Human Vaccines & Immunotherapeutics, Volume 9, Issue 10 (2013)

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Human Vaccines & Immunotherapeutics, Volume 9, Issue 10 (2013)

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Editor's Corner

Editorial
Letter from the Editor
Ronald W. Ellis & Eva M. Riedmann
Page: 2033
Published online: 01 Oct 2013
CitationforLetter from the Editor | PDF (91.7 KB)
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News, Policy & Profiles

News
Human Vaccines & Immunotherapeutics
News
Eva M Riedmann
Pages: 2034-2037
Published online: 18 Oct 2013
AbstractforHuman Vaccines & Immunotherapeutics | Full Text | References | PDF (149.7 KB)
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Editor's Corner

Editorial
DNA vaccines onward and upward! 20 years and counting! Highlights of the DNA Vaccines 2012 Meeting
Kenneth Ugen & David B Weiner
Pages: 2038-2040
Published online: 26 Sep 2013
First Page PreviewforDNA vaccines onward and upward! 20 years and counting! Highlights of the DNA Vaccines 2012 Meeting | Full Text | References | PDF (168.1 KB)
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Research Paper

Article
Electroporation mediated DNA vaccination directly to a mucosal surface results in improved immune responses
Gleb Kichaev, Janess M Mendoza, Dinah Amante, Trevor RF Smith, Jay R McCoy, Niranjan Y Sardesai & Kate E Broderick
Pages: 2041-2048
Published online: 11 Jun 2013
AbstractforElectroporation mediated DNA vaccination directly to a mucosal surface results in improved immune responses | Full Text | References | PDF (1.1 MB)
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Article
Cross reactivity of serum antibody responses elicited by DNA vaccines expressing HA antigens from H1N1 subtype influenza vaccines in the past 30 years
Iman Almansour, Huaiqing Chen, Shixia Wang & Shan Lu
Pages: 2049-2059
Published online: 24 Jul 2013
AbstractforCross reactivity of serum antibody responses elicited by DNA vaccines expressing HA antigens from H1N1 subtype influenza vaccines in the past 30 years | Full Text | References | PDF (2.8 MB)
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Article
Immunization with cross-conserved H1N1 influenza CD4+ T-cell epitopes lowers viral burden in HLA DR3 transgenic mice
Leonard Moise, Ryan Tassone, Howard Latimer, Frances Terry, Lauren Levitz, John P Haran, Ted M Ross, Christine Boyle, William D Martin & Anne S De Groot
Pages: 2060-2068
Published online: 17 Sep 2013
AbstractforImmunization with cross-conserved H1N1 influenza CD4+ T-cell epitopes lowers viral burden in HLA DR3 transgenic mice | Full Text | References | PDF (693 KB) | Supplemental
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Article
Vaccination with Vaxfectin® adjuvanted SIV DNA induces long-lasting humoral immune responses able to reduce SIVmac251 Viremia
Viraj Kulkarni, Margherita Rosati, Antonio Valentin, Rashmi Jalah, Candido Alicea, Lei Yu, Yongjun Guan, Xiaoying Shen, Georgia D Tomaras, Celia LaBranche, David C Montefiori, Carmela Irene, Rajasekhar Prattipati, Abraham Pinter, Sean M Sullivan, George N Pavlakis & Barbara K Felber
Pages: 2069-2080
Published online: 02 Jul 2013
AbstractforVaccination with Vaxfectin® adjuvanted SIV DNA induces long-lasting humoral immune responses able to reduce SIVmac251 Viremia | Full Text | References | PDF (1.5 MB)
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Article
Comparison of intradermal and intramuscular delivery followed by in vivo electroporation of SIV Env DNA in macaques
