References
- Cummings MD, Farnum MA, Nelen MI. Universal screening methods and applications of ThermoFluor®. J Biomol Screen 2006;11:854–63
- The screening and the building block collection of Enamine Ltd. Available from: https://www.enaminestore.com/catalog [last accessed 20 Jan 2016]
- Mai K, Patil G. A fast N-substituted α-aminonitrile synthesis. Synth Commun 1985;15:157–63
- Zali-Boeini H, Mobin M, Hajibabaei K, Ghani M. Approaches to the construction of substituted 4-amino-1H-pyrrol-2(5H)-ones. J Org Chem 2012;77:5808–12
- Deng S, Liu D. Studies on phosphoroheterocycle chemistry II: a simple and new route to 1,3,2-diazaphospholidine-4-thione 2-sulfide derivatives. Synthesis 2001;2445–9
- Lo MC, Aulabaugh A, Jin G, et al. Evaluation of fluorescence-based thermal shift assays for hit identification in drug discovery. Anal Biochem 2004;332:153–9
- Matulis D, Kranz JK, Salemme FR, Todd MJ. Thermodynamic stability of carbonic anhydrase: measurements of binding affinity and stoichiometry using ThermoFluor. Biochemistry 2005;44:5258–66
- Niesen FH, Berglund H, Vedadi M. The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability. Nat Protoc 2007;2:2212–21
- Alterio V, Di Fiore A, D’Ambrosio K, et al. Multiple binding modes of inhibitors to carbonic anhydrases: how to design specific drugs targeting 15 different isoforms? Chem Rev 2012;112:4421–68
- Khalifah RG, Edsall JT. Carbon dioxide hydration activity of carbonic anhydrase: kinetics of alkylated anhydrases B and C from humans. Proc Natl Acad Sci U S A 1972;69:172–6
- Krasavin M, Korsakov M, Dorogov M, et al. Probing the ‘bipolar’ nature of the carbonic anhydrase active site: aromatic sulfonamides containing 1,3-oxazol-5-yl moiety as picomolar inhibitors of cytosolic CA I and CA II isoforms. Eur J Med Chem 2015;101:334–47
- Maresca A, Temperini C, Vu H, et al. Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors. J Am Chem Soc 2009;131:3057–62
- Temperini C, Innocenti A, Scozzafava A, et al. The coumarin-binding site in carbonic anhydrase accommodates structurally diverse inhibitors: the antiepileptic lacosamide as an example and lead molecule for novel classes of carbonic anhydrase inhibitors. J Med Chem 2010;53:850–4
- Alterio V, Hilvo M, Di Fiore A, et al. Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX. Proc Natl Acad Sci U S A 2009;106:16233–8
- Casey JR, Morgan PE, Vullo D, et al. Carbonic anhydrase inhibitors. Design of selective, membrane-impermeant inhibitors targeting the human tumor-associated isozyme IX. J Med Chem 2004;47:2337–47
- Casini A, Scozzafava A, Mincione F, et al. Carbonic anhydrase inhibitors: water-soluble 4-sulfamoylphenylthioureas as topical intraocular pressure-lowering agents with long-lasting effects. J Med Chem 2000;43:4884–92
- Winum JY, Scozzafava A, Montero JL, Supuran CT. Design of zinc binding functions for carbonic anhydrase inhibitors. Curr Pharm Des 2008;14:615–21
- Winnum JY, Cecchi A, Seridi A, et al. Carbonic anhydrase inhibitors. N-Cyanomethylsulfonamides – a new zinc binding group in the design of inhibitors targeting cytosolic and membrane-anchored isoforms. J Enzyme Inhib Med Chem Med 2006;21:477–81
- McDonald PC, Winum JY, Supuran CT, Dedhar S. Recent developments in targeting carbonic anhydrase IX for cancer therapeutics. Oncotarget 2012;3:84–97
- De Simone G, Supuran CT. (In)organic anions as carbonic anhydrase inhibitors. J Inorg Biochem 2012;111:117–29
- Opatz T. The chemistry of deprotonated α-aminonitriles. Synthesis 2009;1941–59
- Sauer S, Keim M. Hydroxocobalamin: improved public health readiness for cyanide disasters. Improved health for disasters. Ann Emerg Med 2001;37:635–41
- Supuran CT, Scozzafava A, Briganti F. Carbonic anhydrase inhibitors: N-cyanosulfonamides, a new class of high affinity isozyme II and IV inhibitors. J Enzyme Inhib 1999;14:289–306