A DNA vaccine targeting p42.3 induces protective antitumor immunity via eliciting cytotoxic CD8⁺T lymphocytes in a murine melanoma model

References

• Flaherty KT, Hodi FS, Fisher DE. From genes to drugs: targeted strategies for melanoma. Nat Rev Cancer 2012; 12:349 - 61; http://dx.doi.org/10.1038/nrc3218; PMID: 22475929
   PubMed Web of Science ®Google Scholar
• Vidwans SJ, Flaherty KT, Fisher DE, Tenenbaum JM, Travers MD, Shrager J. A melanoma molecular disease model. PLoS One 2011; 6:e18257; http://dx.doi.org/10.1371/journal.pone.0018257; PMID: 21479172
   PubMed Web of Science ®Google Scholar
• Pan Z-K, Weiskirch LM, Paterson Y. Regression of established B16F10 melanoma with a recombinant Listeria monocytogenes vaccine. Cancer Res 1999; 59:5264 - 9; PMID: 10537307
   PubMed Web of Science ®Google Scholar
• Zhao F, Dou J, He XF, Wang J, Chu L, Hu W, et al. Enhancing therapy of B16F10 melanoma efficacy through tumor vaccine expressing GPI-anchored IL-21 and secreting GM-CSF in mouse model. Vaccine 2010; 28:2846 - 52; http://dx.doi.org/10.1016/j.vaccine.2010.01.057; PMID: 20153795
   PubMed Web of Science ®Google Scholar
• van den Boorn JG, Konijnenberg D, Tjin EP, Picavet DI, Meeuwenoord NJ, Filippov DV, et al. Effective melanoma immunotherapy in mice by the skin-depigmenting agent monobenzone and the adjuvants imiquimod and CpG. PLoS One 2010; 5:e10626; http://dx.doi.org/10.1371/journal.pone.0010626; PMID: 20498710
   PubMedGoogle Scholar
• Xu X, Li W, Fan X, Liang Y, Zhao M, Zhang J, et al. Identification and characterization of a novel p42.3 gene as tumor-specific and mitosis phase-dependent expression in gastric cancer. Oncogene 2007; 26:7371 - 9; http://dx.doi.org/10.1038/sj.onc.1210538; PMID: 17525738
   PubMed Web of Science ®Google Scholar
• Mao L, Sun W, Li W, Cui J, Zhang J, Xing R, Lu Y. Cell cycle-dependent expression of p42.3 promotes mitotic progression in malignant transformed cells. Mol Carcinog Forthcoming 2012; http://dx.doi.org/10.1002/mc.21982; PMID: 23192843
   PubMed Web of Science ®Google Scholar
• Jung Y, Lee S, Choi H-S, Kim S-N, Lee E, Shin Y, et al. Clinical validation of colorectal cancer biomarkers identified from bioinformatics analysis of public expression data. Clin Cancer Res 2011; 17:700 - 9; http://dx.doi.org/10.1158/1078-0432.CCR-10-1300; PMID: 21304002
   PubMed Web of Science ®Google Scholar
• Zhang J, Lu C, Shang Z, Xing R, Shi L, Lv Y. p42.3 gene expression in gastric cancer cell and its protein regulatory network analysis. Theor Biol Med Model 2012; 9:53; http://dx.doi.org/10.1186/1742-4682-9-53; PMID: 23228105
   PubMed Web of Science ®Google Scholar
• Cui Y, Su W-Y, Xing J, Wang Y-C, Wang P, Chen X-Y, et al. MiR-29a inhibits cell proliferation and induces cell cycle arrest through the downregulation of p42.3 in human gastric cancer. PLoS One 2011; 6:e25872; http://dx.doi.org/10.1371/journal.pone.0025872; PMID: 21998710
   PubMedGoogle Scholar
• Hutchins JR, Toyoda Y, Hegemann B, Poser I, Hériché J-K, Sykora MM, et al. Systematic analysis of human protein complexes identifies chromosome segregation proteins. Science 2010; 328:593 - 9; http://dx.doi.org/10.1126/science.1181348; PMID: 20360068
   PubMed Web of Science ®Google Scholar
• Fioretti D, Iurescia S, Fazio VM, Rinaldi M. DNA vaccines: developing new strategies against cancer. J Biomed Biotechnol 2010; 2010:174378; http://dx.doi.org/10.1155/2010/174378; PMID: 20368780
   PubMed Web of Science ®Google Scholar
• Donnelly JJ, Wahren B, Liu MA. DNA vaccines: progress and challenges. J Immunol 2005; 175:633 - 9; PMID: 16002657
   PubMed Web of Science ®Google Scholar
• Signori E, Iurescia S, Massi E, Fioretti D, Chiarella P, De Robertis M, et al. DNA vaccination strategies for anti-tumour effective gene therapy protocols. Cancer Immunol Immunother 2010; 59:1583 - 91; http://dx.doi.org/10.1007/s00262-010-0853-x; PMID: 20390416
   PubMed Web of Science ®Google Scholar
• Alam S, McNeel DG. DNA vaccines for the treatment of prostate cancer. Expert Rev Vaccines 2010; 9:731 - 45; http://dx.doi.org/10.1586/erv.10.64; PMID: 20624047
   PubMed Web of Science ®Google Scholar
• Kutzler MA, Weiner DB. DNA vaccines: ready for prime time?. Nat Rev Genet 2008; 9:776 - 88; http://dx.doi.org/10.1038/nrg2432; PMID: 18781156
   PubMed Web of Science ®Google Scholar
• Rice J, Ottensmeier CH, Stevenson FK. DNA vaccines: precision tools for activating effective immunity against cancer. Nat Rev Cancer 2008; 8:108 - 20; http://dx.doi.org/10.1038/nrc2326; PMID: 18219306