Viraj Kulkarni, Margherita Rosati, Jenifer Bear, Guy R Pilkington, Rashmi Jalah, Cristina Bergamaschi, Ashish K Singh, Candido Alicea, Bhabadeb Chowdhury, Gen-Mu Zhang, Eun-Young Kim, Steven M Wolinsky, Wensheng Huang, Yongjun Guan, Celia LaBranche, David C Montefiori, Kate E Broderick, Niranjan Y Sardesai, Antonio Valentin, Barbara K Felber & George N Pavlakis
Pages: 2081-2094
Published online: 28 Jun 2013
AbstractforComparison of intradermal and intramuscular delivery followed by in vivo electroporation of SIV Env DNA in macaques | Full Text | References | PDF (1.9 MB)
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Article
Post-translational intracellular trafficking determines the type of immune response elicited by DNA vaccines expressing Gag antigen of Human Immunodeficiency Virus Type 1 (HIV-1)
Aaron Wallace, Kim West, Alan Rothman, Francis Ennis, Shan Lu & Shixia Wang
Pages: 2095-2102
Published online: 13 Aug 2013
AbstractforPost-translational intracellular trafficking determines the type of immune response elicited by DNA vaccines expressing Gag antigen of Human Immunodeficiency Virus Type 1 (HIV-1) | PDF (1.2 MB)
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Article
Short-term HIV-1 treatment interruption is associated with dysregulated TLR-stimuli responsiveness
Salma Nowroozalizadeh, Lindvi Gudmundsdotter, Bo Hejdeman, Lena Andersson, Joakim Esbjörnsson, Patrik Medstrand, Eric Sandström, Hans Gaines, Britta Wahren & Marianne Jansson
Pages: 2103-2110
Published online: 04 Jun 2013
AbstractforShort-term HIV-1 treatment interruption is associated with dysregulated TLR-stimuli responsiveness | Full Text | References | PDF (1.4 MB) | Supplemental
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Article
Oxidative stress induced by HIV-1 reverse transcriptase modulates the enzyme’s performance in gene immunization
Maria Isaguliants, Olga Smirnova, Alexander V. Ivanov, Athina Kilpelainen, Yulia Kuzmenko, Stefan Petkov, Anastasia Latanova, Olga Krotova, Gunnel Engström, Vadim Karpov, Sergey Kochetkov, Britta Wahren & Elizaveta Starodubova
Pages: 2111-2119
Published online: 23 Jul 2013
AbstractforOxidative stress induced by HIV-1 reverse transcriptase modulates the enzyme’s performance in gene immunization | Full Text | References | PDF (2.1 MB) | Supplemental
  • 1056 Views
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Article
DNA vaccine prime followed by boost with live attenuated virus significantly improves antigen-specific T cell responses against human cytomegalovirus
Anna Gil, Siyuan Shen, Scott Coley, Laura Gibson, Don J Diamond, Shixia Wang & Shan Lu
Pages: 2120-2132
Published online: 25 Jul 2013
AbstractforDNA vaccine prime followed by boost with live attenuated virus significantly improves antigen-specific T cell responses against human cytomegalovirus | Full Text | References | PDF (2.1 MB)
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Article
Interleukin-22 as a molecular adjuvant facilitates IL-17-producing CD8+ T cell responses against a HBV DNA vaccine in mice
Bing Wu, Qiang Zou, Yanxin Hu & Bin Wang
Pages: 2133-2141
Published online: 13 Aug 2013
AbstractforInterleukin-22 as a molecular adjuvant facilitates IL-17-producing CD8+ T cell responses against a HBV DNA vaccine in mice | Full Text | References | PDF (1.7 MB)
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Review

Review Article
The current state of tuberculosis vaccines
David A Hokey & Ann Ginsberg
Pages: 2142-2146
Published online: 21 Jun 2013
AbstractforThe current state of tuberculosis vaccines | Full Text | References | PDF (876.6 KB)
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Research Paper

