Gene medicine for cancer treatment: Commercially available medicine and accumulated clinical data in China

References

• Ala-ahoRGrenmanRSethP2002Adenoviral delivery of p53 gene suppresses expression of collagenase-3 (MMP-13) in squamous carcinoma cellsOncogene2111879511850838
   PubMed Web of Science ®Google Scholar
• BischoffJKirnDWilliamsA1996An adenovirus mutant that replicates selectively in p53 deficient human tumor cellsScience27437368832876
   PubMed Web of Science ®Google Scholar
• BlagosklonnyMVEL-DeiryWS1996In vitro evaluation of a p53-expressing adenovirus as an anti-cancer drugInt J Cancer67386928707413
   PubMed Web of Science ®Google Scholar
• BlagosklonnyMVGiannakakouPWojtowiczM1998Effects of p53-expressing adenovirus on the chemosensitivity and differentiation of anaplastic thyroid cancer cellsJ Clin Endocrinol Metab832516229661637
   PubMed Web of Science ®Google Scholar
• BouvardVZaitchoukTVacherM2000Tissue and cell-specific expression of the p53 target genes: bax, fas, mdm2 and waf1/p21, before and following ionizing irradiation in miceOncogene196496010698510
   PubMed Web of Science ®Google Scholar
• CerratoJAYungWKLiuTJ2001Introduction of mutant p53 into a wild-type p53-expressing glioma cell line confers sensitivity to Ad-p53-induced apoptosisNeuro Oncol31132211296482
   PubMed Web of Science ®Google Scholar
• CerwenkaALanierLL2003NKG2D ligands: Unconventional MHC class I-like molecules exploited by viruses and cancerTissue Antigens613354312753652
   PubMed Web of Science ®Google Scholar
• ChenCPanJXuL2003Recombinant adenovirus p53 agent injection combince with radiotherapy in treatment of nasopharyngeal carcinoma: a phase II clinical trialZhonghua Yi Xue Za Zhi232033514703410
   PubMedGoogle Scholar
• ChipukJEKuwanaTBouchierH2004Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosisScience30310101414963330
   PubMed Web of Science ®Google Scholar
• ChuRLPostDEKhuriFR2004Use of replicating oncolytic adenoviruses in combination therapy for cancerClin Cancer Res10529931215328165
   PubMed Web of Science ®Google Scholar
• ClaymanGLEL-NaggarAKLippman1998Adenovirus-mediated p53 gene transfer in patients with advanced recurrent head and neck squamous cell carcinomaJ Clin Oncol162221329626224
   PubMed Web of Science ®Google Scholar
• DameronKMVolpertOVTainskyMA1994Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1Science265158247521539
   PubMed Web of Science ®Google Scholar
• DeweeseTLVanderPHLiS2001A phase I trial of CV706, a replication-competent, PSA selective oncolytic adenovirus, for the treatment of locally recurrent prostate cancer following radiation therapyCancer Res6174647211606381
   PubMed Web of Science ®Google Scholar
• EisoldSLinnebacherMRyschichE2004The effect of adenovirus expressing wild-type p53 on 5-fluorouracil chemosensitivity is related to p53 status in pancreatic cancer cell linesWorld J Gastroenterol103583915534911
   PubMed Web of Science ®Google Scholar
• FulciGIshiiNVan MeirEG1998p53 and brain tumors: from gene mutations to gene therapyBrain Pathol85996139804370
   PubMed Web of Science ®Google Scholar
• GuanYSSunLZhouXP2005Combination therapy with recombinant adenovirus-p53 injection (rAd-p53) via transcatheter hepatic arterial chemoembolization for advanced hepatic carcinomaShijie Huaren Xiaohua Zazhi131257
   Google Scholar
• HabibNAHodgsonHJLemoineN1999A phase I/II study of hepatic artery infusion with wtp53-CMV-Ad in metastatic malignant liver tumorsHum Gene Ther1020193410466636
   PubMed Web of Science ®Google Scholar
• HuangXFRenWRollinsL2003A broadly applicable personalized heat shock protein-mediated oncolytic tumor vaccineCancer Res637321914612530
   PubMed Web of Science ®Google Scholar
• HuFHuXYuP2006Abscopal effect on metastatic tumor induced by oncolytic virus of H101 combining with local heatingAi Zheng259192416965669
   PubMedGoogle Scholar
• InoueANarumiKMatsubaraN2000Administration of wild-type p53 adenoviral vector synergistically enhances the cytotoxicity of anti-cancer drugs in human lung cancer cells irrespective of the status of p53 geneCancer Lett1571051210893449
   PubMed Web of Science ®Google Scholar
