Menopausal hot flushes and night sweats: where are we now?

References

• Voda AM. Climacteric hot flash. Maturitas 1981;3:73–90
   PubMed Web of Science ®Google Scholar
• Politi MC, Schleinitz MD, Col NF. Revisiting the duration of vasomotor symptoms of menopause: a meta-analysis. J Gen Intern Med 2008;23:1507–13
   PubMed Web of Science ®Google Scholar
• Gupta P, Sturdee DW, Palin SL, . Menopausal symptoms in women treated for breast cancer: the prevalence and severity of symptoms and their perceived effects on quality of life. Climacteric 2006;9:49–58
   PubMed Web of Science ®Google Scholar
• LaCroix AZ, Chlebowski RT, Manson JE, . Health outcomes after stopping conjugated equine estrogens among postmenopausal women with prior hysterectomy: a randomized controlled trial. JAMA 2011;305:1305–14
   PubMed Web of Science ®Google Scholar
• Rossouw JE, Anderson GL, Prentice RL, . Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial. JAMA 2002;288:321–33
   PubMed Web of Science ®Google Scholar
• Santen RJ, Allred DC, Ardoin SP, . Postmenopausal hormone therapy: an Endocrine Society scientific statement. J Clin Endocrinol Metab 2010;95:s1–66
   PubMed Web of Science ®Google Scholar
• Sturdee DW, Pines A, on behalf of the International Menopause Society Writing Group. Updated IMS recommendations on postmenopausal hormone therapy and preventive strategies for midlife health. Climacteric 2011;14:302–20
   PubMed Web of Science ®Google Scholar
• Freeman EW, Sherif K. Prevalence of hot flushes and night sweats around the world: a systematic review. Climacteric 2007; 10:197–214
   PubMed Web of Science ®Google Scholar
• Palacios S, Henderson VW, Siseles N, Tan D, Villaseca P. Age of menopause and impact of climacteric symptoms by geographical region. Climacteric 2010;13:419–28
   PubMed Web of Science ®Google Scholar
• Genazzani AR, Schneider HP, Panay N, Nijland EA. The European Menopause Survey 2005: women's perceptions on the menopause and postmenopausal hormone therapy. Gynecol Endocrinol 2006;22:369–75
   PubMed Web of Science ®Google Scholar
• Gold EB, Bromberger J, Crawford S, . Factors associated with age at natural menopause in a multiethnic sample of midlife women. Am J Epidemiol 2001;153:865–74
   PubMed Web of Science ®Google Scholar
• Chedraui P, Blumel JE, Baron G, . Impaired quality of life among middle aged women: a multicentre Latin American study. Maturitas 2008;61:323–9
   PubMed Web of Science ®Google Scholar
• Lam PM, Leung TN, Haines C, Chung TK. Climacteric symptoms and knowledge about hormone replacement therapy among Hong Kong Chinese women aged 40–60 years. Maturitas 2003; 45:99–107
   PubMed Web of Science ®Google Scholar
• Freedman RR, Woodward S. Core body temperature during menopausal hot flushes. Fertil Steril 1996;65:1141–4
   PubMed Web of Science ®Google Scholar
• Freedman RR, Krell W. Reduced thermoregulatory null zone in postmenopausal women with hot flashes. Am J Obstet Gynecol 1999;181:66–70
   PubMed Web of Science ®Google Scholar
• Freedman R, Woodward S. Elevated alpha 2-adrenergic responsiveness in menopausal hot flushes: pharmacologic and biochemical studies. Lomax P, Schönbaum E, Themoregulation: The Pathophysiological Basis of Clinical Disorders. Basel: Karger, 1992:6–9
   Google Scholar
• Freedman RR, Woodward S, Sabharwal SC. Alpha 2-adrenergic mechanism in menopausal hot flushes. Obstet Gynecol 1990; 76:573–8
   PubMed Web of Science ®Google Scholar
• Freedman RR, Roehrs TA. Effects of REM sleep and ambient temperature on hot flash-induced sleep disturbance. Menopause 2006;13:576–83
   PubMed Web of Science ®Google Scholar
• Freedman RR, Kruger ML, Wasson SL. Heart rate variability in menopausal hot flashes during sleep. Menopause 2011;18: 897–900
