Advanced search
Publication Cover
Pediatric Hematology and Oncology Volume 26, 2009 - Issue 6
Submit an article Journal homepage
147
Views
3
CrossRef citations to date
0
Altmetric
Articles

SOLUBLE ENDOTHELIAL PROTEIN C RECEPTOR LEVEL IN CHILDREN WITH SEPSIS

Tanıl KendirliPediatric Intensive Care Unit, Ankara University School of Medicine, Ankara, TurkeyCorrespondence[email protected]
, MD,
Erdal İnceDivision of Infection, Ankara University School of Medicine, Ankara, Turkey
, MD,
Ergin ÇiftçiDivision of Infection, Ankara University School of Medicine, Ankara, Turkey
, MD,
Ülker DoğruDivision of Infection, Ankara University School of Medicine, Ankara, Turkey
, MD,
Yonca EğinDivision of Molecular Genetics, Ankara University School of Medicine, Ankara, Turkey
, MS &
Nejat AkarDivision of Molecular Genetics, Ankara University School of Medicine, Ankara, Turkey
, MD
Pages 432-438 | Accepted 28 Apr 2009, Published online: 11 Nov 2009

REFERENCES

  • Borgel D, Bornstain C, Reitsma PH, A comparative study of the protein C pathway in septic and nonseptic patients with organ failure. Am J Respir Crit Care Med. 2007;176:878–885.
  • Kendirli T, Çiftçi E, Yurdakul E, İnce E, Kansu A, Akar N. Homozygous 23-bp insertion of endothelial protein C receptor gene in a child with fatal sepsis. Pediatr Hematol Oncol. 2007;24:199–204.
  • Esmon CT. The protein C pathway. Chest. 2003;124:26S–32S.
  • Goldstein B, Giroir B, Randolph A. International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics. Pediatr Crit Care Med. 2005;6:2–8.
  • Watson RS, Carcillo JA, Linde-Zwirble WT, Clemont G, Lidicker J, Angus DC. The epidemiology of severe sepsis in children in the United States. Am J Respir Crit Care Med. 2003;167:695–701.
  • Wouwer MV, Collen D, Conway EM. Thrombomodulin–protein C-EPCR system integrated to regulate coagulation and inflammation. Arterioscler Thromb Vasc Biol. 2004;24:1374–1383.
  • Stearns-Kurosawa DJ, Swindle K, D’Angelo A, Plasma levels of endothelial protein C respond to anticoagulant treatment. Blood. 2002;99:526–530.
  • Carcillo JA, Fields AI. American College of Critical Care Medicine Task Force Committee Members. Clinical practice parameters for hemodynamic support of pediatric and neonatal patients in septic shock. Crit Care Med. 2002;30:1365–1378.
  • Liaw PCY, Neuenschwander PF, Smirnov MD, Esmon CT. Mechanisms by which soluble endothelial protein C receptor modulates protein C and activated protein C function. J Biol Chemist. 2000;275:5447–5452.
  • Regan LM, Stearns-Kurosawa DJ, Kurosawa S, Mollica J, Fukudome K, Esmon CT. The endothelial protein C receptor. J Biol Chemist. 2000;271:17499–17503.
  • Sturn DH, Kaneider NC, Feistritzer C, Djanani A, Fukudome K, Wiedermann CJ. Expression and function of the endothelial protein C receptor in human neutrophils. Blood. 2003;102:1499–1505.
  • Taylor FB, Stearns-Kurosawa DJ, Kurosawa S, The endothelial cell protein C receptor aids in host defense against Escherichia coli sepsis. Blood. 2000;95:1680–1686.
  • Aird WC. The role of the endothelium in severe sepsis and multiple organ dysfunction syndome. Blood. 2003;101:3765–3777.
  • Goldstein B, Nadel S, Peters M, ENHANCE: results of a global open-label trial of drotrecogin alfa (activated) in children with severe sepsis. Pediatr Crit Care Med. 2006;7:200–211.
  • Liaw PCY, Esmon CT, Kahnamoui K. Patients with severe sepsis vary markedly in their ability to generate activated protein C. Blood. 2004;104:3958–3964.
  • Pawlinski R, Mackman N. Tissue factor, coagulation proteases, and proteaseactivated receptors in endototexemia and sepsis. Crit Care Med. 2004;32(Suppl):S293–S297.
  • White B, Livingstone W, Murphy C, Hodgson A, Rafferty M, Smith OP. An open-label study of the role of adjuvant hemostatic support with protein C replacement therapy in purpura fulminans-associated meningococcemia. Blood. 2000;96:3719–3724.
  • Vincent JL, Bernard GR, Beale R, Drotrecogin alfa (activated) treatment in severe sepsis from the global open-label trial ENHANCE: further evidence for survival and safety and implications for early treatment. Crit Care Med. 2005;33:2266–2277.
  • Nadel S, Goldstein B, Williams MD, Drotrecogin alfa (activated) in children with severe sepsis: a multicenter phase III randomised controlled trial. Lancet. 2007;369:836–843.
  • Derhaschnig U, Reiter R, Knöble P, Baumgartner M, Keen P, Jilma B. Recombinant human activated protein C (rhAPC; drotrecogin alfa [activated]) has minimal effect on markers of coagulation, fibrinolysis, and inflammation in acute human endotoxemia. Blood. 2003;102:2093–2098.
  • Hazelzet JA, Kleijn ED, Groot R, Stearns-Kurosawa DJ, Swindle K, Hack CE. Levels of activated protein C and soluble protein C reseptor in children with meningococcal sepsis are related to survival. Thromb Haemost. ISTH Paris, France, 2001.
  • Vincent JL, Abraham E, Annane D, Bernard G, Rivers E, Den Berghe GV. Reducing mortality in sepsis: new directions. Crit Care. 2002;6(Suppl 3):S1–S18.
  • Dellinger RP, Carlet JM, Masur H. Surviving sepsis campaign guidelines for management of severe sepsis and septic shock. Intensive Care Med. 2004;30:536–555.
  • Uitte de Willige S, Van Marion V, Rosendaal FR, Vos HL, de Visser MC, Bertina RM. Haplotypes of the EPCR gene, plasma sEPCR levels and the risk of deep venous thrombosis. J Thomb Haemost. 2004;2:1305–1310.
  • Ulu A, Günal D, Tıraş S, Eğin Y, Deda G, Akar N. EPCR gene haplotypes and elevated soluble endothelial protein C receptor (sEPCR) levels in Turkish pediatric stroke patients. Thromb Res. 2007;120:47–52.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.