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ORIGINAL ARTICLE

Genistein and exercise do not improve cardiovascular risk factors in the ovariectomized rat

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Pages 136-147 | Received 01 Mar 2013, Accepted 08 May 2013, Published online: 24 Jul 2013

References

  • Dubey RK, Gillespie D, Imthurn B, Rosselli M, Jackson EK, Keller PJ. Phytoestrogens inhibit growth and MAP kinase activity in human aortic smooth muscle cells. Hypertension 1999; 33:177–82
  • Scuteri A, Ferrucci L. Blood pressure, arterial function, structure, and aging: the role of hormonal replacement therapy in postmenopausal women. J Clin Hypertens 2003;5: 219–25
  • Li HF, Li W, Zheng TZ, Qu SY, Zhang CL. A study of the mechanisms involved in relaxation induced by 17-beta-estradiol in the isolated rabbit aorta. Arch Gynecol Obstet 2002;266:101–4
  • Hulley S, Grady D, Bush T, et al. Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Estrogen/progestin Replacement Study Research Group. JAMA 1998;280:605–13
  • Suetsugi M, Su L, Karlsberg K, Yuan YC, Chen S. Flavone and isoflavone phytoestrogens are agonists of estrogen-related receptors. Mol Cancer Res 2003;1:981–91
  • Cassidy A, Griffin B. Phyto-estrogens: a possible role in the prevention of CHD?Proc Nutri Soc 1999;58:193–9
  • Honore EK, Williams JK, Anthony MS, Clarkson TB. Soy isoflavones enhance coronary vascular reactivity in atherosclerotic female macaques. Fertil Steril 1997;67:148–54
  • Figtree GA, Griffiths H, Lu YQ, Webb CM, MacLeod K, Collins P. Plant-derived estrogens relax coronary arteries in vitro by a calcium antagonistic mechanism. J Am Coll Cardiol 2000;35:1977–85
  • Walker HA, Dean TS, Sanders TA, Jackson G, Ritter JM, Chowienczyk P. The phytoestrogen genistein produces acute nitric oxide-dependent dilation of human forearm vasculature with similar potency to 17beta-estradiol. Circulation 2001; 103:258–62
  • Anthony MS, Clarkson TB, Hughes CL, Morgan TM, Burke GL. Soybean isoflavones improve cardiovasular risk factors without affecting the reproductive system or peripubertal rhesus monkeys. J Nutr 1996;126:43–50
  • Sliva D. Suppression of cancer invasiveness by dietary compounds. Mini Rev Med Chem 2008;8:677–88
  • Al-Nakkash L, Markus B, Bowden K, Batia L, Prozialeck WC, Broderick TL. Effects of acute and 2-day genistein treatment on cardiac function and ischemic tolerance in ovariectomized rats. Gender Med 2009;6:488–97
  • Al-Nakkash L, Markus B, Batia L, Prozialeck WC, Broderick TB. Genistein induces estrogen-like effects in ovariectomized rats but fails to increase cardiac GLUT4 and oxidative stress. J Med Food 2010;13:1–7
  • Al-Nakkash L, Martin JB, Petty D, et al. Dietary genistein induces sex-dependent effects on murine body weight, serum profiles, and vascular function of thoracic aortae. Gender Med 2012;9: 295–308
  • Wegge JK, Roberts CK, Ngo TH, Barnard RJ. Effect of diet and exercise intervention on inflammatory and adhesion molecules in postmenopausal women on hormone replacement therapy and at risk for coronary heart disease. Metabolism 2004;53:377–81
  • Staffileno BA, Braun LT, Rosenson RS. The accumulative effects of physical activity in hypertensive post-menopausal women. J Cardiovasc Risk 2001;8:283–90
  • Wang D, Gutkowska J, Marcinkiewicz M, Rachelska G, Jankowski M. Genistein supplementation stimulates the oxytocin system in the aorta of ovariectomized rats. Cardiovasc Res 2003;57:186–94
