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Future Neurology Volume 3, 2008 - Issue 4
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Review

Traumatic Brain Injury and Gender: What is Known and What is Not

Ron Hirschberga Harvard Medical School, The Department of Physical Medicine & Rehabilitation, Spaulding Rehabilitation Hospital, The Massachusetts General Hospital, MA, USA. Tel: +1 617 573 2754; [email protected]
,
Dorothy Weissb Harvard Medical School, The Department of Physical Medicine & Rehabilitation, Spaulding Rehabilitation Hospital, The Massachusetts General Hospital, MA, USA. Tel: +1 617 573 2754; [email protected]
&
Ross Zafontec Harvard Medical School, Spaulding Rehabilitation Hospital, The Massachusetts General Hospital, 125 Nashua Street, Boston, MA02214, USA. Tel: +1 617 573 2754; Fax: +1 617 573 2759; [email protected]Correspondence[email protected]
Pages 483-489 | Published online: 12 Jun 2008

Bibliography

  • Langlois JA , MarrA, MitchkoJ, Johnson RL: Tracking the silent epidemic and educating the public: CDC‘s traumatic brain injury-associated activities under the TBI Act of 1996 and the Children‘s Health Act of 2000. J. Head Trauma Rehabil.20, 196–204 (2005).
  • Thurman DJ , AlversonC, DunnKA, GuerreroJ, SniezekJE: Traumatic brain injury in the United States: a public health perspective.J. Head Trauma Rehabil.14, 602–615 (1999).
  • Adekoya D , ThurmanDJ, WhiteDD, Webb KW: Surveillance for traumatic brain injury deaths – United States, 1989–1998. MMWR Surveill. Summ.51(10), 1–14 (2000).
  • Cosgrove KP , MazureCM, StaleyJK: Evolving knowledge of sex differences in brain structure, function, and chemistry.Biol. Psychiatry62, 847–855 (2007).
  • Courchesne E , ChizumH, TownsendJet al.: Normal brain development and aging: quantitative analysis and in vivo MR imaging in healthy volunteers. Neuroradiology216, 672–682 (2000).
  • Allen J , DamasioH, GrabowskiT, BrussJ, ZhangW: Sexual dimorphism and asymmetries in the gray–white composition of the human cerebrum.Neuroimage18, 880–894 (2003).
  • Paus T , OtakyN, CaramanosZet al.: In vivo morphometry of the intrasulcal gray matter in the human cingulate, paracingulate, and superior-rostral sulci: hemispheric asymmetries, gender differences and probability maps. J. Comp. Neurol.376, 664–673 (1996).
  • Goldstein J , SeidmanL, HortonNet al.: Normal sexual dimorphism of the adult human brain assessed by in vivo magnetic resonance imaging. Cereb. Cortex11, 490–497 (2001).
  • Haier RJ , JungRE, YeoRA, HeadK, Alkire MT: The neuroanatomy of general intelligence: sex matters. Neuroimage25(1), 320–327 (2005).
  • Filipek PA , RichelmeC, KennedyDN, CavinessVS Jr: The young adult human brain: an MRI-based morphometric analysis. Cereb. Cortex4, 344–360 (1994).
  • Giedd JN , CastellanosFX, RajapakseJC, VaituzisAC, RapoportJL: Sexual dimorphism of the developing human brain.Prog. Neuropsychopharmacol. Biol. Psychiatry21, 1185–1201 (1997).
  • Gundlah C , KohamaSG, MirkesSJ, GaryfallouVT, UrbanskiHF, BetheaCL: Distribution of estrogen receptor β (ERβ) mRNA in hypothalamus, midbrain and temporal lobe of spayed macaque: continued expression with hormone replacement.Brain Res. Mol. Brain Res.76, 191–204 (2000).
  • Murphy D , DeCarliC, McIntoshAet al.: Sex differences in human brain morphometry and metabolism: an in vivo quantitative magnetic resonance imaging and positron emission tomography study on the effect of aging. Arch. Gen. Psychiatry53, 585–594 (1996).
  • Nishizawa S , BenkelfatC, YoungSet al.: Differences between males and females in rates of serotonin synthesis in human brain. Proc. Natl Acad. Sci. USA94, 5308–5313 (1997).
