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OncoImmunology Volume 1, 2012 - Issue 9
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Trogocytosis generates acquired regulatory T cells adding further complexity to the dysfunctional immune response in multiple myeloma

Ross Brown Institute of Haematology; Royal Prince Alfred Hospital; Sydney, AustraliaCorrespondence[email protected]
,
Hayley Suen Institute of Haematology; Royal Prince Alfred Hospital; Sydney, Australia
,
James Favaloro Institute of Haematology; Royal Prince Alfred Hospital; Sydney, Australia
,
Shihong Yang Institute of Haematology; Royal Prince Alfred Hospital; Sydney, Australia
,
P. Joy Ho Institute of Haematology; Royal Prince Alfred Hospital; Sydney, Australia
,
John Gibson Institute of Haematology; Royal Prince Alfred Hospital; Sydney, Australia
&
Douglas Joshua Institute of Haematology; Royal Prince Alfred Hospital; Sydney, Australia
 show all
Pages 1658-1660 | Published online: 06 Dec 2012

References

  • Brown R, Kabani K, Favaloro J, Yang S, Ho PJ, Gibson J, et al. CD86+ or HLA-G+ can be transferred via trogocytosis from myeloma cells to T cells and are associated with poor prognosis. Blood 2012; 120:2055 - 63; http://dx.doi.org/10.1182/blood-2012-03-416792; PMID: 22705596
  • Curiel TJ. Tregs and rethinking cancer immunotherapy. J Clin Invest 2007; 117:1167 - 74; http://dx.doi.org/10.1172/JCI31202; PMID: 17476346
  • Li J, Sze DM, Brown RD, Cowley MJ, Kaplan W, Mo SL, et al. Clonal expansions of cytotoxic T cells exist in the blood of patients with Waldenstrom macroglobulinemia but exhibit anergic properties and are eliminated by nucleoside analogue therapy. Blood 2010; 115:3580 - 8; http://dx.doi.org/10.1182/blood-2009-10-246991; PMID: 20190191
  • Raitakari M, Brown RD, Sze D, Yuen E, Barrow L, Nelson M, et al. T-cell expansions in patients with multiple myeloma have a phenotype of cytotoxic T cells. Br J Haematol 2000; 110:203 - 9; http://dx.doi.org/10.1046/j.1365-2141.2000.02131.x; PMID: 10930999
  • Brown RD, Spencer A, Ho PJ, Kennedy N, Kabani K, Yang S, et al. Prognostically significant cytotoxic T cell clones are stimulated after thalidomide therapy in patients with multiple myeloma. Leuk Lymphoma 2009; 50:1860 - 4; http://dx.doi.org/10.3109/10428190903216804; PMID: 19883313
  • Sze DM-Y, Giesajtis G, Brown RD, Raitakari M, Gibson J, Ho J, et al. Clonal cytotoxic T cells are expanded in myeloma and reside in the CD8(+)CD57(+)CD28(-) compartment. Blood 2001; 98:2817 - 27; http://dx.doi.org/10.1182/blood.V98.9.2817; PMID: 11675356
  • Brown RD, Pope B, Murray A, Esdale W, Hart D, Gibson J, et al. Dendritic cells from patients with myeloma are numerically normal but functionally defective as they fail to up-regulate CD80 (B7-1) expression after huCD40LT stimulation because of inhibition by transforming growth factor-beta1 and interleukin-10. Blood 2001; 98:2992 - 8; http://dx.doi.org/10.1182/blood.V98.10.2992; PMID: 11698282
  • Brown R, Murray A, Pope B, Sze DM, Gibson J, Ho PJ, et al. Either interleukin-12 or interferon-gamma can correct the dendritic cell defect induced by transforming growth factor beta in patients with myeloma. Br J Haematol 2004; 125:743 - 8; http://dx.doi.org/10.1111/j.1365-2141.2004.04984.x; PMID: 15180863
  • Joshua DE, Brown RD, Ho PJ, Gibson J. Regulatory T cells and multiple myeloma. Clin Lymphoma Myeloma 2008; 8:283 - 6; http://dx.doi.org/10.3816/CLM.2008.n.039; PMID: 18854282
  • LeMaoult J, Caumartin J, Daouya M, Favier B, Le Rond S, Gonzalez A, et al. Immune regulation by pretenders: cell-to-cell transfers of HLA-G make effector T cells act as regulatory cells. Blood 2007; 109:2040 - 8; http://dx.doi.org/10.1182/blood-2006-05-024547; PMID: 17077329

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