1,904
Views
25
CrossRef citations to date
0
Altmetric
Report

Co-transplantation of human hematopoietic stem cells and human breast cancer cells in NSG mice

A novel approach to generate tumor cell specific human antibodies

, , , , , & show all
Pages 968-977 | Received 30 Jan 2014, Accepted 05 May 2014, Published online: 08 May 2014

References

  • Harris M. Monoclonal antibodies as therapeutic agents for cancer. Lancet Oncol 2004; 5:292 - 302; http://dx.doi.org/10.1016/S1470-2045(04)01467-6; PMID: 15120666
  • Dalle S, Thieblemont C, Thomas L, Dumontet C. Monoclonal antibodies in clinical oncology. Anticancer Agents Med Chem 2008; 8:523 - 32; http://dx.doi.org/10.2174/187152008784533071; PMID: 18537534
  • Hudis CA. Trastuzumab--mechanism of action and use in clinical practice. N Engl J Med 2007; 357:39 - 51; http://dx.doi.org/10.1056/NEJMra043186; PMID: 17611206
  • Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, McGuire WL. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 1987; 235:177 - 82; http://dx.doi.org/10.1126/science.3798106; PMID: 3798106
  • Lan KH, Lu CH, Yu D. Mechanisms of trastuzumab resistance and their clinical implications. Ann N Y Acad Sci 2005; 1059:70 - 5; http://dx.doi.org/10.1196/annals.1339.026; PMID: 16382045
  • Köhler G, Milstein C. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 1975; 256:495 - 7; http://dx.doi.org/10.1038/256495a0; PMID: 1172191
  • Sgro C. Side-effects of a monoclonal antibody, muromonab CD3/orthoclone OKT3: bibliographic review. Toxicology 1995; 105:23 - 9; http://dx.doi.org/10.1016/0300-483X(95)03123-W; PMID: 8638282
  • Khazaeli MB, Conry RM, LoBuglio AF. Human immune response to monoclonal antibodies. J Immunother Emphasis Tumor Immunol 1994; 15:42 - 52; http://dx.doi.org/10.1097/00002371-199401000-00006; PMID: 8110730
  • Hwang WY, Foote J. Immunogenicity of engineered antibodies. Methods 2005; 36:3 - 10; http://dx.doi.org/10.1016/j.ymeth.2005.01.001; PMID: 15848070
  • Brüggemann M, Winter G, Waldmann H, Neuberger MS. The immunogenicity of chimeric antibodies. J Exp Med 1989; 170:2153 - 7; http://dx.doi.org/10.1084/jem.170.6.2153; PMID: 2584938
  • Mirick GR, Bradt BM, Denardo SJ, Denardo GL. A review of human anti-globulin antibody (HAGA, HAMA, HACA, HAHA) responses to monoclonal antibodies. Not four letter words. Q J Nucl Med Mol Imaging 2004; 48:251 - 7; PMID: 15640788
  • Nakanishi T, Tsumoto K, Yokota A, Kondo H, Kumagai I. Critical contribution of VH-VL interaction to reshaping of an antibody: the case of humanization of anti-lysozyme antibody, HyHEL-10. Protein Sci 2008; 17:261 - 70; http://dx.doi.org/10.1110/ps.073156708; PMID: 18227432
  • Nakanishi T, Maru T, Tahara K, Sanada H, Umetsu M, Asano R, Kumagai I. Development of an affinity-matured humanized anti-epidermal growth factor receptor antibody for cancer immunotherapy. Protein Eng Des Sel 2013; 26:113 - 22; http://dx.doi.org/10.1093/protein/gzs088; PMID: 23118340
  • Queen C, Schneider WP, Selick HE, Payne PW, Landolfi NF, Duncan JF, Avdalovic NM, Levitt M, Junghans RP, Waldmann TA. A humanized antibody that binds to the interleukin 2 receptor. Proc Natl Acad Sci U S A 1989; 86:10029 - 33; http://dx.doi.org/10.1073/pnas.86.24.10029; PMID: 2513570
