3,479
Views
118
CrossRef citations to date
0
Altmetric
Basic Research Paper

Autophagy proteins LC3B, ATG5 and ATG12 participate in quality control after mitochondrial damage and influence lifespan

Pages 47-62 | Received 28 Mar 2011, Accepted 21 Sep 2011, Published online: 01 Jan 2012

References

  • Tatsuta T, Langer T. Quality control of mitochondria: protection against neurodegeneration and ageing. EMBO J 2008; 27:306 - 314; PMID: 18216873; http://dx.doi.org/10.1038/sj.emboj.7601972
  • Bereiter-Hahn J, Jendrach M. Mitochondrial dynamics. Int Rev Cell Mol Biol 2010; 284:1 - 65; PMID: 20875628; http://dx.doi.org/10.1016/S1937-6448(10)84001-8
  • Ono T, Isobe K, Nakada K, Hayashi JI. Human cells are protected from mitochondrial dysfunction by complementation of DNA products in fused mitochondria. Nat Genet 2001; 28:272 - 275; PMID: 11431699; http://dx.doi.org/10.1038/90116
  • Nakada K, Inoue K, Ono T, Isobe K, Ogura A, Goto YI, et al. Intermitochondrial complementation: Mitochondria-specific system preventing mice from expression of disease phenotypes by mutant mtDNA. Nat Med 2001; 7:934 - 940; PMID: 11479626; http://dx.doi.org/10.1038/90976
  • Sato A, Nakada K, Shitara H, Yonekawa H, Hayashi J. In vivo interaction between mitochondria carrying mtDNAs from different mouse species. Genetics 2004; 167:1855 - 1861; PMID: 15342523; http://dx.doi.org/10.1534/genetics.103.021287
  • Busch K, Bereiter-Hahn J, Wittig I, Schägger H, Jendrach M. Mitochondrial dynamics generate equal distribution but patchwork localisation of respiratory complex I. Mol Membr Biol 2006; 23:509 - 520; PMID: 17127623; http://dx.doi.org/10.1080/09687860600877292
  • Malka F, Guillery O, Cifuentes-Diaz C, Guillou E, Belenguer P, Lombès A, et al. Separate fusion of outer and inner mitochondrial membranes. EMBO Rep 2005; 6:853 - 859; PMID: 16113651; http://dx.doi.org/10.1038/sj.embor.7400488
  • Jendrach M, Mai S, Pohl S, Vöth M, Bereiter-Hahn J. Short-and long-term alterations of mitochondrial morphology, dynamics and mtDNA after transient oxidative stress. Mitochondrion 2008; 8:293 - 304; PMID: 18602028; http://dx.doi.org/10.1016/j.mito.2008.06.001
  • Twig G, Elorza A, Molina AJ, Mohamed H, Wikstrom JD, Walzer G, et al. Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. EMBO J 2008; 27:433 - 446; PMID: 18200046; http://dx.doi.org/10.1038/sj.emboj.7601963
  • Gomes LC, Scorrano L. High levels of Fis1, a pro-fission mitochondrial protein, trigger autophagy. Biochim Biophys Acta 2008; 1777:860 - 866
  • Narendra D, Tanaka A, Suen DF, Youle RJ. Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J Cell Biol 2008; 183:795 - 803; PMID: 19029340; http://dx.doi.org/10.1083/jcb.200809125
  • Narendra DP, Jin SM, Tanaka A, Suen DF, Gautier CA, Shen J, et al. PINK1 is selectively stabilized on impaired mitochondria to activate Parkin. PLoS Biol 2010; 8:e1000298; PMID: 20126261; http://dx.doi.org/10.1371/journal.pbio.1000298
  • Hanada T, Noda NN, Satomi Y, Ichimura Y, Fujioka Y, Takao T, et al. The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy. J Biol Chem 2007; 282:37298 - 37302; PMID: 17986448; http://dx.doi.org/10.1074/jbc.C700195200
  • Tanida I, Ueno T, Kominami E. LC3 conjugation system in mammalian autophagy. Int J Biochem Cell Biol 2004; 36:2503 - 2518; PMID: 15325588; http://dx.doi.org/10.1016/j.biocel.2004.05.009
