Advanced search
Publication Cover
Journal of Enzyme Inhibition and Medicinal Chemistry Volume 27, 2012 - Issue 5
Submit an article Journal homepage
1,363
Views
3
CrossRef citations to date
0
Altmetric
Research Article

Nitrogen-containing polyhydroxylated aromatics as HIV-1 integrase inhibitors: synthesis, structure-activity relationship analysis, and biological activity

Shenghui YuDepartment of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong, PR China
,
Linna ZhangQilu Hospital of Shandong University, Jinan, Shandong, PR China
,
Shifeng YanDepartment of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong, PR China
,
Peng WangDepartment of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong, PR China
,
Tino SanchezDepartment of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, USA
,
Frauke ChristLaboratory for Molecular Virology and Gene Therapy, Department of Molecular and Cellular Medicine IRC KULAK and KULeuven, Leuven, Flanders, Belgium
,
Zeger DebyserLaboratory for Molecular Virology and Gene Therapy, Department of Molecular and Cellular Medicine IRC KULAK and KULeuven, Leuven, Flanders, Belgium
,
Nouri NeamatiDepartment of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, USA
&
Guisen ZhaoDepartment of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong, PR ChinaCorrespondence[email protected] [email protected]
 show all
Pages 628-640 | Received 16 May 2011, Accepted 10 Jul 2011, Published online: 11 Jan 2012

References

  • De Clercq E. New approaches toward anti-HIV chemotherapy. j Med Chem 2005;48:1297–1313.
  • Geffen N. Beyond HAART: scientists and activists need to work together. Lancet 2009;374:860–861.
  • Dayam R, Gundla R, Al-Mawsawi LQ, Neamati N. HIV-1 integrase inhibitors: 2005-2006 update. Med Res Rev 2008;28:118–154.
  • Zhao G, Wang C, Liu C, Lou H. New developments in diketo-containing inhibitors of HIV-1 integrase. Mini Rev Med Chem 2007;7:707–725.
  • Johnson AA, Marchand C, Pommier Y. HIV-1 integrase inhibitors: a decade of research and two drugs in clinical trial. Curr Top Med Chem 2004;4:1059–1077.
  • Fesen MR, Kohn KW, Leteurtre F, Pommier Y. Inhibitors of human immunodeficiency virus integrase. Proc Natl Acad Sci usa 1993;90:2399–2403.
  • Ho CC, Lin SS, Chou MY, Chen FL, Hu CC, Chen CS et al. Effects of CAPE-like compounds on HIV replication in vitro and modulation of cytokines in vivo. j Antimicrob Chemother 2005;56:372–379.
  • Neamati N, Lin Z, Karki RG, Orr A, Cowansage K, Strumberg D et al. Metal-dependent inhibition of HIV-1 integrase. j Med Chem 2002;45:5661–5670.
  • Tchertanov L, Mouscadet JF. Target recognition by catechols and beta-ketoenols: potential contribution of hydrogen bonding and Mn/Mg chelation to HIV-1 integrase inhibition. j Med Chem 2007;50:1133–1145.
  • Zhao H, Neamati N, Mazumder A, Sunder S, Pommier Y, Burke TR Jr. Arylamide inhibitors of HIV-1 integrase. j Med Chem 1997;40:1186–1194.
  • King PJ, Ma G, Miao W, Jia Q, McDougall BR, Reinecke MG et al. Structure-activity relationships: analogues of the dicaffeoylquinic and dicaffeoyltartaric acids as potent inhibitors of human immunodeficiency virus type 1 integrase and replication. j Med Chem 1999;42:497–509.
  • Supuran CT, Innocenti A, Mastrolorenzo A, Scozzafava A. Antiviral sulfonamide derivatives. Mini Rev Med Chem 2004;4:189–200.
  • Fisher TE, Kim B, Staas DD, Lyle TA, Young SD, Vacca JP et al. 8-Hydroxy-3,4-dihydropyrrolo[1,2-a]pyrazine-1(2H)-one HIV-1 integrase inhibitors. Bioorg Med Chem Lett 2007;17:6511–6515.
  • Marchand C, Maddali K, Métifiot M, Pommier Y. HIV-1 IN inhibitors: 2010 update and perspectives. Curr Top Med Chem 2009;9:1016–1037.
  • Serrao E, Odde S, Ramkumar K, Neamati N. Raltegravir, elvitegravir, and metoogravir: the birth of “me-too” HIV-1 integrase inhibitors. Retrovirology 2009;6:25.
  • Lee-Huang S, Huang PL, Zhang D, Lee JW, Bao J, Sun Y et al. Discovery of small-molecule HIV-1 fusion and integrase inhibitors oleuropein and hydroxytyrosol: part II. integrase inhibition. Biochem Biophys Res Commun 2007;354:879–884.
  • Wu B, Zhou L, Cai HH. Synthesis and neuroprotective properties of novel cinnamide derivatives. Chinese Chem Lett 2008;19:1163–1166.
  • Andrus MB, Liu J, Meredith EL, Nartey E. Synthesis of resveratrol using a direct decarbonylative Heck approach from resorcylic acid. Tetrahedron Lett 2003;44:4819–4822.
  • Dayam R, Al-Mawsawi LQ, Zawahir Z, Witvrouw M, Debyser Z, Neamati N. Quinolone 3-carboxylic acid pharmacophore: design of second generation HIV-1 integrase inhibitors. J Med Chem 2008;51:1136–1144.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.