Article
DNA electroporation in rabbits as a method for generation of high-titer neutralizing antisera
Examples of the botulinum toxins types A, B, and E
Aurore Burgain, Alice Rochard, Capucine Trollet, Christelle Mazuet, Michel R Popoff, Virginie Escriou, Daniel Scherman & Pascal Bigey
Pages: 2147-2156
Published online: 22 Jul 2013
AbstractforDNA electroporation in rabbits as a method for generation of high-titer neutralizing antisera | Full Text | References | PDF (1.1 MB)
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Article
Potent monoclonal antibodies against Clostridium difficile toxin A elicited by DNA immunization
Chunhua Zhang, Ke Jin, Yanling Xiao, Ying Cheng, Zuhu Huang, Shixia Wang & Shan Lu
Pages: 2157-2164
Published online: 12 Jul 2013
AbstractforPotent monoclonal antibodies against Clostridium difficile toxin A elicited by DNA immunization | Full Text | References | PDF (1.6 MB)
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Article
Human adenovirus 5-vectored Plasmodium falciparum NMRC-M3V-Ad-PfCA vaccine encoding CSP and AMA1 is safe, well-tolerated and immunogenic but does not protect against controlled human malaria infection
Cindy Tamminga, Martha Sedegah, Santina Maiolatesi, Charlotte Fedders, Sharina Reyes, Anatalio Reyes, Carlos Vasquez, Yolanda Alcorta, Ilin Chuang, Michele Spring, Michael Kavanaugh, Harini Ganeshan, Jun Huang, Maria Belmonte, Esteban Abot, Arnel Belmonte, JoGlenna Banania, Fouzia Farooq, Jittawadee Murphy, Jack Komisar, Nancy O Richie, Jason Bennett, Keith Limbach, Noelle B Patterson, Joseph T Bruder, Meng Shi, Edward Miller, Sheetij Dutta, Carter Diggs, Lorraine A Soisson, Michael R Hollingdale, Judith E Epstein & Thomas L Richie
Pages: 2165-2177
Published online: 04 Jun 2013
AbstractforHuman adenovirus 5-vectored Plasmodium falciparum NMRC-M3V-Ad-PfCA vaccine encoding CSP and AMA1 is safe, well-tolerated and immunogenic but does not protect against controlled human malaria infection | Full Text | References | PDF (973.9 KB)
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Article
A microarray method for identifying tumor antigens by screening a tumor cDNA expression library against cancer sera
Kurt Whittemore & Kathryn Sykes
Pages: 2178-2188
Published online: 12 Jul 2013
AbstractforA microarray method for identifying tumor antigens by screening a tumor cDNA expression library against cancer sera | Full Text | References | PDF (634.1 KB)
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Article
NF-κB activation during intradermal DNA vaccination is essential for eliciting tumor protective antigen-specific CTL responses
Maarten A Ligtenberg, Nicole Rojas-Colonelli, Rolf Kiessling & Alvaro Lladser
Pages: 2189-2195
Published online: 24 Jul 2013
AbstractforNF-κB activation during intradermal DNA vaccination is essential for eliciting tumor protective antigen-specific CTL responses | Full Text | References | PDF (1.4 MB)
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Article
A DNA vaccine targeting p42.3 induces protective antitumor immunity via eliciting cytotoxic CD8+T lymphocytes in a murine melanoma model
Hu Liu, Shuang Geng, Congcong Feng, Xiaoping Xie, Bing Wu, Xuan Chen, Qiang Zou, Shuang Wang, Jiantao Cui, Rui Xing, Wenmei Li, Youyong Lu & Bin Wang
Pages: 2196-2202
Published online: 04 Jun 2013
AbstractforA DNA vaccine targeting p42.3 induces protective antitumor immunity via eliciting cytotoxic CD8+T lymphocytes in a murine melanoma model | Full Text | References | PDF (1.3 MB) | Supplemental
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Article
Use of Staby® technology for development and production of DNA vaccines free of antibiotic resistance gene
Anca Reschner, Sophie Scohy, Gaëlle Vandermeulen, Marc Daukandt, Céline Jacques, Benjamin Michel, Hans Nauwynck, Florence Xhonneux, Véronique Préat, Alain Vanderplasschen & Cédric Szpirer
Pages: 2203-2210
Published online: 04 Jun 2013
AbstractforUse of Staby® technology for development and production of DNA vaccines free of antibiotic resistance gene | Full Text | References | PDF (1.9 MB)
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Article
Antibiotic-free production of a herpes simplex virus 2 DNA vaccine in a high yield cGMP process
Jared Nelson, Stephen Rodriguez, Neil Finlayson, Jim Williams & Aaron Carnes
Pages: 2211-2215
Published online: 30 Jul 2013
AbstractforAntibiotic-free production of a herpes simplex virus 2 DNA vaccine in a high yield cGMP process | Full Text | References | PDF (940.3 KB)
  • 1988 Views
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Review