  • Eskelinen EL, Schmidt CK, Neu S, Willenborg M, Fuertes G, Salvador N, et al. Disturbed cholesterol traffic but normal proteolytic function in LAMP-1/LAMP-2 double-deficient fibroblasts. Mol Biol Cell 2004; 15:3132 - 3145; PMID: 15121881; http://dx.doi.org/10.1091/mbc.E04-02-0103
  • Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S. LAMP proteins are required for fusion of lysosomes with phagosomes. EMBO J 2007; 26:313 - 324; PMID: 17245426; http://dx.doi.org/10.1038/sj.emboj.7601511
  • Terman A, Gustafsson B, Brunk UT. Mitochondrial damage and intralysosomal degradation in cellular aging. Mol Aspects Med 2006; 27:471 - 482; PMID: 16973208; http://dx.doi.org/10.1016/j.mam.2006.08.006
  • Jendrach M, Pohl S, Voth M, Kowald A, Hammerstein P, Bereiter-Hahn J. Morpho-dynamic changes of mitochondria during ageing of human endothelial cells. Mech Ageing Dev 2005; 126:813 - 821; PMID: 15888336; http://dx.doi.org/10.1016/j.mad.2005.03.002
  • Mai S, Klinkenberg M, Auburger G, Bereiter-Hahn J, Jendrach M. Drp1 and Fis1 decrease mediates mitochondrial elongation in senescent cells and enhances resistance against oxidative stress via PINK1. J Cell Sci 2010; 124:917 - 927; http://dx.doi.org/10.1242/jcs.059246
  • Simonsen A, Cumming RC, Brech A, Isakson P, Schubert DR, Finley KD. Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila. Autophagy 2008; 4:176 - 184; PMID: 18059160
  • Kiffin R, Bandyopadhyay U, Cuervo AM. Oxidative stress and autophagy. Antioxid Redox Signal 2006; 8:152 - 162; PMID: 16487049; http://dx.doi.org/10.1089/ars.2006.8.152
  • Lamming DW, Latorre-Esteves M, Medvedik O, Wong SN, Tsang FA, Wang C, et al. HST2 mediates SIR2-independent life-span extension by calorie restriction. Science 2005; 309:1861 - 1864; PMID: 16051752; http://dx.doi.org/10.1126/science.1113611
  • Berdichevsky A, Viswanathan M, Horvitz HR, Guarente L. C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span. Cell 2006; 125:1165 - 1177; PMID: 16777605; http://dx.doi.org/10.1016/j.cell.2006.04.036
  • Tullet JM, Hertweck M, An JH, Baker J, Hwang JY, Liu S, et al. Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans. Cell 2008; 132:1025 - 1038; PMID: 18358814; http://dx.doi.org/10.1016/j.cell.2008.01.030
  • Wang PY, Neretti N, Whitaker R, Hosier S, Chang C, Lu D, et al. Long-lived Indy and calorie restriction interact to extend life span. Proc Natl Acad Sci USA 2009; 106:9262 - 9267; PMID: 19470468; http://dx.doi.org/10.1073/pnas.0904115106
  • Cuervo AM, Bergamini E, Brunk UT, Dröge W, Ffrench M, Terman A. Autophagy and aging: the importance of maintaining “clean” cells. Autophagy 2005; 1:131 - 140; PMID: 16874025; http://dx.doi.org/10.4161/auto.1.3.2017
  • Yen WL, Klionsky DJ. How to live long and prosper: autophagy, mitochondria, and aging. Physiology (Bethesda) 2008; 23:248 - 262; PMID: 18927201; http://dx.doi.org/10.1152/physiol.00013.2008
  • Morselli E, Maiuri MC, Markaki M, Megalou E, Pasparaki A, Palikaras K, et al. The life span-prolonging effect of sirtuin-1 is mediated by autophagy. Autophagy 2010; 6:186 - 188; PMID: 20023410; http://dx.doi.org/10.4161/auto.6.1.10817
  • Alvers AL, Wood MS, Hu D, Kaywell AC, Dunn WA, Aris JP. Autophagy is required for extension of yeast chronological life span by rapamycin. Autophagy 2009; 5:847 - 849; PMID: 19458476
  • Young AR, Narita M, Ferreira M, Kirschner K, Sadaie M, Darot JF, et al. Autophagy mediates the mitotic senescence transition. Genes Dev 2009; 23:798 - 803; PMID: 19279323; http://dx.doi.org/10.1101/gad.519709