   PubMed Web of Science ®Google Scholar
• Sassarini J, Fox H, Ferrell W, Sattar N, Lumsden MA. Vascular function and cardiovascular risk factors in women with severe flushing. Clin Endocrinol (Oxf) 2011;74: 97–103
   PubMed Web of Science ®Google Scholar
• Ginsburg J, Swinhoe J, O'Reilly B. Cardiovascular responses during the menopausal hot flush. Br J Obstet Gynaecol 1981; 88:925–30
   PubMedGoogle Scholar
• Sassarini J, Fox H, Ferrell W, Sattar N, Lumsden MA. Enhanced peripheral vascular reactivity seen in flushing women is atered by treatment with venlafaxine. Climacteric 2011;14(Suppl 1): 87 (Abstr)
   Google Scholar
• Romanovsky AA. Thermoregulation: some concepts have changed. Functional architecture of the thermoregulatory system. Am J Physiol Regul Integr Comp Physiol 2007;292: R37–46
   PubMed Web of Science ®Google Scholar
• Boulant JA. Role of the preoptic-anterior hypothalamus in thermoregulation and fever. Clin Infect Dis 2000;31(Suppl 5): S157–61
   PubMed Web of Science ®Google Scholar
• Zhang YH, Yamada K, Hosono T, Chen XM, Shiosaka S, Kanosue K. Efferent neuronal organization of thermoregulatory vasomotor control. Ann NY Acad Sci 1997;813: 117–22
   PubMed Web of Science ®Google Scholar
• Charkoudian N. Skin blood flow in adult human thermoregulation: how it works, when it does not, and why. Mayo Clin Proc 2003;78:603–12
   PubMed Web of Science ®Google Scholar
• Freedman RR, Blacker CM. Estrogen raises the sweating threshold in postmenopausal women with hot flashes. Fertil Steril 2002;77:487–90
   PubMed Web of Science ®Google Scholar
• Schindler AE, Muller D, Keller E, Goser R, Runkel F. Studies with clonidine (dixarit) in menopausal women. Arch Gynecol 1979;227:341–7
   PubMedGoogle Scholar
• Berendsen HH. The role of serotonin in hot flushes. Maturitas 2000;36:155–64
   PubMed Web of Science ®Google Scholar
• Quan N, Xin L, Blatteis CM. Microdialysis of norepinephrine into preoptic area of guinea pigs: characteristics of hypothermic effect. Am J Physiol 1991;261:R378–85
   PubMed Web of Science ®Google Scholar
• Freedman RR. Pathophysiology and treatment of menopausal hot flashes. Semin Reprod Med 2005;23:117–25
   PubMed Web of Science ®Google Scholar
• Quan N, Xin L, Ungar AL, Blatteis CM. Preoptic norepinephrine-induced hypothermia is mediated by alpha 2-adrenoceptors. Am J Physiol 1992;262:R407–11
   PubMed Web of Science ®Google Scholar
• Clark WG, Lipton JM. Changes in body temperature after administration of adrenergic and serotonergic agents and related drugs including antidepressants. II. Neurosci Biobehav Rev 1986;10:153–220
   PubMed Web of Science ®Google Scholar
• Sipe K, Leventhal L, Burroughs K, Cosmi S, Johnston GH, Deecher DC. Serotonin 2A receptors modulate tail-skin temperature in two rodent models of estrogen deficiency-related thermoregulatory dysfunction. Brain Res 2004;1028: 191–202
   PubMed Web of Science ®Google Scholar
• Roelands B, Goekint M, Heyman E, . Acute norepinephrine reuptake inhibition decreases performance in normal and high ambient temperature. J Appl Physiol 2008;105:206–12
   PubMed Web of Science ®Google Scholar
• Freedman RR. Biochemical, metabolic, and vascular mechanisms in menopausal hot flashes. Fertil Steril 1998;70: 332–7
   PubMed Web of Science ®Google Scholar
• Freedman RR, Dinsay R. Clonidine raises the sweating threshold in symptomatic but not in asymptomatic postmenopausal women. Fertil Steril 2000;74:20–3
   PubMed Web of Science ®Google Scholar
• Goldberg RM, Loprinzi CL, O'Fallon JR, . Transdermal clonidine for ameliorating tamoxifen-induced hot flashes. J Clin Oncol 1994;12:155–8
   PubMed Web of Science ®Google Scholar