  • Yoon SO, Lee TS, Kim SJ, Jang MH, Kang YJ, Park JH, Kim KS, Lee HS, Ryu CJ, Gonzales NR, et al. Construction, affinity maturation, and biological characterization of an anti-tumor-associated glycoprotein-72 humanized antibody. J Biol Chem 2006; 281:6985 - 92; http://dx.doi.org/10.1074/jbc.M511165200; PMID: 16407221
  • Wege AK, Ernst W, Vollmann-Zwerenz A, Männel DN, Ortmann O, Kroemer A, Brockhoff G. Humanized tumor mice--a new model to study and manipulate the immune response in advanced cancer therapy. Int J Cancer 2011; 129:2194 - 206; http://dx.doi.org/10.1002/ijc.26159; PMID: 21544806
  • Wege AK, Schardt K, Schaefer S, Brockhoff G, Jung EM. High resolution ultrasound including elastography and contrast-enhanced ultrasound (CEUS) for early detection and characterization of liver lesions in the humanized tumor mouse model. Clin Hemorheol Microcirc 2012; 52:93 - 106; PMID: 22975935
  • Brehm MA, Jouvet N, Greiner DL, Shultz LD. Humanized mice for the study of infectious diseases. Curr Opin Immunol 2013; 25:428 - 35; http://dx.doi.org/10.1016/j.coi.2013.05.012; PMID: 23751490
  • Macchiarini F, Manz MG, Palucka AK, Shultz LD. Humanized mice: are we there yet?. J Exp Med 2005; 202:1307 - 11; http://dx.doi.org/10.1084/jem.20051547; PMID: 16301740
  • Ernst W, Zimara N, Hanses F, Männel DN, Seelbach-Göbel B, Wege AK. Humanized mice, a new model to study the influence of drug treatment on neonatal sepsis. Infect Immun 2013; 81:1520 - 31; http://dx.doi.org/10.1128/IAI.01235-12; PMID: 23439310
  • Schmidt M, Micke P, Gehrmann M, Hengstler JG. Immunoglobulin kappa chain as an immunologic biomarker of prognosis and chemotherapy response in solid tumors. Oncoimmunology 2012; 1:1156 - 8; http://dx.doi.org/10.4161/onci.21653; PMID: 23170262
  • Kitchen S, Krutzik S, Levin B, Rezek V, Kitchen C, Zack J. Ligation of CD4 on human blood monocytes triggers macrophage differentiation. J Immunol 2011; 186:158
  • Tanaka S, Saito Y, Kunisawa J, Kurashima Y, Wake T, Suzuki N, Shultz LD, Kiyono H, Ishikawa F. Development of mature and functional human myeloid subsets in hematopoietic stem cell-engrafted NOD/SCID/IL2rγKO mice. J Immunol 2012; 188:6145 - 55; http://dx.doi.org/10.4049/jimmunol.1103660; PMID: 22611244
  • Chen Q, He F, Kwang J, Chan JK, Chen J. GM-CSF and IL-4 stimulate antibody responses in humanized mice by promoting T, B, and dendritic cell maturation. J Immunol 2012; 189:5223 - 9; http://dx.doi.org/10.4049/jimmunol.1201789; PMID: 23089398
  • Chen Q, Khoury M, Chen J. Expression of human cytokines dramatically improves reconstitution of specific human-blood lineage cells in humanized mice. Proc Natl Acad Sci U S A 2009; 106:21783 - 8; http://dx.doi.org/10.1073/pnas.0912274106; PMID: 19966223
  • Billerbeck E, Barry WT, Mu K, Dorner M, Rice CM, Ploss A. Development of human CD4+FoxP3+ regulatory T cells in human stem cell factor-, granulocyte-macrophage colony-stimulating factor-, and interleukin-3-expressing NOD-SCID IL2Rγ(null) humanized mice. Blood 2011; 117:3076 - 86; http://dx.doi.org/10.1182/blood-2010-08-301507; PMID: 21252091
