References
- Anonymous. (1994). Final report on the safety assessment of propylene glycol and polypropylene glycols. J Am Coll Toxicol 13:437–91
- Bartsch W, Spooner G, Dietmann K, Fuchs G. (1976). Acute toxicity of various solvents in the mouse and rat: LD50 of ethanol, diethylacetamide, dimethylformamide, dimethylsufloxide, glycerine, N-methylpyrrolidone, polyethylene glycol 400, 1,2-propanediol, and Tween 20. Arzneimittelforschung 26:1581–3
- Bayliss MK, Frick LW. (1999). High-throughput pharmacokinetics: cassette dosing. Curr Opin Drug Discov Devel 2:20–5
- Bruce R. (1985). An up-and-down procedure for acute toxicity testing. Fundam App Toxicol 5:151–7
- Bruce R. (1987). A confirmatory study of the up-and-down method for acute oral toxicity testing. Fundam App Toxicol 8:97–100
- Gad SC, Cassidy CD, Aubert N, et al. (2006). Nonclinical vehicle use in studies by multiple routes in multiple species. Int J Toxicol 25:499–521
- Jacob S, de La Torre J. (2009). Pharmacology of dimethyl sulfoxide in cardiac and CNS damage. Pharmacol Rep 61:225–35
- Jouyban A, Fakhree M, Shayanfar A. (2010). Review of pharmaceutical applications of N-methyl-2-pyrrolidone. J Pharm Pharm Sci 13:524–35
- Kim S. (1987). Preclinical toxicology and pharmacology of dimethylacetamide, with clinical notes. Drug Metabol Rev 19:345–68
- Lewis RJ. (1996a). Sax’s dangerous properties of industrial materials, 9th edn, Vol. 1–3. New York, NY: Van Nostrand Reinhold, 2307 p
- Lewis RJ. (1996b). Sax’s dangerous properties of industrial materials, 9th edn, Vol. 1–3. New York, NY: Van Nostrand Reinhold, 1364 p
- Lewis RJ. (1996c). Sax’s dangerous properties of industrial materials, 9th edn, Vol. 1–3. New York, NY: Van Nostrand Reinhold, 1273 p
- Lewis RJ. (1996d). Sax’s dangerous properties of industrial materials, 9th edn, Vol. 1–3. New York, NY: Van Nostrand Reinhold, 1628 p
- Lewis RJ. (1996e). Sax’s dangerous properties of industrial materials, 9th edn, Vol. 1–3. New York, NY: Van Nostrand Reinhold, 3061 p
- Lipnick R, Cotruvo J, Hill R, et al. (1995). Comparison of the up-and-down, conventional LD50, and fixed-dose acute toxicity procedures. Food Chem Toxicol 33:223–31
- Montaguti P, Melloni E, Cavalletti E. (1994). Acute intravenous toxicity of dimethyl sulfoxide, polyethylene glycol 400, dimethylformamide, absolute ethanol, and benzyl alcohol in inbred mouse strains. Arzneimittelforschung 44:566–70
- Mottu F, Laurent A, Rufenacht DA, Doelker E. (2000). Organic solvents for pharmaceutical patenterals and embolic liquids: a review of the toxicity data. PDA J Pharm Sci Tech 54:456–69
- Rowe RC, Sheskey PJ, Quinn ME. (2009). Handbook of pharmaceutical excipients, 6th edn. London, England: Pharmaceutical Press, 521 p
- Snyder R. (1990). Ethyl Browning’s toxicity and metabolism of industrial solvents, 2nd edn, Vol. II: nitrogen and phosphorus solvents. Amsterdam/New York/Oxford: Elsevier, 241 p
- Strickley RG. (2008). Formulation in drug discovery. Annu Rep Med Chem 43:419–51
- Venkatesh S, Lipper RA. (2000). Role of development scientists in compound lead selection and optimization. J Pharm Sci 89:145–54