References
- World Health Organization, Alzheimer's Disease International. Dementia: A public health Priority. 2012. http://apps.who.int/iris/bitstream/10665/75263/1/9789241564458_eng.pdf
- Selkoe DJ. Alzheimer’s disease results from the cerebral accumulation and cytotoxicity of amyloid beta-protein. J Alzheimers Dis 2001; 3:75 - 80; PMID: 12214075
- Li YT, Woodruff-Pak DS, Trojanowski JQ. Amyloid plaques in cerebellar cortex and the integrity of Purkinje cell dendrites. Neurobiol Aging 1994; 15:1 - 9; http://dx.doi.org/10.1016/0197-4580(94)90139-2; PMID: 8159255
- Selkoe DJ. Normal and abnormal biology of the beta-amyloid precursor protein. Annu Rev Neurosci 1994; 17:489 - 517; http://dx.doi.org/10.1146/annurev.ne.17.030194.002421; PMID: 8210185
- Thal DR, Rüb U, Orantes M, Braak H. Phases of A beta-deposition in the human brain and its relevance for the development of AD. Neurology 2002; 58:1791 - 800; http://dx.doi.org/10.1212/WNL.58.12.1791; PMID: 12084879
- Fukutani Y, Cairns NJ, Rossor MN, Lantos PL. Cerebellar pathology in sporadic and familial Alzheimer’s disease including APP 717 (Val-->Ile) mutation cases: a morphometric investigation. J Neurol Sci 1997; 149:177 - 84; http://dx.doi.org/10.1016/S0022-510X(97)05399-9; PMID: 9171327
- Lemere CA, Lopera F, Kosik KS, Lendon CL, Ossa J, Saido TC, et al. The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology. Nat Med 1996; 2:1146 - 50; http://dx.doi.org/10.1038/nm1096-1146; PMID: 8837617
- Giaccone G, Morbin M, Moda F, Botta M, Mazzoleni G, Uggetti A, et al. Neuropathology of the recessive A673V APP mutation: Alzheimer disease with distinctive features. Acta Neuropathol 2010; 120:803 - 12; http://dx.doi.org/10.1007/s00401-010-0747-1; PMID: 20842367
- Sepulveda-Falla D, Matschke J, Bernreuther C, Hagel C, Puig B, Villegas A, et al. Deposition of hyperphosphorylated tau in cerebellum of PS1 E280A Alzheimer’s disease. Brain Pathol 2011; 21:452 - 63; http://dx.doi.org/10.1111/j.1750-3639.2010.00469.x; PMID: 21159009
- Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, Kayed R, et al. Triple-transgenic model of Alzheimer’s disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron 2003; 39:409 - 21; http://dx.doi.org/10.1016/S0896-6273(03)00434-3; PMID: 12895417
- Clinton LK, Billings LM, Green KN, Caccamo A, Ngo J, Oddo S, et al. Age-dependent sexual dimorphism in cognition and stress response in the 3xTg-AD mice. Neurobiol Dis 2007; 28:76 - 82; http://dx.doi.org/10.1016/j.nbd.2007.06.013; PMID: 17659878
- Mastrangelo MA, Bowers WJ. Detailed immunohistochemical characterization of temporal and spatial progression of Alzheimer’s disease-related pathologies in male triple-transgenic mice. BMC Neurosci 2008; 9:81; http://dx.doi.org/10.1186/1471-2202-9-81; PMID: 18700006
- Alzheimer's Disease International. World Alzheimer Report 2011: The benefits of early diagnosis and intervention. 2011. www.alz.co.uk/research/WorldAlzheimerReport2011.pdf
- Carroll JC, Rosario ER, Kreimer S, Villamagna A, Gentzschein E, Stanczyk FZ, et al. Sex differences in β-amyloid accumulation in 3xTg-AD mice: role of neonatal sex steroid hormone exposure. Brain Res 2010; 1366:233 - 45; http://dx.doi.org/10.1016/j.brainres.2010.10.009; PMID: 20934413