  • Wu J, Wang XX, Takasaki M, Ohta A, Higuchi M, Ishimi Y. Cooperative effects of exercise training and genistein adminstration on bone mass in ovariectomized mice. J Bone Miner Res 2001;16:1829–36
  • Ekskulkla S, Suksom D, Siriviriyakul P, Patumraj S. Increased NO bioavialability in aging male rats by genistein and exercise training: using 4,5-diaminofluorescein diacetate. Reprod Biol Endocrinol 2009;7:93
  • Kohrt WM, Bloomfield SA, Little KD, Nelson ME, Yingling VR. American College of Sports Medicine Position Stand: physical activity and bone health. Med Sci Sports Exerc 2004;36: 1985–96
  • Ramos JE, Al-Nakkash L, Peterson A, et al. The soy isoflavone genistein inhibits the reduction in Achilles tendon collagen content induced by ovariectomy in rats. Scand J Med Sci Sports 2012;22:e108–14
  • Gutkowska J, Broderick TB, Bogdan D, Wang D, Lavoie J-M, Jankowski M. Downregulation of oxytocin and natriuretic peptides in diabetes: possible implications in cardiomyopathy. J Physiol 2009;587:4725–36
  • Ellman GL. Tissue sulfhydryl groups. Arch Biochem Biophys 1959;82:70–7
  • Bhathena SJ, Velasquez MT. Beneficial role of dietary phytoestrogens in obesity and diabetes. Am J Clin Nutr 2002;76: 1191–201
  • Tissier R, Waintraub X, Couvreur N, et al. Pharmacological postconditioning with the phytoestrogen genistein. J Mol Cell Cardiol 2007;42:79–87
  • Gutkowska J, Paquette A, Wang D, Lavoie JM, Jankowski M. Effect of exercise training on cardiac oxytocin and natriuretic peptide systems in ovariectomized rats. Am J Physiol Regul Integr Comp Physiol 2007;293:R267–75
  • Nevala R, Lassila M, Finckenberg P, Paukku K, Korpela R, Vapaatalo H. Genistein treatment reduces arterial contractions by inhibiting tyrosine kinases in ovariectomized hypertensive rats. Eur J Pharmacol 2002;452:87–96
  • Small CJ, Bloom SR. The therapeutic potential of gut hormone peptide YY3-36 in the treatment of obesity. Expert Opin Investig Drugs 2005;14:647–53
  • Orgaard A, Jensen L. The effects of soy isoflavones on obesity. Exp Biol Med 2008;233:1066–80
  • Kim H-K, Nelson-Dooley C, Della-Fera MA, et al. Genistein decreases food intake, body weight, and fat pad weight and causes adipose tissue apoptosis in ovariectomized female mice. J Nutr 2006;136:409–14
  • Riggs BL, Melton LR. Osteoporosis and age-related fracture syndromes. Ciba Foundation Symp 1988;134:129–42
  • Beyer R, Huang JC, Wilshire G. The effect of endurance exercise on bone dimensions, collagen, and calcium in the aged male rat. Exp Gerontol 1985;20:315–23
  • Steinberg ME, Trueta J. Effects of activity on bone growth and development in the rat. Clin Orthop Relat Res 1981;156:52–60
  • Raab DM, Smith EL, Crenshaw TD, Thomas DP. Bone mechanical properties after exercise training in young and old rats. J Appl Physiol 1990;68:130–4
  • Squadrito F, Altavilla D, Squadrito G, et al. Genistein supplementation and estrogen replacement therapy improve endothelial dysfunction induced by ovariectomy in rats. Cardiovasc Res 2000;45:454–62
  • Si H, Liu D. Genistein, a soy phytoestrogen, upregulates the expression of human endothelial nitric oxide synthase and lowers blood pressure in spontaneously hypertensive rats. J Nutr 2008;138:297–304
