464
Views
0
CrossRef citations to date
0
Altmetric
Editorial

How Does the Oncogene Astrocyte Elevated gene-1 (AEG-1) Augment Glioma Progression?

, , , , &
Pages 293-296 | Published online: 14 Aug 2015

References

  • Cuddapah VA , RobelS, WatkinsS, SontheimerH. A neurocentric perspective on glioma invasion. Nature Rev. Neurosci.15(7), 455–465 (2014).
  • Wen PY , KesariS. Malignant gliomas in adults. N. Engl. J. Med.359(5), 492–507 (2008).
  • Wang H , XuT, JiangYet al. The challenges and the promise of molecular targeted therapy in malignant gliomas. Neoplasia17(3), 239–255 (2015).
  • Su ZZ , KangDC, ChenYet al. Identification and cloning of human astrocyte genes displaying elevated expression after infection with HIV-1 or exposure to HIV-1 envelope glycoprotein by rapid subtraction hybridization, rash. Oncogene21(22), 3592–3602 (2002).
  • Brown DM , RuoslahtiE. Metadherin, a cell surface protein in breast tumors that mediates lung metastasis. Cancer Cell5(4), 365–374 (2004).
  • Britt DE , YangDF, YangDQet al. Identification of a novel protein, LYRIC, localized to tight junctions of polarized epithelial cells. Experimental Cell Res.300(1), 134–148 (2004).
  • Sutherland HG , LamYW, BriersS, LamondAI, BickmoreWA. 3D3/lyric: a novel transmembrane protein of the endoplasmic reticulum and nuclear envelope, which is also present in the nucleolus. Experimental Cell Res.294(1), 94–105 (2004).
  • Sarkar D , FisherPB. AEG-1/MTDH/LYRIC: Clinical significance. Adv. Cancer Res.120, 39–74 (2013).
  • Huang Y , LiLP. Progress of cancer research on astrocyte elevated gene-1/Metadherin (review). Oncol. Letters8(2), 493–501 (2014).
  • Emdad L , SarkarD, LeeSGet al. Astrocyte elevated gene-1: a novel target for human glioma therapy. Mol. Cancer Therap.9(1), 79–88 (2010).
  • Liu L , WuJ, YingZet al. Astrocyte elevated gene-1 upregulates matrix metalloproteinase-9 and induces human glioma invasion. Cancer Res.70(9), 3750–3759 (2010).
  • Hu B , EmdadL, BacolodMDet al. Astrocyte elevated gene-1 interacts with Akt isoform 2 to control glioma growth, survival, and pathogenesis. Cancer Res.74(24), 7321–7332 (2014).
  • Kang DC , SuZZ, SarkarD, EmdadL, VolskyDJ, FisherPB. Cloning and characterization of HIV-1-inducible astrocyte elevated gene-1, AEG-1. Gene353(1), 8–15 (2005).
  • Emdad L , LeeSG, SuZZet al. Astrocyte elevated gene-1 (AEG-1) functions as an oncogene and regulates angiogenesis. Proc. Natl Acad. Sci. USA106(50), 21300–21305 (2009).
  • Lee SG , SuZZ, EmdadL, SarkarD, FrankeTF, FisherPB. Astrocyte elevated gene-1 activates cell survival pathways through PI3K-Akt signaling. Oncogene27(8), 1114–1121 (2008).
  • Emdad L , DasSK, DasguptaS, HuB, SarkarD, FisherPB. AEG-1/MTDH/LYRIC: signaling pathways, downstream genes, interacting proteins, and regulation of tumor angiogenesis. Adv. Cancer Res.120, 75–111 (2013).
  • Sarkar D , EmdadL, LeeSG, YooBK, SuZZ, FisherPB. Astrocyte elevated gene-1: far more than just a gene regulated in astrocytes. Cancer Res.69(22), 8529–8535 (2009).
  • Noch E , BooklandM, KhaliliK. Astrocyte-elevated gene-1 (AEG-1) induction by hypoxia and glucose deprivation in glioblastoma. Cancer Biol. Ther.11(1), 32–39 (2011).
  • Bhutia SK , KegelmanTP, DasSKet al. Astrocyte elevated gene-1 induces protective autophagy. Proc. Natl Acad. Sci. USA107(51), 22243–22248 (2010).
  • Lee SG , KimK, KegelmanTPet al. Oncogene AEG-1 promotes glioma-induced neurodegeneration by increasing glutamate excitotoxicity. Cancer Res.71(20), 6514–6523 (2011).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.