• Pandya KJ, Raubertas RF, Flynn PJ, . Oral clonidine in postmenopausal patients with breast cancer experiencing tamoxifen-induced hot flashes: a University of Rochester Cancer Center Community Clinical Oncology Program study. Ann Intern Med 2000;132:788–93
   PubMed Web of Science ®Google Scholar
• Andrikoula M, Prelevic G. Menopausal hot flushes revisited. Climacteric 2009;12:3–15
   PubMed Web of Science ®Google Scholar
• Avis NE, Colvin A, Bromberger JT, . Change in health-related quality of life over the menopausal transition in a multiethnic cohort of middle-aged women: Study of Women's Health Across the Nation. Menopause 2009;16:860–9
   PubMed Web of Science ®Google Scholar
• Hunter M, Rendall M. Biopsychosociocultural perspectives on menopause. Best Pract Res Clin Obstet Gynaecol 2007;21: 261–74
   PubMed Web of Science ®Google Scholar
• Whiteman MK, Staropoli CA, Langenberg PW, McCarter RJ, Kjerulff KH, Flaws JA. Smoking, body mass, and hot flashes in midlife women. Obstet Gynecol 2003;101:264–72
   PubMed Web of Science ®Google Scholar
• Utian WH. Psychosocial and socioeconomic burden of vasomotor symptoms in menopause: a comprehensive review. Health Qual Life Outcomes 2005;3:47
   PubMedGoogle Scholar
• Rand KL, Otte JL, Flockhart D, . Modeling hot flushes and quality of life in breast cancer survivors. Climacteric 2011; 14:171–80
   PubMed Web of Science ®Google Scholar
• Carpenter JS. The Hot Flash Related Daily Interference Scale: a tool for assessing the impact of hot flashes on quality of life following breast cancer. J Pain Symptom Management 2001; 22:979–89
   PubMed Web of Science ®Google Scholar
• Hunter MS, Liao KL. A psychological analysis of menopausal hot flushes. Br J Clin Psychol 1995;34:589–99
   PubMed Web of Science ®Google Scholar
• Gold EB, Sternfeld B, Kelsey JL, . Relation of demographic and lifestyle factors to symptoms in a multi-racial/ethnic population of women 40–55 years of age. Am J Epidemiol 2000; 152:463–73
   PubMed Web of Science ®Google Scholar
• Sievert LL, Obermeyer CM, Price K. Determinants of hot flashes and night sweats. Ann Hum Biol 2006;33:4–16
   PubMed Web of Science ®Google Scholar
• Hunter MS, Grunfeld EA, Mittal S, . Menopausal symptoms in women with breast cancer: prevalence and treatment preferences. Psychooncology 2004;13:769–78
   PubMed Web of Science ®Google Scholar
• Mom CH, Buijs C, Willemse PH, Mourits MJ, de Vries EG. Hot flushes in breast cancer patients. Crit Rev Oncol/Haematol 2006;57:63–77
   PubMed Web of Science ®Google Scholar
• Rendall MJ, Simonds LM, Hunter MS. The Hot Flush Beliefs Scale: a tool for assessing thoughts and beliefs associated with the experience of menopausal hot flushes and night sweats. Maturitas 2008;60:158–69
   PubMed Web of Science ®Google Scholar
• Hunter M, Ayers B, Smith M. The Hot Flush Behavior Scale: a measure of behavioral reactions to menopausal hot flushes and night sweats. Menopause 2011 June 24. Epub ahead of print
   Web of Science ®Google Scholar
• Hunter MS, Mann E. A cognitive model of menopausal hot flushes and night sweats. J Psychosom Res 2010;69:491–501
   PubMed Web of Science ®Google Scholar
• Hunter MS, Coventry S, Hamed H, Fentiman I, Grunfeld EA. Evaluation of a group cognitive behavioural intervention for women suffering from menopausal symptoms following breast cancer treatment. Psychooncology 2009;18:560–3
   PubMed Web of Science ®Google Scholar
• Gast GC, Grobbee DE, Pop VJ, . Menopausal complaints are associated with cardiovascular risk factors. Hypertension 2008;51:1492–8
   PubMed Web of Science ®Google Scholar
• Bechlioulis A, Kalantaridou SN, Naka KK, . Endothelial function, but not carotid intima-media thickness, is affected early in menopause and is associated with severity of hot flushes. J Clin Endocrinol Metab 2010;95:1199–206
   PubMed Web of Science ®Google Scholar