• KatayoseDGudasJNguyenH1995Cytotoxic effects of adenovirus-mediated wild-type p53 protein expression in normal and tumor mammary epithelial cellsClin Cancer Res1889979816059
   PubMed Web of Science ®Google Scholar
• KrishnaRMayerLD2000Multidrug resistance (MDR) in cancer: Mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugsEur J Pharm Sci112658311033070
   PubMed Web of Science ®Google Scholar
• LeuJDumontPHafeyM2004Mitochondrial p53 activates Bak and causes disruption of a Bak–Mcl1 complexNat Cell Biol64435015077116
   PubMed Web of Science ®Google Scholar
• LuYHuXLiF2006Radiotherapy combined with chemotherapy and intratumoral injection of EIB gene-deleted adenovirus (H101) for nasopharyngeal carcinomaZhong Liu264535
   Google Scholar
• MatsudaKYoshidaKTayaY2002p53AIP1 regulates the mitochondrial apoptotic pathwayCancer Res622883912019168
   PubMed Web of Science ®Google Scholar
• MullerMWilderSBannaschD1998p53 activates the CD95 (APO-1/Fas) gene in response to DNA damage by anticancer drugsJ Exp Med1882033459841917
   PubMed Web of Science ®Google Scholar
• NemunaitisJSwisherSGTimmonsT2000Adenovirus-mediated p53 gene transfer in sequence with cisplatin to tumors of patients with non-small-cell lung cancerJ Clin Oncol186092210653876
   PubMed Web of Science ®Google Scholar
• NemunaitisJCunninghamCTongAW2003Pilot trial of intravenous infusion of a replication selective adenovirus (ONYX-015) in combination with chemotherapy or IL-2 treatment in refractory cancer patientsCancer Gene Ther103415212719704
   PubMed Web of Science ®Google Scholar
• O’SheaCCSoriaCBagusB2005Heat shock phenocopies E1B-55K late functions and selectively sensitizes refractory tumor cells to ONYX-015 oncolytic viral therapyCancer Cell8617416023599
   PubMed Web of Science ®Google Scholar
• PagliaroLCKeyhaniAWilliamsD2003Repeated intravesical instillations of an adenoviral vector in patients with locally advanced bladder cancer: A phase I study of p53 gene therapyJ Clin Oncol2122475312805322
   PubMed Web of Science ®Google Scholar
• PalSDattaKMukhopadhyayD2001Central role of p53 on regulation of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) expression in mammary carcinomaCancer Res616952711559575
   PubMed Web of Science ®Google Scholar
• QuistSRWang-GohrkeSKohlerT2004Cooperative effect of adenoviral p53 gene therapy and standard chemotherapy in ovarian cancer cells independent of the endogenous p53 statusCancer Gene Ther115475415153938
   PubMed Web of Science ®Google Scholar
• ReidTGalanisEAbbruzzeseJ2002Hepatic arterial infusion of a replicationselective oncolytic adenovirus (dl520): Phase II viral, immunologic, and clinical endpointsCancer Res626070912414631
   PubMed Web of Science ®Google Scholar
• RogulskiKRFreytagSOZhangK2000In vivo antitumor activity of ONYX-015 is influenced by radiotherapyCancer Res601193610728673
   PubMed Web of Science ®Google Scholar
• RosenblumMDOlaszEWoodliffJE2004CD200 is a novel p53-target gene involved in apoptosis-associated immune toleranceBlood1032691814644999
   PubMed Web of Science ®Google Scholar
• RotherKJohneCSpiesbachK2004Identification of Tcf-4 as a transcriptional target of p53 signallingOncogene2333768414990988
   PubMed Web of Science ®Google Scholar
• RothmannTHengstermannAWhitakerNJ1998Replication of ONYX-015, a potential anticancer adenovirus, is independent of p53 status in tumor cellsJ Virol72947089811680
   PubMed Web of Science ®Google Scholar
• RoydsJAHibmaMDixBR2006p53 promotes adenoviral replication and increases late viral gene expressionOncogene2515092016247442
   PubMed Web of Science ®Google Scholar
• SabineL2004Can China bring its own pipeline to the market?Nat Bio-technol2214979
   PubMed Web of Science ®Google Scholar
• SahNKMunshiANishikawaT2003Adenovirus-mediated wild type p53 radiosensitizes human tumor cells by suppressing DNA repair capacityMol Cancer Ther212233114617796
   PubMed Web of Science ®Google Scholar
• SchulerMHerrmanRDE GreveJL2001Adenovirus-mediated wild-type p53 gene transfer in patients receiving chemotherapy for advanced non-small-cell lung cancer: Results of a multicenter phase II studyJ Clin Oncol191750811251006
   PubMed Web of Science ®Google Scholar
