Advanced search
Publication Cover
Future Medicinal Chemistry Volume 8, 2016 - Issue 7
Submit an article Journal homepage
79
Views
0
CrossRef citations to date
0
Altmetric
Editorial

Targeting Autophagy in Antitumor Agent Design: Furthering the ‘Lysosomal Love’ Strategy

Sumit Sahni1 Molecular Pharmacology & Pathology Program, Department of Pathology and the Bosch Institute, Blackburn Building (D06), University of Sydney, Sydney, New South Wales, 2006, AustraliaView further author information
,
Zaklina Kovacevic1 Molecular Pharmacology & Pathology Program, Department of Pathology and the Bosch Institute, Blackburn Building (D06), University of Sydney, Sydney, New South Wales, 2006, AustraliaView further author information
,
Danuta S Kalinowski1 Molecular Pharmacology & Pathology Program, Department of Pathology and the Bosch Institute, Blackburn Building (D06), University of Sydney, Sydney, New South Wales, 2006, AustraliaView further author information
,
Michael Huang1 Molecular Pharmacology & Pathology Program, Department of Pathology and the Bosch Institute, Blackburn Building (D06), University of Sydney, Sydney, New South Wales, 2006, AustraliaView further author information
,
Sharleen Menezes1 Molecular Pharmacology & Pathology Program, Department of Pathology and the Bosch Institute, Blackburn Building (D06), University of Sydney, Sydney, New South Wales, 2006, AustraliaView further author information
,
Sukriti Krishan1 Molecular Pharmacology & Pathology Program, Department of Pathology and the Bosch Institute, Blackburn Building (D06), University of Sydney, Sydney, New South Wales, 2006, AustraliaView further author information
,
Darius JR Lane1 Molecular Pharmacology & Pathology Program, Department of Pathology and the Bosch Institute, Blackburn Building (D06), University of Sydney, Sydney, New South Wales, 2006, AustraliaView further author information
,
Patric J Jansson1 Molecular Pharmacology & Pathology Program, Department of Pathology and the Bosch Institute, Blackburn Building (D06), University of Sydney, Sydney, New South Wales, 2006, AustraliaCorrespondence[email protected]
View further author information
&
Des R Richardson1 Molecular Pharmacology & Pathology Program, Department of Pathology and the Bosch Institute, Blackburn Building (D06), University of Sydney, Sydney, New South Wales, 2006, AustraliaCorrespondence[email protected]
View further author information
 show all
Pages 727-729 | Received 21 Mar 2016, Accepted 23 Mar 2016, Published online: 05 May 2016

References

  • Erkan M , Reiser-ErkanC, MichalskiC, KleeffJ. Tumor microenvironment and progression of pancreatic cancer. Exp. Oncol.32 (3), 128–131 (2010).
  • Fujii S , MitsunagaS, YamazakiMet al. Autophagy is activated in pancreatic cancer cells and correlates with poor patient outcome. Cancer Sci.99 (9), 1813–1819 (2008).
  • Hashimoto D , BlauerM, HirotaM, IkonenNH, SandJ, LaukkarinenJ. Autophagy is needed for the growth of pancreatic adenocarcinoma and has a cytoprotective effect against anticancer drugs. Eur. J. Cancer50 (7), 1382–1390 (2014).
  • Kim SE , ParkHJ, JeongHKet al. Autophagy sustains the survival of human pancreatic cancer PANC-1 cells under extreme nutrient deprivation conditions. Biochem. Biophys. Res. Commun.463 (3), 205–210 (2015).
  • Yang S , WangX, ContinoGet al. Pancreatic cancers require autophagy for tumor growth. Genes Develop.25 (7), 717–729 (2011).
  • Sahni S , BaeDH, LaneDJet al. The metastasis suppressor, N-myc downstream-regulated gene 1 (NDRG1), inhibits stress-induced autophagy in cancer cells. J. Biol. Chem.289 (14), 9692–9709 (2014).
  • Gutierrez E , RichardsonDR, JanssonPJ. The anticancer agent di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes prosurvival autophagy by two mechanisms: persistent induction of autophagosome synthesis and impairment of lysosomal integrity. J. Biol. Chem.289 (48), 33568–33589 (2014).
  • Tsuchihara K , FujiiS, EsumiH. Autophagy and cancer: dynamism of the metabolism of tumor cells and tissues. Cancer Lett.278 (2), 130–138 (2009).
  • Morselli E , GalluzziL, KeppOet al. Oncosuppressive functions of autophagy. Antioxid. Redox Signal.14 (11), 2251–2269 (2011).
  • Yang X , YuDD, YanFet al. The role of autophagy induced by tumor microenvironment in different cells and stages of cancer. Cell. Biosci.5, 14 (2015).
  • Hamacher-Brady A . Autophagy regulation and integration with cell signaling. Antioxid. Redox Signal.17 (5), 756–765 (2012).
  • Maiuri MC , ZalckvarE, KimchiA, KroemerG. Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat. Rev. Mol. Cell Biol.8 (9), 741–752 (2007).
  • Degenhardt K , MathewR, BeaudoinBet al. Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell10 (1), 51–64 (2006).
  • White E . Deconvoluting the context-dependent role for autophagy in cancer. Nat. Rev. Cancer12 (6), 401–410 (2012).
  • Wojtkowiak JW , RothbergJM, KumarVet al. Chronic autophagy is a cellular adaptation to tumor acidic pH microenvironments. Cancer Res.72 (16), 3938–3947 (2012).
  • Capparelli C , GuidoC, Whitaker-MenezesDet al. Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis via glycolysis and ketone production. Cell Cycle11 (12), 2285–2302 (2012).
  • Bae DH , JanssonPJ, HuangMLet al. The role of NDRG1 in the pathology and potential treatment of human cancers. J. Clin. Pathol.66 (11), 911–917 (2013).
  • Kalinowski DS , StefaniC, ToyokuniSet al. Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics. Biochim. Biophys. Acta1863 (4), 727–748 (2016).
  • Whitnall M , HowardJ, PonkaPet al. A class of iron chelators with a wide spectrum of potent anti-tumor activity that overcome resistance to chemotherapeutics. Proc. Natl Acad. Sci. USA103, 14901–14906 (2006).
  • Liu W , XingF, Iiizumi-GairaniMet al. N-myc downstream regulated gene 1 modulates Wnt-beta-catenin signalling and pleiotropically suppresses metastasis. EMBO Mol. Med.4 (2), 93–108 (2012).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.