• Thurston R, Sutton-Tyrrell K, Everson-Rose SA, Hess R, Powell LH, Matthews KA. Hot flashes and carotid intima media thickness among midlife women. Menopause 2011;18:352–8
   PubMed Web of Science ®Google Scholar
• Allison M, Manson JE, Aragaki A, . Vasomotor symptoms and coronary artery calcium in postmenopausal women. Menopause 2010;17:1136–45
   PubMed Web of Science ®Google Scholar
• Szmuilowicz ED, Manson JE, Rossouw JE, . Vasomotor symptoms and cardiovascular events in postmenopausal women. Menopause 2011;18:603–10
   PubMed Web of Science ®Google Scholar
• Huang Y, Malone KE, Cushing-Haugen KL, Daling JR, Li CI. Relationship between menopausal symptoms and risk of postmenopausal breast cancer. Cancer Epidemiol Biomarkers Prev 2011;20:379–88
   PubMed Web of Science ®Google Scholar
• Schilling C, Gallicchio L, Miller SR, Langenberg P, Zacur H, Flaws JA. Genetic polymorphisms, hormone levels, and hot flashes in midlife women. Maturitas 2007;57:120–31
   PubMed Web of Science ®Google Scholar
• Guthrie JR, Dennerstein L, Hopper JL, Burger HG. Hot flushes, menstrual status, and hormone levels in a population-based sample of midlife women. Obstet Gynecol 1996;88:437–42
   PubMed Web of Science ®Google Scholar
• Erlik Y, Meldrum DR, Judd HL. Estrogen levels in postmenopausal women with hot flashes. Obstet Gynecol 1982;59: 403–7
   PubMed Web of Science ®Google Scholar
• Cuzick J, Sestak I, Cella D, Fallowfield L. Treatment-emergent endocrine symptoms and the risk of breast cancer recurrence: a retrospective analysis of the ATAC trial. Lancet Oncol 2008; 9:1143–8
   PubMed Web of Science ®Google Scholar
• Crandall C, Palla S, Reboussin BA, Ursin G, Greendale GA. Positive association between mammographic breast density and bone density. Breast Cancer Res 2005;7:R922–8
   PubMed Web of Science ®Google Scholar
• Baber R, Hickey M, Kwik M. Therapy for menopausal symptoms during and after treatment for breast cancer: safety considerations. Drug Saf 2005;28:1085–100
   PubMed Web of Science ®Google Scholar
• Hickey M, Saunders CM, Stuckey BG. Management of menopausal symptoms in patients with breast cancer: an evidence-based approach. Lancet Oncol 2005;6:687–95
   PubMed Web of Science ®Google Scholar
• Hickey M, Emery LI, Gregson J, Doherty DA, Saunders CM. The multidisciplinary management of menopausal symptoms after breast cancer: a unique model of care. Menopause 2011; 17:727–33
   Web of Science ®Google Scholar
• MacLennan AH. Evidence-based review of therapies at the menopause. Int J Evid Based Healthc 2009;7:112–23.
   PubMedGoogle Scholar
• MacLennan AH, Broadbent JL, Lester S, Moore V. Oral oestrogen and combined oestrogen/progestogen therapy versus placebo for hot flushes. Cochrane Database of Systematic Reviews (Online) 2004:CD002978
   Google Scholar
• Norman RJ, Flight IH, Rees MC. Oestrogen and progestogen hormone replacement therapy for peri-menopausal and post-menopausal women: weight and body fat distribution. Cochrane Database of Systematic Reviews (Online) 2000:CD001018
   Google Scholar
• Anderson GL, Limacher M, Assaf AR, . Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial. JAMA 2004;291:1701–12
   PubMed Web of Science ®Google Scholar
• Panay N, Ylikorkala O, Archer DF, Gut R, Lang E. Ultra-low dose estradiol and norethisterone acetate: effective menopausal symptom relief. Climacteric 2007;10:120–31
   PubMed Web of Science ®Google Scholar
• Bachmann GA, Schaefors M, Uddin A, Utian WH. Lowest effective transdermal 17β-estradiol dose for relief of hot flushes in postmenopausal women: a randomized controlled trial. Obstet Gynecol 2007;110:770–9
   Web of Science ®Google Scholar