  • Nicolini FE, Cashman JD, Hogge DE, Humphries RK, Eaves CJ. NOD/SCID mice engineered to express human IL-3, GM-CSF and Steel factor constitutively mobilize engrafted human progenitors and compromise human stem cell regeneration. Leukemia 2004; 18:341 - 7; http://dx.doi.org/10.1038/sj.leu.2403222; PMID: 14628073
  • Willinger T, Rongvaux A, Takizawa H, Yancopoulos GD, Valenzuela DM, Murphy AJ, Auerbach W, Eynon EE, Stevens S, Manz MG, et al. Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung. Proc Natl Acad Sci U S A 2011; 108:2390 - 5; http://dx.doi.org/10.1073/pnas.1019682108; PMID: 21262803
  • Manz MG. Human-hemato-lymphoid-system mice: opportunities and challenges. Immunity 2007; 26:537 - 41; http://dx.doi.org/10.1016/j.immuni.2007.05.001; PMID: 17521579
  • Shi Y, Liu CH, Roberts AI, Das J, Xu G, Ren G, Zhang Y, Zhang L, Yuan ZR, Tan HS, et al. Granulocyte-macrophage colony-stimulating factor (GM-CSF) and T-cell responses: what we do and don’t know. Cell Res 2006; 16:126 - 33; http://dx.doi.org/10.1038/sj.cr.7310017; PMID: 16474424
  • Eichbaum C, Meyer AS, Wang N, Bischofs E, Steinborn A, Bruckner T, Brodt P, Sohn C, Eichbaum MH. Breast cancer cell-derived cytokines, macrophages and cell adhesion: implications for metastasis. Anticancer Res 2011; 31:3219 - 27; PMID: 21965729
  • Asano S, Urabe A, Okabe T, Sato N, Kondo Y. Demonstration of granulopoietic factor(s) in the plasma of nude mice transplanted with a human lung cancer and in the tumor tissue. Blood 1977; 49:845 - 52; PMID: 300638
  • Suda T, Miura Y, Mizoguchi H, Kubota K, Takaku F. A case of lung cancer associated with granulocytosis and production of colony-stimulating activity by the tumour. Br J Cancer 1980; 41:980 - 4; http://dx.doi.org/10.1038/bjc.1980.177; PMID: 6968569
  • Shijubo N, Inoue Y, Hirasawa M, Igarashi T, Mori M, Matsuura A, Uede T, Suzuki A. Granulocyte colony-stimulating factor-producing large cell undifferentiated carcinoma of the lung. Intern Med 1992; 31:277 - 80; http://dx.doi.org/10.2169/internalmedicine.31.277; PMID: 1376180
  • Chavey C, Bibeau F, Gourgou-Bourgade S, Burlinchon S, Boissière F, Laune D, Roques S, Lazennec G. Oestrogen receptor negative breast cancers exhibit high cytokine content. Breast Cancer Res 2007; 9:R15; http://dx.doi.org/10.1186/bcr1648; PMID: 17261184
  • Huntington ND, Alves NL, Legrand N, Lim A, Strick-Marchand H, Mention JJ, Plet A, Weijer K, Jacques Y, Becker PD, et al. IL-15 transpresentation promotes both human T-cell reconstitution and T-cell-dependent antibody responses in vivo. Proc Natl Acad Sci U S A 2011; 108:6217 - 22; http://dx.doi.org/10.1073/pnas.1019167108; PMID: 21444793
  • De Giovanni C, Nicoletti G, Landuzzi L, Romani F, Croci S, Palladini A, Murgo A, Antognoli A, Ianzano ML, Stivani V, et al. Human responses against HER-2-positive cancer cells in human immune system-engrafted mice. Br J Cancer 2012; 107:1302 - 9; http://dx.doi.org/10.1038/bjc.2012.394; PMID: 22929887
  • Vuyyuru R, Patton J, Manser T. Human immune system mice: current potential and limitations for translational research on human antibody responses. Immunol Res 2011; 51:257 - 66; http://dx.doi.org/10.1007/s12026-011-8243-9; PMID: 22038527
