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Research Article

Overexpression of Human MRP1 in Neurons causes resistance to Antiepileptic Drugs in Drosophila Seizure Mutants

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Pages 201-206 | Received 10 Mar 2011, Accepted 01 Sep 2011, Published online: 25 Oct 2011

REFERENCES

  • Aronica, E., Gorter, J. A., Jansen, G. H., van Veelen, C. W., van Rijen, P. C., Leenstra, S., Ramkema, M., Scheffer, G. L., Scheper, R. J., & Troost, D. (2003). Expression and cellular distribution of multidrug transporter proteins in two major causes of medically intractable epilepsy: Focal cortical dysplasia and glioneuronal tumors. Neuroscience, 118, 417–429.
  • Benzer, S. (1971). From the gene to behavior. JAMA, 218, 1015–1022.
  • Borst, P., & Schinkel, A. H. (1997). Genetic dissection of the function of mammalian P-glycoproteins. Trends Genet, 13, 217–222.
  • Ganetzky, B., & Wu, C. F. (1982). Indirect suppression involving behavioral mutants with altered nerve excitability in Drosophila melanogaster. Genetics, 100, 597–614.
  • Ito, K., Olsen, S. L., Qiu, W., Deeley, R. G., & Cole, S. P. (2001). Mutation of a single conserved tryptophan in multidrug resistance protein 1 (MRP1/ABCC1) results in loss of drug resistance and selective loss of organic anion transport. J Biol Chem, 276, 15616–15624.
  • Kuebler, D., & Tanouye, M. (2002). Anticonvulsant valproate reduces seizure-susceptibility in mutant Drosophila. Brain Res, 958, 36–42.
  • Kwan, P., Arzimanoglou, A., Berg, A. T., Brodie, M. J., Allen Hauser, W., Mathern, G., Moshe, S. L., Perucca, E., Wiebe, S., & French, J. (2010). Definition of drug resistant epilepsy: Consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies. Epilepsia, 51, 1069–1077.
  • Kwan, P., & Brodie, M. J. (2005). Potential role of drug transporters in the pathogenesis of medically intractable epilepsy. Epilepsia, 46, 224–235.
  • Lee, J., & Wu, C. F. (2002). Electroconvulsive seizure behavior in Drosophila: Analysis of the physiological repertoire underlying a stereotyped action pattern in bang-sensitive mutants. J Neurosci, 22, 11065–11079.
  • Loscher, W., & Potschka, H. (2002). Role of multidrug transporters in pharmacoresistance to antiepileptic drugs. J Pharmacol Exp Ther, 301, 7–14.
  • Luna-Tortos, C., Fedrowitz, M., & Loscher, W. (2008). Several major antiepileptic drugs are substrates for human P-glycoprotein. Neuropharmacology, 55, 1364–1375.
  • Luna-Tortos, C., Fedrowitz, M., & Loscher, W. (2010). Evaluation of transport of common antiepileptic drugs by human multidrug resistance-associated proteins (MRP1, 2 and 5) that are overexpressed in pharmacoresistant epilepsy. Neuropharmacology, 58, 1019–1032.
  • Mantegazza, M., Curia, G., Biagini, G., Ragsdale, D.S., & Avoli, M. (2010). Voltage-gated sodium channels as therapeutic targets in epilepsy and other neurological disorders. Lancet Neurol, 9, 413–424.
  • Pavlidis, P., & Tanouye, M. A. (1995). Seizures and failures in the giant fiber pathway of Drosophila bang-sensitive paralytic mutants. J Neurosci, 15, 5810–5819.
  • Ragsdale, D. S., McPhee, J. C., Scheuer, T., & Catterall, W. A. (1996). Common molecular determinants of local anesthetic, antiarrhythmic, and anticonvulsant block of voltage-gated Na+ channels. Proc Natl Acad Sci U S A, 93, 9270–9275.
  • Reynolds, E. R., Stauffer, E. A., Feeney, L., Rojahn, E., Jacobs, B., & McKeever, C. (2004). Treatment with the antiepileptic drugs phenytoin and gabapentin ameliorates seizure and paralysis of Drosophila bang-sensitive mutants. J Neurobiol, 58, 503–513.
  • Sander, J. W. (1993). Some aspects of prognosis in the epilepsies: A review. Epilepsia, 34, 1007–1016.
  • Sisodiya, S. (2007). Etiology and management of refractory epilepsies. Nat Clin Pract, 3, 320–330.
  • Song, J., Hu, J., & Tanouye, M. (2007). Seizure suppression by top1 mutations in Drosophila. J Neurosci, 27, 2927–2937.

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