  • Harman D. The biologic clock: the mitochondria?. J Am Geriatr Soc 1972; 20:145 - 147; PMID: 5016631
  • Strecker V, Mai S, Muster B, Beneke S, Bürkle A, Bereiter-Hahn J, et al. Aging of different avian cultured cells is independent of ROS-induced damage. Mech Ageing Dev 2010; 131:48 - 59; PMID: 19948180; http://dx.doi.org/10.1016/j.mad.2009.11.005
  • Pyo JO, Jang MH, Kwon YK, Lee HJ, Jun JI, Woo HN, et al. Essential roles of Atg5 and FADD in autophagic cell death: dissection of autophagic cell death into vacuole formation and cell death. J Biol Chem 2005; 280:20722 - 20729; PMID: 15778222; http://dx.doi.org/10.1074/jbc.M413934200
  • Jounai N, Takeshita F, Kobiyama K, Sawano A, Miyawaki A, Xin KQ, et al. The Atg5 Atg12 conjugate associates with innate antiviral immune responses. Proc Natl Acad Sci USA 2007; 104:14050 - 14055; PMID: 17709747; http://dx.doi.org/10.1073/pnas.0704014104
  • Unterluggauer H, Hütter E, Voglauer R, Grillari J, Vöth M, Bereiter-Hahn J, et al. Identification of cultivation-independent markers of human endothelial cell senescence in vitro. Biogerontology 2007; 8:383 - 397; PMID: 17377850; http://dx.doi.org/10.1007/s10522-007-9082-x
  • Van Laar VS, Arnold B, Cassady SJ, Chu CT, Burton EA, Berman SB. Bioenergetics of neurons inhibit the translocation response of Parkin following rapid mitochondrial depolarization. Hum Mol Genet 2011; 20:927 - 940; PMID: 21147754; http://dx.doi.org/10.1093/hmg/ddq531
  • Ali F, Ali NS, Bauer A, Boyle JJ, Hamdulay SS, Haskard DO, et al. PPARdelta and PGC1alpha act cooperatively to induce haem oxygenase-1 and enhance vascular endothelial cell resistance to stress. Cardiovasc Res 2010; 85:701 - 710; PMID: 19903700; http://dx.doi.org/10.1093/cvr/cvp365
  • Chen SD, Lin TK, Yang DI, Lee SY, Shaw FZ, Liou CW, et al. Protective effects of peroxisome proliferator-activated receptors gamma coactivator1alpha against neuronal cell death in the hippocampal CA1 subfield after transient global ischemia. J Neurosci Res 2010; 88:605 - 613; PMID: 19774674
  • Wu Z, Puigserver P, Andersson U, Zhang C, Adelmant G, Mootha V, et al. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 1999; 98:115 - 124; PMID: 10412986; http://dx.doi.org/10.1016/S0092-8674(00)80611-X
  • Gutsaeva DR, Carraway MS, Suliman HB, Demchenko IT, Shitara H, Yonekawa H, et al. Transient hypoxia stimulates mitochondrial biogenesis in brain subcortex by a neuronal nitric oxide synthase-dependent mechanism. J Neurosci 2008; 28:2015 - 2024; PMID: 18305236; http://dx.doi.org/10.1523/JNEUROSCI.5654-07.2008
  • Gamboa JL, Andrade FH. Mitochondrial content and distribution changes specific to mouse diaphragm after chronic normobaric hypoxia. Am J Physiol Regul Integr Comp Physiol 2010; 298:R575 - R583; PMID: 20007520; http://dx.doi.org/10.1152/ajpregu.00320.2009
  • Zhu JH, Horbinski C, Guo F, Watkins S, Uchiyama Y, Chu CT. Regulation of autophagy by extracellular signal-regulated protein kinases during 1-methyl-4-phenylpyridinium-induced cell death. Am J Pathol 2007; 170:75 - 86; PMID: 17200184; http://dx.doi.org/10.2353/ajpath.2007.060524
  • Radoshevich L, Murrow L, Chen N, Fernandez E, Roy S, Fung C, et al. ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and cell death. Cell 2010; 142:590 - 600; PMID: 20723759; http://dx.doi.org/10.1016/j.cell.2010.07.018
  • Erusalimsky JD, Kurz DJ. Endothelial cell senescence. Handb Exp Pharmacol 2006; 176:213 - 248; PMID: 17001772; http://dx.doi.org/10.1007/3-540-36028-X_7