Review Article
DNA vaccines
A simple DNA sensing matter?
Cevayir Coban, Kouji Kobiyama, Nao Jounai, Miyuki Tozuka & Ken J Ishii
Pages: 2216-2221
Published online: 02 Aug 2013
AbstractforDNA vaccines | Full Text | References | PDF (315.7 KB)
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Research Paper

Article
Mucosal genetic immunization through microsphere–based oral carriers
Rozita Rosli, Nadine Nograles, Aimi Hanafi, Mariana Nor Shamsudin & Syahril Abdullah
Pages: 2222-2227
Published online: 11 Jun 2013
AbstractforMucosal genetic immunization through microsphere–based oral carriers | Full Text | References | PDF (736.8 KB)
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Article
Evaluation of immunogen delivery by DNA immunization using non-invasive bioluminescence imaging
Stefan P Petkov, Frank Heuts, Olga A Krotova, Athina Kilpelainen, Gunnel Engström, Elizaveta S Starodubova & Maria G Isaguliants
Pages: 2228-2236
Published online: 03 Jul 2013
AbstractforEvaluation of immunogen delivery by DNA immunization using non-invasive bioluminescence imaging | Full Text | References | PDF (1.7 MB)
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Article
DNA and protein co-administration induces tolerogenic dendritic cells through DC-SIGN mediated negative signals
Jinyao Li, Shuang Geng, Xiuping Liu, Hu Liu, Huali Jin, Chang-Gong Liu & Bin Wang
Pages: 2237-2245
Published online: 04 Jun 2013
AbstractforDNA and protein co-administration induces tolerogenic dendritic cells through DC-SIGN mediated negative signals | Full Text | References | PDF (1.2 MB)
  • 751 Views
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Article
Tolerability of intramuscular and intradermal delivery by CELLECTRA® adaptive constant current electroporation device in healthy volunteers
Malissa C Diehl, Jessica C Lee, Stephen E Daniels, Pablo Tebas, Amir S Khan, Mary Giffear, Niranjan Y Sardesai & Mark L Bagarazzi
Pages: 2246-2252
Published online: 04 Jun 2013
AbstractforTolerability of intramuscular and intradermal delivery by CELLECTRA® adaptive constant current electroporation device in healthy volunteers | Full Text | References | PDF (871.8 KB)
  • 2809 Views
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Article
Optimized and enhanced DNA plasmid vector based in vivo construction of a neutralizing anti-HIV-1 envelope glycoprotein Fab
Kar Muthumani, Seleeke Flingai, Megan Wise, Colleen Tingey, Kenneth E Ugen & David B Weiner
Pages: 2253-2262
Published online: 17 Sep 2013
AbstractforOptimized and enhanced DNA plasmid vector based in vivo construction of a neutralizing anti-HIV-1 envelope glycoprotein Fab | Full Text | References | PDF (1.5 MB)
  • 1831 Views
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Review

Review Article
A novel, disruptive vaccination technology
Self-adjuvanted RNActive® vaccines
Karl-Josef Kallen, Regina Heidenreich, Margit Schnee, Benjamin Petsch, Thomas Schlake, Andreas Thess, Patrick Baumhof, Birgit Scheel, Sven D Koch & Mariola Fotin-Mleczek
Pages: 2263-2276
Published online: 04 Jun 2013
AbstractforA novel, disruptive vaccination technology | Full Text | References | PDF (4 MB)
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