713
Views
0
CrossRef citations to date
0
Altmetric
Editorial

Bringing Ion Channel Crystal Structures into Sharper Focus with Computer Modeling: Examples from Mechanosensitive Channels

Pages 909-913 | Published online: 14 Jun 2010

Bibliography

  • Perozo E , CuelloLG, CortesDM, LiuYS, SompornpisutP. EPR approaches to ion channel structure and function.Novartis Found. Symp.245, 146–158 (2002).
  • Bass RB , ButlerSL, ChervitzSA, GloorSL, FalkeJJ. Use of site-directed cysteine and disulfide chemistry to probe protein structure and dynamics: applications to soluble and transmembrane receptors of bacterial chemotaxis.Methods Enzymol.42, 325–351 (2007).
  • Machiyama H , TatsumiH, SokabeM. Structural changes in the cytoplasmic domain of the mechanosensitive channel MscS during opening.Biophys. J.97(4), 1048–1057 (2009).
  • Hamill OP , MartinacB. Molecular basis of mechanotransduction in living cells.Physiol. Rev.81(2), 685–740 (2001).
  • Corry B , MartinacB. Bacterial mechanosensitive channels: experiment and theory.Biochim. Biophys. Acta1778(9), 1859–1870 (2008).
  • Bass RB , StropP, BarclayM, ReesDC. Crystal structure of Escherichia coli MscS, a voltage-modulated and mechanosensitive channel. Science298(5598), 1582–1587 (2002).
  • Chang G , SpencerRH, LeeAT, BarclayMT, ReesDC. Structure of the MscL homolog from Mycobacterium tuberculosis : a gated mechanosensitive ion channel. Science282(5397), 2220–2226 (1998).
  • Steinbacher S , BassR, StropP, ReesDC. Structures of the prokaryotic mechanosensitive channels MscL and MscS.Curr. Topics Membr.581–524 (2007).
  • Liu Z , GandhiCS, ReesDC. Structure of a tetrameric MscL in an expanded intermediate state.Nature461(7260), 120–124 (2009).
  • Wang W , BlackSS, EdwardsMDet al. The structure of an open form of an E. coli mechanosensitive channel at 3.45 Å resolution. Science 321(5893), 1179–1183 (2008).
  • Corry B , MartinacB. Bacterial mechanosensitive channels: experiment and theory.Biochim Biophys Acta1778(9), 1859–1870 (2008).
  • Khalili-Araghi F , GumbartJ, WenPC, SotomayorM, TajkhorshidE, SchultenK. Molecular dynamics simulations of membrane channels and transporters.Curr. Opin. Struct. Biol.19(2), 128–137 (2009).
  • Lindahl E , SansomMS. Membrane proteins: molecular dynamics simulations.Curr. Opin. Struct. Biol.18(4), 425–431 (2008).
  • Blount P , SukharevSI, SchroederMJ, NagleSK, KungC. Single residue substitutions that change the gating properties of a mechanosensitive channel in Escherichia coli. Proc. Natl Acad. Sci. USA93(21), 11652–11657 (1996).
  • Anishkin A , GendelV, SharifiNAet al. On the conformation of the COOH-terminal domain of the large mechanosensitive channel MscL. J. Gen. Physiol. 121(3), 227–244 (2003).
  • Kloda A , GhaziA, MartinacB. C-terminal charged cluster of MscL, RKKEE, functions as a pH sensor.Biophys. J.90(6), 1992–1998 (2006).
  • Elmore DE , DoughertyDA. Molecular dynamics simulations of wild-type and mutant forms of the Mycobacterium tuberculosis MscL channel. Biophys. J.81(3), 1345–1359 (2001).
  • Kochendoerfer GG , TackJM, CressmanS. Total chemical synthesis of a 27 kDa TASP protein derived from the MscL ion channel of M. tuberculosis by ketoxime-forming ligation. Bioconjugate Chem.13(3), 474–480 (2002).
  • Maurer JA , ElmoreDE, ClaytonD, XiongL, LesterHA, DoughertyDA. Confirming the revised C-terminal domain of the MscL crystal structure.Biophys. J.94(12), 4662–4667 (2008).
  • Long SB , CampbellEB, MackinnonR. Crystal structure of a mammalian voltage-dependent Shaker family K+ channel. Science309(5736), 897–903 (2005).
  • Anishkin A , SukharevS. Water dynamics and dewetting transitions in the small mechanosensitive channel MscS.Biophys. J.86(5), 2883–2895 (2004).
  • Sotomayor M , SchultenK. Molecular dynamics study of gating in the mechanosensitive channel of small conductance MscS.Biophys. J.87(5), 3050–3065 (2004).
  • Spronk SA , ElmoreDE, DoughertyDA. Voltage-dependent hydration and conduction properties of the hydrophobic pore of the mechanosensitive channel of small conductance.Biophys. J.90(10), 3555–3569 (2006).
  • Sotomayor M , VasquezV, PerozoE, SchultenK. Ion conduction through MscS as determined by electrophysiology and simulation.Biophys. J.92(3), 886–902 (2007).
  • Vora T , CorryB, ChungSH. Brownian dynamics investigation into the conductance state of the MscS channel crystal structure.Biochim. Biophys. Acta1758(6), 730–737 (2006).
  • Sotomayor M , van der Straaten TA, Ravaioli U, Schulten K. Electrostatic properties of the mechanosensitive channel of small conductance MscS. Biophys. J.90(10), 3496–3510 (2006).
  • Miller S , EdwardsMD, OzdemirC, BoothIR. The closed structure of the MscS mechanosensitive channel. Cross-linking of single cysteine mutants.J. Biol. Chem.278(34), 32246–32250 (2003).
  • Anishkin A , AkitakeB, SukharevS. Characterization of the resting MscS: modeling and analysis of the closed bacterial mechanosensitive channel of small conductance.Biophys. J.94(4), 1252–1266 (2008).
  • Vasquez V , SotomayorM, CortesDM, RouxB, SchultenK, PerozoE. Three-dimensional architecture of membrane-embedded MscS in the closed conformation.J. Mol. Biol.378(1), 55–70 (2008).
  • Anishkin A , KamarajuK, SukharevS. Mechanosensitive channel MscS in the open state: modeling of the transition, explicit simulations, and experimental measurements of conductance.J. Gen. Physiol.132(1), 67–83 (2008).
  • Vasquez V , SotomayorM, Cordero-MoralesJ, SchultenK, PerozoE. A structural mechanism for MscS gating in lipid bilayers.Science321(5893), 1210–1214 (2008).
  • Yefimov S , van der Giessen E, Onck PR, Marrink SJ. Mechanosensitive membrane channels in action. Biophys. J.94(8), 2994–3002 (2008).
  • Li S , ZhangX, WangW. Coarse-grained model for mechanosensitive ion channels.J. Phys. Chem. B113(43), 14431–14438 (2009).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.