  • Anisimov VN, Zabezhinski MA, Popovich IG, Piskunova TS, Semenchenko AV, Tyndyk ML, et al. Rapamycin extends maximal lifespan in cancer-prone mice. Am J Pathol 2010; 176:2092 - 2097; PMID: 20363920; http://dx.doi.org/10.2353/ajpath.2010.091050
  • Andrejewski N, Punnonen EL, Guhde G, Tanaka Y, Lullmann-Rauch R, Hartmann D, et al. Normal lysosomal morphology and function in LAMP-1-deficient mice. J Biol Chem 1999; 274:12692 - 12701; PMID: 10212251; http://dx.doi.org/10.1074/jbc.274.18.12692
  • Wagner M, Hampel B, Bernhard D, Hala M, Zwerschke W, Jansen-Durr P. Replicative senescence of human endothelial cells in vitro involves G1 arrest, polyploidization and senescence-associated apoptosis. Exp Gerontol 2001; 36:1327 - 1347; PMID: 11602208; http://dx.doi.org/10.1016/S0531-5565(01)00105-X
  • Tiwari M, Bajpai VK, Sahasrabuddhe AA, Kumar A, Sinha RA, Behari S, et al. Inhibition of N-(4-hydroxyphenyl)retinamide-induced autophagy at a lower dose enhances cell death in malignant glioma cells. Carcinogenesis 2008; 29:600 - 609; PMID: 18174255; http://dx.doi.org/10.1093/carcin/bgm264
  • Cheng Y, Qiu F, Guo ZM, Tashiro SI, Onodera S, Ikejima TY. Autophagy inhibits reactive oxygen species-mediated apoptosis via activating p38-nuclear factor-kappa B survival pathways in oridonin-treated murine fibrosarcoma L929 cells. FEBS J 2009; 276:1291 - 1306; PMID: 19187231; http://dx.doi.org/10.1111/j.17424658.2008.06864.x
  • Bhutia SK, Dash R, Das SK, Azab B, Su ZZ, Lee SG, et al. Mechanism of autophagy to apoptosis switch triggered in prostate cancer cells by antitumor cytokine melanoma differentiation-associated gene 7/interleukin-24. Cancer Res 2010; 70:3667 - 3676; PMID: 20406981; http://dx.doi.org/10.1158/0008-5472.CAN-09-3647
  • Colell A, Ricci JE, Tait S, Milasta S, Maurer U, Bouchier-Hayes L, et al. GAPDH and autophagy preserve survival after apoptotic cytochrome c release in the absence of caspase activation. Cell 2007; 129:983 - 997; PMID: 17540177; http://dx.doi.org/10.1016/j.cell.2007.03.045
  • Dewaele M, Martinet W, Rubio N, Verfaillie T, de Witte PA, Piette J, et al. Autophagy pathways activated in response to PDT contribute to cell resistance against ROS damage. J Cell Mol Med 2011; 15:1402 - 1414; PMID: 20626525; http://dx.doi.org/10.1111/j.1582-4934.2010.01118.x
  • Yang Y, Xing D, Zhou F, Chen Q. Mitochondrial autophagy protects against heat shock-induced apoptosis through reducing cytosolic cytochrome c release and downstream caspase-3 activation. Biochem Biophys Res Commun 2010; 395:190 - 195; PMID: 20361931; http://dx.doi.org/10.1016/j.bbrc.2010.03.155
  • Trifunovic A, Wredenberg A, Falkenberg M, Spelbrink JN, Rovio AT, Bruder CE, et al. Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature 2004; 429:417 - 423; PMID: 15164064; http://dx.doi.org/10.1038/nature02517
  • Trifunovic A, Hansson A, Wredenberg A, Rovio AT, Dufour E, Khvorostov I, et al. Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production. Proc Natl Acad Sci USA 2005; 102:17993 - 17998; PMID: 16332961; http://dx.doi.org/10.1073/pnas.0508886102
  • Federspiel MJ, Hughes SH. Retroviral gene delivery. Methods Cell Biol 1997; 52:179 - 214; PMID: 9379950; http://dx.doi.org/10.1016/S0091-679X(08)60379-9
  • Santos JH, Mandavilli BS, Van Houten B. Measuring oxidative mtDNA damage and repair using quantitative PCR. Methods Mol Biol 2002; 197:159 - 176; PMID: 12013794