- Giménez-Llort L, Rivera-Hernández G, Marín-Argany M, Sánchez-Quesada JL, Villegas S. Early intervention in the 3xTg-AD mice with an amyloid β-antibody fragment ameliorates first hallmarks of Alzheimer disease. MAbs 2013; 5 In press
- Marín-Argany M, Rivera-Hernández G, Martí J, Villegas S. An anti-Aβ (amyloid β) single-chain variable fragment prevents amyloid fibril formation and cytotoxicity by withdrawing Aβ oligomers from the amyloid pathway. Biochem J 2011; 437:25 - 34; http://dx.doi.org/10.1042/BJ20101712; PMID: 21501114
- Panza F, Frisardi V, Imbimbo BP, Seripa D, Paris F, Santamato A, et al. Anti-β-amyloid immunotherapy for Alzheimer’s disease: focus on bapineuzumab. Curr Alzheimer Res 2011; 8:808 - 17; http://dx.doi.org/10.2174/156720511798192718; PMID: 21592055
- Panza F, Frisardi V, Solfrizzi V, Imbimbo BP, Logroscino G, Santamato A, et al. Immunotherapy for Alzheimer's disease: From anti-beta-amyloid to tau-based immunization strategies. Immunotherapy 2012.
- Oddo S, Caccamo A, Kitazawa M, Tseng BP, LaFerla FM. Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer’s disease. Neurobiol Aging 2003; 24:1063 - 70; http://dx.doi.org/10.1016/j.neurobiolaging.2003.08.012; PMID: 14643377
- Lomoio S, López-González I, Aso E, Carmona M, Torrejón-Escribano B, Scherini E, et al. Cerebellar amyloid-β plaques: disturbed cortical circuitry in AßPP/PS1 transgenic mice as a model of familial Alzheimer’s disease. J Alzheimers Dis 2012; 31:285 - 300; PMID: 22561329
- Heath RG, Harper JW. Ascending projections of the cerebellar fastigial nucleus to the hippocampus, amygdala, and other temporal lobe sites: evoked potential and histological studies in monkeys and cats. Exp Neurol 1974; 45:268 - 87; http://dx.doi.org/10.1016/0014-4886(74)90118-6; PMID: 4422320
- Delgado-García JM. [Structure and function of the cerebellum] Rev Neurol 2001; 33:635 - 42; PMID: 11784952
- Cattepoel S, Hanenberg M, Kulic L, Nitsch RM. Chronic intranasal treatment with an anti-Aβ(30-42) scFv antibody ameliorates amyloid pathology in a transgenic mouse model of Alzheimer’s disease. PLoS ONE 2011; 6:e18296; http://dx.doi.org/10.1371/journal.pone.0018296; PMID: 21483675
- Rivera-Hernández G, Marín-Argany M, Blasco-Moreno B, Bonet J, Oliva B, Villegas S. Elongation of the C-terminal domain of an anti-amyloid β single-chain variable fragment increases its thermodynamic stability and decreases its aggregation tendency. MAbs 2013; 5 In press
- Giménez-Llort L, Blázquez G, Cañete T, Rosa R, Vivó M, Oddo S, et al. Modeling neuropsychiatric symptoms of Alzheimer’s disease dementia in 3xTg-AD mice. In: Alzheimer’s Disease: New Advances. Iqbal K, Winblad B, Avila J, eds. Pianoro (BO), Italy: Medimond SRL,eds., 2006:513-516.
- Martí J, Santa-Cruz MC, Serra R, Valero O, Molina V, Hervás JP, et al. Principal component and cluster analysis of morphological variables reveals multiple discrete sub-phenotypes in weaver mouse mutants. Cerebellum 2013; 12:406 - 17; http://dx.doi.org/10.1007/s12311-012-0429-8; PMID: 23179325