Plasmacytoid dendritic cells and their therapeutic activity in cancer

References

• GeurtsvanKessel CH, Lambrecht BN. Division of labor between dendritic cell subsets of the lung. Mucosal Immunol 2008; 1:442 - 50; http://dx.doi.org/10.1038/mi.2008.39; PMID: 19079211
   PubMed Web of Science ®Google Scholar
• Sozzani S, Vermi W, Del Prete A, Facchetti F. Trafficking properties of plasmacytoid dendritic cells in health and disease. Trends Immunol 2010; 31:270 - 7; http://dx.doi.org/10.1016/j.it.2010.05.004; PMID: 20579936
   PubMed Web of Science ®Google Scholar
• Ghosh HS, Cisse B, Bunin A, Lewis KL, Reizis B. Continuous expression of the transcription factor e2-2 maintains the cell fate of mature plasmacytoid dendritic cells. Immunity 2010; 33:905 - 16; http://dx.doi.org/10.1016/j.immuni.2010.11.023; PMID: 21145760
   PubMed Web of Science ®Google Scholar
• Henri S, Vremec D, Kamath A, Waithman J, Williams S, Benoist C, et al. The dendritic cell populations of mouse lymph nodes. J Immunol 2001; 167:741 - 8; PMID: 11441078
   PubMed Web of Science ®Google Scholar
• Yoneyama H, Matsuno K, Zhang Y, Nishiwaki T, Kitabatake M, Ueha S, et al. Evidence for recruitment of plasmacytoid dendritic cell precursors to inflamed lymph nodes through high endothelial venules. Int Immunol 2004; 16:915 - 28; http://dx.doi.org/10.1093/intimm/dxh093; PMID: 15159375
   PubMed Web of Science ®Google Scholar
• Colonna M, Trinchieri G, Liu YJ. Plasmacytoid dendritic cells in immunity. Nat Immunol 2004; 5:1219 - 26; http://dx.doi.org/10.1038/ni1141; PMID: 15549123
   PubMed Web of Science ®Google Scholar
• Sorrentino R, Morello S, Pinto A. Role of plasmacytoid dendritic cells in lung-associated inflammation. Recent Pat Inflamm Allergy Drug Discov 2010; 4:138 - 43; http://dx.doi.org/10.2174/187221310791163062; PMID: 20394583
   PubMedGoogle Scholar
• Yoneyama H, Matsuno K, Zhang Y, Nishiwaki T, Kitabatake M, Ueha S, et al. Evidence for recruitment of plasmacytoid dendritic cell precursors to inflamed lymph nodes through high endothelial venules. Int Immunol 2004; 16:915 - 28; http://dx.doi.org/10.1093/intimm/dxh093; PMID: 15159375
   PubMed Web of Science ®Google Scholar
• Penna G, Sozzani S, Adorini L. Cutting edge: selective usage of chemokine receptors by plasmacytoid dendritic cells. J Immunol 2001; 167:1862 - 6; PMID: 11489962
   PubMed Web of Science ®Google Scholar
• Vanbervliet B, Bendriss-Vermare N, Massacrier C, Homey B, de Bouteiller O, Brière F, et al. The inducible CXCR3 ligands control plasmacytoid dendritic cell responsiveness to the constitutive chemokine stromal cell-derived factor 1 (SDF-1)/CXCL12. J Exp Med 2003; 198:823 - 30; http://dx.doi.org/10.1084/jem.20020437; PMID: 12953097
   PubMed Web of Science ®Google Scholar
• Lande R, Gilliet M. Plasmacytoid dendritic cells: key players in the initiation and regulation of immune responses. Ann N Y Acad Sci 2010; 1183:89 - 103; http://dx.doi.org/10.1111/j.1749-6632.2009.05152.x; PMID: 20146710
   PubMed Web of Science ®Google Scholar
• Zou W, Machelon V, Coulomb-L’Hermin A, Borvak J, Nome F, Isaeva T, et al. Stromal-derived factor-1 in human tumors recruits and alters the function of plasmacytoid precursor dendritic cells. Nat Med 2001; 7:1339 - 46; http://dx.doi.org/10.1038/nm1201-1339; PMID: 11726975