   PubMed Web of Science ®Google Scholar
• Saade F, Petrovsky N. Technologies for enhanced efficacy of DNA vaccines. Expert Rev Vaccines 2012; 11:189 - 209; http://dx.doi.org/10.1586/erv.11.188; PMID: 22309668
   PubMed Web of Science ®Google Scholar
• Demoulin S, Herfs M, Delvenne P, Hubert P. Tumor microenvironment converts plasmacytoid dendritic cells into immunosuppressive/tolerogenic cells: insight into the molecular mechanisms. J Leukoc Biol 2013; 93:343 - 52; http://dx.doi.org/10.1189/jlb.0812397; PMID: 23136258
   PubMed Web of Science ®Google Scholar
• van Drunen Littel-van den Hurk S, Hannaman D. Electroporation for DNA immunization: clinical application. Expert Rev Vaccines 2010; 9:503 - 17; http://dx.doi.org/10.1586/erv.10.42; PMID: 20450325
   PubMed Web of Science ®Google Scholar
• Sardesai NY, Weiner DB. Electroporation delivery of DNA vaccines: prospects for success. Curr Opin Immunol 2011; 23:421 - 9; http://dx.doi.org/10.1016/j.coi.2011.03.008; PMID: 21530212
   PubMed Web of Science ®Google Scholar
• van Duikeren S, Fransen MF, Redeker A, Wieles B, Platenburg G, Krebber W-J, et al. Vaccine-induced effector-memory CD8+ T cell responses predict therapeutic efficacy against tumors. J Immunol 2012; 189:3397 - 403; http://dx.doi.org/10.4049/jimmunol.1201540; PMID: 22914049
   PubMed Web of Science ®Google Scholar
• Restifo NP, Dudley ME, Rosenberg SA. Adoptive immunotherapy for cancer: harnessing the T cell response. Nat Rev Immunol 2012; 12:269 - 81; http://dx.doi.org/10.1038/nri3191; PMID: 22437939
   PubMed Web of Science ®Google Scholar
• Widera G, Austin M, Rabussay D, Goldbeck C, Barnett SW, Chen M, et al. Increased DNA vaccine delivery and immunogenicity by electroporation in vivo. J Immunol 2000; 164:4635 - 40; PMID: 10779767
   PubMed Web of Science ®Google Scholar
• Luxembourg A, Hannaman D, Ellefsen B, Nakamura G, Bernard R. Enhancement of immune responses to an HBV DNA vaccine by electroporation. Vaccine 2006; 24:4490 - 3; http://dx.doi.org/10.1016/j.vaccine.2005.08.014; PMID: 16140436
   PubMed Web of Science ®Google Scholar
• Low L, Mander A, McCann K, Dearnaley D, Tjelle T, Mathiesen I, et al. DNA vaccination with electroporation induces increased antibody responses in patients with prostate cancer. Hum Gene Ther 2009; 20:1269 - 78; http://dx.doi.org/10.1089/hum.2009.067; PMID: 19619001
   PubMed Web of Science ®Google Scholar
• Gill DR, Pringle IA, Hyde SC. Progress and prospects: the design and production of plasmid vectors. Gene Ther 2009; 16:165 - 71; http://dx.doi.org/10.1038/gt.2008.183; PMID: 19129858
   PubMed Web of Science ®Google Scholar
• Di Carlo E, Comes A, Basso S, De Ambrosis A, Meazza R, Musiani P, et al. The combined action of IL-15 and IL-12 gene transfer can induce tumor cell rejection without T and NK cell involvement. J Immunol 2000; 165:3111 - 8; PMID: 10975824
   PubMed Web of Science ®Google Scholar
• Klebanoff CA, Finkelstein SE, Surman DR, Lichtman MK, Gattinoni L, Theoret MR, et al. IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8+ T cells. Proc Natl Acad Sci U S A 2004; 101:1969 - 74; http://dx.doi.org/10.1073/pnas.0307298101; PMID: 14762166
   PubMed Web of Science ®Google Scholar
• Xu H, Zhao G, Huang X, Ding Z, Wang J, Wang X, et al. CD40-expressing plasmid induces anti-CD40 antibody and enhances immune responses to DNA vaccination. J Gene Med 2010; 12:97 - 106; http://dx.doi.org/10.1002/jgm.1412; PMID: 19950201
   PubMed Web of Science ®Google Scholar
• Zitvogel L, Apetoh L, Ghiringhelli F, Kroemer G. Immunological aspects of cancer chemotherapy. Nat Rev Immunol 2008; 8:59 - 73; http://dx.doi.org/10.1038/nri2216; PMID: 18097448
   PubMed Web of Science ®Google Scholar
• Lundegaard C, Lund O, Keşmir C, Brunak S, Nielsen M. Modeling the adaptive immune system: predictions and simulations. Bioinformatics 2007; 23:3265 - 75; http://dx.doi.org/10.1093/bioinformatics/btm471; PMID: 18045832
   PubMed Web of Science ®Google Scholar
• Zhou G, Parthasarathy G, Somasundaram T, Ables A, Roy L, Strong SJ, et al. Expression, purification from inclusion bodies, and crystal characterization of a transition state analog complex of arginine kinase: a model for studying phosphagen kinases. Protein Sci 1997; 6:444 - 9; http://dx.doi.org/10.1002/pro.5560060222; PMID: 9041648
   PubMed Web of Science ®Google Scholar