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Methodology

UHPLC–MS/MS Bioanalysis of Human Plasma Coproporphyrins as Potential Biomarkers for Organic Anion-Transporting Polypeptide-Mediated Drug Interactions

, , , , , , , , , , , , , , & show all
Pages 633-644 | Received 13 Nov 2017, Accepted 12 Mar 2018, Published online: 11 May 2018

References

  • Niemi M , PasanenMK, NeuvonenPJ. Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol. Rev.63, 157–181 (2011).
  • Shitara Y , MaedaK, IkejiriK, YoshidaK, HorieT, SugiyamaY. Clinical significance of organic anion transporting polypeptides (OATPs) in drug disposition: their roles in hepatic clearance and intestinal absorption. Biopharm. Drug Dispos.34, 45–78 (2013).
  • US FDA . Draft guidance for industry. In vitro metabolism- and transporter-mediated drug–drug interaction studies and clinical drug interaction studies. Silver Spring, MD, USA (2017). www.fda.gov/downloads/drugs/guidances/ucm292362.pdf.
  • Shen H , DaiJ, LiuTet al. Coproporphyrins I and III as functional markers for OATP1B activity: In vitro and in vivo evaluation in preclinical species. J. Pharmacol. Exp. Ther.357, 382–393 (2016).
  • Lai Y , MandlekarS, ShenHet al. Coproporphyrins in plasma and urine can be appropriate clinical biomarkers to recapitulate drug-drug interactions mediated by organic anion transporting polypeptide inhibition. J. Pharmacol. Exp. Ther.358, 397–404 (2016).
  • Moan J , RimingtonC, EvensenJF, WesternA. Binding of porphyrins to serum proteins. In : Methods in Porphyrin Photosensitization. Advances in Experimental Medicine and Biology. KesselD ( Ed). Springer, Boston, MA, USA, 193–205 (1985).
  • Pottier R , KennedyJC. Use of photodiode array fluorescence spectroscopy in biochemistry, pharmacology, and oncology. In : Analytical Use of Fluorescent Probes in Oncology. NATO ASI Series (Series A: Life Sciences). KohenE, HirschbergJG ( Eds). Springer, Boston, MA, USA (1996).
  • Fateen AE , Abd-ElfattahA, GoudaL, RagabWN. Porphyrins profile by high performance liquid chromatography/electrospray ionization tandem mass spectrometry for the diagnosis of porphyria. Egyptian J. Med. Hum. Genet.12 (1), 49–58 (2011).
  • Hur Y , TaeS, KohY-Jet al. Simultaneous determination of five porphyrins in human urine and plasma using high performance liquid chromatography-tandem mass spectrometry. Mass Spectr. Lett.5, 42–48 (2014).
  • Bullock E , JohnsonAW, MarkhamE, ShawKB. A synthesis of coproporphyrin III. J. Chem. Soc. doi:10.1039/JR9580001430 (1958).
  • Diaz L , BuldainG, FrydmanB. Preparation of intermediates for coproporphyrin synthesis. J. Org. Chem.44 (6), 973–977 (1979).
  • Pinchon-Santander C , SantanderPJ, ScottAI. Synthesis of substrate analogs of methyltransferases in the vitamin B12 biosynthetic pathway and characterization of their enzymatic products. Biorg. Med. Chem.14, 3904–3922 (2006).

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