   PubMed Web of Science ®Google Scholar
• Penna G, Volcano M, Sozzani S, Adorini L. Differential migration Behavior and chemokine production by myeloid and plasmacytoid Dendridic cells. Hum Immunol 2002; 36:1164 - 71; http://dx.doi.org/10.1016/S0198-8859(02)00755-3
   Web of Science ®Google Scholar
• Xu H, Zhang GX, Ciric B, Rostami A. IDO: a double-edged sword for T(H)1/T(H)2 regulation. Immunol Lett 2008; 121:1 - 6; http://dx.doi.org/10.1016/j.imlet.2008.08.008; PMID: 18824197
   PubMed Web of Science ®Google Scholar
• Diebold SS, Kaisho T, Hemmi H, Akira S, Reis e Sousa C. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 2004; 303:1529 - 31; http://dx.doi.org/10.1126/science.1093616; PMID: 14976261
   PubMed Web of Science ®Google Scholar
• Gilliet M, Cao W, Liu Y-J. Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases. Nat Rev Immunol 2008; 8:594 - 606; http://dx.doi.org/10.1038/nri2358; PMID: 18641647
   PubMed Web of Science ®Google Scholar
• Hirsch I, Caux C, Hasan U, Bendriss-Vermare N, Olive D. Impaired Toll-like receptor 7 and 9 signaling: from chronic viral infections to cancer. Trends Immunol 2010; 31:391 - 7; http://dx.doi.org/10.1016/j.it.2010.07.004; PMID: 20832362
   PubMed Web of Science ®Google Scholar
• Liu YJ. IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. Annu Rev Immunol 2005; 23:275 - 306; http://dx.doi.org/10.1146/annurev.immunol.23.021704.115633; PMID: 15771572
   PubMed Web of Science ®Google Scholar
• Swiecki M, Wang Y, Vermi W, Gilfillan S, Schreiber RD, Colonna M. Type I interferon negatively controls plasmacytoid dendritic cell numbers in vivo. J Exp Med 2011; 208:2367 - 74; http://dx.doi.org/10.1084/jem.20110654; PMID: 22084408
   PubMed Web of Science ®Google Scholar
• Blasius AL, Colonna M. Sampling and signaling in plasmacytoid dendritic cells: the potential roles of Siglec-H. Trends Immunol 2006; 27:255 - 60; http://dx.doi.org/10.1016/j.it.2006.04.005; PMID: 16679063
   PubMed Web of Science ®Google Scholar
• Kassner N, Krueger M, Yagita H, Dzionek A, Hutloff A, Kroczek R, et al. Cutting edge: Plasmacytoid dendritic cells induce IL-10 production in T cells via the Delta-like-4/Notch axis. J Immunol 2010; 184:550 - 4; http://dx.doi.org/10.4049/jimmunol.0903152; PMID: 20008296
   PubMed Web of Science ®Google Scholar
• Boonstra A, Rajsbaum R, Holman M, Marques R, Asselin-Paturel C, Pereira JP, et al. Macrophages and myeloid dendritic cells, but not plasmacytoid dendritic cells, produce IL-10 in response to MyD88- and TRIF-dependent TLR signals, and TLR-independent signals. J Immunol 2006; 177:7551 - 8; PMID: 17114424
   PubMed Web of Science ®Google Scholar
• Drobits B, Holcmann M, Amberg N, Swiecki M, Grundtner R, Hammer M, et al. Imiquimod clears tumors in mice independent of adaptive immunity by converting pDCs into tumor-killing effector cells. J Clin Invest 2012; 122:575 - 85; http://dx.doi.org/10.1172/JCI61034; PMID: 22251703
   PubMed Web of Science ®Google Scholar
