Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 42, 2012 - Issue 5
105
Views
4
CrossRef citations to date
0
Altmetric
Animal Pharmacokinetics and Metabolism

Chronic quercetin feeding decreases plasma concentrations of salicylamide phase II metabolites in pigs following oral administration

, , &
Pages 477-482 | Received 13 Sep 2011, Accepted 14 Nov 2011, Published online: 22 Dec 2011

References

  • Ader P, Wessmann A, Wolffram S. (2000). Bioavailability and metabolism of the flavonol quercetin in the pig. Free Radic Biol Med 28:1056–1067.
  • Bock KW, Bock-Hennig BS. (2010). UDP-glucuronosyltransferases (UGTs): from purification of Ah-receptor-inducible UGT1A6 to coordinate regulation of subsets of CYPs, UGTs, and ABC transporters by nuclear receptors. Drug Metab Rev 42:6–13.
  • Boots AW, Haenen GR, Bast A. (2008). Health effects of quercetin: from antioxidant to nutraceutical. Eur J Pharmacol 585:325–337.
  • Brouard C, Siess MH, Vernevaut MF, Suschetet M. (1988). Comparison of the effects of feeding quercetin or flavone on hepatic and intestinal drug-metabolizing enzymes of the rat. Food Chem Toxicol 26:99–103.
  • Canivenc-Lavier MC, Vernevaut MF, Totis M, Siess MH, Magdalou J, Suschetet M. (1996). Comparative effects of flavonoids and model inducers on drug-metabolizing enzymes in rat liver. Toxicology 114:19–27.
  • Cermak R, Landgraf S, Wolffram S. (2003). The bioavailability of quercetin in pigs depends on the glycoside moiety and on dietary factors. J Nutr 133:2802–2807.
  • Cermak R, Wein S, Wolffram S, Langguth P. (2009). Effects of the flavonol quercetin on the bioavailability of simvastatin in pigs. Eur J Pharm Sci 38:519–524.
  • Critchfield JW, Welsh CJ, Phang JM, Yeh GC. (1994). Modulation of adriamycin accumulation and efflux by flavonoids in HCT-15 colon cells. Activation of P-glycoprotein as a putative mechanism. Biochem Pharmacol 48:1437–1445.
  • Egert S, Wolffram S, Bosy-Westphal A, Boesch-Saadatmandi C, Wagner AE, Frank J, Rimbach G, Mueller MJ. (2008). Daily quercetin supplementation dose-dependently increases plasma quercetin concentrations in healthy humans. J Nutr 138:1615–1621.
  • Galijatovic A, Walle UK, Walle T. (2000). Induction of UDP-glucuronosyltransferase by the flavonoids chrysin and quercetin in Caco-2 cells. Pharm Res 17:21–26.
  • Graefe EU, Derendorf H, Veit M. (1999). Pharmacokinetics and bioavailability of the flavonol quercetin in humans. Int J Clin Pharmacol Ther 37:219–233.
  • Harborne JB, Williams CA. (2000). Advances in flavonoid research since 1992. Phytochemistry 55:481–504.
  • Hertog MGL, Hollman PCH, Katan MB, Kromhout D. (1993). Intake of potentially anticarcinogenic flavonoids and their determinants in adults in the Netherlands. Nutr Cancer, 20, 21–29.
  • James MO, Sacco JC, Faux LR. (2008). Effects of Food Natural Products on the Biotransformation of PCBs. Environ Toxicol Pharmacol 25:211–217.
  • Lesser S, Cermak R, Wolffram S. (2004). Bioavailability of quercetin in pigs is influenced by the dietary fat content. J Nutr 134:1508–1511.
  • Levy G, Matsuzawa T. (1967). Pharmacokinetics of salicylamide elimination in man. J Pharmacol Exp Ther 156:285–293.
  • Levy G, Procknal JA. (1968). Drug biotransformation interactions in man. I. Mutual inhibition in glucuronide formation of salicylic acid and salicylamide in man. J Pharm Sci 57:1330–1335.
  • Manach C, Morand C, Demigné C, Texier O, Régérat F, Rémésy C. (1997). Bioavailability of rutin and quercetin in rats. FEBS Lett 409:12–16.
  • Middleton E Jr, Kandaswami C, Theoharides TC. (2000). The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev 52:673–751.
  • Morand C, Crespy V, Manach C, Besson C, Demigné C, Rémésy C. (1998). Plasma metabolites of quercetin and their antioxidant properties. Am J Physiol 275:R212–R219.
  • Morris ME, Levy G. (1983). Determination of salicylamide and five metabolites in biological fluids by high-performance liquid chromatography. J Pharm Sci 72:612–617.
  • Morris ME, Zhang S. (2006). Flavonoid-drug interactions: effects of flavonoids on ABC transporters. Life Sci 78:2116–2130.
  • Nielsen SE, Breinholt V, Justesen U, Cornett C, Dragsted LO. (1998). In vitro biotransformation of flavonoids by rat liver microsomes. Xenobiotica 28:389–401.
  • Nishimuta H, Ohtani H, Tsujimoto M, Ogura K, Hiratsuka A, Sawada Y. (2007). Inhibitory effects of various beverages on human recombinant sulfotransferase isoforms SULT1A1 and SULT1A3. Biopharm Drug Dispos 28:491–500.
  • Odbayar TO, Kimura T, Tsushida T, Ide T. (2009). Isoenzyme-specific up-regulation of glutathione transferase and aldo-keto reductase mRNA expression by dietary quercetin in rat liver. Mol Cell Biochem 325:121–130.
  • Rafferty AP, McGee HB, Miller CE, Reyes M. (2002). Prevalence of complementary and alternative medicine use: state-specific estimates from the 2001 Behavioral Risk Factor Surveillance System. Am J Public Health 92:1598–1600.
  • Siess MH, Guillermic M, Le Bon AM, Suschetet M. (1989). Induction of monooxygenase and transferase activities in rat by dietary administration of flavonoids. Xenobiotica 19:1379–1386.
  • Tukey RH, Strassburg CP. (2000). Human UDP-glucuronosyltransferases: metabolism, expression, and disease. Annu Rev Pharmacol Toxicol 40:581–616.
  • Van der Heiden E, Bechoux N, Muller M, Sergent T, Schneider YJ, Larondelle Y, Maghuin-Rogister G, Scippo ML. (2009). Food flavonoid aryl hydrocarbon receptor-mediated agonistic/antagonistic/synergic activities in human and rat reporter gene assays. Anal Chim Acta 637:337–345.
  • van der Logt EM, Roelofs HM, Nagengast FM, Peters WH. (2003). Induction of rat hepatic and intestinal UDP-glucuronosyltransferases by naturally occurring dietary anticarcinogens. Carcinogenesis 24:1651–1656.
  • Walle UK, Walle T. (2002). Induction of human UDP-glucuronosyltransferase UGT1A1 by flavonoids-structural requirements. Drug Metab Dispos 30:564–569.
  • Zhu BT, Taneja N, Loder DP, Balentine DA, Conney AH. (1998). Effects of tea polyphenols and flavonoids on liver microsomal glucuronidation of estradiol and estrone. J Steroid Biochem Mol Biol 64:207–215.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.