  • Lavalaye J , BooijJ, RenemanL, HabrakenJ, RoyenEV: Effect of age and gender on dopamine transporter imaging with [123I] FP-CIT SPECT in healthy volunteers.Eur. J. Nucl. Med.27, 867–869 (2000).
  • Seeman MV : Psychopathology in women and men: focus on female hormones.Am. J. Psychiatry154, 1641–1647 (1997).
  • Bachman DL , WolfPA, LinnRet al.: Prevalence of dementia and probable senile dementia of the Alzheimer type in the Framingham study. Neurology42, 115–119 (1992).
  • Majewska MD : Neurosteroids: endogenous modulators of the GABA-A receptor; mechanism of action and physiological significance.Prog. Neurobiol.38, 379–395 (1992).
  • Maggi A , PerezJ: Estrogen-induced up-regulation of γ-aminobutyric receptors in the CNS of rodents.J. Neurochem.47, 1793–1797 (1986).
  • Luine VN , BeckKD, BowmanRE, Frankfurt M, MacLusky NJ: Chronic stress and neural function: accounting for sex and age. J. Neuroendocrinol.19, 743–751 (2007).
  • Wagner A , SasserH: Gender associations with disability and community integration after TBI.Arch. Phys. Med. Rehabil.81, 1267–1268 (2000).
  • Ponsford JL , WillmottC, RothwellAet al.: Factors influencing outcome following mild traumatic brain injury. J. Int. Neuropsychol.6, 568–579 (2000).
  • Wagner AK , HammondFM, SasserHet al.: The use of injury severity variables to predict disability and community integration after traumatic brain injury. J. Trauma49, 411–419 (2000).
  • Mushkudiani NA , EngelDC, Steyerberg EW: Prognostic value of demographic characteristics in traumatic brain injury: results from the IMPACT study. J. Neurotrauma24(2), 259–269 (2007).
  • Farace E , AlvesWM: Do women fare worse: a metaanalysis of gender differences in traumatic brain injury outcome.J. Neurosurg.93(4), 539–545 (2000).
  • Slewa-Younan S , GreenAM, BaguleyIJ, GurkaJA, MarosszekyJE: Sex differences in injury severity and outcome measures after TBI.Arch. Phys. Med. Rehab.85(3), 376–369 (2004).
  • Ratcliff JJ , GreenspanAI, GoldsteinFCet al.: Gender and traumatic brain injury: do the sexes fare differently?Brain Injury21(10), 1023–1030 (2007).
  • Britton SW , KlineRF: Age, sex, carbohydrate, adrenal cortex and other factors in anoxia.Am. J. Physiol.145, 190–202 (1945).
  • Sadoshima S , NakatomiY, FujiiKet al.: Mortality and histological findings of the brain during and after cerebral ischemia in male and female spontaneously hypertensive rats. Brain Res.454, 238–243 (1998).
  • Kassell NF , HaleyEC, Apperson-HansenC, StatM, AlvesWM: Randomized, double blind, vehicle-controlled trial of tirilazad mesylate in patients with aneurismal subarachnoid hemorrhage: a cooperative study in Europe, Australia, and New Zealand.J. Neurosurg.84, 221–228 (1996).
  • Roof RL , DuvdevaniR, HeyburnJWet al.: Progesterone rapidly decreases brain edema: treatment delayed up to 24 hours is still effective. Exp. Neurol.138, 246–251 (1996).
  • Roof RL , DuvdevaniR, SteinDG: Progesterone treatment attenuates brain edema following contusion injury in male and female rats.Restor. Neurol. Neurosci.4, 425–429 (1992).
  • Roof RL , HoffmanSW, SteinDG: Progesterone protects against lipid peroxidation following traumatic brain injury in rats.Mol. Chem. Neuropathol.31, 1–11 (1997).
  • O‘Connor CA , CernakI, VinkR: The temporal profile of edema formation differs between male and female rats following diffuse traumatic brain injury.Acta Neurochir. Suppl.96, 121–124 (2006).
  • Jones NC , ConstantinD, PriorMJW, MorrisPG, MarsdenCA, MurphyS: The neuroprotective effect of progesterone after traumatic brain injury in male mice is independent of both the inflammatory response and growth factor expression.Eur. J. Neurosci.21(6), 1547–1554 (2005).
  • Stein DG : The case for progesterone.Ann. NY Acad. Sci.1052, 152–169 (2005).
