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Leukemia & Lymphoma Volume 54, 2013 - Issue 6
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Research Article

Abundant expression of interleukin-21 receptor in follicular lymphoma cells is associated with more aggressive disease

Brianne WoodDepartment of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada
,
Soma SikdarDepartment of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada
,
Suk Jin ChoiDepartment of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada;Inha University Hospital, Incheon, Korea
,
Shakeel VirkDepartment of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada
,
Abdulmohsen AlhejailyDepartment of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada
,
Tara BaetzCancer Centre of Southeastern Ontario, Kingston General Hospital, Kingston, Ontario, Canada
&
David P. LeBrunDepartment of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, CanadaCorrespondence[email protected]
 show all
Pages 1212-1220 | Received 18 Jul 2012, Accepted 17 Oct 2012, Published online: 23 Nov 2012

References

  • Bastion Y, Sebban C, Berger F, et al. Incidence, predictive factors, and outcome of lymphoma transformation in follicular lymphoma patients. J Clin Oncol 1997;15:1587–1594.
  • Longo DL. Idiotype vaccination in follicular lymphoma: knocking on the doorway to cure. J Natl Cancer Inst 2006;98:1263–1265.
  • Klein U, Dalla-Favera R. Germinal centres: role in B-cell physiology and malignancy. Nat Rev Immunol 2008;8:22–33.
  • Spolski R, Leonard WJ. Interleukin-21: basic biology and implications for cancer and autoimmunity. Annu Rev Immunol 2008;26:57–79.
  • Jin H, Carrio R, Yu A, et al. Distinct activation signals determine whether IL-21 induces B cell costimulation, growth arrest, or Bim-dependent apoptosis. J Immunol 2004;173:657–665.
  • Parrish-Novak J, Dillon SR, Nelson A, et al. Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature 2000;408:57–63.
  • Good KL, Bryant VL, Tangye SG. Kinetics of human B cell behavior and amplification of proliferative responses following stimulation with IL-21. J Immunol 2006;177:5236–5247.
  • Konforte D, Simard N, Paige CJ. IL-21: an executor of B cell fate. J Immunol 2009;182:1781–1787.
  • Sondergaard H, Skak K. IL-21: roles in immunopathology and cancer therapy. Tissue Antigens 2009;74:467–479.
  • Vogelzang A, McGuire HM, Yu D, et al. A fundamental role for interleukin-21 in the generation of T follicular helper cells. Immunity 2008;29:127–137.
  • Akamatsu N, Yamada Y, Hasegawa H, et al. High IL-21 receptor expression and apoptosis induction by IL-21 in follicular lymphoma. Cancer Lett 2007;256:196–206.
  • de Totero D, Capaia M, Fabbi M, et al. Heterogeneous expression and function of IL-21R and susceptibility to IL-21-mediated apoptosis in follicular lymphoma cells. Exp Hematol 2010;38:373–383.
  • Hashmi MH, Van Veldhuizen PJ. Interleukin-21: updated review of phase I and II clinical trials in metastatic renal cell carcinoma, metastatic melanoma and relapsed/refractory indolent non-Hodgkin's lymphoma. Expert Opin Biol Ther 2010;10:807–817.
  • Alhejaily A, Wood B, Foster CJ, et al. Differential expression of cell-cycle regulatory proteins defines distinct classes of follicular lymphoma. Hum Pathol 2011;42:972–982.
  • Dolled-Filhart M, Gustavson M, Camp RL, et al. Automated analysis of tissue microarrays. Methods Mol Biol 2010;664:151–162.
  • Camp RL, Dolled-Filhart M, Rimm DL. X-tile: a new bio-informatics tool for biomarker assessment and outcome-based cut-point optimization. Clin Cancer Res 2004;10:7252–7259.
  • LeBien TW, Tedder TF. B lymphocytes: how they develop and function. Blood 2008;112:1570–1580.
  • Relander T, Johnson NA, Farinha P, et al. Prognostic factors in follicular lymphoma. J Clin Oncol 2010;28:2902–2913.
  • Chtanova T, Tangye SG, Newton R, et al. T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells. J Immunol 2004;173:68–78.
  • Jin H, Malek TR. Redundant and unique regulation of activated mouse B lymphocytes by IL-4 and IL-21. J Leukoc Biol 2006;80: 1416–1423.
  • Linterman MA, Vinuesa CG. Signals that influence T follicular helper cell differentiation and function. Semin Immunopathol 2010;32:183–196.
  • Burger JA, Ghia P, Rosenwald A, et al. The microenvironment in mature B-cell malignancies: a target for new treatment strategies. Blood 2009;114:3367–3375.
  • Johnson PW, Watt SM, Betts DR, et al. Isolated follicular lymphoma cells are resistant to apoptosis and can be grown in vitro in the CD40/stromal cell system. Blood 1993;82:1848–1857.
  • Ghia P, Boussiotis VA, Schultze JL, et al. Unbalanced expression of bcl-2 family proteins in follicular lymphoma: contribution of CD40 signaling in promoting survival. Blood 1998;91:244–251.
  • Travert M, Ame-Thomas P, Pangault C, et al. CD40 ligand protects from TRAIL-induced apoptosis in follicular lymphomas through NF-kappaB activation and up-regulation of c-FLIP and Bcl-xL. J Immunol 2008;181:1001–1011.
  • Bahler DW, Levy R. Clonal evolution of a follicular lymphoma: evidence for antigen selection. Proc Natl Acad Sci USA 1992;89: 6770–6774.
  • Glas AM, Knoops L, Delahaye L, et al. Gene-expression and immunohistochemical study of specific T-cell subsets and accessory cell types in the transformation and prognosis of follicular lymphoma. J Clin Oncol 2007;25:390–398.
  • Rimm DL. What brown cannot do for you. Nat Biotechnol 2006;24:914–916.

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