google Scholar
• StammbergerUUduehiANKubisaB2002Non-viral gene delivery to atelectatic and ventilated lungsAnn Thorac Surg734326 discussion 436–711845855
   PubMed Web of Science ®Google Scholar
• SubbaraoNKParenteRASzokaFCJ1987pH-dependent bilayer destabilization by an amphipathic peptideBiochemistry262964722886149
   PubMed Web of Science ®Google Scholar
• SuhJPaikH-JHwangBK1994Ionization of poly(ethylenimine) and poly(allylamine) at various pH’sBioorganic Chemistry2231827
   Web of Science ®Google Scholar
• SungSJMinSHChoKY2003Effect of polyethylene glycol on gene delivery of polyethylenimineBiol Pharm Bull2649250012673031
   PubMed Web of Science ®Google Scholar
• TachibanaRHarashimaHShinoharaY2001Quantitative studies on the nuclear transport of plasmid DNA and gene expression employing nonviral vectorsAdv Drug Deliv Rev522192611718946
   PubMed Web of Science ®Google Scholar
• TalcottBMooreMS1999Getting across the nuclear pore complexTrends Cell Biol9312810407410
   PubMed Web of Science ®Google Scholar
• TalsmaHCherngJLehrmannH1997Stabilization of gene delivery systems by freeze-dryingInt J Pharm157233810477820
   PubMed Web of Science ®Google Scholar
• TangMXSzokaF1997The influence of polymer structure on the interactions of cationic polymers with DNA and morphology of the resulting complexesGene Ther4823329338011
   PubMed Web of Science ®Google Scholar
• ThomasCEEhrhardtAKayMA2003Progress and problems with the use of viral vectors for gene therapyNat Rev Genet43465812728277
   PubMed Web of Science ®Google Scholar
• ThomasMLuJJChenJ2007Non-viral siRNA delivery to the lungAdv Drug Deliv Rev591243317459519
   PubMed Web of Science ®Google Scholar
• ThomasMLuJJGeQ2005Full deacylation of polyethylenimine dramatically boosts its gene delivery efficiency and specificity to mouse lungProc Natl Acad Sci U S A10256798415824322
   PubMed Web of Science ®Google Scholar
• Urban-KleinBWerthSAbuharbeidS2005RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivoGene Ther12461615616603
   PubMed Web of Science ®Google Scholar
• VaysseLBurgelinIMerlioJP2000Improved transfection using epithelial cell line-selected ligands and fusogenic peptidesBiochim Biophys Acta14753697610913838
   PubMed Web of Science ®Google Scholar
• VaysseLGuillaumeCBurgelinI2002Proteolipidic vectors for gene transfer to the lungBiochem Biophys Res Commun29014899811820790
   PubMed Web of Science ®Google Scholar
• von GersdorffKSandersNNVandenbrouckeR2006The internalization route resulting in successful gene expression depends on both cell line and polyethylenimine polyplex typeMol Ther147455316979385
   PubMed Web of Science ®Google Scholar
• WagnerE1999Application of membrane-active peptides for nonviral gene deliveryAdv Drug Deliv Rev382798910837761
   PubMed Web of Science ®Google Scholar
• WalkerWEPorteousDJBoydAC2004The effects of plasmid copy number and sequence contect upon transfection efficiencyJ Control Release942455214684288
   PubMed Web of Science ®Google Scholar
• WangSMaNGaoSJ2001Transgene expression in the brain stem effected by intramuscular injection of polyethylenimine/DNA complexesMol Ther36586411356070
   PubMed Web of Science ®Google Scholar
• WattiauxRLaurentNWattiaux-De ConinckS2000Endosomes, lysosomes: their implication in gene transferAdv Drug Deliv Rev41201810699315
   PubMed Web of Science ®Google Scholar
• WerthSUrban-KleinBDaiL2006A low molecular weight fraction of polyethylenimine (PEI) displays increased transfection efficiency of DNA and siRNA in fresh or lyophilized complexesJ Control Release1122577016574264
   PubMed Web of Science ®Google Scholar
• WightmanLKircheisRRosslerV2001Different behaviour of branched and linear polyethylenimine for gene delivery in vitro and in vivoJ Gene Med33627211529666
   PubMed Web of Science ®Google Scholar
• WisemanJWGoddardCAMcLellandD2003A comparison of linear and branched polyethylenimine (PEI) with DCChol/DOPE liposomes for gene delivery to epithelial cells in vitro and in vivoGene Ther1016546212923564
   PubMed Web of Science ®Google Scholar
• WolfertMASeymourLW1998Chloroquine and amphipathic peptide helices show synergistic transfection in vitroGene Ther5409149614562
   PubMed Web of Science ®Google Scholar
• WriterMJMarshallBPilkington-MiksaMA2004Targeted gene delivery to human airway epithelial cells with synthetic vectors incorporating novel targeting peptides selected by phage displayJ Drug Target121859315506167
   PubMed Web of Science ®Google Scholar
• WymanTBNicolFZelphatiO1997Design, synthesis, and characterization of a cationic peptide that binds to nucleic acids and permeabilizes bilayersBiochemistry363008179062132
   PubMed Web of Science ®Google Scholar
• YewNSPrzybylskaMZieglerRJ2001High and sustained transgene expression in vivo from plasmid vectors containing a hybrid ubiquitin promoterMol Ther4758211472109
   PubMed Web of Science ®Google Scholar
• YewNSZhaoHPrzybylskaM2002CpG-depleted plasmid DNA vectors with enhanced safety and long-term gene expression in vivoMol Ther5731812027557
   PubMed Web of Science ®Google Scholar
• ZantaMABelguise-ValladierPBehrJ-P1999Gene delivery: A single nuclear localization signal peptide is sufficient to carry DNA to the cell nucleusProc Natl Acad Sci U S A969169874777
   PubMed Web of Science ®Google Scholar
• ZhangLGuFXChanJM2008Nanoparticles in medicine: Therapeutic applications and developmentsClin Pharmacol Ther83761917957183
   PubMed Web of Science ®Google Scholar
• ZhangZYSmithBD2000High-generation polycationic dendrimers are unusually effective at disrupting anionic vesicles: membrane bending modelBioconjug Chem118051411087328
   PubMed Web of Science ®Google Scholar
• ZiadyAGKelleyTJMillikenE2002Functional evidence of CFTR gene transfer in nasal epithelium of cystic fibrosis mice in vivo following luminal application of DNA complexes targeted to the serpin-enzyme complex receptorMol Ther5413911945068
   PubMed Web of Science ®Google Scholar
• ZouSMErbacherPRemyJS2000Systemic linear polyethylenimine (L-PEI)-mediated gene delivery in the mouseJ Gene Med21283410809146
   PubMed Web of Science ®Google Scholar