  • Li H-F, Wang L-D, Qu S-Y. Phytoestrogen genistein decreases contractile response to aortic artery in vitro and arterial blood pressure in vivo. Acta Pharmacol Sin 2004;25:313–18
  • Kitayama J, Kitazono T, Ooboshi H, et al. Chronic administration of a tyrosine kinase inhibitor restores functional and morphological changes of the basilar artery during chronic hypertension. J Hypertens 2002;20:2205–11
  • Irigoyen MC, Paulini J, Flores LJ, et al. Exercise training improves baroreflex sensitivity associated with oxidative stress reduction in ovariectomized rats. Hypertension 2005;46:998–1003
  • Villa P, Costantini B, Suriano R, et al. The differential effect of the phytoestrogen genistein on cardiovascular risk factors in postmenopausal women: relationship with the metabolic status. J Clin Endocrinol Metab 2009;94:552–8
  • Salih SM, Nallasamy P, Muniyandi P, Periyasami V, Ventkatraman AC. Genistein improves liver function and attenuates non-alcoholic fatty liver disease in a rat model of insulin resistance. J Diabetes 2009;1:278–87
  • Sorenson RL, Brelje TC, Roth C. Effect of tyrosine kinase inhibitors on islets of Langerhans: evidence for tyrosine kinases in the regulation of insulin secretion. Endocrinology 1994; 134:1955–8
  • Fu Z, Zhang W, Zhen W, et al. Genistein induces pancreatic B-cell proliferation through activation of multiple signaling pathways and prevents insulin-deficient diabetes in mice. Endocrinology 2010;151:3026–37
  • Patton JS, Shepard HM, Wilking H, et al. Interferons and tumor necrosis factors have similar catabolic effects on 3T3L1 cells. Proc Natl Acad Sci USA 1986;83:8313–17
  • Ito Y, Nomura S, Ueda H, et al. Exercise training increases membrane bound form of tumor necrosis factor-alpha receptors with decreases in the secretion of soluble forms of receptors in rat adipocytes. Life Sci 2002;71:601–9
  • Bukowiecki L, Lupien J, Follea N, Paradis A, Richard D, Leblanc J. Mechanism of enhanced lipolysis in adipose tissue of exercise-trained rats. Am J Physiol 1980;239:E422–9
  • Bonyadi M, Badalzadeh R, Mohammadi M, Poozesh S, Salehi I. The effect of regular training on plasma cytokines response in healthy and diabeteic rats. Saudi Med J 2009; 30:1390–4
  • Benedusi V, Meda C, Della Torre S, Monteleone G, Vegeto E, Maggi A. A lack of ovarian function increases neuroinflammation in aged mice. Endocrinology 2012;153:2777–88
  • Marques CMM, Nascimento FAM, Mandarim-de-Lacerdo CA, Aguila MB. Exercise attenuates cardiovascular adverse remodelling in adult ovariectomized spontaneously hypertensive rats. Menopause 2006;13:87–95
  • Paquette A, Wang D, Gauthier M-S, et al. Specific adaptations of estrogen receptor α and β transcripts in liver and heart after endurance training in rats. Mol Cell Biochem 2007;306: 179–87
  • Suzuki K, Koike H, Matsui H, et al. Genistein, a soy isoflavone, induces glutathione peroxidase in the human prostate cancer cell lines LNCAP and PC-3. Int J Cancer 2002;99:846–52
  • Mahn K, Borras C, Knock GA, et al. Dietary soy isoflavone- induced increases in antioxidant and eNOS gene expression lead to improved edothelial function and reduced blood pressure in vivo. FASEB J 2005;19:1755–7
  • Zhu X, Tang Z, Cong B, et al. Estrogens increase cystathionine-γ-lyase expression and decrease inflammation and oxidative stress in the myocardium of ovariectomized rats. Menopause 2013 April 8. [Epub ahead of print]

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