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OncoImmunology Volume 1, 2012 - Issue 7
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Targeting the right regulatory T-cell population for tumor immunotherapy

Vivian L. Weiss The Sidney Kimmel Cancer Center; Johns Hopkins University School of Medicine; Baltimore, MD USA; Department of Oncology; Johns Hopkins University School of Medicine; Baltimore, MD USA; Graduate Program in Immunology; Johns Hopkins School of Medicine; Baltimore, MD USA
,
Timothy H. Lee The Sidney Kimmel Cancer Center; Johns Hopkins University School of Medicine; Baltimore, MD USA; Department of Oncology; Johns Hopkins University School of Medicine; Baltimore, MD USA
,
Elizabeth M. Jaffee The Sidney Kimmel Cancer Center; Johns Hopkins University School of Medicine; Baltimore, MD USA; Department of Oncology; Johns Hopkins University School of Medicine; Baltimore, MD USA; Graduate Program in Immunology; Johns Hopkins School of Medicine; Baltimore, MD USA; Graduate Programs in Cellular and Molecular Medicine and Pharmacology; Johns Hopkins School of Medicine; Baltimore, MD USA; The Skip Viragh Pancreatic Cancer Center; Johns Hopkins School of Medicine; Baltimore, MD USA
&
Todd D. Armstrong The Sidney Kimmel Cancer Center; Johns Hopkins University School of Medicine; Baltimore, MD USA; Department of Oncology; Johns Hopkins University School of Medicine; Baltimore, MD USACorrespondence[email protected]
Pages 1191-1193 | Received 07 May 2012, Accepted 07 May 2012, Published online: 01 Oct 2012

References

  • Jacobs JF, Punt CJ, Lesterhuis WJ, Sutmuller RP, Brouwer HM, Scharenborg NM, et al. Dendritic cell vaccination in combination with anti-CD25 monoclonal antibody treatment: a phase I/II study in metastatic melanoma patients. Clin Cancer Res 2010; 16:5067 - 78; http://dx.doi.org/10.1158/1078-0432.CCR-10-1757; PMID: 20736326
  • Quezada SA, Peggs KS, Simpson TR, Shen Y, Littman DR, Allison JP. Limited tumor infiltration by activated T effector cells restricts the therapeutic activity of regulatory T cell depletion against established melanoma. J Exp Med 2008; 205:2125 - 38; http://dx.doi.org/10.1084/jem.20080099; PMID: 18725522
  • Ercolini AM, Ladle BH, Manning EA, Pfannenstiel LW, Armstrong TD, Machiels JP, et al. Recruitment of latent pools of high-avidity CD8(+) T cells to the antitumor immune response. J Exp Med 2005; 201:1591 - 602; http://dx.doi.org/10.1084/jem.20042167; PMID: 15883172
  • Weiss VL, Lee TH, Song H, Kouo TS, Black CM, Sgouros G, et al. Trafficking of high avidity HER-2/neu-specific T cells into HER-2/neu-expressing tumors after depletion of effector/memory-like regulatory T cells. PLoS One 2012; 7:e31962; http://dx.doi.org/10.1371/journal.pone.0031962; PMID: 22359647
  • Huehn J, Siegmund K, Lehmann JC, Siewert C, Haubold U, Feuerer M, et al. Developmental stage, phenotype, and migration distinguish naive- and effector/memory-like CD4+ regulatory T cells. J Exp Med 2004; 199:303 - 13; http://dx.doi.org/10.1084/jem.20031562; PMID: 14757740
  • Leao IC, Ganesan P, Armstrong TD, Jaffee EM. Effective depletion of regulatory T cells allows the recruitment of mesothelin-specific CD8 T cells to the antitumor immune response against a mesothelin-expressing mouse pancreatic adenocarcinoma. Clin Transl Sci 2008; 1:228 - 39; http://dx.doi.org/10.1111/j.1752-8062.2008.00070.x; PMID: 20357913
  • Uram JN, Black CM, Flynn E, Huang L, Armstrong TD, Jaffee EM. Nondominant CD8 T cells are active players in the vaccine-induced antitumor immune response. J Immunol 2011; 186:3847 - 57; http://dx.doi.org/10.4049/jimmunol.1000361; PMID: 21346233
  • Mitchell DA, Cui X, Schmittling RJ, Sanchez-Perez L, Snyder DJ, Congdon KL, et al. Monoclonal antibody blockade of IL-2 receptor α during lymphopenia selectively depletes regulatory T cells in mice and humans. Blood 2011; 118:3003 - 12; http://dx.doi.org/10.1182/blood-2011-02-334565; PMID: 21768296

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