391
Views
33
CrossRef citations to date
0
Altmetric
Research Article

In vitro/in vivo correlation and modeling of emitted dose and lung deposition of inhaled salbutamol from metered dose inhalers with different types of spacers in noninvasively ventilated patients

, , , , &
Pages 871-880 | Received 28 Sep 2015, Accepted 28 Oct 2015, Published online: 25 Nov 2015

References

  • Martin AR, Finlay, WH. Nebulizers for drug delivery to the lungs. Expert Opin Drug Deliv 2015;12:889–900
  • Fink JB, Dhand R, Duarte AG, et al. Aerosol delivery from a metered-dose inhaler during mechanical ventilation. An in vitro model. Am J Respir Crit Care Med 1996;154:382–387
  • Hess DR. Aerosol therapy during noninvasive ventilation or high-flow nasal cannula. Respir Care 2015;60:880–893
  • Nava S, Karakurt S, Rampulla C, et al. Salbutamol delivery during non-invasive mechanical ventilation in patients with chronic obstructive pulmonary disease: a randomized, controlled study. Intensive Care Med 2001;27:1627–1635
  • Branconnier MP, Hess DR. Albuterol delivery during noninvasive ventilation. Respir Care, 2005;50:1649–1653
  • Dhand R. Aerosol therapy in patients receiving noninvasive positive pressure ventilation. J Aerosol Med Pulmon Drug Deliv 2012;25:63–78
  • Hassan A, Rabea H, Hussein RRS, et al. In vitro characterisation of aerosolised drug during non-invasive ventilation (NIV) [Abstract]. J Aerosol Med Pulmon Drug Deliv 2015;28:A-10 (P-014)
  • Ali AM, Abdelrahim MEA. Modeling and optimization of terbutaline emitted from a dry powder inhaler and influence on systemic bioavailability using data mining technology. J Pharm Innovat 2014;9:38–47
  • Ali AA, Ali AM. Optimization of propranolol HCl release kinetics from press coated sustained release tablets. Pharm Dev Technol 2013;18:1238–1246
  • Abdelrahman AA, Salem HF, Khallaf RA, et al. Modeling, optimization, and in vitro corneal permeation of chitosan-lomefloxacin HCl nanosuspension intended for ophthalmic delivery. J Pharm Innovat 2015;10:254–268
  • de Matas M, Shao Q, Silkstone VL, et al. Evaluation of an in vitro in vivo correlation for nebulizer delivery using artificial neural networks. J Pharm Sci 2007;96:3293–3303
  • de Matas M, Shao Q, Richardson CH, et al. Evaluation of in vitro in vivo correlations for dry powder inhaler delivery using artificial neural networks. Eur J Pharm Sci 2008;33:80–90
  • Sun Y, Peng Y, Chen Y, et al. Application of artificial neural networks in the design of controlled release drug delivery systems. Adv Drug Deliv Rev 2003;55:1201–1215
  • Chen Y, Thosar SS, Forbess RA, et al. Prediction of drug content and hardness of intact tablets using artificial neural network and near-infrared spectroscopy. Drug Dev Ind Pharm 2001;27:623–631
  • Hussain AS, Yu XQ, Johnson RD. Application of neural computing in pharmaceutical product development. Pharm Res 1991;8:1248–1252
  • Abdelrahim ME, Plant P, Chrystyn H. In-vitro characterisation of the nebulised dose during non-invasive ventilation. J Pharm Pharmacol 2010;62:966–972
  • Abdelrahim ME. Aerodynamic characteristics of nebulized terbutaline sulphate using the Andersen Cascade Impactor compared to the next generation impactor. Pharm Dev Technol 2011;16:137–145
  • National Institute for Health and Clinical Excellence (NICE). Chronic obstractive pulmonary disease: national clinical guideline for management of chronic obstructive pulmonary disease in adults in primary and secondary care. Thorax 2015 [cited 1 Apr 2015]. Available from: http://www.nice.org.uk/guidance/
  • Plumb AP, Rowe RC, York P, et al. The effect of experimental design on the modeling of a tablet coating formulation using artificial neural networks. Eur J Pharm Sci 2002;16:281–288
  • Hindle M, Chrystyn H. Determination of the relative bioavailability of salbutamol to the lung following inhalation. Br J Clin Pharmacol 1992;34:311–315
  • Mazhar SH, Ismail NE, Newton DA, et al. Relative lung deposition of salbutamol following inhalation from a spacer and a Sidestream jet nebulizer following an acute exacerbation. Br J Clin Pharmacol 2008;65:334–337
  • Ammari WGS. Evaluation of novel tool to ensure asthma and COPD patients use the approved inhalation technique when they use an inhaler. Clinical pharmacy studies investigating the impact of novel inhalation technique training devices and spacers on the inspiratory characteristics, disease control and quality of life of patients when using their inhalers. 2010, University of Bradford
  • Terzano C. Pressurized metered dose inhalers and add-on devices. Pulm Pharmacol Ther 2001;14:351–366
  • Newman SP, Chan H-K. In vitro/in vivo comparisons in pulmonary drug delivery. J Aerosol Med Pulmon Drug Deliv 2008;21:77–84
  • Nahar K, Gupta N, Gauvin R, et al. In vitro, in vivo and ex vivo models for studying particle deposition and drug absorption of inhaled pharmaceuticals. Eur J Pharm Sci 2013;49:805–818
  • Byron PR, Hindle M, Lange CF, et al. In vivo–in vitro correlations: predicting pulmonary drug deposition from pharmaceutical aerosols. J Aerosol Med Pulmon Drug Deliv 2010;23:S-59–S-69
  • Fink JB, Dhand R, Grychowski J, et al. Reconciling in vitro and in vivo measurements of aerosol delivery from a metered-dose inhaler during mechanical ventilation and defining efficiency-enhancing factors. Am J Respir Crit Care Med 1999;159:63–68
  • Abdelrahim M, Plant P, Chrystyn H. The relative lung and systemic bioavailability of terbutaline following nebulisation in non-invasively ventilated patients. Int J Pharm 2011;420:313–318
  • Abdelrahim M, Assi K, Chrystyn H. Dose emission and aerodynamic characterization of the terbutaline sulphate dose emitted from a Turbuhaler at low inhalation flow. Pharm Dev Technol 2013;18:944–949
  • Abdelrahim ME, Chrystyn H. Aerodynamic characteristics of nebulized terbutaline sulphate using the next generation impactor (NGI) and CEN method. J Aerosol Med Pulm Drug Deliv 2009;22:19–28
  • Mohsenin V. Gender differences in the expression of sleep-disordered breathing: role of upper airway dimensions. Chest J 2001;120:1442–1447
  • Lavorini F, Fontana GA. Targeting drugs to the airways: the role of spacer devices. Expert Opin Drug Deliv 2009;6:91–102
  • Newman SP. Spacer devices for metered dose inhalers. Clin Pharmacokinet 2004;43:349–360
  • Ahrens R, Lux C, Bahl T, et al. Choosing the metered-dose inhaler spacer or holding chamber that matches the patient's need: evidence that the specific drug being delivered is an important consideration. J Allergy Clin Immunol 1995;96:288–294
  • Boe J, Dennis J, O'Driscoll B, et al. European Respiratory Society Guidelines on the use of nebulizers: guidelines prepared by a European Respiratory Society Task Force on the use of nebulizers. Eur Respir J 2001;18:228–242

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.