• Schwartzenberg-bar-YosephFArmoniMKarnieliE2004The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expressionCancer Res6426273315059920
   PubMed Web of Science ®Google Scholar
• ShiraishiKKatoSHanSY2004Isolation of temperaturesensitive p53 mutations from a comprehensive missense mutation libraryJ Biol Chem2793485514559903
   PubMed Web of Science ®Google Scholar
• SinghBReddyPGGoberdhanA2002p53 regulates cell survival by inhibiting PIK3CA in squamous cell carcinomasGenes Dev169849311959846
   PubMed Web of Science ®Google Scholar
• SmithRRHuebnerRJRoweWP1956Studies on the use of viruses in the treatment of carcinoma of the cervixCancer91211813383455
   PubMed Web of Science ®Google Scholar
• St JohnLSSauterERHerlynM2000Endogenous p53 gene status predicts the response of human squamous cell carcinomas to wild-type p53Cancer Gene Ther77495610830722
   PubMed Web of Science ®Google Scholar
• SunYZengXRWengerL2004p53 down-regulates matrix metal-loproteinase-1 by targeting the communications between AP-1 and the basal transcription complexJ Cell Biochem922586915108353
   PubMed Web of Science ®Google Scholar
• SwisherSGRothJANemunaitisJ1999Adenovirus-mediated p53 gene transfer in advanced non-small-cell lung cancerJ Natl Cancer Inst917637110328106
   PubMed Web of Science ®Google Scholar
• TahaTAOstaWKozhayaL2004Down-regulation of sphingosine kinase-1 by DNA damage: Dependence on proteases and p53J Biol Chem279205465414988393
   PubMed Web of Science ®Google Scholar
• ToschiERotaRAntoniniA2000Wild-type p53 gene transfer inhibits invasion and reduces matrix metalloproteinase-2 levels in p53-mutated human melanoma cellsJ Invest Dermatol11411889410844565
   PubMed Web of Science ®Google Scholar
• WangHQianHYuJ2006Administration of PUMA adenovirus increases the sensitivity of esophageal cancer cells to anticancer drugsCancer Biol Ther5380516481741
   PubMed Web of Science ®Google Scholar
• WangXYLiYYangG2005Current ideas about applications of heat shock proteins in vaccine design and immunotherapyInt J Hyperthermia217172216338854
   PubMed Web of Science ®Google Scholar
• WengZQinTLTanSY2004Clinical trial for the treatment of advanced lung cancer by intratumoral injection of rAd p53Shenzhen Zhong Xi Yi Jie He Za Zhi1420610
   Google Scholar
• WhiteE1994Tumour biology: p53, guardian of RbNature3712128072521
   PubMed Web of Science ®Google Scholar
• XiaZJChangJHZhangL2004Phase III randomized clinical trial of intratumoral injection of E1B gene-deleted adenovirus (H101) combined with cisplatin-based chemotherapy in treating squamous cell cancer of head and neck or esophagusAi Zheng2316667015601557
   PubMedGoogle Scholar
• XiaoSLiuCSunY2007Clinical observation of the effect of recombinant adenovirus- p53 plus radio-thermotherapy on soft tissue sarcomaZhong Guo Zhong Liu Lin Chuang34657
   Google Scholar
• YenNIoannidesCGXuK2000Cellular and humoral immune responses to adenovirus and p53 protein antigens in patients following intratumoral injection of an adenovirus vector expressing wildtype P53 (Ad-p53)Cancer Gene Ther7530610811470
   PubMed Web of Science ®Google Scholar
• YewPRBerkAJ1992Inhibition of p53 transactivation required for transformation by adenovirus early 1B proteinNature3578251533443
   PubMed Web of Science ®Google Scholar
• YinYLiuYXJinYJ2003PAC1 phosphatase is a transcription target of p53 in signalling apoptosis and growth suppressionNature4225273112673251
   PubMed Web of Science ®Google Scholar
• ZeimetAGMarthC2003Why did p53 gene therapy fail in ovarian cancer?Lancet Oncol44152212850192
   PubMed Web of Science ®Google Scholar
• ZhanJGaoYWangW2005Tumor-specific intravenous gene delivery using oncolytic adenovirusesCancer Gene Ther12192515514685
   PubMed Web of Science ®Google Scholar
• ZhangSXiaoSLiuC2003Treatment of head and neck squamous cell carcinoma by recombinant adenovirus-p53 combined with radiotherapy: a phase II clinical trial of 42 casesZhonghua Yi Xue Za Zhi232023814703408
   PubMedGoogle Scholar
• ZhouCXuYNiJ2006Oncolytic adenovirus H101 in combination with vinorelbine/cisplatin chemotherapy for advanced non-small cell lung cancerZhong Liu2661317
   Google Scholar