• Kalb ML, Glaser A, Stary G, Koszik F, Stingl G. TRAIL(+) human plasmacytoid dendritic cells kill tumor cells in vitro: mechanisms of imiquimod- and IFN-α-mediated antitumor reactivity. J Immunol 2012; 188:1583 - 91; http://dx.doi.org/10.4049/jimmunol.1102437; PMID: 22231699
   PubMed Web of Science ®Google Scholar
• Dzionek A, Sohma Y, Nagafune J, Cella M, Colonna M, Facchetti F, et al. BDCA-2 a novel plasmacytoid cell-specific tipe II C-type of lectin, mediates antigen capture and is a potent inhibitor of interferon a/B induction. J Exp Med 2001; 194:1823 - 34; http://dx.doi.org/10.1084/jem.194.12.1823; PMID: 11748283
   PubMed Web of Science ®Google Scholar
• Swiecki M, Gilfillan S, Vermi W, Wang Y, Colonna M. Plasmacytoid dendritic cell ablation impacts early interferon responses and antiviral NK and CD8(+) T cell accrual. Immunity 2010; 33:955 - 66; http://dx.doi.org/10.1016/j.immuni.2010.11.020; PMID: 21130004
   PubMed Web of Science ®Google Scholar
• Takagi H, Fukaya T, Eizumi K, Sato Y, Sato K, Shibazaki A, et al. Plasmacytoid dendritic cells are crucial for the initiation of inflammation and T cell immunity in vivo. Immunity 2011; 35:958 - 71; http://dx.doi.org/10.1016/j.immuni.2011.10.014; PMID: 22177923
   PubMed Web of Science ®Google Scholar
• Asselin-Paturel C, Brizard G, Pin JJ, Brière F, Trinchieri G. Mouse strain differences in plasmacytoid dendritic cell frequency and function revealed by a novel monoclonal antibody. J Immunol 2003; 171:6466 - 77; PMID: 14662846
   PubMed Web of Science ®Google Scholar
• Blasius AL, Giurisato E, Cella M, Schreiber RD, Shaw AS, Colonna M. Bone marrow stromal cell antigen 2 is a specific marker of type I IFN-producing cells in the naive mouse, but a promiscuous cell surface antigen following IFN stimulation. J Immunol 2006; 177:3260 - 5; PMID: 16920966
   PubMed Web of Science ®Google Scholar
• Krug A, French AR, Barchet W, Fischer JA, Dzionek A, Pingel JT, et al. TLR9-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function. Immunity 2004; 21:107 - 19; http://dx.doi.org/10.1016/j.immuni.2004.06.007; PMID: 15345224
   PubMed Web of Science ®Google Scholar
• Asselin-Paturel C, Trinchieri G. Production of type I interferons: plasmacytoid dendritic cells and beyond. J Exp Med 2005; 202:461 - 5; http://dx.doi.org/10.1084/jem.20051395; PMID: 16103406
   PubMed Web of Science ®Google Scholar
• Shaw J, Wang YH, Ito T, Arima K, Liu YJ. Plasmacytoid dendritic cells regulate B-cell growth and differentiation via CD70. Blood 2010; 115:3051 - 7; http://dx.doi.org/10.1182/blood-2009-08-239145; PMID: 20139096
   PubMed Web of Science ®Google Scholar
• Asselin-Paturel C, Boonstra A, Dalod M, Durand I, Yessaad N, Dezutter-Dambuyant C, et al. Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology. Nat Immunol 2001; 2:1144 - 50; http://dx.doi.org/10.1038/ni736; PMID: 11713464
   PubMed Web of Science ®Google Scholar
• Björck P. Isolation and characterization of plasmacytoid dendritic cells from Flt3 ligand and granulocyte-macrophage colony-stimulating factor-treated mice. Blood 2001; 98:3520 - 6; http://dx.doi.org/10.1182/blood.V98.13.3520; PMID: 11739152
   PubMed Web of Science ®Google Scholar
• Villadangos JA, Young L. Antigen-presentation properties of plasmacytoid dendritic cells. Immunity 2008; 29:352 - 61; http://dx.doi.org/10.1016/j.immuni.2008.09.002; PMID: 18799143