• Utian WH, Shoupe D, Bachmann G, Pinkerton JV, Pickar JH. Relief of vasomotor symptoms and vaginal atrophy with the lower doses of conjugated equine estrogens and medroxyprogesterone acetate. Fertil Steril 2001;75:1065–79
   PubMed Web of Science ®Google Scholar
• Olié V, Canonico M, Scarabin PY. Postmenopausal hormone therapy and venous thromboembolism. Thromb Res 2011;127 (Suppl 3):S26–9
   PubMed Web of Science ®Google Scholar
• Hammar ML, van de Weijer P, Franke HR, Pornel B, von Mauw EM, Nijland EA. Tibolone and low-dose continuous combined hormone treatment: vaginal bleeding pattern, efficacy and tolerability. BJOG 2007;114:1522–9
   PubMed Web of Science ®Google Scholar
• MacLennan AH. HRT in difficult circumstances: are there any absolute contraindications? Climacteric 2011;14:409–16
   PubMed Web of Science ®Google Scholar
• Paterson MEL. A randomized double-blind cross-over trial into the effect of norethisterone on climacteric symptoms and biochemical profiles. Br J Obstet Gynaecol 1982;89:464–72
   PubMedGoogle Scholar
• Farish E, Barnes JF, O'Donoghue F, . The role of megestrol acetate as an alternative to conventional hormone replacement therapy. Climacteric 2000;3:125–34
   PubMedGoogle Scholar
• Loprinzi CL, Levitt R, Barton D, . Phase III comparison of depomedroxyprogesterone acetate to venlafaxine for managing hot flashes: North Central Cancer Treatment Group Trial N99C7. J Clin Oncol 2006;24:1409–14
   PubMed Web of Science ®Google Scholar
• Prior JC, Hitchcock CL. Progesterone for vasomotor symptoms: a l2-week randomized, masked placebo-controlled trial in healthy, normal-weight women 1-LO years since final menstrual flow. Presented at ENDO 2010, Abstract S19-2
   Google Scholar
• Albertazzi P. Non-estrogenic approaches for the treatment of climacteric symptoms. Climacteric 2007;10(Suppl 2): 115–20
   PubMed Web of Science ®Google Scholar
• Archer DF, Seidman L, Constantine GD, Pickar JH, Olivier S. A double-blind, randomly assigned, placebo-controlled study of desvenlafaxine efficacy and safety for the treatment of vasomotor symptoms associated with menopause. Am J Obstet Gynecol 2009;200:172 e1–10
   PubMed Web of Science ®Google Scholar
• Speroff L, Gass M, Constantine G, Olivier S. Efficacy and tolerability of desvenlafaxine succinate treatment for menopausal vasomotor symptoms: a randomized controlled trial. Obstet Gynecol 2008;111:77–87
   PubMed Web of Science ®Google Scholar
• Archer DF, Dupont CM, Constantine GD, Pickar JH, Olivier S. Desvenlafaxine for the treatment of vasomotor symptoms associated with menopause: a double-blind, randomized, placebo-controlled trial of efficacy and safety. Am J Obstet Gynecol 2009;200:238 e1–10
   PubMed Web of Science ®Google Scholar
• Pawlyk AC, Cosmi S, Alfinito PD, Maswood N, Deecher DC. Effects of the 5-HT2A antagonist mirtazapine in rat models of thermoregulation. Brain Res 2006;1123:135–44
   PubMed Web of Science ®Google Scholar
• Biglia N, Kubatzki F, Sgandurra P, . Mirtazapine for the treatment of hot flushes in breast cancer survivors: a prospective pilot trial. Breast J 2007;13:490–5
   PubMed Web of Science ®Google Scholar
• Evans ML, Pritts E, Vittinghoff E, McClish K, Morgan KS, Jaffe RB. Management of postmenopausal hot flushes with venlafaxine hydrochloride: a randomized, controlled trial. Obstet Gynecol 2005;105:161–6
   PubMed Web of Science ®Google Scholar
• Suvanto-Luukkonen E, Koivunen R, Sundstrom H, . Citalopram and fluoxetine in the treatment of postmenopausal symptoms: a prospective, randomized, 9-month, placebo-controlled, double-blind study. Menopause 2005;12:18–26
   PubMed Web of Science ®Google Scholar
• Loprinzi CL, Sloan J, Stearns V, Iyengar M, . Newer antidepressants and gabapentin for hot flashes: an individual patient pooled analysis. J Clin Oncol 2009;27:2831–7
   PubMed Web of Science ®Google Scholar