  • Traggiai E, Chicha L, Mazzucchelli L, Bronz L, Piffaretti JC, Lanzavecchia A, Manz MG. Development of a human adaptive immune system in cord blood cell-transplanted mice. Science 2004; 304:104 - 7; http://dx.doi.org/10.1126/science.1093933; PMID: 15064419
  • Ito R, Shiina M, Saito Y, Tokuda Y, Kametani Y, Habu S. Antigen-specific antibody production of human B cells in NOG mice reconstituted with the human immune system. Curr Top Microbiol Immunol 2008; 324:95 - 107; http://dx.doi.org/10.1007/978-3-540-75647-7_6; PMID: 18481455
  • Ishikawa F, Yasukawa M, Lyons B, Yoshida S, Miyamoto T, Yoshimoto G, Watanabe T, Akashi K, Shultz LD, Harada M. Development of functional human blood and immune systems in NOD/SCID/IL2 receptor gamma chain(null) mice. Blood 2005; 106:1565 - 73; http://dx.doi.org/10.1182/blood-2005-02-0516; PMID: 15920010
  • Choi B, Chun E, Kim M, Kim ST, Yoon K, Lee KY, Kim SJ. Human B cell development and antibody production in humanized NOD/SCID/IL-2Rγ(null) (NSG) mice conditioned by busulfan. J Clin Immunol 2011; 31:253 - 64; http://dx.doi.org/10.1007/s10875-010-9478-2; PMID: 20981478
  • Rajesh D, Zhou Y, Jankowska-Gan E, Roenneburg DA, Dart ML, Torrealba J, Burlingham WJ. Th1 and Th17 immunocompetence in humanized NOD/SCID/IL2rgammanull mice. Hum Immunol 2010; 71:551 - 9; http://dx.doi.org/10.1016/j.humimm.2010.02.019; PMID: 20298731
  • Scheeren FA, Nagasawa M, Weijer K, Cupedo T, Kirberg J, Legrand N, Spits H. T cell-independent development and induction of somatic hypermutation in human IgM+ IgD+ CD27+ B cells. J Exp Med 2008; 205:2033 - 42; http://dx.doi.org/10.1084/jem.20070447; PMID: 18695003
  • Becker PD, Legrand N, van Geelen CM, Noerder M, Huntington ND, Lim A, Yasuda E, Diehl SA, Scheeren FA, Ott M, et al. Generation of human antigen-specific monoclonal IgM antibodies using vaccinated “human immune system” mice. PLoS One 2010; 5:5; http://dx.doi.org/10.1371/journal.pone.0013137; PMID: 20957227
  • Ippolito GC, Hoi KH, Reddy ST, Carroll SM, Ge X, Rogosch T, Zemlin M, Shultz LD, Ellington AD, Vandenberg CL, et al. Antibody repertoires in humanized NOD-scid-IL2Rγ(null) mice and human B cells reveals human-like diversification and tolerance checkpoints in the mouse. PLoS One 2012; 7:e35497; http://dx.doi.org/10.1371/journal.pone.0035497; PMID: 22558161
  • Kuruvilla JG, Troyer RM, Devi S, Akkina R. Dengue virus infection and immune response in humanized RAG2(-/-)gamma(c)(-/-) (RAG-hu) mice. Virology 2007; 369:143 - 52; http://dx.doi.org/10.1016/j.virol.2007.06.005; PMID: 17707071
  • Seung E, Tager AM. Humoral immunity in humanized mice: a work in progress. J Infect Dis 2013; 208:Suppl 2 S155 - 9; http://dx.doi.org/10.1093/infdis/jit448; PMID: 24151323
  • Karpas A, Dremucheva A, Czepulkowski BH. A human myeloma cell line suitable for the generation of human monoclonal antibodies. Proc Natl Acad Sci U S A 2001; 98:1799 - 804; http://dx.doi.org/10.1073/pnas.98.4.1799; PMID: 11172031
  • Schuster U, Büttner R, Hofstädter F, Knüchel R. A heterologous in vitro coculture system to study interaction between human bladder cancer cells and fibroblasts. J Urol 1994; 151:1707 - 11; PMID: 8189601

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.