   PubMed Web of Science ®Google Scholar
• Wilson NS, Villadangos JA. Regulation of antigen presentation and cross-presentation in the dendritic cell network: facts, hypothesis, and immunological implications. Adv Immunol 2005; 86:241 - 305; http://dx.doi.org/10.1016/S0065-2776(04)86007-3; PMID: 15705424
   PubMed Web of Science ®Google Scholar
• Dzionek A, Sohma Y, Nagafune J, Cella M, Colonna M, Facchetti F, et al. BDCA-2, a novel plasmacytoid dendritic cell-specific type II C-type lectin, mediates antigen capture and is a potent inhibitor of interferon alpha/beta induction. J Exp Med 2001; 194:1823 - 34; http://dx.doi.org/10.1084/jem.194.12.1823; PMID: 11748283
   PubMed Web of Science ®Google Scholar
• Villadangos JA, Schnorrer P, Wilson NS. Control of MHC class II antigen presentation in dendritic cells: a balance between creative and destructive forces. Immunol Rev 2005; 207:191 - 205; http://dx.doi.org/10.1111/j.0105-2896.2005.00317.x; PMID: 16181337
   PubMed Web of Science ®Google Scholar
• Jaehn PS, Zaenker KS, Schmitz J, Dzionek A. Functional dichotomy of plasmacytoid dendritic cells: antigen-specific activation of T cells versus production of type I interferon. Eur J Immunol 2008; 38:1822 - 32; http://dx.doi.org/10.1002/eji.200737552; PMID: 18581320
   PubMed Web of Science ®Google Scholar
• Meyer-Wentrup F, Benitez-Ribas D, Tacken PJ, Punt CJ, Figdor CG, de Vries IJ, et al. Targeting DCIR on human plasmacytoid dendritic cells results in antigen presentation and inhibits IFN-alpha production. Blood 2008; 111:4245 - 53; http://dx.doi.org/10.1182/blood-2007-03-081398; PMID: 18258799
   PubMed Web of Science ®Google Scholar
• Loschko J, Heink S, Hackl D, Dudziak D, Reindl W, Korn T, et al. Antigen targeting to plasmacytoid dendritic cells via Siglec-H inhibits Th cell-dependent autoimmunity. J Immunol 2011; 187:6346 - 56; http://dx.doi.org/10.4049/jimmunol.1102307; PMID: 22079988
   PubMed Web of Science ®Google Scholar
• Sharma MD, Baban B, Chandler P, Hou DY, Singh N, Yagita H, et al. Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase. J Clin Invest 2007; 117:2570 - 82; http://dx.doi.org/10.1172/JCI31911; PMID: 17710230
   PubMed Web of Science ®Google Scholar
• Kassner N, Krueger M, Yagita H, Dzionek A, Hutloff A, Kroczek R, et al. Cutting edge: Plasmacytoid dendritic cells induce IL-10 production in T cells via the Delta-like-4/Notch axis. J Immunol 2010; 184:550 - 4; http://dx.doi.org/10.4049/jimmunol.0903152; PMID: 20008296
   PubMed Web of Science ®Google Scholar
• Lee SM, Lee YS, Choi JH, Park SG, Choi IW, Joo YD, et al. Tryptophan metabolite 3-hydroxyanthranilic acid selectively induces activated T cell death via intracellular GSH depletion. Immunol Lett 2010; 132:53 - 60; http://dx.doi.org/10.1016/j.imlet.2010.05.008; PMID: 20570696
   PubMed Web of Science ®Google Scholar
• Munn DH, Sharma MD, Baban B, Harding HP, Zhang Y, Ron D, et al. GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase. Immunity 2005; 22:633 - 42; http://dx.doi.org/10.1016/j.immuni.2005.03.013; PMID: 15894280
   PubMed Web of Science ®Google Scholar