• Reddy SY, Warner H, Guttuso T, Jr, . Gabapentin, estrogen, and placebo for treating hot flushes: a randomized controlled trial. Obstet Gynecol 2006;108:41–8
   PubMed Web of Science ®Google Scholar
• Albertazzi P, Bottazzi M, Purdie DW. Gabapentin for the management of hot flushes: a case series. Menopause 2003;10: 214–17
   PubMed Web of Science ®Google Scholar
• Aguirre W, Chedraui P, Mendoza J, Ruilova I. Gabapentin vs. low-dose transdermal estradiol for treating post-menopausal women with moderate to very severe hot flushes. Gynecol Endocrinol 2010;26:333–7
   PubMed Web of Science ®Google Scholar
• Pandya KJ, Morrow GR, Roscoe JA, . Gabapentin for hot flashes in 420 women with breast cancer: a randomised double-blind placebo-controlled trial. Lancet 2005;366: 818–24
   PubMed Web of Science ®Google Scholar
• Loprinzi CL, Sloan J, Stearns V, . Newer antidepressants and gabapentin for hot flashes: an individual patient pooled analysis. J Clin Oncol 2009;27:2831–7
   PubMed Web of Science ®Google Scholar
• MacLennan AH, Wilson DH, Taylor AW. The escalating cost and prevalence of alternative medicine. Prev Med 2002;35: 166–73
   PubMed Web of Science ®Google Scholar
• Geller SE, Shulman LP, van Breemen RB, . Safety and efficacy of black cohosh and red clover for the management of vasomotor symptoms: a randomized controlled trial. Menopause 2009;16:1156–66
   PubMed Web of Science ®Google Scholar
• Borrelli F, Ernst E. Alternative and complementary therapies for the menopause. Maturitas 2010;66:333–43
   PubMed Web of Science ®Google Scholar
• Carmody JF, Crawford S, Salmoirago-Blotcher E, Leung K, Churchill L, Olendzki N. Mindfulness training for coping with hot flashes: results of a randomized trial. Menopause 2011;18: 611–20
   PubMed Web of Science ®Google Scholar
• Towey M, Bundy C, Cordingley L. Psychological and social interventions in the menopause. Curr Opin Obstet Gynecol 2006;18:413–17
   PubMed Web of Science ®Google Scholar
• Freedman RR. Hot flashes: behavioral treatments, mechanisms, and relation to sleep. Am J Med 2005;124–30S
   PubMed Web of Science ®Google Scholar
• What is biofeedback? Consensus definition from Association for Applied Psychophysiology and biofeedback, May 18, 2008. Retrieved 22 February, 2010. http://www.aapb.org
   Google Scholar
• Freedman RR, Woodward S. Behavioral treatment of menopausal hot flushes: evaluation by ambulatory monitoring. Am J Obstet Gynecol 1992;167:436–9
   PubMed Web of Science ®Google Scholar
• Freedman RR, Woodward S, Brown B, . Biochemical and thermoregulatory effects of behavioral treatment for menopausal hot flashes. Menopause 1995;2:211–18
   Web of Science ®Google Scholar
• Lee MS, Shin BC, Ernst E. Acupuncture for treating menopausal hot flushes: a systematic review. Climacteric 2009;12:16–25
   PubMed Web of Science ®Google Scholar
• Rada G, Capurro D, Pantoja T, . Non-hormonal interventions for hot flushes in women with a history of breast cancer. Cochrane Database of Systematic Reviews 2010, Issue 9. Art. No.: CD004923. DOI:10.1002/14651858.CD004923.pub2
   Web of Science ®Google Scholar
• Deng G, Vickers AJ, Yeung KS, . Randomized, controlled trial of acupuncture for the treatment of hot flashes in breast cancer patients. J Clin Oncol 2007;25:5584–90
   PubMed Web of Science ®Google Scholar
• Borud EK, Alraek T, White A, . The acupuncture on hot flushes among menopausal women (ACUFLASH) study, a randomized controlled trial. Menopause 2009;16:484–93
   PubMed Web of Science ®Google Scholar
• Freedman RR, Benton MD, Genik RJ, . Cortical activation during menopausal hot flashes. Fertil Steril 2006;85:674–678
   PubMed Web of Science ®Google Scholar