  • Stein DG , WrightDW, KellermannAL: Does progesterone have neuroprotective properties?Ann. Emerg. Med.51(2), 164–172 (2007).
  • Attella MJ , NattinvilleA, SteinDG: Hormonal state affects recovery from frontal cortex lesions in adult female rats.Behav. Neural Biol.48(3), 352–367 (1987).
  • Pan DS , LiuWG, YangXF, CaoF: Inhibitory effect of progesterone on inflammatory factors after experimental traumatic brain injury.Biomed. Environ. Sci.20(5), 432–438 (2007).
  • VanLandingham JW , CekicM, CutlerS, HoffmanSW, SteinDG: Neurosteroids reduce inflammation after TBI through CD55 induction.Neurosci. Lett.425(2), 94–98 (2007).
  • O‘Connor CA , CernakI, JohnsonF, Vink R: Effects of progesterone on neurologic and morphologic outcome following diffuse traumatic brain injury in rats. Exp. Neurol.205(1), 145–153 (2007).
  • Roof RL , HallED: Estrogen-related gender differences in survival rate and cortical blood flow after impact-acceleration head injury in rats.J. Neurotrauma17(12), 1155–1169 (2000).
  • Roof RL , HallED: Gender differences in acute CNS trauma and stroke: neuroprotective effects of estrogen and progesterone.J. Neurotrauma17(5), 367–388 (2000).
  • Wagner AK , KlineAE, RenDet al.: Gender associations with chronic methylphenidate treatment and behavioral performance following experimental traumatic brain injury. Behav. Brain Res.181(2), 200–209 (2007).
  • Rogers E , WagnerAK: Gender, sex steroids, and neuroprotection following traumatic brain injury.J. Head Trauma Rehabil.21(3), 279–281 (2006).
  • Wagner AK , KlineAE, SokoloskiJ, Zafonte RD, Capulong E, Dixon CE: Intervention with environmental enrichment after experimental brain trauma enhances cognitive recovery in male but not female rats. Neurosci. Lett.334(3), 165–168 (2002).
  • Emerson CS , HeadrickJP, VinkR: Estrogen improves biochemical and neurologic outcome following traumatic brain injury in male rats, but not in females.Brain Res.608(1), 95–100 (1993).
  • Ahlbom E , PrinsGS, CeccatelliS: Testosterone protects cerebellar granule cells from oxidative stress-induced cell death through a receptor mediated mechanism.Brain Res.892, 255–262 (2001).
  • Yang SH , PerezE, CutrightJet al.: Testosterone increases neurotoxicity of glutamate in vitro and ischemia-reperfusion injury in an animal model. J. Appl. Physiol.92, 195–201 (2002).
  • Hoffman SW , VirmaniS, SimkinsRM, Stein DG: The delayed administration of dehydroepiandrosterone sulfate (DHEAS) improves recovery of function after traumatic brain injury in rats. J. Neurotrauma20(9), 859–870 (2003).
  • Wagner AK , WillardLA, KlineAEet al.: Evaluation of estrous cycle stage and gender on behavioral outcome after experimental traumatic brain injury. Brain Res.998(1), 113–121 (2004).
  • Wagner AK , BayirH, RenD, PuccioA, ZafonteRD, KockanekPM: Relationships between CSF fluid markers of exciteotoxicity, ischemia, and oxidative damage after severe TBI: the impact of gender, age, and hypothermia:J. Neurotrauma21(2), 125–136 (2004).
  • Wagner AK , FabioA, PuccioAMet al.: Gender associations with cerebrospinal fluid glutamate and lactate/pyruvate levels after severe traumatic brain injury. Crit. Care Med.33(2), 407–413 (2005).
  • Clifton GI , MillerER, ChoiSCet al.: Lack of effect of induction of hypothermia after acute brain injury. N. Engl. J. Med.344, 556–563 (2001).
  • Marion DW , PenrodLE, KelseySFet al.: Treatment of traumatic brain injury with moderate hypothermia. N. Eng. J. Med.336, 540–546 (1997).
  • Wright DW , KellermanAL, HertzbergVSet al.: ProTECT: a randomized clinical trial of progesterone for acute traumatic brain injury. Ann. Emerg. Med.49(4), 391–402 (2007).

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