• Sharma MD, Baban B, Chandler P, Hou DY, Singh N, Yagita H, et al. Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase. J Clin Invest 2007; 117:2570 - 82; http://dx.doi.org/10.1172/JCI31911; PMID: 17710230
   PubMed Web of Science ®Google Scholar
• Prendergast GC. Immune escape as a fundamental trait of cancer: focus on IDO. Oncogene 2008; 27:3889 - 900; http://dx.doi.org/10.1038/onc.2008.35; PMID: 18317452
   PubMed Web of Science ®Google Scholar
• Sorrentino R, Gray P, Chen S, Shimada K, Crother TR, Arditi M. Plasmacytoid Dendritic Cells Prevent Cigarette Smoke and Chlamydophila pneumoniae—induced Th2 Inflammatory Responses. Am J Respir Cell Mol Biol 2010; 43:422 - 31; http://dx.doi.org/10.1165/rcmb.2009-0224OC; PMID: 19901344
   PubMed Web of Science ®Google Scholar
• Fallarino F, Grohmann U, You S, McGrath BC, Cavener DR, Vacca C, et al. The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor zeta-chain and induce a regulatory phenotype in naive T cells. J Immunol 2006; 176:6752 - 61; PMID: 16709834
   PubMed Web of Science ®Google Scholar
• Tokita D, Mazariegos GV, Zahorchak AF, Chien N, Abe M, Raimondi G, et al. High PD-L1/CD86 ratio on plasmacytoid dendritic cells correlates with elevated T-regulatory cells in liver transplant tolerance. Transplantation 2008; 85:369 - 77; http://dx.doi.org/10.1097/TP.0b013e3181612ded; PMID: 18301333
   PubMed Web of Science ®Google Scholar
• Puccetti P, Fallarino F. Generation of T cell regulatory activity by plasmacytoid dendritic cells and tryptophan catabolism. Blood Cells Mol Dis 2008; 40:101 - 5; http://dx.doi.org/10.1016/j.bcmd.2007.06.026; PMID: 17881253
   PubMed Web of Science ®Google Scholar
• Uyttenhove C, Pilotte L, Théate I, Stroobant V, Colau D, Parmentier N, et al. Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase. Nat Med 2003; 9:1269 - 74; http://dx.doi.org/10.1038/nm934; PMID: 14502282
   PubMed Web of Science ®Google Scholar
• Katz JB, Muller AJ, Prendergast GC. Indoleamine 2,3-dioxygenase in T-cell tolerance and tumoral immune escape. Immunol Rev 2008; 222:206 - 21; http://dx.doi.org/10.1111/j.1600-065X.2008.00610.x; PMID: 18364004
   PubMed Web of Science ®Google Scholar
• Vermi W, Soncini M, Melocchi L, Sozzani S, Facchetti F. Plasmacytoid dendritic cells and cancer. J Leukoc Biol 2011; 90:681 - 90; http://dx.doi.org/10.1189/jlb.0411190; PMID: 21730085
   PubMed Web of Science ®Google Scholar
• Liu C, Lou Y, Lizée G, Qin H, Liu S, Rabinovich B, et al. Plasmacytoid dendritic cells induce NK cell-dependent, tumor antigen-specific T cell cross-priming and tumor regression in mice. J Clin Invest 2008; 118:1165 - 75; PMID: 18259609
   PubMed Web of Science ®Google Scholar
• Erreni M, Mantovani A, Allavena P. Tumor-associated Macrophages (TAM) and Inflammation in Colorectal Cancer. Cancer Microenviron 2011; 4:141 - 54; http://dx.doi.org/10.1007/s12307-010-0052-5; PMID: 21909876
   PubMedGoogle Scholar
• Sorrentino R, Morello S, Luciano A, Crother TR, Maiolino P, Bonavita E, et al. Plasmacytoid dendritic cells alter the antitumor activity of CpG-oligodeoxynucleotides in a mouse model of lung carcinoma. J Immunol 2010; 185:4641 - 50; http://dx.doi.org/10.4049/jimmunol.1000881; PMID: 20855872