• Lipov EG, Lipov S, Joshi JR, . Stellate ganglion block may relieve hot flashes by interrupting the sympathetic nervous system. Med Hypotheses 2007;69:758–63
   PubMed Web of Science ®Google Scholar
• Lipov EG, Jaydeep RJ, Sanders S, . Effects of stellate-ganglion block on hot flushes and night awakenings in survivors of breast cancer: a pilot study. Lancet Oncol 2008;9: 523–32
   PubMed Web of Science ®Google Scholar
• Lipov EG, Joshi JR, Xie H, . Updated findings on the effects of stellate-ganglion block on hot flushes and night awakenings. Reflection and Reaction. Lancet Oncol 2008;9:819–20
   PubMed Web of Science ®Google Scholar
• van Boxem K, van Eerd M, Brinkhuize T, . Radiofrequency and pulsed radiofrequency treatment of chronic pain syndromes: the available evidence. Pain Pract 2008;8:385–93
   PubMedGoogle Scholar
• North American Menopause Society. Treatment of menopause-associated vasomotor symptoms: position statement of The North American Menopause Society. Menopause 2004;11: 11–33
   PubMed Web of Science ®Google Scholar
• Nedrow A, Miller J, Walker M, Nygren P, Huffman LH, Nelson HD. Complementary and alternative therapies for the management of menopause-related symptoms: a systematic evidence review. Arch Intern Med 2006;166:1453–65
   PubMed Web of Science ®Google Scholar
• Lee MS, Kim JI, Ha JY, Boddy K, Ernst E. Yoga for menopausal symptoms: a systematic review. Menopause 2009;16:602–8
   PubMed Web of Science ®Google Scholar
• de Villiers TJ, Chines AA, Palacios S, . Safety and tolerability of bazedoxifene in postmenopausal women with osteoporosis: results of a 5-year, randomized, placebo-controlled phase 3 trial. Osteoporos Int 2011;22:567–76
   PubMed Web of Science ®Google Scholar
• Lobo RA, Pinkerton JV, Gass ML, . Evaluation of bazedoxifene/conjugated estrogens for the treatment of menopausal symptoms and effects on metabolic parameters and overall safety profile. Fertil Steril 2009;92:1025–38
   PubMed Web of Science ®Google Scholar
• Carpenter JS, Elam JL, Ridner SH, Carney PH, Cherry GJ, Cucullu HL. Sleep, fatigue, and depressive symptoms in breast cancer survivors and matched healthy women experiencing hot flashes. Oncol Nurs Forum 2004;31:591–8
   PubMed Web of Science ®Google Scholar
• Carpenter J, Azzouz F, Monahan P, Storniolo A, Ridner S. Is sternal skin conductance monitoring a valid measure of hot flash intensity or distress? Menopause 2005;12:512–19
   PubMed Web of Science ®Google Scholar
• Maki PM, Rubin LH, Fornelli D, . Effects of botanicals and combined hormone therapy on cognition in postmenopausal women. Menopause 2009;16:1167–77
   PubMed Web of Science ®Google Scholar
• Carpenter JS, Storniolo AM, Johns S, . Randomized, double-blind, placebo-controlled crossover trials of venlafaxine for hot flashes after breast cancer. Oncologist 2007;12:124–35
   PubMed Web of Science ®Google Scholar
• Freedman RR, Wasson S. Miniature hygrometric hot flash recorder. Fertil Steril 2007;88:494–6
   PubMed Web of Science ®Google Scholar
• Wilkin JK. The red face: flushing disorders. Clin Dermatol 1993;11:211–23
   PubMed Web of Science ®Google Scholar
• Geha RS, Beiser A, Ren C, . Review of alleged reaction to monosodium glutamate and outcome of a multicenter double-blind placebo-controlled study. J Nutr 2000;130:1058–62S
   PubMed Web of Science ®Google Scholar
• Oroszi G, Goldman D. Alcoholism: genes and mechanisms. Pharmacogenomics 2004;5:1037–48
   PubMed Web of Science ®Google Scholar
• Ray D, Williams G. Pathophysiological causes and clinical significance of flushing. Br J Hosp Med 1993;50:594–8
   PubMed Web of Science ®Google Scholar
• Izikson L, English JC 3rd, Zirwas MJ. The flushing patient: differential diagnosis, workup, and treatment. J Am Acad Dermatol 2006;55:193–208
   PubMed Web of Science ®Google Scholar