   PubMed Web of Science ®Google Scholar
• Bekeredjian-Ding I, Schäfer M, Hartmann E, Pries R, Parcina M, Schneider P, et al. Tumour-derived prostaglandin E and transforming growth factor-β synergize to inhibit plasmacytoid dendritic cell-derived interferon-α. Immunology 2009; 128:439 - 50; http://dx.doi.org/10.1111/j.1365-2567.2009.03134.x; PMID: 20067543
   PubMed Web of Science ®Google Scholar
• Bellocq A, Antoine M, Flahault A, Philippe C, Crestani B, Bernaudin JF, et al. Neutrophil alveolitis in bronchioloalveolar carcinoma: induction by tumor-derived interleukin-8 and relation to clinical outcome. Am J Pathol 1998; 152:83 - 92; PMID: 9422526
   PubMed Web of Science ®Google Scholar
• Voorzanger N, Touitou R, Garcia E, Delecluse HJ, Rousset F, Joab I, et al. Interleukin (IL)-10 and IL-6 are produced in vivo by non-Hodgkin’s lymphoma cells and act as cooperative growth factors. Cancer Res 1996; 56:5499 - 505; PMID: 8968107
   PubMed Web of Science ®Google Scholar
• Kurtz J, Raval F, Vallot C, Der J, Sykes M. CTLA-4 on alloreactive CD4 T cells interacts with recipient CD80/86 to promote tolerance. Blood 2009; 113:3475 - 84; http://dx.doi.org/10.1182/blood-2008-01-133736; PMID: 19179471
   PubMed Web of Science ®Google Scholar
• Pallotta MT, Orabona C, Volpi C, Vacca C, Belladonna ML, Bianchi R, et al. Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells. Nat Immunol 2011; 12:870 - 8; http://dx.doi.org/10.1038/ni.2077; PMID: 21804557
   PubMed Web of Science ®Google Scholar
• Tsukamoto N, Okada S, Onami Y, Sasaki Y, Umezawa K, Kawakami Y. Impairment of plasmacytoid dendritic cells for IFN production by the ligand for immunoglobulin-like transcript 7 expressed on human cancer cells. Clin Cancer Res 2009; 15:5733 - 43; http://dx.doi.org/10.1158/1078-0432.CCR-09-0171; PMID: 19723650
   PubMed Web of Science ®Google Scholar
• de Heer HJ, Hammad H, Soullié T, Hijdra D, Vos N, Willart MA, et al. Essential role of lung plasmacytoid dendritic cells in preventing asthmatic reactions to harmless inhaled antigen. J Exp Med 2004; 200:89 - 98; http://dx.doi.org/10.1084/jem.20040035; PMID: 15238608
   PubMed Web of Science ®Google Scholar
• Smit JJ, Lindell DM, Boon L, Kool M, Lambrecht BN, Lukacs NW. The balance between plasmacytoid DC versus conventional DC determines pulmonary immunity to virus infections. PLoS One 2008; 3:e1720; http://dx.doi.org/10.1371/journal.pone.0001720; PMID: 18320041
   PubMedGoogle Scholar
• Bratke K, Klein C, Kuepper M, Lommatzsch M, Virchow JC. Differential development of plasmacytoid dendritic cells in Th1- and Th2-like cytokine milieus. Allergy 2011; 66:386 - 95; http://dx.doi.org/10.1111/j.1398-9995.2010.02497.x; PMID: 21039603
   PubMed Web of Science ®Google Scholar
• Battaglia M, Gianfrani C, Gregori S, Roncarolo MG. IL-10-producing T regulatory type 1 cells and oral tolerance. Ann N Y Acad Sci 2004; 1029:142 - 53; http://dx.doi.org/10.1196/annals.1309.031; PMID: 15681753
   PubMed Web of Science ®Google Scholar
• Lesterhuis WJ, Aarntzen EH, De Vries IJ, Schuurhuis DH, Figdor CG, Adema GJ, et al. Dendritic cell vaccines in melanoma: from promise to proof?. Crit Rev Oncol Hematol 2008; 66:118 - 34; http://dx.doi.org/10.1016/j.critrevonc.2007.12.007; PMID: 18262431
   PubMed Web of Science ®Google Scholar
• Hurtado P, Peh CA. LL-37 promotes rapid sensing of CpG oligodeoxynucleotides by B lymphocytes and plasmacytoid dendritic cells. J Immunol 2010; 184:1425 - 35; http://dx.doi.org/10.4049/jimmunol.0902305; PMID: 20042575
   PubMed Web of Science ®Google Scholar
• Chuang CM, Monie A, Wu A, Mao CP, Hung CF. Treatment with LL-37 peptide enhances antitumor effects induced by CpG oligodeoxynucleotides against ovarian cancer. Hum Gene Ther 2009; 20:303 - 13; http://dx.doi.org/10.1089/hum.2008.124; PMID: 19272013
   PubMed Web of Science ®Google Scholar
• Allavena P, Sica A, Solinas G, Porta C, Mantovani A. The inflammatory micro-environment in tumor progression: the role of tumor-associated macrophages. Crit Rev Oncol Hematol 2008; 66:1 - 9; http://dx.doi.org/10.1016/j.critrevonc.2007.07.004; PMID: 17913510
   PubMed Web of Science ®Google Scholar
• Schlecht G, Garcia S, Escriou N, Freitas AA, Leclerc C, Dadaglio G. Murine plasmacytoid dendritic cells induce effector/memory CD8+ T-cell responses in vivo after viral stimulation. Blood 2004; 104:1808 - 15; http://dx.doi.org/10.1182/blood-2004-02-0426; PMID: 15166034
   PubMed Web of Science ®Google Scholar
• Aspord C, Charles J, Leccia MT, Laurin D, Richard MJ, Chaperot L, et al. A novel cancer vaccine strategy based on HLA-A*0201 matched allogeneic plasmacytoid dendritic cells. PLoS One 2010; 5:e10458; http://dx.doi.org/10.1371/journal.pone.0010458; PMID: 20454561
   PubMed Web of Science ®Google Scholar
• Lou Y. liu C, Kim GJ, Liu Y-J, Hwu P., Wang G. Plasmacytoid dendritic cells synergize with myeloid dendritic cells ie induction of antigen-specific antitumour immune responses. J Immunol 2007; 178:1534 - 41; PMID: 17237402
   PubMed Web of Science ®Google Scholar
• Lonsdorf AS, Kuekrek H, Stern BV, Boehm BO, Lehmann PV, Tary-Lehmann M. Intratumor CpG-oligodeoxynucleotide injection induces protective antitumor T cell immunity. J Immunol 2003; 171:3941 - 6; PMID: 14530311
   PubMed Web of Science ®Google Scholar
• Interleukin-3 receptor alpha chain (CD123) is widely expressed in hematologic malignancies.Muñoz L, Nomdedéu JF, López O, Carnicer MJ, Bellido M, Aventín A, Brunet S. Sierra J.Haematologica 2001; 86:1261 - 9
   Google Scholar
• Manavalan JS, Rossi PC, Vlad G, Piazza F, Yarilina A, Cortesini R, et al. High expression of ILT3 and ILT4 is a general feature of tolerogenic dendritic cells. Transpl Immunol 2003; 11:245 - 58; http://dx.doi.org/10.1016/S0966-3274(03)00058-3; PMID: 12967778
   PubMed Web of Science ®Google Scholar
• Cho M, Ishida K, Chen J, Ohkawa J, Chen W, Namiki S, et al. SAGE library screening reveals ILT7 as a specific plasmacytoid dendritic cell marker that regulates type I IFN production. Int Immunol 2008; 20:155 - 64; http://dx.doi.org/10.1093/intimm/dxm127; PMID: 18048391
   PubMed Web of Science ®Google Scholar
• Sadhu C, Ting HJ, Lipsky B, Hensley K, Garcia-Martinez LF, Simon SI, et al. CD11c/CD18: novel ligands and a role in delayed-type hypersensitivity. J Leukoc Biol 2007; 81:1395 - 403; http://dx.doi.org/10.1189/jlb.1106680; PMID: 17389580
   PubMed Web of Science ®Google Scholar